Search Results - (Author, Cooperation:J. Beauchamp)
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1Latest Papers from Table of Contents or Articles in PressThompson, E. J., Beauchamp, M. H., Darling, S. J., Hearps, S. J. C., Brown, A., Charalambous, G., Crossley, L., Darby, D., Dooley, J. J., Greenham, M., Jaimangal, M., McDonald, S., Muscara, F., Turkstra, L., Anderson, V. A.
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-02-09Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, Mental healthPublished by: -
2Latest Papers from Table of Contents or Articles in PressC. A. Rietveld ; S. E. Medland ; J. Derringer ; J. Yang ; T. Esko ; N. W. Martin ; H. J. Westra ; K. Shakhbazov ; A. Abdellaoui ; A. Agrawal ; E. Albrecht ; B. Z. Alizadeh ; N. Amin ; J. Barnard ; S. E. Baumeister ; K. S. Benke ; L. F. Bielak ; J. A. Boatman ; P. A. Boyle ; G. Davies ; C. de Leeuw ; N. Eklund ; D. S. Evans ; R. Ferhmann ; K. Fischer ; C. Gieger ; H. K. Gjessing ; S. Hagg ; J. R. Harris ; C. Hayward ; C. Holzapfel ; C. A. Ibrahim-Verbaas ; E. Ingelsson ; B. Jacobsson ; P. K. Joshi ; A. Jugessur ; M. Kaakinen ; S. Kanoni ; J. Karjalainen ; I. Kolcic ; K. Kristiansson ; Z. Kutalik ; J. Lahti ; S. H. Lee ; P. Lin ; P. A. Lind ; Y. Liu ; K. Lohman ; M. Loitfelder ; G. McMahon ; P. M. Vidal ; O. Meirelles ; L. Milani ; R. Myhre ; M. L. Nuotio ; C. J. Oldmeadow ; K. E. Petrovic ; W. J. Peyrot ; O. Polasek ; L. Quaye ; E. Reinmaa ; J. P. Rice ; T. S. Rizzi ; H. Schmidt ; R. Schmidt ; A. V. Smith ; J. A. Smith ; T. Tanaka ; A. Terracciano ; M. J. van der Loos ; V. Vitart ; H. Volzke ; J. Wellmann ; L. Yu ; W. Zhao ; J. Allik ; J. R. Attia ; S. Bandinelli ; F. Bastardot ; J. Beauchamp ; D. A. Bennett ; K. Berger ; L. J. Bierut ; D. I. Boomsma ; U. Bultmann ; H. Campbell ; C. F. Chabris ; L. Cherkas ; M. K. Chung ; F. Cucca ; M. de Andrade ; P. L. De Jager ; J. E. De Neve ; I. J. Deary ; G. V. Dedoussis ; P. Deloukas ; M. Dimitriou ; G. Eiriksdottir ; M. F. Elderson ; J. G. Eriksson ; D. M. Evans ; J. D. Faul ; L. Ferrucci ; M. E. Garcia ; H. Gronberg ; V. Guethnason ; P. Hall ; J. M. Harris ; T. B. Harris ; N. D. Hastie ; A. C. Heath ; D. G. Hernandez ; W. Hoffmann ; A. Hofman ; R. Holle ; E. G. Holliday ; J. J. Hottenga ; W. G. Iacono ; T. Illig ; M. R. Jarvelin ; M. Kahonen ; J. Kaprio ; R. M. Kirkpatrick ; M. Kowgier ; A. Latvala ; L. J. Launer ; D. A. Lawlor ; T. Lehtimaki ; J. Li ; P. Lichtenstein ; P. Lichtner ; D. C. Liewald ; P. A. Madden ; P. K. Magnusson ; T. E. Makinen ; M. Masala ; M. McGue ; A. Metspalu ; A. Mielck ; M. B. Miller ; G. W. Montgomery ; S. Mukherjee ; D. R. Nyholt ; B. A. Oostra ; L. J. Palmer ; A. Palotie ; B. W. Penninx ; M. Perola ; P. A. Peyser ; M. Preisig ; K. Raikkonen ; O. T. Raitakari ; A. Realo ; S. M. Ring ; S. Ripatti ; F. Rivadeneira ; I. Rudan ; A. Rustichini ; V. Salomaa ; A. P. Sarin ; D. Schlessinger ; R. J. Scott ; H. Snieder ; B. St Pourcain ; J. M. Starr ; J. H. Sul ; I. Surakka ; R. Svento ; A. Teumer ; H. Tiemeier ; F. J. van Rooij ; D. R. Van Wagoner ; E. Vartiainen ; J. Viikari ; P. Vollenweider ; J. M. Vonk ; G. Waeber ; D. R. Weir ; H. E. Wichmann ; E. Widen ; G. Willemsen ; J. F. Wilson ; A. F. Wright ; D. Conley ; G. Davey-Smith ; L. Franke ; P. J. Groenen ; M. Johannesson ; S. L. Kardia ; R. F. Krueger ; D. Laibson ; N. G. Martin ; M. N. Meyer ; D. Posthuma ; A. R. Thurik ; N. J. Timpson ; A. G. Uitterlinden ; C. M. van Duijn ; P. M. Visscher ; D. J. Benjamin ; D. Cesarini ; P. D. Koellinger
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-06-01Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Cognition ; *Educational Status ; Endophenotypes ; Female ; Genetic Loci ; *Genome-Wide Association Study ; Humans ; Male ; Multifactorial Inheritance ; *Polymorphism, Single NucleotidePublished by: -
3Articles: DFG German National LicensesShin, Seung Koo ; Goddard, William A. ; Beauchamp, J. L.
College Park, Md. : American Institute of Physics (AIP)
Published 1990Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: We report singlet and triplet state splittings (ΔEST) for fluorine-substituted methylenes and silylenes using dissociation-consistent configuration interaction (CI) (based on generalized valence bond wave functions). These relatively simple CI calculations emphasize correlation consistency between the singlet and triplet states. Values of ΔEST for CH2, CF2, SiH2, and SiF2 are in excellent agreement with available experimental results, and we expect the predictions for the other cases CHF (14.5) and SiHF (41.3) to be equally accurate. This result strongly suggests that the correct choice among the experimental values for ΔEST of CHF is 14.7±0.2 kcal/mol.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesUnger, M. A. ; Kossakovski, D. A. ; Kongovi, R. ; Beauchamp, J. L. ; Baldeschwieler, J. D.
[S.l.] : American Institute of Physics (AIP)
Published 1998Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: Typical infrared transmitting fibers comprise a chalcogenide core surrounded by a sulfur-selenide cladding, which is in turn coated with a polymer such as polyamide. For use in a near-field scanning infrared microscope (NSIM), such infrared-transmitting fibers must be tapered to a sharp point. Sharper points allow smaller apertures, which allow higher resolution. The light throughput of the probe depends on the length of the taper region: the longer the taper length, the further the infrared radiation must propagate through a waveguide smaller than its wavelength. Thus, shorter taper lengths should give higher light throughput. We describe a method for etching chalcogenide fibers to submicron points by simple chemical means. Methods are described for removal of the polyamide coating, stripping of the SSe cladding surrounding the core, and etching the chalcogenide fiber core to a sharp point. Removal of the polyamide coating is most easily accomplished by dissolution in 4-Chloro-1-butanol. The SSe cladding is removed by soaking the fiber in 0.1 M NaOH overnight. The chalcogenide core is tapered to a sharp point by immersion in a two-phase etching system, where the top phase is an inert organic solvent, and the bottom phase is a strong oxidant. Fibers both with and without cladding have been tapered. The resulting fibers have a taper length on the order of the core diameter, and terminate with a submicron end radius of curvature. The potential for use in a NSIM, as well as other uses, is discussed. © 1998 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesWRIGHT, L. L. ; MATTICE, J. S. ; BEAUCHAMP, J. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1982Staff ViewISSN: 1365-2427Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: SUMMARY. Eggs collected from Hexagenia bilineata females were successfully reared in the laboratory at temperatures of 15, 20, 25 and 30°C. Eggs did not hatch at 10°C and although hatching was successful at 35°C, all nymphs at this temperature died while in early instars.Survival of nymphs between the approximate size interval of 4–14 mm showed a significant decrease with increased temperatures. Nymphs at 15°C, however, generally did not survive transformation to the subaduit stage.The growth pattern of individual nymphs was well described by a logistic curve at most temperatures. Furthermore, growth pattern was significantly affected by both temperature and sex.Rate of development from oviposition to first emergence increased with increasing temperatures in a linear fashion between 15 and 30°C. The relationship was equally well described by a hyperbolic equation and a power-law equation. By extrapolation from the hyperbolic equation, the lower threshold temperature for development was estimated to be 10.1°C3.1°C. The degree (°C)-days required for development from oviposition to first emergence was calculated to be 2337 days with 95% confidence limits of 2045–2727 days under laboratory conditions.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1745-6584Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Energy, Environment Protection, Nuclear Power EngineeringGeosciencesNotes: In the Data Quality Objectives (DQO) process, statistical methods are used to determine an optimal sampling and analysis plan. When the DQO decision rule for instituting remedial actions is based on a critical change in water quality, the monitoring program design must ensure that this change can be detected and measured with a specified confidence. Usually the focus is on the change at a single monitoring location and the process is limited to addressing the uncertainty inherent in the analytical methods and the variability at that location. However, new strategies that permit ranking the waste sites and prioritizing remedial activities require the means for assessing overall changes for small regions over time, where both spatial and temporal variability exist and where the uncertainty associated with these variations far exceeds measurement error. Two new methods for assessing these overall changes have been developed and are demonstrated by application to a waste disposal site in Oak Ridge, Tennessee. These methods incorporate historical data where available and allow the user to either test the statistical significance of a linear trend or of an annual change compared to a baseline year for a group of water quality wells.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesAustin, Daniel E. ; Ahrens, Thomas J. ; Beauchamp, J. L.
[S.l.] : American Institute of Physics (AIP)
Published 2002Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: We report on the design and testing of a compact impact-ionization time-of-flight mass spectrometer for analysis of cosmic dust, suitable for use on deep space missions. The instrument, Dustbuster, incorporates a large target area with a reflectron, simultaneously optimizing mass resolution, particle detection, and ion collection. Dust particles hit the 65-cm2 target plate and are partially ionized by the impact. The resulting ions, with broad energy and angular distributions, are accelerated through a modified reflectron, focusing ions of specific m/z in space and time to produce high-resolution mass spectra. The cylindrically symmetric instrument is 10 cm in diameter and 20 cm in length, considerably smaller than previous in situ dust analyzers, and can be easily scaled as needed for specific mission requirements. Laser desorption ionization of metal and mineral samples embedded in the impact plate simulated particle impacts for evaluations of instrument performance. Mass resolution in these experiments ranged from 60–180, permitting resolution of isotopes. The mass spectrometer can be combined with other instrument components to determine dust particle trajectories and sizes. © 2002 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0014-4827Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0196-9781Keywords: B"1 receptor ; B"2 receptor ; Blood pressure ; Bradykinin ; Capsaicin ; Cardiovascular reflexes ; Heart rate ; Kinins ; Sympathetic nervous system ; Visceral afferentsSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesBlanchet, C. ; Dodin, S. ; Dumont, M. ; Giguère, Y. ; Turcot-Lemay, L. ; Beauchamp, J. ; Prud'homme, D.
Springer
Published 1998Staff ViewISSN: 1433-2965Keywords: Key words: Aging – Bone loss – Bone mineral density – French Canadian women, Postmenopausal womenSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract: This cross-sectional study investigated bone mineral density (BMD) at the lumbar spine (L2–4) and femoral neck in French Canadian women residing in the Quebec city area. Data collection was initiated in 1988 and completed in 1994. A total of 747 French Canadian Caucasian women (16–79 years of age) with no metabolic bone disease were evaluated. BMD measurements were obtained using dual-photon absorptiometry (DPA) or dual-energy X-ray absorptiometry (DXA). Anthropometric measures such as weight, height and body mass index (BMI) were recorded. Medical files provided information on demographic characteristics, hormonal profile and lifestyle habits. Results show a curvilinear trend of BMD with aging. Furthermore, the peak BMD at the lumbar spine (L2–4) was reached at 29 years followed by a stable phase until 35 years, after which BMD started to decrease. The pattern of bone evolution at the femoral neck was different, peak BMD being achieved earlier, at 21 years, while after age 26 years a significant decrease was already observed. Women older than 60 years showed the lowest BMD. Regression analysis showed that age, weight and height are determinants of BMD at the lumbar spine and explained 33.9% of inter-individual variation. At the femoral neck, 29.1% of variation was explained by age and height only. In conclusion, our data suggest that French Canadian women have a different pattern of bone loss at the femoral neck compared with the lumbar spine, according to their mean BMD values.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-0703Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineNotes: Abstract The bioconcentration and metabolism of benz(a)acridine in fathead minnows (Pimephales promelas) was investigated using14C-labelled benz(a)acridine. The rates of uptake, elimination, and metabolic transformation of benz(a)acridine were estimated in the fish. The equilibrium concentration factor [ratio of benz(a)acridine concentration in fish (wet weight) to benz(a)acridine concentration in water] was estimated at 106±17. The observed bioconcentration factor was about one tenth of that predicted by octanol-water partitioning models. Metabolic alteration was estimated to reduce the degree of bioconcentration 50 to 90% from the hypothetical case in which metabolic transformation did not occur. Benz(a)acridine metabolites attained concentrations in the fish considerably in excess of benz(a)acridine itself.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Keywords: Key words. Fatty acid binding proteins; lipocalins; cellular retinol-binding proteins; cytosolic lipid-binding proteins; protein:membrane interaction; tryptophan.Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract. The cytosolic lipid-binding proteins (cLBPs) comprise a large family of small (14–15 kDa) intracellular proteins involved in the transport of small lipids, including fatty acids and retinoids within cells. Their presumed function is to solubilise, protect from chemical damage and deliver to the correct destination lipids for purposes ranging from energy metabolism (e.g. fatty acids) to signalling, gene activation and cellular differentiation (e.g. retinoids and eicosanoids). It is therefore probable that cLBPs interact directly with cellular components (membranes and/or proteins) to collect and deposit their ligands, and some external features of the different cLBPs may be involved in such interactions and determine which cellular component (integral membrane or cytosolic proteins, or membranes of different lipid compositions or domain structures) with which a given cLBP will interact. Here we have focussed on a previously unrecognised feature of cLBPs which descriminates between those for which there is empiral evidence for direct interaction with membranes, and those which do not. This is a group of bulky hydrophobic amino acid side chains (e.g. tryptophans, phenylalanines, leucines) which project directly into solvent adjacent to the portal of entry and exit of the lipid ligands. Such side chains are usually found internal to proteins, but are common at sites of protein:protein or protein:membrane interactions. These ‘sticky fingers’ could therefore be critical to the nature and specificity of the interactions cLBPs undergo in the web of cross-traffic in lipid movements within cells.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1573-3009Keywords: gamma distribution ; left censoring ; product limit estimate ; risk assessment ; truncated normal distributionSource: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringNotes: Abstract A frequent assumption in environmental risk assessment is that the underlying distribution of an analyte concentration is lognormal. However, the distribution of a random variable whose log has a t-distribution has infinite mean. Because of the proximity of the standard normal and t-distribution, this suggests that a distribution such as the gamma or truncated normal, with smaller right tail probabilities, might make a better statistical model for mean estimation than the lognormal. In order to assess the effect of departures from lognormality on lognormal-based statistics, we simulated complete lognormal, truncated normal, and gamma data for various sample sizes and coefficients of variation. In these cases, departures from lognormality were not easily detected with the Shapiro-Wilk test. Various lognormal-based estimates and tests were compared with alternate methods based on the ordinary sample mean and standard error. The examples were also considered in the presence of random left censoring with the mean and standard error of the product limit estimate replacing the ordinary sample mean and standard error. The results suggest that in the estimation of or tests about a mean, if the assumption of lognormality is at all suspect, then lognormal-based approaches may not be as good as the alternative methods.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1573-174XSource: Springer Online Journal Archives 1860-2000Topics: Nature of Science, Research, Systems of Higher Education, Museum ScienceNotes: Abstract An increased value is being placed on quality teaching in higher education. An important step in developing approaches to better instruction is understanding how those who are successful go about improving their teaching. Thus, several years ago we undertook a program of research in which the concept of “reflection” provided the frame of reference. We envisaged reflection as a process of formative evaluation, and also saw links between reflection and metacognition. What we have documented and analyzed in detail are the reflective processes of six university professors in their day-to-day planning, instructing and evaluating of learners. The result is a metacognitive model and coding scheme that operationalize the process of reflection. Both provide a language for describing reflection and therefore a way to think about how to improve teaching. In this paper, we describe the research and the model and the contributions they make to our understanding of teacher thinking in higher education.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1573-8868Keywords: discriminant analysis ; variable selection ; uranium favorability ; generalized distance measures ; regional variables ; geochemical fingerprintSource: Springer Online Journal Archives 1860-2000Topics: GeosciencesMathematicsNotes: Abstract The National Uranium Resource Evaluation (NURE) Program has as its goal the estimation of the nation's uranium resources. It is possible to use discriminant analysis methods on hydrogeochemical data collected in the NURE Program to aid in formulating geochemical models that can be used to identify the anomalous areas used in resource estimation. Discriminant analysis methods have been applied to data from the Plainview, Texas Quadrangle which has approximately 850 groundwater samples with more than 40 quantitative measurements per sample. Discriminant analysis topics involving estimation of misclassification probabilities, variable selection, and robust discrimination are applied. A method using generalized distance measures is given which enables the assignment of samples to a background population or a mineralized population whose parameters were estimated from separate studies. Each topic is related to its relevance in identifying areas of possible interest to uranium exploration. However, the methodology presented here is applicable to the identification of regions associated with other types of resources.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1573-2932Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringNotes: Abstract Azaarenes are one of several classes of organic compounds which contain mutagenic and carcinogenic substances that are found in synthetic fuels effluents. This study investigated the potential for a mutagenic azaarene, acridine, to accumulate in freshwater fish (Pimephales promelas) via four possible pathways: (1) direct uptake from water, (2) uptake via interaction with contaminated sediments, (3) uptake via ingestion of contaminated zooplankton (Daphnia pulex), and (4) uptake via ingestion of benthic invertebrates (Chironomus tentans) living in contaminated sediments. The results showed that acridine was rapidly accumulated from water by fathead minnows. Equilibrium concentration was attained within 24 h at a concentration factor ([acridine]fish, wet wt/[acridine]water) of 125±10. Depuration was rapid and appeared to occur in two stages, with a net elimination rate of 0.23 h−1 [acridine]fish at equilibrium. Equilibrium concentration factors of 51±5, 30±2, and 874±275 were observed forChironomus, Daphnia, and sediment, respectively. The calculated rates of uptake of acridine via ingestion of contaminated invertebrates (0.02 μg g−1 h−1) and ingestion of sediment (0.01 μg g−1 h−1) were negligible compared with direct uptake from water (1.40 μg g−1 h−1) in a hypothetical system with all compartments in equilibrium.Type of Medium: Electronic ResourceURL: