Search Results - (Author, Cooperation:J. Dissing)
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1Latest Papers from Table of Contents or Articles in PressM. Raghavan ; M. DeGiorgio ; A. Albrechtsen ; I. Moltke ; P. Skoglund ; T. S. Korneliussen ; B. Gronnow ; M. Appelt ; H. C. Gullov ; T. M. Friesen ; W. Fitzhugh ; H. Malmstrom ; S. Rasmussen ; J. Olsen ; L. Melchior ; B. T. Fuller ; S. M. Fahrni ; T. Stafford, Jr. ; V. Grimes ; M. A. Renouf ; J. Cybulski ; N. Lynnerup ; M. M. Lahr ; K. Britton ; R. Knecht ; J. Arneborg ; M. Metspalu ; O. E. Cornejo ; A. S. Malaspinas ; Y. Wang ; M. Rasmussen ; V. Raghavan ; T. V. Hansen ; E. Khusnutdinova ; T. Pierre ; K. Dneprovsky ; C. Andreasen ; H. Lange ; M. G. Hayes ; J. Coltrain ; V. A. Spitsyn ; A. Gotherstrom ; L. Orlando ; T. Kivisild ; R. Villems ; M. H. Crawford ; F. C. Nielsen ; J. Dissing ; J. Heinemeier ; M. Meldgaard ; C. Bustamante ; D. H. O'Rourke ; M. Jakobsson ; M. T. Gilbert ; R. Nielsen ; E. Willerslev
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-08-30Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Alaska/ethnology ; Arctic Regions/ethnology ; Base Sequence ; Bone and Bones ; Canada/ethnology ; DNA, Mitochondrial/genetics ; Genome, Human/*genetics ; Greenland/ethnology ; Hair ; History, Ancient ; *Human Migration ; Humans ; Inuits/ethnology/*genetics/history ; Molecular Sequence Data ; Siberia/ethnology ; Survivors/history ; ToothPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1573-5036Source: Springer Online Journal Archives 1860-2000Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Summary Results of a laboratory investigation showed that among soils in Denmark it are chiefly those rich in clay minerals that will fix and release potassium and ammonium. The two cations were fixed in nearly equivalent proportions, but ammonium was fixed preferentially to potassium when added together to the soil. The maximum fixation reached 20 to 30 per cent of the addition in top soil layer but 50 to 80 in subsoil. Soils from a permanent fertilizer experiment showed the strongest fixation and least release of potassium where no potassic fertilizer had been applied for more than 70 years. In soils from another field experiment on residual effect of various nitrogenous fertilizers there was a small but significant increase in content of inorganically fixed ammonium where urea had been applied.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1573-5036Source: Springer Online Journal Archives 1860-2000Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Summary Results of a laboratory investigation showed that among soils in Denmark it are chiefly those rich in clay minerals that will fix and release potassium and ammonium. The two cations were fixed in nearly equivalent proportions, but ammonium was fixed preferentially to potassium when added together to the soil. The maximum fixation reached 20 to 30 per cent of the addition in top soil layer but 50 to 80 in subsoil. Soils from a permanent fertilizer experiment showed the strongest fixation and least release of potassium where no potassic fertilizer had been applied for more than 70 years. In soils from another field experiment on residual effect of various nitrogenous fertilizers there was a small but significant increase in content of inorganically fixed ammonium where urea had been applied.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1573-5036Source: Springer Online Journal Archives 1860-2000Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Summary The effect of nitrogen applications on the amino acid composition of wheat grain was studied in a pot experiment, in which spring wheat was supplied with increasing amounts of ammonium sulphate. The ensuing yield curve extended from very small N-applications to applications resulting in a toxic effect on the yield. The contents of dry matter, total N, 15 amino acids and ammonia were determined in samples taken from 9 representative treatments. The relationship between the yield of dry matter and the concentration in the dry matte rof the individual amino acids showed the same characteristic variations as those previously found for total N and for a number of plant nutrients. In accordance with the results cited in the literature, increasing applications of N caused an increase of glumatic acid and proline on a nitrogen basis, whereas lysine and arginine decreased.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesInvestigations on the relationship between P-fertility, phosphatase activity and ATP content in soilStaff View
ISSN: 1573-5036Keywords: ATP ; P-fertility ; Phosphatase ; SoilSource: Springer Online Journal Archives 1860-2000Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Summary It was shown from laboratory investigations of P depleted soil that phosphatase activity and ATP content were dependent partly on the content of plant available P and partly on the root intensity in soils. Phosphatase activity and ATP content were higher in soil samples from plots supplied with P compared with plots not receiving any P. Addition of phosphatase to soil or pure sand was only to a small extent followed by an increase in phosphatase activity.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: An enzyme activity, enolase (2-phospho-D-glycerate hydro-lyase, E.C. 4.2.1.11), was shown to be connected to the brain-specific protein 14.3.2. Specific staining methods were used on immuno precipitates of the protein. The enzyme activity was strongly inhibited by the addition of fluoride in the presence of phosphate. Metal ion binding capacity of the protein was shown by means of an auto radiographic method.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0005-2744Keywords: (Affinity chromatography) ; Acid phosphatase inhibitor ; Arsonic acid ; Phosphonic acidSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0167-4838Keywords: Allelic product ; Alternative splicing ; Amino acid sequence ; Cytosolic ; Erythrocyte ; Signature sequenceSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicineType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0167-4838Keywords: ACP1 ; Acid phosphatase ; Effector ; Isozyme ; Kinetics ; Parasteric binding ; Phenotypic differenceSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0167-4838Keywords: (Human red cell) ; Amino acid composition ; Enzyme kinetics ; Erythrocyte acid phosphatase (ACP1) ; Transition temperatureSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0165-4608Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-1203Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Genetic markers controlled by 21 genetic systems were studied in 13 families containing members suffering from various hereditary disorders involving ataxia. Classical cerebellar ataxia was present in four, Friedreich ataxia in two, hereditary spastic paraplegia in four, and the Charcot-Marie-Tooth syndrome in three families. In each family, every available member above the lowest age at onset observed in that family, was subjected to a thorough clinical investigation and blood was sampled for investigation of genetic markers. The families with cerebellar ataxia and with Charcot-Marie-Tooth syndrome contained enough informative relatives to allow a formal linkage study using the lodscore method. Three of the pedigress with cerebellar ataxia gave evidence of linkage between the disease and the HLA system with a combined lodscore of 2.128 at a recombination fraction θ of 0.05 for both sexes combined. The recombination fraction was considerably higher in females than in males, although the difference between the two sexes was not statistically significant. Negative lodscores were obtained for the remaining family with cerebellar ataxia, which might be due to the fact that this family only provided information on recombination in females. However, the clinical features in this family differed from those in the other three families by a significantly higher frequency of dementia and pyramidal tract lesions. Based on these observations and on contradictory results in the literature concerning linkage between cerebellar ataxia and HLA, we suggest that there are two forms of cerebellar ataxia: One (CA1) linked to HLA with symptoms restricted to lesions in the cerebellum and spinocerebellar system and another (CA2) not linked to HLA with symptoms from more wide-spread lesions of the CNS. None of the other genetic markers (except perhaps GLO) showed linkage to the cerebellar ataxias. Negative lodscores throughout with all 21 genetic markers were found in the families with Charcot-Marie-Tooth syndrome. There was no evidence for linkage between HLA on the one hand and Friedreich ataxia or hereditary spastic paraplegia on the other.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1573-4927Keywords: erythrocyte acid phosphatase (ACP1) ; isozymes ; peptide mapping ; high-performance liquid chromatography (HPLC) ; alternative mRNA splicingSource: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyNotes: Abstract Molecular properties of the two isozymes expressed by the B allele at the red cell acid phosphatase locus (ACP1) have been studied to distinguish between possible mechanisms for their production. The difference in electric charge exhibited by the native isozymes was retained under denaturing conditions; the unfolded peptide chains renatured without conversion of one form to the other. Chromatographic analysis [thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC)] of tryptic digests showed 12 peptides common to both isozymes but also revealed 5 peptides unique to one isozyme and 3 (possibly 4) peptides unique to the other. These findings argue against both conformational isomerization and simple posttranslational modification as the mechanism of generation of the two isozymes. We suggest that the two isozymes are synthesized as discrete molecular entities.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1573-4927Keywords: erythrocyte acid phosphatase (ACP1) ; isozymes ; immunochemical properties ; quantitationSource: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyNotes: Abstract An immunological study was performed on human red cell acid phosphatase (ACP1) isozymes encoded by different alleles, each of which is expressed as an electrophoretically fast (f) isozyme and a slow (s) isozyme. These isozymes reacted as two immunochemically different groups. Allele-specific reactions were not detected between either the f isozymes or the s isozymes. Quantitation of ACP1 isozymes in red cells by crossed immunoelectrophoresis revealed a phenotype-dependent variation in the concentration of isozyme protein. A simple gene dosage effect was indicated and the ordering of the ACP1 alleles (ACP1*A 〈 ACP1*B 〈 ACP1*C 〈 ACP1*E) was identical to that found for enzyme activity levels. Also, an allele effect on the proportion between s and f isozymes (s/f) was observed; the ordering here was ACP1* B 〈 ACP1*A 〈 ACP1*, which is the same as that reported for the susceptibility to modulation with purines. These variations in isozyme protein levels appear to account for the phenotypic differences in the intensity of the isozyme bands, when activity-stained after electrophoresis, and in the red cell enzyme activity levels. Investigation of two carriers of a Null allele showed no evidence of an aberrant protein product, and half-normal concentrations of enzyme protein were observed in the red cells of these individuals.Type of Medium: Electronic ResourceURL: