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1Latest Papers from Table of Contents or Articles in PressL. A. Diaz, Jr. ; R. T. Williams ; J. Wu ; I. Kinde ; J. R. Hecht ; J. Berlin ; B. Allen ; I. Bozic ; J. G. Reiter ; M. A. Nowak ; K. W. Kinzler ; K. S. Oliner ; B. Vogelstein
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-06-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Antibodies, Monoclonal/*pharmacology/therapeutic use ; Colorectal Neoplasms/blood/*drug therapy/*genetics/pathology ; DNA, Neoplasm/blood ; Drug Resistance, Neoplasm/*drug effects/genetics ; *Evolution, Molecular ; Genes, ras/genetics ; Humans ; Mutation/genetics ; Proto-Oncogene Proteins/*genetics ; Receptor, Epidermal Growth Factor/*antagonists & inhibitors ; Selection, Genetic/drug effects ; Time Factors ; ras Proteins/*geneticsPublished by: -
2Articles: DFG German National LicensesDeFotis, G. C. ; McMahon, J. G. ; Berlin, J. M. ; Duling, J. A. ; Jeffers, R. B.
[S.l.] : American Institute of Physics (AIP)
Published 2000Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The magnetic behavior of NiCl2⋅H2O has been studied for the first time. A Curie–Weiss fit, χM=C/(T−θ), to the susceptibility between 90 and 300 K yields g=2.23±0.01(S=1) and θ=30.4±0.05 K. Systematic curvature in χ−1(T) is evident below 90 K. Despite the very positive θ, NiCl2⋅H2O appears to order antiferromagnetically at Tc=5.65±0.1 K, somewhat below a maximum in χ(T) at T(χmax)=8.4±0.1 K, with χmax=0.1297±0.0005 emu/mol. The ratios Tc/T(χmax)=0.67±0.01 and Tc/θ=0.186±0.005 suggest lower magnetic dimensionality, most likely one-dimensional character. Plausible looking fits to the low temperature susceptibility based on a one-dimensional antiferromagnetic Heisenberg model can be obtained. However, these presuppose antiferromagnetic intrachain exchange, and in NiCl2⋅H2O such exchange is almost certainly ferromagnetic, with weaker antiferromagnetic interchain interactions. Well above Tc the susceptibility can be accounted for assuming axial and rhombic crystal-field distortions, i.e., D[S(circumflex)z2−S(S+1)/3] and E[S(circumflex)x2−S(circumflex)y2] spin Hamiltonian terms, with exchange included in a mean field approximation. In the absence of single crystal data the parameters are only provisional, but clearly |D| and |E| are very large; the associated mean exchange interaction zJ/k=25.1 K is consistent with the observed θ value. Magnetization versus field isotherms exhibit an unusual evolution in shape with varying temperature; significant hysteresis is present even for temperatures somewhat above Tc. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesLEDERER, W. J. ; BERLIN, J. R. ; COHEN, N. M. ; HADLEY, R. W. ; BERS, D. M. ; CANNELL, M. B.
Oxford, UK : Blackwell Publishing Ltd
Published 1990Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesCHALMERS, T.C. ; BERRIER, J. ; HEWITT, P. ; BERLIN, J. ; REITMAN, D. ; NAGALINGAM, R. ; SACKS, H.
Oxford, UK : Blackwell Publishing Ltd
Published 1988Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The design of randomized controlled trials to assess the efficacy of pharmacological measures for the prevention of the gastrointestinal side-effects of anti-inflammatory drugs requires an accurate estimate of excess risk under controlled conditions. Photocopies of 952 randomized controlled trial publications were obtained after scanning titles and abstracts of a MEDLINE computer search, 427 were excluded for obvious reasons, and 525 were again photocopied after obliterating source and results. Selection criteria were: the presence of a non-anti-inflammatory drug control group; at least 4 days of therapy; at least 3 days without anti-inflammatory drugs before randomization; no complicating background drugs; mention of side-effects; and a clear differentiation of gastrointestinal complications. Observer error, with two independent readings, for inclusion suitability in the study was 19% for Methods and 9% for Results. For the 44 aspirin trials, the mean therapy duration was 357 days; the unweighted rate difference between therapy and control groups (± 1 S.E.M.) for ulcer was 0.006 ± 0.003, for gross haemorrhage 0.006 ± 0.002 and for unspecified gastric symptoms 0.03 ± 0.01. In 123 non-aspirin non-steroidal anti-inflammatory drug (NA—NSAID) trials, the mean duration was 67 days; the unweighted rate difference for ulcer was 0.0005 ± 0.0003, for gross haemorrhage 0.007 ± 0.004 and for unspecified gastric symptoms 0.02 ± 0.005. Risk differences were also pooled using the DerSimonian and Laird method, which weights studies inversely according to variance. Using this method, only the unspecified gastric symptoms for non-aspirin non-steroidal anti-inflammatory drugs (NA—NSAIDs) and the haemorrhage for aspirin were found to be statistically significant. Longer studies have higher risk differences. Randomized control trials to determine prophylactic efficacy against haemorrhage (that is, to demonstrate a reduction of ulcer rate in the therapy group to the rate of controls) would require 190 patients in each group for NA—NSAIDs in studies of 2–6 months; 950 subjects would be needed to detect a 50% reduction. Randomized control trials to determine a reduction in ulcer rate to that of controls in patients on aspirin for more than 6 months would require 700 subjects in each group; 3346 subjects would be needed to detect a 50% reduction. Such studies are feasible.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0003-9861Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0920-5632Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesAndersen, N.H. ; Fiig, T. ; Lindgard, P.-A. ; Mannstaedt, S. ; Mouritsen, O.G. ; Berlin, J.
Amsterdam : ElsevierStaff ViewISSN: 0921-4534Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0021-9673Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0031-9422Keywords: Cupressaceae ; Miglyol. ; Thuja occidentalis ; cell cultures ; monoterpene accumulationSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0031-9422Keywords: Nicotiana tabacum ; Solanaceae ; arginine decarboxylase ; cinnamoyl putrescines ; ornithine decarboxylase. ; putrescine ; tobacco cell cultures ; variant linesSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0031-9422Keywords: Apocynaceae ; Catharanthus roseus ; anthocyanins. ; biosynthesis ; indole alkaloids ; light ; medium ; tissue cultureSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesBerlin, J. ; Rugenhagen, C. ; Greidziak, N. ; Kuzovkina, I.N. ; Witte, L. ; Wray, V.
Amsterdam : ElsevierStaff ViewISSN: 0031-9422Keywords: Peganum harmala ; Zygophyllaceae ; bioconversion. ; root cultures ; serotonin ; suspension cultures ; tryptophan decarboxylase ; β-carboline alkaloidsSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0031-9422Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0031-9422Keywords: Nicotiana tabacum ; Solanaceae ; amino acid analogs ; aromatic amino acids ; mutants ; polyphenols. ; suspension culturesSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0031-9422Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0031-9422Keywords: Thuja occidentalis ; cell cultures ; diterpenes ; monoterpenes ; two phase culture.Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesBerlin, J. ; Cartellieri, S. ; Schwendner, H. ; Pfotenhauer, M. ; David, E. ; Edrdman, W.
Amsterdam : ElsevierStaff ViewISSN: 0167-8760Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicinePsychologyType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0167-8760Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicinePsychologyType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0370-2693Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: