Search Results - (Author, Cooperation:I. L. Weissman)
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1Latest Papers from Table of Contents or Articles in PressA. Voskoboynik ; A. M. Newman ; D. M. Corey ; D. Sahoo ; D. Pushkarev ; N. F. Neff ; B. Passarelli ; W. Koh ; K. J. Ishizuka ; K. J. Palmeri ; I. K. Dimov ; C. Keasar ; H. C. Fan ; G. L. Mantalas ; R. Sinha ; L. Penland ; S. R. Quake ; I. L. Weissman
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-07-28Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Animals ; *Genes ; Genome ; Genotype ; Histocompatibility/*genetics ; Immune Tolerance ; Molecular Sequence Data ; Sequence Analysis, DNA ; Transcriptome ; Up-Regulation ; Urochordata/*genetics/*immunology/physiologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressK. Weiskopf ; A. M. Ring ; C. C. Ho ; J. P. Volkmer ; A. M. Levin ; A. K. Volkmer ; E. Ozkan ; N. B. Fernhoff ; M. van de Rijn ; I. L. Weissman ; K. C. Garcia
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-06-01Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: *Adjuvants, Immunologic ; Animals ; Antibodies, Monoclonal/*therapeutic use ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Antibodies, Neoplasm/*therapeutic use ; Antigens, CD47/*immunology ; Antigens, Differentiation/chemistry/genetics/*therapeutic use ; Cell Line, Tumor ; Directed Molecular Evolution ; Humans ; Immunotherapy ; Macrophage Activation ; Mice ; Neoplasms/immunology/*therapy ; Phagocytosis ; Receptors, Immunologic/chemistry/genetics/*therapeutic use ; RituximabPublished by: -
3Latest Papers from Table of Contents or Articles in PressA. Sharma ; V. Sebastiano ; C. T. Scott ; D. Magnus ; N. Koyano-Nakagawa ; D. J. Garry ; O. N. Witte ; H. Nakauchi ; J. C. Wu ; I. L. Weissman ; S. M. Wu
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-11-07Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; *Bioethical Issues ; Blastocyst ; *Chimera ; Financial Management/ethics ; Humans ; Mice ; National Institutes of Health (U.S.)/economics/ethics ; Pluripotent Stem Cells/*transplantation ; Stem Cell Research/economics/*ethics ; United StatesPublished by: -
4Latest Papers from Table of Contents or Articles in PressY. Rinkevich ; G. G. Walmsley ; M. S. Hu ; Z. N. Maan ; A. M. Newman ; M. Drukker ; M. Januszyk ; G. W. Krampitz ; G. C. Gurtner ; H. P. Lorenz ; I. L. Weissman ; M. T. Longaker
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-04-18Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Lineage/genetics ; Cell Separation/*methods ; Cicatrix/metabolism/*pathology ; Disease Models, Animal ; Embryonic Development ; Embryonic Stem Cells/cytology ; Fibroblasts/cytology/pathology/*physiology ; Gene Expression ; Homeodomain Proteins/genetics ; Mice ; Mouth/injuries/pathology/surgery ; Skin/injuries/*pathology ; Translational Medical Research ; *Wound HealingPublished by: -
5Latest Papers from Table of Contents or Articles in PressJ. Y. Chen ; M. Miyanishi ; S. K. Wang ; S. Yamazaki ; R. Sinha ; K. S. Kao ; J. Seita ; D. Sahoo ; H. Nakauchi ; I. L. Weissman
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-02-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antigens, CD/metabolism ; Biomarkers/analysis ; Bone Marrow/metabolism ; Cadherins/metabolism ; Cell Self Renewal ; Gene Expression Regulation ; Genes, Reporter/genetics ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/*cytology/*metabolism ; Homeodomain Proteins/genetics/*metabolism ; Immunophenotyping ; Male ; Mice ; Mice, Inbred C57BL ; *Stem Cell NichePublished by: -
6Latest Papers from Table of Contents or Articles in PressY. Rinkevich ; P. Lindau ; H. Ueno ; M. T. Longaker ; I. L. Weissman
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-08-26Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bone and Bones/cytology ; *Cell Lineage ; Clone Cells ; Ectoderm/cytology/growth & development ; Endothelium/cytology/growth & development ; Extremities/*growth & development ; Female ; Germ Layers/*cytology ; Hematopoietic Stem Cells/cytology ; Male ; Mesoderm/cytology/growth & development ; Mice ; Organ Specificity ; Regeneration/*physiology ; Stem Cells/*cytology ; Tendons/cytology/growth & developmentPublished by: -
7Articles: DFG German National LicensesStaff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: CD3−4−8− interleukin-2 receptor positive (IL-2R+) thymocyte precursors from adult mice were cocultured with thymic stromal cells from syngeneic adult mice. The IL-2R+CD3−4−8− thymocytes were obtained by positive panning of IL-2R+ cells followed by either sorting or negative panning of triple negative cells, and they were cocultured with primary or secondary cultures of heterogeneous thymic stromal cells. Phenotypic maturation of these precursor cells was extremely rapid. Within 2½ days significant numbers of CD4+8+ and CD3+4+8− cell populations developed, the latter expressing the αβ T-cell receptor (αβ-TCR). Thus heterogeneous stromal cell cultures support the development of IL-2R+ precursors and with these methods it will now be possible to isolate the particular stromal cells involved at each stromal-dependent step.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesEichwald, E. J. ; Anthony, M. ; Weissman, I. L. ; Lustgraaf, E.C.
Oxford, UK : Blackwell Publishing Ltd
Published 1962Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Germinal centre B cells possess unique cell-surface features. One of the most important of these is defined by peanut agglutinin (PNA)4"7, a plant lectin with specificity for terminal galactosyl residues. In antigen-stimulated lymphoid organs, fluorescence-labelled PNA defines a discrete population ...Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesScofield, V. L. ; Schlumpberger, J. M. ; West, L. A. ; Weissman, I. L.
[s.l.] : Nature Publishing Group
Published 1982Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Colonial tunicates, unlike vertebrates, undergo transplantation in nature. Rejection or acceptance between colonies of Botryllus is controlled by a single gene locus with multiple alleles. The same genetic region apparently maintains this polymorphism by preventing fertilization between gametes ...Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Very early after intravenous injection of normal or irradiated hosts with fluorochrome (fluorescein isothiocyanate (FITC) or rhodamine isothyocyanate (RITC)) labelled bone marrow (BM) cells, a small number of the donor cells were detectable in the recipient thymuses. To test whether this homing was ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-1211Keywords: Key words Heat-shock protein ; Historecognition ; Major histocompatibility complex ; Linkage analysisSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract The protochordate allorecognition system has long invited comparison with the vertebrate major histocompatibility complex (MHC). In the colonial species Botryllus schlosseri, a rapid fusion or rejection response resembling graft acceptance or rejection in vertebrates is controlled by a single highly polymorphic genetic region. Because linkage between heat shock protein 70 (HSP70) genes and the MHC appears to be conserved within the vertebrate lineage, linkage relationships between two HSP70 genes (HSP70.1 and HSP70.2) and the historecognition locus (FuHC) have been analyzed in B. schlosseri. Segregation patterns of restriction fragment length polymorphisms located in the 3′ flanking regions of HSP70.1 and HSP70.2 were determined for progeny of defined crosses. These progeny were also analyzed for fusibility type by an in vivo cut colony assay. No close linkage was detected between any of the three loci. These results do not support the hypothesis that the allorecognition response in B. schlosseri is determined by an MHC homologue. However, it remains a possibility that orthologues of other MHC-linked genes will be linked to the B. schlosseri FuHC.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-1211Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1432-1211Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Two genes belonging to the heat shock protein 70 gene family have been cloned from the colonial protochordate Botryllus schlosseri. The two intronless genes (HSP70.1 and HSP70.2) exhibit 93.6% sequence identity within the predicted coding region, and 83.3% and 81.7% sequence identity in the 5′ and 3′ flanking regions, respectively. The predicted amino acid sequences are 95% identical and contain several signatures characteristic of cytoplasmic eukaryotic HSP70 genes (Gupta et al. 1994; Rensing and Maier 1994). Northern blotting and sequence analysis suggest that both genes are heat-inducible members of the HSP70 gene family. Given these characteristics, HSP70.1 and HSP70.2 appear to be good candidates for protochordate homologues of the major histocompatibility complex-linked HSP70 genes of human, mouse, and rat (Milner and Campbell 1990; Walter et al. 1994). Further experiments to determine whether there is functional evidence for such similarity are in progress.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1573-6865Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary The effect of different fixation solutions on the denaturation of membrane-associated antigens in murine lymphoid cells was determined quantitatively using microfluorometric analysis and a radioimmunoassay. Paraformaldehyde and periodate-lysine-paraformaldehyde solutions preserved the antigenicity of cell surface-associated immunoglobulin (S−Ig) antigens when used in concentrations ranging from 0.01 to 4%. However, glutaraldehyde destroyed the antigenicity of S−Ig and Thy 1.2 molecules at concentrations higher than 0.1%. Electron microscopic analysis of the different fixed cell suspensions, after labelling of the cells with a rabbit anti-mouse immunoglobulin-horseradish peroxidase conjugate (RaM-Ig-HRP) showed that prefixation of the sample with 0.1% glutaraldehyde was optimal for immunoelectron microscopical studies, since this concentration preserved both the antigenicity of membrane-associated antigens as well as the ultrastructure of the cells under study. Prolonged fixation periods affected antibody binding. However, S−Ig molecules denatured at a slower rate than Thy 1.2 molecules. A preparation method for the immunoelectron microscopical localization of lymphoid and non-lymphoid cell types in lymphoid organs is reported.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesWeissman, I. L. ; McGrath, M. S. ; Pillemer, E. ; Hollander, N. ; Rouse, R. V. ; Jerabek, L. ; Stevens, S. K. ; Scollay, R. G. ; Butcher, E. G.
New York, NY : Wiley-Blackwell
Published 1981Staff ViewISSN: 0275-3723Keywords: Chemistry ; Molecular Cell BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyChemistry and PharmacologyMedicineNotes: Lymphocytes arc cells that are responsible for processes of specific antigen recognition and for those aspects of the immune response that characterize adaptive immunity. In this respect adaptive immunity can be characterized as antigen-induced immune memory and effector functions as compared to native immunity - the nonspecific phagocytic and humoral protective elements in lower vertebrates. In vertebrates both B and T lymphocytes apparently express self-synthesized receptors that (1) are involved in the recognition of antigens, and (2) mediate the interactions between various important cells in the hematolymphoid system. There are three major subclasses of T lymphocytes - those involved with helper/inducer functions, those involved with suppressor functions, and those involved in direct cytotoxicity of antigenic target cells [1,2].Additional Material: 8 Ill.Type of Medium: Electronic ResourceURL: