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1Latest Papers from Table of Contents or Articles in PressA. Kaur ; M. R. Webster ; K. Marchbank ; R. Behera ; A. Ndoye ; C. H. Kugel, 3rd ; V. M. Dang ; J. Appleton ; M. P. O'Connell ; P. Cheng ; A. A. Valiga ; R. Morissette ; N. B. McDonnell ; L. Ferrucci ; A. V. Kossenkov ; K. Meeth ; H. Y. Tang ; X. Yin ; W. H. Wood, 3rd ; E. Lehrmann ; K. G. Becker ; K. T. Flaherty ; D. T. Frederick ; J. A. Wargo ; Z. A. Cooper ; M. T. Tetzlaff ; C. Hudgens ; K. M. Aird ; R. Zhang ; X. Xu ; Q. Liu ; E. Bartlett ; G. Karakousis ; Z. Eroglu ; R. S. Lo ; M. Chan ; A. M. Menzies ; G. V. Long ; D. B. Johnson ; J. Sosman ; B. Schilling ; D. Schadendorf ; D. W. Speicher ; M. Bosenberg ; A. Ribas ; A. T. Weeraratna
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-04-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adult ; Aging/*metabolism ; Animals ; Cell Line, Tumor ; Culture Media, Conditioned/pharmacology ; DNA Damage ; DNA-(Apurinic or Apyrimidinic Site) Lyase/metabolism ; Disease Progression ; *Drug Resistance, Neoplasm ; Fibroblasts/secretion ; Humans ; Indoles/pharmacology/therapeutic use ; Male ; Melanoma/blood supply/*drug therapy/genetics/*pathology ; Membrane Proteins/*metabolism/secretion ; Mice ; Microphthalmia-Associated Transcription Factor/metabolism ; Middle Aged ; Molecular Targeted Therapy ; *Neoplasm Metastasis ; Neovascularization, Pathologic ; Oxidative Stress ; Phenotype ; Reactive Oxygen Species/metabolism ; Sulfonamides/pharmacology/therapeutic use ; *Tumor Microenvironment ; Wnt Signaling Pathway ; Wnt1 Protein/antagonists & inhibitors ; beta Catenin/metabolismPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1600-0714Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract. Ultrastructural studies have been carried out on epithelium taken from seven cases of non-erosive oral lichen planus. Structural abnormalities observed have been consistent with light microscopic findings but no cellular changes specific to lichen planus have been noted. In particular the intranuclear structures seen have been similar to those described in a number of other epithelial disorders. Discontinuities of the basement membrane have been observed, without thickening or duplication of the lamina densa. No evidence of a viral etiology for the condition has been detected.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1600-0765Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The surface features of porcine oral mucosa were examined in the scanning electron microscope. A large number of regularly occurring surface features were recorded and some of these appeared to be unique to particular areas of oral mucosa. It is suggested that an objective investigation of these apparently area-specific surface features may show whether they can be used as a new accurate method of identifying types of oral mucosa.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0169-4758Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0739-6260Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Electrical Engineering, Measurement and Control TechnologyNatural Sciences in GeneralType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1600-051XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract Twenty-seven proprietory periodontal dressings were applied to the lower labial segments of 18 subjects showing low levels of gingival inflammation when assessed by the Gingival Index system at the time of application. Specimens of each dressing type were subsequently removed at intervals ranging from 3 h to 5 days. The material adhering to the deep surface of the dressing was examined by light, transmission and scanning electron microscopy and was shown to be a complex heterogeneous structure consisting of large intact epithelial cell sheets and oral bacteria in a proteinaceous matrix. Possible mechanisms which could contribute the epithelial cell and protein components to this structure were discussed. It was concluded that the dressings themselves caused little damage to the normal periodontium but could be associated with increased levels of inflammation at longer time intervals because of bacterial growth. The significance of these findings to current clinical practice is discussed.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0305-7488Topics: GeographyDescription / Table of Contents: The British Isles and the European mainlandNotes: ReviewsURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1432-0827Keywords: Ultrastructure ; Cartilage ; CalcificationSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicinePhysicsDescription / Table of Contents: Résumé Une solution de sulfate de chrome est utilisée à la fois comme fixateur, colorant et agent de déminéralisation pour l'étude ultrastructurale de cartilage, en voie de minéralisation. Cette technique permet de mettre en évidence un “fantôme cristallin” organique, en rapport avec chaque cristal. L'intérêt du sulfate de chrome comme agent de déminéralisation est souligné.Abstract: Zusammenfassung Bei Ultrastrukturuntersuchungen von mineralisierendem Knorpel wurde eine Chromsulfatlösung als Agens zur kombinierten Fixation, Färbung und Demineralisierung verwendet. Diese Technik zeigte das Vorhandensein eines organischen “Kristallschattens”, der jedem Kriställchen zugehört. Die Tauglichkeit von Chromsulfat als demineralisierendes Agens wird besprochen.Notes: Abstract A solution of chromium sulphate was used as a combined fixative, stain and demineralizing agent for the ultrastructural study of mineralizing cartilage. This technique revealed the presence of an organic ‘crystal ghost’ associated with each crystallite. The effectiveness of chromium sulphate as a demineralizing agent is discussed.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1432-0827Keywords: Ultrastructure ; Calcium ; Cartilage ; VesiclesSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicinePhysicsNotes: Summary The potassium pyroantimonate technique was utilized for the selective subcellular localization of calcium in the mandibular condylar cartilage of 1-day-old rats. Electron dense calcium pyroantimonate precipitates were localized principally in mitochondria and at the cell membrane of the chondrocytes. In addition, small intracellular vesicles 0.1–0.2µm in diameter were observed in proximity to the cell membrane of chondrocytes of the mid-hypertrophic zone. The results suggest that these vesicles were being extruded from the cell into the extracellular matrix. Energy-dispersive analysis by X-rays confirmed that calcium is the principal cation of the electron-dense precipitates.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-0827Keywords: Ultrastructure ; Cartilage ; Calcification ; Inorganic ; OrganicSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicinePhysicsDescription / Table of Contents: Résumé La phase organique (ou fantôme des cristaux) associéc à chaque cristal, ainsi que la substance de base associée à chaque cristal, ainsi que la substance de base associée à chaque amas cristallin, sont mises en évidence au niveau du cartilage calcifié en utilisant le sulfate de chrome basique comme agent de fixation, de coloration et de déminéralisation. Le traitement ultérieur du tissu, à l'aide de papaïne ou d'hyaluronidase, indique que les fantômes cristallins constitutent un complexe protéino-polysaccharidique et que la substance de base est formée par une protéine associée à un polysaccharide acide. Les rapports entre phases inorganique et organique sont discutés.Abstract: Zusammenfassung Die organische Phase (oder Kristallit-Schatten), die zu jedem Kristallit gehört, sowie das Hintergrundmaterial, das zu jeder Kristallitgruppe gehört, wurden in calcifiziertem Knorpel sichtbar gemacht. Zu diesem Zweck wurde basisches Chromsulfat als ein kombiniertes Fixierungs-, Färbe- und Demineralisierungsmittel verwendet. Nachfolgende Behandlung des Gewebes mit Papain oder Hyaluronidase läßt vermuten, daß die Kristallitschatten einen Proteinpolysaccharidkomplex darstellen und daß das Hintergrundmaterial hauptsächlich aus Protein mit einigen sauren Polysacchariden besteht. Die Beziehung zwischen anorganischen und organischen Phasen wird diskutiert.Notes: Abstract The organic phase (or crystallite ghost) associated with each crystallite, together with the background material associated with each crystallite cluster, was demonstrated in calcified cartilage using basic chromium sulphate as a combined fixative, stain, and demineralizing agent. Subsequent treatment of the tissue with papain, or with hyaluronidase, suggests that the crystallite ghosts represented a protein-polysaccharide complex and that the background material was principally protein together with some acid polysaccharide. The relationship between inorganic and organic phases is discussed.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1432-1130Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyNotes: Abstract Calcified tissues are good indicators of exposure to environmental pollution since the mineral phase incorporates heavy metals to which it is exposed during development. Analysis of these specimens is difficult due to the low concentration of the elements of interest compared with the high concentration of the matrix elements. ICP-MS allows rapid multielement determination of samples and a method for the determination of trace elements in calcified tissues is presented with reference to an SRM of Bone Ash (NIST 1400).Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesIsotopic evidence for the derivation of some Roman region volcanics from anomalously enriched mantleStaff View
ISSN: 1432-0967Source: Springer Online Journal Archives 1860-2000Topics: GeosciencesNotes: Abstract Strontium isotope data are reported for primitive lavas (leucitites, tephritic leucitites, K-rich basalts, and related types) from the Roccamonfina volcano. A strong positive correlation is found between 87Sr/86Sr and the abundances of K, Rb, Sr, Ba and Zr. It is argued that the present contents of these elements in the lavas are not far removed from their concentrations in their parental primary magmas. Models involving disequilibrium and equilibrium melting of respectively homogeneous and heterogeneous source rocks are discussed. It is concluded that a heterogeneous source highly enriched in incompatible elements at some stage in the past (? 300 m.y.) is indicated.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1573-1987Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Summary A theoretical and experimental investigation of the limitation on shock tube test times which is caused by the development of laminar and turbulent boundary layers behind the incident shock is presented. Two theoretical methods of predicting the test time have been developed. In the first a linearised solution of the unsteady one-dimensional conservation equations is obtained which describes the variations in the average flow properties external to the boundary layer. The boundary layer growth behind the shock is related to the actual extent of the hot flow and not, as in previous unsteady analyses, to its ideal extent. This new unsteady analysis is consequently not restricted to regions close to the diaphragm. Shock tube test times are determined from calculations of the perturbed shock and interface trajectories. In the second method a constant velocity shock is assumed and test times are determined by approximately satisfying only the condition of mass continuity between the shock and the interface. A critical comparison is made between this and previous theories which assume a constant velocity shock. Test times predicted by the constant shock speed theory are generally in agreement with those predicted by the unsteady theory, although the latter predicts a transient maximum test time in excess of the final asymptotic value. Shock tube test times have also been measured over a wide range of operating conditions and these measurements, supplemented by those reported elsewhere, are compared with the predictions of the theories; good agreement is generally obtained. Finally, a simple method of estimating shock tube test times is outlined, based on self similar solutions of the constant shock speed analysis.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0362-2525Keywords: Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyMedicineAdditional Material: 29 Ill.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0002-9106Keywords: Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: MedicineAdditional Material: 3 Ill.Type of Medium: Electronic ResourceURL: