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1Latest Papers from Table of Contents or Articles in PressLisheng Liao, Amy L. Schaefer, Bruna G. Coutinho, Pamela J. B. Brown, E. Peter Greenberg
National Academy of Sciences
Published 2018Staff ViewPublication Date: 2018-07-18Publisher: National Academy of SciencesPrint ISSN: 0027-8424Electronic ISSN: 1091-6490Topics: BiologyMedicineNatural Sciences in GeneralPublished by: -
2Latest Papers from Table of Contents or Articles in PressJ. B. Brown ; N. Boley ; R. Eisman ; G. E. May ; M. H. Stoiber ; M. O. Duff ; B. W. Booth ; J. Wen ; S. Park ; A. M. Suzuki ; K. H. Wan ; C. Yu ; D. Zhang ; J. W. Carlson ; L. Cherbas ; B. D. Eads ; D. Miller ; K. Mockaitis ; J. Roberts ; C. A. Davis ; E. Frise ; A. S. Hammonds ; S. Olson ; S. Shenker ; D. Sturgill ; A. A. Samsonova ; R. Weiszmann ; G. Robinson ; J. Hernandez ; J. Andrews ; P. J. Bickel ; P. Carninci ; P. Cherbas ; T. R. Gingeras ; R. A. Hoskins ; T. C. Kaufman ; E. C. Lai ; B. Oliver ; N. Perrimon ; B. R. Graveley ; S. E. Celniker
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-03-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alternative Splicing/genetics ; Animals ; Drosophila melanogaster/anatomy & histology/cytology/*genetics ; Female ; *Gene Expression Profiling ; Male ; Molecular Sequence Annotation ; Nerve Tissue/metabolism ; Organ Specificity ; Poly A/genetics ; Polyadenylation ; Promoter Regions, Genetic/genetics ; RNA, Long Noncoding/genetics ; RNA, Messenger/genetics/metabolism ; Sex Characteristics ; Stress, Physiological/genetics ; Transcriptome/*geneticsPublished by: -
3Latest Papers from Table of Contents or Articles in PressM. B. Gerstein ; J. Rozowsky ; K. K. Yan ; D. Wang ; C. Cheng ; J. B. Brown ; C. A. Davis ; L. Hillier ; C. Sisu ; J. J. Li ; B. Pei ; A. O. Harmanci ; M. O. Duff ; S. Djebali ; R. P. Alexander ; B. H. Alver ; R. Auerbach ; K. Bell ; P. J. Bickel ; M. E. Boeck ; N. P. Boley ; B. W. Booth ; L. Cherbas ; P. Cherbas ; C. Di ; A. Dobin ; J. Drenkow ; B. Ewing ; G. Fang ; M. Fastuca ; E. A. Feingold ; A. Frankish ; G. Gao ; P. J. Good ; R. Guigo ; A. Hammonds ; J. Harrow ; R. A. Hoskins ; C. Howald ; L. Hu ; H. Huang ; T. J. Hubbard ; C. Huynh ; S. Jha ; D. Kasper ; M. Kato ; T. C. Kaufman ; R. R. Kitchen ; E. Ladewig ; J. Lagarde ; E. Lai ; J. Leng ; Z. Lu ; M. MacCoss ; G. May ; R. McWhirter ; G. Merrihew ; D. M. Miller ; A. Mortazavi ; R. Murad ; B. Oliver ; S. Olson ; P. J. Park ; M. J. Pazin ; N. Perrimon ; D. Pervouchine ; V. Reinke ; A. Reymond ; G. Robinson ; A. Samsonova ; G. I. Saunders ; F. Schlesinger ; A. Sethi ; F. J. Slack ; W. C. Spencer ; M. H. Stoiber ; P. Strasbourger ; A. Tanzer ; O. A. Thompson ; K. H. Wan ; G. Wang ; H. Wang ; K. L. Watkins ; J. Wen ; K. Wen ; C. Xue ; L. Yang ; K. Yip ; C. Zaleski ; Y. Zhang ; H. Zheng ; S. E. Brenner ; B. R. Graveley ; S. E. Celniker ; T. R. Gingeras ; R. Waterston
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-08-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Caenorhabditis elegans/embryology/*genetics/growth & development ; Chromatin/genetics ; Cluster Analysis ; Drosophila melanogaster/*genetics/growth & development ; *Gene Expression Profiling ; Gene Expression Regulation, Developmental/genetics ; Histones/metabolism ; Humans ; Larva/genetics/growth & development ; Models, Genetic ; Molecular Sequence Annotation ; Promoter Regions, Genetic/genetics ; Pupa/genetics/growth & development ; RNA, Untranslated/genetics ; Sequence Analysis, RNA ; Transcriptome/*geneticsPublished by: -
4Latest Papers from Table of Contents or Articles in PressB. R. Graveley ; A. N. Brooks ; J. W. Carlson ; M. O. Duff ; J. M. Landolin ; L. Yang ; C. G. Artieri ; M. J. van Baren ; N. Boley ; B. W. Booth ; J. B. Brown ; L. Cherbas ; C. A. Davis ; A. Dobin ; R. Li ; W. Lin ; J. H. Malone ; N. R. Mattiuzzo ; D. Miller ; D. Sturgill ; B. B. Tuch ; C. Zaleski ; D. Zhang ; M. Blanchette ; S. Dudoit ; B. Eads ; R. E. Green ; A. Hammonds ; L. Jiang ; P. Kapranov ; L. Langton ; N. Perrimon ; J. E. Sandler ; K. H. Wan ; A. Willingham ; Y. Zhang ; Y. Zou ; J. Andrews ; P. J. Bickel ; S. E. Brenner ; M. R. Brent ; P. Cherbas ; T. R. Gingeras ; R. A. Hoskins ; T. C. Kaufman ; B. Oliver ; S. E. Celniker
Nature Publishing Group (NPG)
Published 2010Staff ViewPublication Date: 2010-12-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alternative Splicing/genetics ; Animals ; Base Sequence ; Drosophila Proteins/genetics ; Drosophila melanogaster/embryology/*genetics/*growth & development ; Exons/genetics ; Female ; *Gene Expression Profiling ; Gene Expression Regulation, Developmental/*genetics ; Genes, Insect/genetics ; Genome, Insect/genetics ; Male ; MicroRNAs/genetics ; Oligonucleotide Array Sequence Analysis ; Protein Isoforms/genetics ; RNA Editing/genetics ; RNA, Messenger/analysis/genetics ; RNA, Small Untranslated/analysis/genetics ; Sequence Analysis ; Sex Characteristics ; Transcription, Genetic/*geneticsPublished by: -
5Articles: DFG German National LicensesAnderws, A. G. ; Brown, J. B. ; Jeffery, P. E. ; Horacek, I.
Oxford, UK : Blackwell Publishing Ltd
Published 1979Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The lecithin/sphingomyelin (L/S) ratio, palmitic acid concentration and palmitic to stearic acid (P/S) ratio were estimated on samples of amniotic fluid obtained from 66 patients with diabetes. These were compared with similar estimates on amniotic fluid obtained from 127 non-diabetic patients. At 35 to 40 weeks, significant differences were observed between the L/S ratio and palmitic acid concentration in diabetics and non-diabetics, whereas the P/S ratio was similar in the two groups. The amniotic fluid L/S ratio, palmitic acid concentration, and P/S ratio were estimated on amniotic fluid obtained from 20 diabetic patients within 48 hours of induction, and the clinical outcome of the newborn infant was used to assess the predictive value of the three parameters. In 19 out of the 20 diabetics the P/S ratio correctly predicted fetal lung maturity, whereas the palmitic acid concentration was correct in 12 patients and the L/S ratio in only 10 patients.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesRome, M. ; Brown, J. B. ; Mason, T. ; Smith, Margery A. ; Laverty, C. ; Fortune, D.
Oxford, UK : Blackwell Publishing Ltd
Published 1977Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Urinary oestrogen and pregnanediol excretion were measured before and after hysterectomy and bilateral salpingo-oophorectomy in 26 postmenopausal women with adenocarcinoma of the endometrium, 10 postmenopausal women with mixed adenosquamous carcinoma and 11 postmenopausal women with atypical hyperplasia (the patient groups). The results were compared with the values obtained in 22 active postmenopausal women, 20 hospitalized postmenopausal women and 18 women who had been subjected to hysterectomy and bilateral salpingo-oophorectomy for cancer of the cervix (the control groups). The ovaries and Fallopian tubes obtained at operation were examined for evidence of current or past excessive oestrogen production. Preoperative oestrogen values were higher in the patient groups than in the controls and the elevated values persisted after oophorectomy. The implications of these findings are discussed.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesPepperell, R. J. ; Evans, J. H. ; Brown, J. B. ; Bright, Margaret I. ; Smith, Margery A. ; Burger, H. G. ; Healy, D.
Oxford, UK : Blackwell Publishing Ltd
Published 1977Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Twelve anovulatory patients with normal serum prolactin values and six with elevated values were treated with bromocriptine and the effects on serum prolactin, FSH and LH levels were recorded. Ovulation resulted in one patient who had normal prolactin values and in all six who had raised values. No patient with normal basal prolactin values showed an increase in serum FSH during therapy with bromocriptine, whereas 5 of the 6 patients with elevated values showed significant increases. Similar results were obtained for LH. Although these differences were highly significant (P〈0·005) the majority of the serum FSH and LH values remained within the normal ranges. Five patients with normal basal prolactin values and one with elevated values were also treated with human pituitary gonadotrophin (HPG). An increase in ovarian responsiveness to HPG during therapy with bromocriptine was recorded in the one patient with initially elevated prolactin values. It was concluded that bromocriptine acts by allowing FSH to rise above threshold requirements for follicular stimulation.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesBierlein, J. D. ; Laubacher, D. B. ; Brown, J. B. ; van der Poel, C. J.
Woodbury, NY : American Institute of Physics (AIP)
Published 1990Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: A new phase matching technique is described which is based on phase mismatch balancing in crystal or waveguide segments that are short compared to their respective coherence lengths. The technique is demonstrated experimentally in a mixed bulk crystal/waveguide structure in KTiOPO4, resulting in a second-harmonic generation conversion efficiency of 15%/W/cm2 at 1.064 μm, close to the theoretical maximum. We show that this technique can significantly broaden processing latitude for fabricating practical nonlinear optical waveguide devices.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesQuinn, M. A. ; Jmurphy, A. ; Kuhn, R. J. P. ; Robinson, H. P. ; Brown, J. B.
Oxford, UK : Blackwell Publishing Ltd
Published 1981Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Forty nulliparous patients with a Bishop score of 3 or less were given 15 mg oestriol gel, 10 mg PGF2α gel or gel alone via the extra-amniotic route. Both the oestriol and prostaglandin treated patients had a significant increase in Bishop score and a significant reduction in induction-delivery interval compared to con-trols. Oestriol gel had significantly less stimulatory effect on uterine activity than prostaglandin gel, indicating a possible local action.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesTHE INVESTIGATION OF OVARIAN FUNCTION BY MEASUREMENT OF URINARY OESTROGEN AND PREGNANEDIOL EXCRETIONPepperell, R. J. ; Brown, J. B. ; Evans, J. H. ; Rennie, G. C. ; Burger, H. G.
Oxford, UK : Blackwell Publishing Ltd
Published 1975Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Urinary oestrogen and pregnanediol excretion was measured daily (“daily monitoring”) for a complete cycle in 20 normally menstruating women, in one patient with an anovulatory cycle and for 28 days in a patient with secondary amenorrhoea. The measurements were also performed on urine specimens collected at weekly intervals for 4 to 6 weeks (“weekly tracking”) from 506 patients with evidence of abnormal ovarian function. These included 9 patients with primary amenorrhoea, 132 patients with secondary amenorrhoea, 138 patients with oligomenorrhoea and 227 patients with evidence of ovarian dysfunction and cycle lengths of 25 to 42 days. The results were subjected to statistical analysis. In the normal cycles, ovulation could be identified on the criteria of a rising pregnanediol value reaching or exceeding 2.0 mg. per 24 hours for a period of 7 days or more. Valid conclusions on the overall mean oestrogen and pregnanediol values for a complete cycle could be made from the results of weekly tracking, irrespective of which day the tracking commenced. Correlations were obtained by comparing the mean and maximum urinary oestrogen values and the variability of the values with the evidence of ovarian function indicated by the clinical classifications of the patients, the duration of the disorders and the subsequent occurrence of uterine bleeding. Mean oestrogen values of 10μ g. per 24 hours or less were associated with lack of ovarian function. For values higher than this a discriminant function based on both the mean oestrogen value and the variability of the oestrogen values was useful in predicting onset of spontaneous menstruation. A single urine specimen collected 4 to 8 days before onset of menstruation showing a raised pregnanediol value of 2.0mg. per 24 hours or more provided a valid test for ovulation in women with regular cycles, and a single urine specimen giving an oestrogen value of 10 pg. per 24 hours or less gave a valid indication of absent ovarian function in women with amenorrhoea for two years or more. In all other circumstances serial sampling at weekly intervals provided a valid assessment of ovarian activity. Application of these principles allows the greatest amount of information on ovarian function to be obtained with the greatest economy of effort.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesEXCRETION OF OESTROGENS, PREGNANEDIOL AND CHORIONIC GONADOTROPHIN IN PATIENTS WITH HYDATIDIFORM MOLECampbell, D. G. ; Brown, J. B. ; Fortune, D. W. ; Pepperell, R. ; Beischer, N. A.
Oxford, UK : Blackwell Publishing Ltd
Published 1970Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Forty-one patients with a diagnosis of possible hydatidiform mole were studied by HCG, oestrogen and pregnanediol determinations performed on 24-hour collections of urine. The results were compared with those obtained in a control series involving 5000 HCG analyses, 679 oestrogen analyses and 1080 pregnanediol analyses performed over the relevant period of gestation in single pregnancies which produced surviving infants. Of the 17 patients who were shown to have a hydatidiform mole, 8 (47 per cent) had high HCG levels, 5 (29 per cent) had oestrogen levels below the first percentile for the control series and 5 of 13 patients had low pregnanediol levels (38 per cent). Five of the nine patients with molar pregnancies associated with normal HCG excretion had oestrogen excretion below the first percentile and one of the remaining four with normal oestrogen values had non-pregnancy levels of pregnanediol. Thus the diagnosis of an abnormal pregnancy could be made in 14 of the 17 molar pregnancies studied (82 per cent). Two of the three exceptions had a fetus co-existent with the mole. There were no viable pregnancies when the oestrogen and pregnanediol values were below the first percentile. Oestrogen and/or pregnanediol values in the range consistent with multiple pregnancy were found in four patients with molar pregnancies. In the molar pregnancies there was a correlation between the levels of HCG and the levels of oestrogens and pregnanediol excreted. After evacuation of the mole, the levels of oestrogens and pregnanediol remained elevated for up to three weeks in approximately half of the patients, whereas the HCG levels fell immediately. These findings support the view that in molar pregnancies, levels of oestrogens above 300 μg. per 24 hours and of pregnanediol above 10 mg. per 24 hours are derived mainly from the stimulation of theca lutein cysts in the ovaries.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesBrown, J. B. ; Evans, J. H. ; Adey, F. D. ; Taft, H. P. ; Townsend, Lance
Oxford, UK : Blackwell Publishing Ltd
Published 1969Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesBeavis, E. L. G. ; Brown, J. B. ; Smith, Margery A.
Oxford, UK : Blackwell Publishing Ltd
Published 1969Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesFliecner, J. R. H. ; Schindler, Irene ; Brown, J. B.
Oxford, UK : Blackwell Publishing Ltd
Published 1972Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The clinical details and outcome of eight pregnancies associated with very low oestriol excretion are reported. Three cases were associated with congenital adrenal hypoplasia which was confirmed at autopsy. In the remaining five cases the infants showed no clinical evidence of adrenal insufficiency, and the two placentae which were examined from these pregnancies were found to be deficient in placental sulphatase activity. It is likely that in all five cases placental sulphatase deficiency was present. To date all the reported cases of placental sulphatase deficiency have been with male fetuses and the condition appears to be sex linked.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesBeischer, N. A. ; Bhargava, V. L. ; Brown, J. B. ; Smith, M. A.
Oxford, UK : Blackwell Publishing Ltd
Published 1968Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesEvans, J. H. ; Taft, H. P. ; Brown, J. B. ; Adey, F. D. ; Johnstone, J. W.
Oxford, UK : Blackwell Publishing Ltd
Published 1967Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesPepperell, R. J. ; McBain, J. C. ; Winstone, S. M. ; Smith, Margery A. ; Brown, J. B.
Oxford, UK : Blackwell Publishing Ltd
Published 1977Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Serum prolactin levels and urinary oestrogen and pregnanediol excretion were measured during early pregnancy in 12 hyperprolactinaemic subjects who became pregnant during treatment with bromocriptine. Prolactin levels were suppressed below normal whilst taking the bromocriptine, but rose significantly when this drug was stopped and by eight weeks of gestation reached values significantly higher than those observed in normal pregnancy. Further increases in prolactin levels were, however, not observed. Urinary oestrogen and pregnanediol excretion was initially normal but, following cessation of bromocriptine, urinary pregnanediol excretion decreased and was significantly less than normal at 11 to 14 weeks gestation. These results suggest that elevated prolactin levels affect corpus luteum function of early pregnancy. Because the effect is maintained until at least 14 weeks gestation, prolactin may also affect progesterone production by the placenta.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesReti, L. L. ; Rome, R. M. ; Brown, J. B. ; Fortune, D. W.
Oxford, UK : Blackwell Publishing Ltd
Published 1978Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Urinary oestrogen and pregnanediol excretion in 102 women who had a curettage for postmenopausal bleeding was correlated with the histological appearance of the endometrium, with age and with weight, and were compared with the values obtained in 42 normal postmenopausal women. The 36 patients with proliferative and hyperplastic endometrium and the 16 patients with endometrial carcinoma had significantly higher oestrogen excretion than the controls. The 27 patients with atrophic endometrium had only slightly higher mean oestrogen values than the controls. Twenty-three patients had taken hormones and the 20 patients who bled during treatment had the same urinary hormone values as the controls (excluding three patients with ovarian and/or endometrial carcinoma). The ovaries were examined in 37 patients who had a total hysterectomy and bilateral salpingo-oophorectomy. Significantly higher oestrogen values were found in those patients with ovarian tumours in which the stroma showed hyperplasia. When an ovarian tumour was associated with normal stroma or when the ovary showed cortical stromal hyperplasia without a tumour, urinary hormone values were normal. Oestrogen excretion and age were not related, but a correlation was found between oestrogen excretion and body weight.Type of Medium: Electronic ResourceURL: