Search Results - (Author, Cooperation:J. E. Thornton)
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1Latest Papers from Table of Contents or Articles in PressK. Xu ; Z. J. Wu ; A. C. Groner ; H. H. He ; C. Cai ; R. T. Lis ; X. Wu ; E. C. Stack ; M. Loda ; T. Liu ; H. Xu ; L. Cato ; J. E. Thornton ; R. I. Gregory ; C. Morrissey ; R. L. Vessella ; R. Montironi ; C. Magi-Galluzzi ; P. W. Kantoff ; S. P. Balk ; X. S. Liu ; M. Brown
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-12-15Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Castration ; Cell Line, Tumor ; Cohort Studies ; Gene Expression Regulation, Neoplastic ; Gene Silencing ; Humans ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Male ; Methyltransferases/chemistry/genetics/metabolism ; Mice ; Mice, Inbred ICR ; Mice, SCID ; Oncogene Proteins/genetics/*metabolism ; Polycomb Repressive Complex 2/genetics/*metabolism ; Prostatic Neoplasms/genetics/*metabolism/mortality ; Protein Structure, Tertiary ; Receptors, Androgen/metabolism ; Xenograft Model Antitumor AssaysPublished by: -
2Latest Papers from Table of Contents or Articles in PressH. M. Chang ; R. Triboulet ; J. E. Thornton ; R. I. Gregory
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-04-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cells, Cultured ; Embryonic Stem Cells/metabolism ; Exonucleases/*metabolism ; Exoribonucleases/*metabolism ; Fetal Macrosomia/*enzymology/*genetics/metabolism ; HEK293 Cells ; Humans ; Mice ; MicroRNAs/genetics/*metabolism ; RNA Precursors/genetics/metabolism ; RNA Processing, Post-Transcriptional ; *RNA Stability ; RNA-Binding Proteins/*metabolism ; Ribonucleases/*metabolism ; Substrate Specificity ; Uridine Monophosphate/analogs & derivatives/metabolism ; Wilms Tumor/*enzymology/etiology/*genetics/metabolismPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 1432-1955Keywords: AbbreviationsMBHA 4-Methyl benzhydral amine Peptidyl-MIMs Synthetic peptidyl membrane-interactive molecules ; pMIMs Peptidyl-MIMs ; PBEL Parasite Biology and Epidemiology LaboratorySource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract This study examined the lytic effect of seven different synthetic peptidyl membrane-interactive molecules (Peptidyl-MIMs) on sporozoites of five different species of Eimeria infecting chickens and merozoites of two different species that infect chickens. All Peptidyl-MIMs (pMIMs) demonstrated antiparasitic effects at concentrations of 1–50 μM during incubation periods varying from 1 to 20 min. In addition, electron microscopy showed that ultrastructural degeneration of the pellicle of sporozoite stages of the parasites occurred within 5–10 min of exposure to 5-μM concentrations of three different pMIMs. Pore-like openings were seen in the pellicle of the sporozoites at the ultrastructural level, which indicated that the pMIMs had the same mechanism of action on the parasites as that reported from studies done on bacteria. A reduction in lesion scores was seen in chickens treated orally with 10-, 50-, or ␣␣␣␣␣75-μM concentrations of two different proteolytic stabilized (methylated) pMIMs after challenge with three different species of avian coccidia in battery-cage trials. Collectively these data indicate that pMIMs may be useful in the control of coccidiosis in poultry.Type of Medium: Electronic ResourceURL: