Search Results - (Author, Cooperation:J. Axford)

2011-08-26

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Aedes/*microbiology/physiology/*virology ; Animals ; Dengue/*prevention & control/transmission/virology ; Dengue Virus/classification/isolation & purification/*physiology ; Female ; Genetic Fitness ; Humans ; Insect Vectors/microbiology/physiology/virology ; Male ; Pest Control, Biological/*methods ; Reproduction/physiology ; Saliva/virology ; Wolbachia/*classification/*physiology

2011-08-26

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Aedes/*microbiology/physiology/*virology ; Animals ; Dengue/microbiology/*prevention & control/*transmission/virology ; Dengue Virus/isolation & purification/*physiology ; Drosophila melanogaster/microbiology ; Female ; Humans ; Insect Vectors/microbiology/physiology/virology ; Male ; Pest Control, Biological/*methods ; Queensland ; Time Factors ; Wolbachia/isolation & purification/*physiology

1365-3083

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

There are several sites on IgG Fc that have been reported to be the epitopes for binding rheumatoid factors (RF). It is now established that there are alterations in the oligosaccharides on IgG from patients with rheumatoid arthritis and it has been suggested that these changes may enhance immune complex and cryoglobulin formation.We have used a series of IgG preparations differing in their content of oligosaccharide chains lacking galactose from 18 to 86% to determine whether changes in sugar content affect the binding of rheumatoid factor. Five of 16 monoclonal rheumatoid factors prepared from synovial tissue, from patients with juvenile or adult rheumatoid arthritis, bound better to IgG which was deficient in galactose. Six of the 16 rheumatoid factors from the same patients bound independently of the galactose content. Four of the 16 rheumatoid factors could not be absolutely grouped in this manner but seemed to demonstrate a preference for agalactosyl IgG. One rheumatoid factor bound better to fully galactosylated IgG. There was an association between enhanced binding to galactosc-deficient IgG and monoreactivity and a very strong association between the functional affinity of the rheumatoid factors and the dependent binding.

Electronic Resource

1432-1106

Visual evoked potentials ; Cortical sources ; Man

Springer Online Journal Archives 1860-2000

Medicine

Summary Further studies are reported on the influence of retinal stimulus location on the surface distributions of individual pattern-related VEP components. The following results were observed for stimulation of different central and annular regions of the upper and lower field in four subjects: 1. Consistent differences in polarity and form of the longitudinal distributions of (a) components C.I (peak latency 65–80 msec) and C.II (latency 90–110 msec) of the same VEPs; and (b) component C.II of the upper and lower half-field responses for the same subject. 2. Differences in the relative contributions from the central and outer regions of the stimulus field to (a) the C.I and C.II half-field distributions; and (b) the upper and lower half-field C.II distributions. 3. For C.II (as for C.I) an additive relationship was demonstrated between the half-field and constituent quadrant distributions. 4. The binocular and monocular distributions of C.I and C.II were found to be almost identical in form and comparable in magnitude. These results again indicate that C.I and C.II have spatially separate sources. The longitudinal distributions of C.II are shown to conform with those of a simple dipolar model based on the retinotopic organization of the extrastriate cortex on the outer surfaces of the occipital lobes. Also, the longitudinal distributions of C.I appear consistent with its proposed striate cortical origin. Both C.I and C.II are thought to originate from surface negative cortical activity. Experiments indicating that C.I and C.II are influenced differently by pattern pre-exposure provide supporting evidence for the separability of these components and suggest that they are produced in functionally different cortical regions. The implications of this work are discussed.

Electronic Resource

1432-1106

Visual evoked potentials ; Cortical sources ; Man

Springer Online Journal Archives 1860-2000

Medicine

Summary A study was made of the transverse distributions of human scalprecorded potentials evoked by the brief presentation of a pattern into different regions of a continuously illuminated diffuse field. The first two components of these visual evoked potentials (VEPs), designated C.I. (latency 65–80 msec) and C. II (latency 90–110 msec), were both greatly influenced by the retinal location of the stimulus pattern. In an initial study of the VEP waveforms with 12 subjects, followed by a more detailed investigation of the distribution of the individual components in 4 subjects, the following results were found. 1. Corresponding peaks (C. I and C. II) of the VEPs to stimulation of the upper and lower half-fields were inverted in polarity. 2. For the left and right half-field VEPs, the transverse distribution of C. I, but not of C. II, showed a polarity reversal across the midline. 3. Consistent differences were observed between the distributions of C. I for adjacent upper and lower quadrants, as well as between those for adjacent horizontal and vertical octants of the upper field. 4. Subjects differed in the degree of left-right asymmetry shown. There was also a much greater degree of interindividual consistency of quadrant and upper and lower half-field VEPs than for full-field or left and right half-field responses. 5. For C. I, an additive relationship was demonstrated between the half-field and the constituent quadrant VEP distributions. These results indicate that C. I and C. II have spatially separate sources. Assuming a simple dipolar model based on the known retinotopic organization of the striate cortex, it is shown that the measured distributions are compatible with the hypothesis that component C. I, but not C. II, originates in striate cortex, from surface negative cortical activity.

Electronic Resource