Search Results - (Author, Cooperation:J. C. Morris)
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1Latest Papers from Table of Contents or Articles in PressC. Cruchaga ; C. M. Karch ; S. C. Jin ; B. A. Benitez ; Y. Cai ; R. Guerreiro ; O. Harari ; J. Norton ; J. Budde ; S. Bertelsen ; A. T. Jeng ; B. Cooper ; T. Skorupa ; D. Carrell ; D. Levitch ; S. Hsu ; J. Choi ; M. Ryten ; J. Hardy ; D. Trabzuni ; M. E. Weale ; A. Ramasamy ; C. Smith ; C. Sassi ; J. Bras ; J. R. Gibbs ; D. G. Hernandez ; M. K. Lupton ; J. Powell ; P. Forabosco ; P. G. Ridge ; C. D. Corcoran ; J. T. Tschanz ; M. C. Norton ; R. G. Munger ; C. Schmutz ; M. Leary ; F. Y. Demirci ; M. N. Bamne ; X. Wang ; O. L. Lopez ; M. Ganguli ; C. Medway ; J. Turton ; J. Lord ; A. Braae ; I. Barber ; K. Brown ; P. Passmore ; D. Craig ; J. Johnston ; B. McGuinness ; S. Todd ; R. Heun ; H. Kolsch ; P. G. Kehoe ; N. M. Hooper ; E. R. Vardy ; D. M. Mann ; S. Pickering-Brown ; N. Kalsheker ; J. Lowe ; K. Morgan ; A. David Smith ; G. Wilcock ; D. Warden ; C. Holmes ; P. Pastor ; O. Lorenzo-Betancor ; Z. Brkanac ; E. Scott ; E. Topol ; E. Rogaeva ; A. B. Singleton ; M. I. Kamboh ; P. St George-Hyslop ; N. Cairns ; J. C. Morris ; J. S. Kauwe ; A. M. Goate
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-12-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: African Americans/genetics ; Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease/*genetics/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Brain/metabolism ; Case-Control Studies ; Europe/ethnology ; Exome/genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Genetic Variation/*genetics ; Humans ; Male ; Peptide Fragments/metabolism ; Phospholipase D/deficiency/*genetics/metabolism ; Protein Processing, Post-Translational/genetics ; ProteolysisPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1432-0533Keywords: Leukoencephalopathy ; glycosaminoglycans ; Binswanger's disease ; Cerebral blood vessels ; DementiaSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Three cases of adult dementia with periventricular leukoencephalopathy demonstrated staining with alcian blue dye (alcianophilia) in thickened cerebral arteries and arterioles of the abnormal white matter. The property of alcianophilia identifies glycosaminoglycans (GAGs); retention of alcian blue staining at high MgCl2 concentrations (0.7 M) in these cases indicates that the GAGs are highly sulfated and are likely to represent heparan sulfate. Arteriosclerotic risk factors (including hypertension) were absent in all cases, suggesting that GAG deposition occurred as part of a separate cerebral vasculopathic process. These findings suggest that cerebral white matter changes associated with dementia do not always represent Binswanger's disease.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1435-1463Keywords: Tyrosine hydroxylase ; ventral tegmental area ; perforant pathway ; neural fibrillary tangles ; Parkinson's disease ; Alzheimer's diseaseSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary We used tyrosine hydroxylase immunoreactivity (TH) to mark dopaminergic fibers in cerebral tissue from adult persons with Parkinson's disease (PD) or Alzheimer's disease (AD). In the PD cases we found a loss of dopaminergic neurons in the ventral tegmental area (VTA), severely reduced TH fibers in dopaminergic terminal fields (particularly in the hippocampal perforant pathway) and neurofibrillary tangles (NFT), that occurred only in the perforant pathway. In contrast, AD cases were characterized by a lack of significant neuron loss in the VTA and by mild loss of TH fibers. A decreased dopaminergic innervation of the perforant pathway in cases of PD appears to be associated with the occurrence of NFT in these structures.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0887-624XKeywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: Copolyesters of trans-4,4-stilbenedicarboxylic acid (SDA), terephthalic acid, and 1,4-butanediol exhibit thermotropic liquid crystallinity if at least 40 mol % SDA is present (acids total 100 mol %); SDA/2,6-naphthalenedicarboxylic acid/1,4-butanediol copolyesters are liquid crystalline if at least 30 mol % SDA is present. The effects of SDA content on the thermal, rheological, plastic, and fiber properties of the copolyesters were determined. The SDA component increases the relaxation times of the polymers and enables injection-molded plastics and melt-spun fibers to have significantly increased tensile strength and stiffness.Additional Material: 7 Ill.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0887-624XKeywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: In our recent overview of liquid crystalline polyesters of trans-4,4′-stilbenedicarboxylic acid (SDA) and aliphatic glycols,1 we reported that “… the 1,3-propanediol polyester did not exhibit thermotropic liquid crystallinity (no stir opalescence or DSC endotherm above Tm), perhaps because of the relatively high Tm (303°C) for a polymer of a glycol having an odd number of carbon atoms.” We now have studied the melting characteristics of another sample of this polymer more carefully and have concluded that it does exhibit a liquid crystalline mesophase over a very narrow temperature range. In this Note we give the thermal properties of this polymer and the thermal and mechanical properties of an SDA/1,3-propanediol copolyester which we also injection molded. These properties are compared and contrasted with those of the similar polyester and copolyester prepared with 1,4-butanediol instead of 1,3-propanediol.Additional Material: 1 Ill.Type of Medium: Electronic ResourceURL: