Search Results - (Author, Cooperation:J. A. West)

2011-01-22

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Adaptor Proteins, Signal Transducing/*antagonists & ; inhibitors/chemistry/genetics/metabolism ; Amino Acid Sequence ; Apoptosis ; Apoptosis Regulatory Proteins/*antagonists & ; Carrier Proteins/metabolism ; Caspase 1/metabolism ; Caspase Inhibitors ; Cell Line ; Cell Line, Tumor ; Herpesvirus 8, Human/genetics/immunology/*physiology ; Humans ; *Immune Evasion ; *Immunity, Innate ; Inflammasomes/*antagonists & inhibitors/metabolism ; Interleukin-1beta/metabolism ; Molecular Sequence Data ; Monocytes/virology ; Nod2 Signaling Adaptor Protein/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Transfection ; Viral Proteins/chemistry/genetics/*metabolism ; Virus Activation ; Virus Latency ; Virus Replication

2014-03-22

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

2018-08-07

The American Society for Pharmacology and Experimental Therapeutics (ASPET)

0090-9556

1521-009X

Chemistry and Pharmacology

Medicine

1440-1681

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

1. Animal studies have implicated the angiotensin-converting enzyme (ACE) gene as an inherited risk factor contributing towards elevation of blood pressure.2. A polymorphism of the ACE gene, involving the presence or absence of a 287 base pair (bp) segment within the gene region, was assessed for association with high blood pressure in a large, multigeneration Australian family. The association of these alleles with hypertension in unrelated individuals was also examined.3. There was no evidence to link the ACE gene and high blood pressure in the large family. Similarly, there was no significant association between this gene and high blood pressure in the population tested. As has been reported previously, plasma levels of the enzyme were associated with genotype. These results suggest that this gene is unlikely to be a major risk factor for hypertension in this group.

Electronic Resource

1432-2048

Blue light ; Geographical distribution (alga, daylength) ; Photoperiodism ; Phytochrome ; Reproduction (alga) ; Rhodochorton ; Rhodophyta

Springer Online Journal Archives 1860-2000

Biology

Abstract Six geographical isolates of Rhodochorton purpureum (Lightfoot) Rosenvinge (Rhodophyta, Nemalionales) formed tetrasporangia only in short days at 10°C. For most isolates, the critical day-length increased with latitude of origin from 9.5 h for an isolate from California to 14.5 h for one from Antarctica. Tetrasporangium production could be induced by 9–15 short-day cycles followed by a further 22–28 cycles in long days. A night-break consisting of 1 h of white light in the middle of a 16-h dark period inhibited the short-day response of isolates from low latitudes, but not those from higher latitudes. When a similar night-break was given in the middle of a 14-h dark period, however, the response of all isolates was at least partially inhibited. Night-breaks given at any time in the central 7 h of a 14-h dark period were equally inhibitory. Broad-band red light (0.3–0.4 mmol m-2), given as a night-break, caused 50% inhibition of the short-day response. At a slightly higher photon exposure (0.6 mmol m-2, given as 1 μmol m-2 s-1 for 10 min), narrow-band red (662 nm) and blue (448 nm) light caused similar inhibition, but green (547 nm) and far-red (731 nm) were ineffective as night-breaks. The inhibitory effect of a 10-min night-break with red light could not be reversed by subsequent exposure to an equal photon exposure of far-red light. These results add to the existing evidence that the pigments mediating photoperiodic responses among algae are more varied than those among flowering plants.

Electronic Resource

1615-6102

Cutleria ; Gametogenesis ; Morphogenesis ; Phaeophyta ; Developmental ultrastructure

Springer Online Journal Archives 1860-2000

Biology

Summary Development of the plurilocular male gametangium inCutleria hancockii Dawson is fundamentally similar to that of the female gametangium. However, the sequence of mitoses is less regular and the number of divisions is more variable in the male structure. During mitosis the nucleolus disappears and the nuclear envelope breaks down into vesicles and cisternae. No well-defined chromosomal kinetochores were observed. The spindle does not persist during telophase. At least two types of vesicles, but no microtubules, are associated with cytokinesis. After cleavages are completed, each of the cells develops an eyespot and two flagella. The flagellar rootlet system consists of 4–5 bands of 5–10 microtubules radiating posteriorly from the basal bodies. Flocculent material surrounding the gamete at maturity may be involved with liberation. Prior to release, a pore is formed in each locule when the outermost layers of the surficial wall break, and the innermost layers expand out through this weakened region. The inner wall eventually bursts, releasing the gamete and flocculent material through the pore. The liberated gamete has a long, pleuronematic anterior flagellum, and a short, acronematic posterior flagellum which has a swollen base appressed to the plasmalemma.

Electronic Resource

1615-6102

Springer Online Journal Archives 1860-2000

Biology

Summary Differentiation of the female gametangium inCutleria bancockii Dawson is described. Four series of mitoses result in a 16-locule structure (four tiers of four cells each). The organelles in each locule become polarized after partitioning is complete, with the mitochondria lying near the longitudinal axis of the gametangium. The nucleus and plastids are centrally located, with abundant osmiophilic material present in the cytoplasm subjacent to the gametangial surface. Both electron density and Toluidine Blue 0 staining of the material increase. Two flagella are then produced: one becomes tightly appressed to the plasmalemma near its base, and the other is free. A prominent eyespot forms in the plastid nearest the developing flagella. Golgi and endoplasmic reticulum vesicles are prolific in this region and seem to be involved with mastigoneme production and deposition on the free flagellum. Immediately beneath the plasmalemma, flagellar rootlet tubules emanate from amorphous masses near the basal bodies. Some of these tubules are associated with the eyespot. Most of the osmiophilic material is then secreted into the extracytoplasmic spaces while the gametes are rounding up. Granular-cored vesicles may be involved with pore formation and gamete release.

Electronic Resource

1615-6102

Springer Online Journal Archives 1860-2000

Biology

Summary Ultrastructural examination ofStreblonema sp. revealed icosahedral virus-like particles (135–150 nm) throughout the cytoplasm of vegetative cells. The densely packed particles consist of an osmiophilic coat around a fibrillar core. Most cytoplasmic organelles are excluded from the regions where the particles are extremely abundant, but no degeneration of plastids, mitochondria or dictyosomes is evident. The “virogenic stroma” contains many ribosomes and fibers possibly representing DNA strands remaining from the lysed nucleus. No decrease in vigor seemed to be associated with the presence of the particles.

Electronic Resource

1573-5117

diurnal ; long-term ; carpospore-discharge ; Ceramiaceae ; Delesseriaceae ; Rhodomelaceae

Springer Online Journal Archives 1860-2000

Biology

Abstract In laboratory culture, controlled fertilization resulted in mature carposporophytes of the Ceramiales indicated below. Carpospore discharge was observed daily. In the Ceramiaceae Spyridia filamentosa cystocarp-pairs released spores twice in succession (range: 32–537 total spores/carposporophyte). Discharge by all cystocarp-pairs occurred during the dark period of the daily light:dark cycle (12:12 LD) and was completed in 12 d. In reverse cycle (12:12 and 16:8 DL) spore release reversed in 3d. In the Rhodomelaceae Bostrychia moritziana, Pterosiphonia pennata and Murrayella periclados discharged spores from isolated cystocarps over periods up 58 d (ranges: 318–4112, 1051–2271 and 451–3162 total spores/carposporophyte respectively) without any diurnal or long-term rhythmicity. In the Delesseriaceae cystocarps of Caloglossa leprieurii and Caloglossa ogasawaraensis released spores for up to 31 d (ranges: 271–3050 and 565–1286 total spores/carposp orophyte respectively). Discharge peaks occurred at 5–7 d intervals with viable cystocarps and spore numbers gradually declining. Thus, in the plants studied, there are at least three patterns of carpospore release from individual mature carposporophytes: a relatively short- term dual release pattern, a long-term non-rhythmic release pattern and a long-term rhythmic release pattern. Results also indicated that excised cystocarps without associated vegetative branches showed a much reduced spore production.

Electronic Resource