Search Results - (Author, Cooperation:J. D. Neill)
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1Latest Papers from Table of Contents or Articles in PressD. C. Martin ; M. Matuszewski ; P. Morrissey ; J. D. Neill ; A. Moore ; S. Cantalupo ; J. X. Prochaska ; D. Chang
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-08-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressS. Gezari ; R. Chornock ; A. Rest ; M. E. Huber ; K. Forster ; E. Berger ; P. J. Challis ; J. D. Neill ; D. C. Martin ; T. Heckman ; A. Lawrence ; C. Norman ; G. Narayan ; R. J. Foley ; G. H. Marion ; D. Scolnic ; L. Chomiuk ; A. Soderberg ; K. Smith ; R. P. Kirshner ; A. G. Riess ; S. J. Smartt ; C. W. Stubbs ; J. L. Tonry ; W. M. Wood-Vasey ; W. S. Burgett ; K. C. Chambers ; T. Grav ; J. N. Heasley ; N. Kaiser ; R. P. Kudritzki ; E. A. Magnier ; J. S. Morgan ; P. A. Price
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-05-12Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The interaction of purified preparations of human and simian (rhesus monkey) luteinizing hormone and follicle stimulating hormone with antibodies against several human gonadotropins was studied with a modification of the radioimmunoassay devised for insulin by Herbert et al.s. Human pituitary LH ...Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Keywords: Key words. Molecular recognition; ouabain; Na+ K+ ATPase; vasopressin-neurophysin; glycopeptide 1-39; complementary peptide; ouabain-like peptide.Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract. The molecular recognition hypothesis for peptides is that binding sites of ligands and their receptors are encoded by short, complementary segments of DNA. A corollary hypothesis for nonpeptide ligands posited here is that peptide replicas may be encoded by the DNA segment complementary to the receptor binding sites for nonpeptides. This corollary was tested for digitalis, a family of cardiotonic and natriuretic steroids including ouabain. A hexapeptide (ouabain-like peptide, OLP) complementary to a ouabain binding site on sodium/potassium dependent adenosine triphosphatase (Na+ K+ ATPase) exhibited activity in a digitalis bioassay. Antisera to the complementary peptide (OLP) stained the neurohypophysis in an immunocytochemical procedure. The complementary peptide was found to share an identical 4-amino acid region with the 39-amino acid glycopeptide moiety of the vasopressin-neurophysin precursor. This glycopeptide was isolated from pituitary extracts; it exhibited digitalis-like activity in the submicromolar range and cross-reacted with complementary peptide antibodies. Another digitalis-like substance with high activity also was detected in the extracts. These results demonstrate that the vasopressin-neurophysin glycopeptide has digitalis-like activity. Moreover, the findings are consistent with the hypothesis that peptide mimetics of nonpeptides are encoded in the genome.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1432-1041Keywords: oxprenolol ; propranolol ; sotalol ; slow release preparation ; plasma level ; exercise tachycardiaSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Summary Observations were made in 5 healthy subjects who exercised before and 1, 3, 6, 8 and 24 h after the oral administration on separate occasions of 160 mg oxprenolol, 160 mg slow release oxprenolol, 160 mg long acting propranolol and 400 mg sotalol. Blood samples were obtained before and at 1, 2, 3, 6, 8, 10 and 24 h after drug administration and assayed for drug concentration. Although the plasma concentration of oxprenolol after S. R. oxprenolol was significantly less at 1 and 2 h and significantly greater at 24 h than after conventional oxprenolol, there was little difference between the effects of the two drugs on an exercise tachycardia. The plasma level of propranolol and the reduction in an exercise tachycardia after L. A. propranolol increased slowly to reach a peak at 6 h and then declined gradually to 24 h. The maximum plasma concentration and effect after sotalol occurred at 3 h and then declined with an elimination half-life of 12.1 h. At 24 h the percentage reduction in an exercise tachycardia was 8.3±2.5 after oxprenolol, 10.0±2.3 after S. R. oxprenolol, 18.0±3.2 after L. A. propranolol and 14.7±3.4% after sotalol.Type of Medium: Electronic ResourceURL: