Search Results - (Author, Cooperation:I. Stamenkovic)
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1Latest Papers from Table of Contents or Articles in PressM. J. Garnett ; E. J. Edelman ; S. J. Heidorn ; C. D. Greenman ; A. Dastur ; K. W. Lau ; P. Greninger ; I. R. Thompson ; X. Luo ; J. Soares ; Q. Liu ; F. Iorio ; D. Surdez ; L. Chen ; R. J. Milano ; G. R. Bignell ; A. T. Tam ; H. Davies ; J. A. Stevenson ; S. Barthorpe ; S. R. Lutz ; F. Kogera ; K. Lawrence ; A. McLaren-Douglas ; X. Mitropoulos ; T. Mironenko ; H. Thi ; L. Richardson ; W. Zhou ; F. Jewitt ; T. Zhang ; P. O'Brien ; J. L. Boisvert ; S. Price ; W. Hur ; W. Yang ; X. Deng ; A. Butler ; H. G. Choi ; J. W. Chang ; J. Baselga ; I. Stamenkovic ; J. A. Engelman ; S. V. Sharma ; O. Delattre ; J. Saez-Rodriguez ; N. S. Gray ; J. Settleman ; P. A. Futreal ; D. A. Haber ; M. R. Stratton ; S. Ramaswamy ; U. McDermott ; C. H. Benes
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-03-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Cell Line, Tumor ; Cell Survival/drug effects ; Drug Resistance, Neoplasm/drug effects/*genetics ; *Drug Screening Assays, Antitumor ; Gene Expression Regulation, Neoplastic/genetics ; Genes, Neoplasm/*genetics ; Genetic Markers/*genetics ; Genome, Human/*genetics ; Genomics ; Humans ; Indoles/pharmacology ; Neoplasms/*drug therapy/*genetics/pathology ; Oncogene Proteins, Fusion/genetics ; Pharmacogenetics ; Phthalazines/pharmacology ; Piperazines/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors ; Proto-Oncogene Protein c-fli-1/genetics ; RNA-Binding Protein EWS/genetics ; Sarcoma, Ewing/drug therapy/genetics/pathologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressBoulay, G., Volorio, A., Iyer, S., Broye, L. C., Stamenkovic, I., Riggi, N., Rivera, M. N.
Cold Spring Harbor Laboratory Press
Published 2018Staff ViewPublication Date: 2018-08-02Publisher: Cold Spring Harbor Laboratory PressPrint ISSN: 0890-9369Topics: BiologyPublished by: -
3Articles: DFG German National LicensesBRAESCH-ANDERSEN, S. ; PAULIE, S. ; STAMENKOVIC, I.
Oxford, UK : Blackwell Publishing Ltd
Published 1992Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Dopamine inhibits prolactin release from pituitary cells and seems to affect the release of several other hormones as well. We report here that dopamine may have similar effects on human B lymphoma cells leading to inhibition of production or release of endogenous factors required for cell viability and proliferation. Thus, addition of dopamine to serum-free cultures of Burkitt lymphoma cells (Raji, Namalwa, Daudi and Jijoye) resulted in rapid and extensive cell death while a myeloma cell line, SKO, appeared to be refractory to this treatment. The addition of FCS or supernatant from serum-free cultures of Raji or T24 bladder carcinoma cells could, to a variable degree, counteract the effect of dopamine, suggesting that dopamine acts by inhibiting the production of essential autocrine factors. When two of the hormones known to be under dopamine control, i.e. prolactin (PRL) and thyrotropin (TSH), were tested, they were able to prevent dopamine-induced cell death if combined with heparin. We further observed that the reducing agent 2-mercaptoethanol (2-ME), which is known to inhibit the binding of TSH to its receptor, displayed similar effects to those of dopamine and was strongly inhibitory for Burkitt lymphoma but not for myeloma cells. As expected from its blocking activity at the receptor level, the effect of 2-ME could not be reversed by adding exogenous factors. Contrary to its effect on B lymphoma cells, 2-ME is essential for growth of the murine T-cell lymphoma line CTLL. However, we show here that dopamine can fully compensate for 2-ME, suggesting that TSH or another factor under dopamine control is intimately involved in the regulation of T-cell growth. This study lends further support to the notion of an active interplay between the neuroendocrine and immune systems and emphasizes PRL and TSH as important regulators of lymphoid cell function. It also shows that these hormones may contribute to the autonomous growth pattern of B lymphoma cells and suggests a potential role for dopamine in the treatment of B-cell tumours.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: CD22 is a B cell lineage restricted cell-surface adhesion glycoprotein which recognizes ligands on human T and B cells and cell lines. A soluble recombinant form of human CD22 (hCD22Rg) has been used to identify and characterize CD22-specific ligands on human T cells, one of which has been shown to be the receptor-linked phosphotyrosine phosphatase CD45. Because CD45 plays a pivotal role in lymphocyte activation, we assessed whether human CD22 might display cross-species reactivity with CD45. In the study presented here we demonstrate that human CD22Rg recognizes several murine cell-surface sialoglycoproteins. including CD45, containing sialic acid in a2, 6 linkage. Furthermore, hCD22Rg recognizes different ligands on functionally distinct T helper-cell subpopulations and selectively binds medullary thymocytes in rivo. Our results confirm and extend previous observations that CD22 is a sialic acid-binding lectin which interacts with CD45 and other glycoproteins capable of presenting α2, 6-linked sialic acid in a manner that promotes high affinity binding. The cross-species reactivity ofCD22 with its ligands underscores the potential physiologic importance ofCD22-mediated lymphocyte interactions.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1573-4838Source: Springer Online Journal Archives 1860-2000Topics: MedicineTechnologyNotes: Composite bioceramic materials could find use in a wide range of biomedical applications; however, their processing technologies are quite complex or not sufficiently developed. In order to eliminate deleterious influences of powder inhomogeneities and to reduce the machining time of final components, a novel procedure for multiphase powders using wet pretreatment and direct forming of green bodies having the desired geometries was studied. During the experimental work alumina, yttria-stabilized zirconia, and their mixtures were used. The forming of discs and femoral heads was done by pressure casting of aqueous suspensions of powders. The measurements of physical, mechanical and tribological properties of sintered samples were performed; the results obtained showed the effectiveness of the process since the property values approached those of similar materials actually on the market, while requiring less machining labour.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesAgathopoulos, S. ; Nikolopoulos, P. ; Salomoni, A. ; Tucci, A. ; Stamenkovic, I.
Springer
Published 1996Staff ViewISSN: 1573-4838Source: Springer Online Journal Archives 1860-2000Topics: MedicineTechnologyNotes: Candidate inert bioceramics based on Al2O3 and ZrO2 and on SiO2-TiO2 were prepared via slip casting and sol-gel/hot-pressing techniques, respectively. Their properties relevant to applicability in biomedicine-microstructure, microhardness and coefficient of thermal expansion-were determined. The affinity of the oxides with body-liquids was evaluated by wetting experiments at 37°C. High-quality materials were achieved due to the advantages offered by the preparation techniques employed. The Al2O3 and ZrO2 based ceramics have high hardness, a constant coefficient of thermal expansion within a wide temperature range and low adhesion with biological liquids. The SiO2-TiO2 samples, the crystallinity of which depends on the preparation conditions, have lower hardness and lower coefficient of thermal expansion, which in the case of crystalline samples considerably changes at low temperatures, and display good affinity with biological liquids, strongly affected by the presence of glassy phase in the oxide.Type of Medium: Electronic ResourceURL: