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1D. P. Hibar ; J. L. Stein ; M. E. Renteria ; A. Arias-Vasquez ; S. Desrivieres ; N. Jahanshad ; R. Toro ; K. Wittfeld ; L. Abramovic ; M. Andersson ; B. S. Aribisala ; N. J. Armstrong ; M. Bernard ; M. M. Bohlken ; M. P. Boks ; J. Bralten ; A. A. Brown ; M. M. Chakravarty ; Q. Chen ; C. R. Ching ; G. Cuellar-Partida ; A. den Braber ; S. Giddaluru ; A. L. Goldman ; O. Grimm ; T. Guadalupe ; J. Hass ; G. Woldehawariat ; A. J. Holmes ; M. Hoogman ; D. Janowitz ; T. Jia ; S. Kim ; M. Klein ; B. Kraemer ; P. H. Lee ; L. M. Olde Loohuis ; M. Luciano ; C. Macare ; K. A. Mather ; M. Mattheisen ; Y. Milaneschi ; K. Nho ; M. Papmeyer ; A. Ramasamy ; S. L. Risacher ; R. Roiz-Santianez ; E. J. Rose ; A. Salami ; P. G. Samann ; L. Schmaal ; A. J. Schork ; J. Shin ; L. T. Strike ; A. Teumer ; M. M. van Donkelaar ; K. R. van Eijk ; R. K. Walters ; L. T. Westlye ; C. D. Whelan ; A. M. Winkler ; M. P. Zwiers ; S. Alhusaini ; L. Athanasiu ; S. Ehrlich ; M. M. Hakobjan ; C. B. Hartberg ; U. K. Haukvik ; A. J. Heister ; D. Hoehn ; D. Kasperaviciute ; D. C. Liewald ; L. M. Lopez ; R. R. Makkinje ; M. Matarin ; M. A. Naber ; D. R. McKay ; M. Needham ; A. C. Nugent ; B. Putz ; N. A. Royle ; L. Shen ; E. Sprooten ; D. Trabzuni ; S. S. van der Marel ; K. J. van Hulzen ; E. Walton ; C. Wolf ; L. Almasy ; D. Ames ; S. Arepalli ; A. A. Assareh ; M. E. Bastin ; H. Brodaty ; K. B. Bulayeva ; M. A. Carless ; S. Cichon ; A. Corvin ; J. E. Curran ; M. Czisch ; G. I. de Zubicaray ; A. Dillman ; R. Duggirala ; T. D. Dyer ; S. Erk ; I. O. Fedko ; L. Ferrucci ; T. M. Foroud ; P. T. Fox ; M. Fukunaga ; J. R. Gibbs ; H. H. Goring ; R. C. Green ; S. Guelfi ; N. K. Hansell ; C. A. Hartman ; K. Hegenscheid ; A. Heinz ; D. G. Hernandez ; D. J. Heslenfeld ; P. J. Hoekstra ; F. Holsboer ; G. Homuth ; J. J. Hottenga ; M. Ikeda ; C. R. Jack, Jr. ; M. Jenkinson ; R. Johnson ; R. Kanai ; M. Keil ; J. W. Kent, Jr. ; P. Kochunov ; J. B. Kwok ; S. M. Lawrie ; X. Liu ; D. L. Longo ; K. L. McMahon ; E. Meisenzahl ; I. Melle ; S. Mohnke ; G. W. Montgomery ; J. C. Mostert ; T. W. Muhleisen ; M. A. Nalls ; T. E. Nichols ; L. G. Nilsson ; M. M. Nothen ; K. Ohi ; R. L. Olvera ; R. Perez-Iglesias ; G. B. Pike ; S. G. Potkin ; I. Reinvang ; S. Reppermund ; M. Rietschel ; N. Romanczuk-Seiferth ; G. D. Rosen ; D. Rujescu ; K. Schnell ; P. R. Schofield ; C. Smith ; V. M. Steen ; J. E. Sussmann ; A. Thalamuthu ; A. W. Toga ; B. J. Traynor ; J. Troncoso ; J. A. Turner ; M. C. Valdes Hernandez ; D. van 't Ent ; M. van der Brug ; N. J. van der Wee ; M. J. van Tol ; D. J. Veltman ; T. H. Wassink ; E. Westman ; R. H. Zielke ; A. B. Zonderman ; D. G. Ashbrook ; R. Hager ; L. Lu ; F. J. McMahon ; D. W. Morris ; R. W. Williams ; H. G. Brunner ; R. L. Buckner ; J. K. Buitelaar ; W. Cahn ; V. D. Calhoun ; G. L. Cavalleri ; B. Crespo-Facorro ; A. M. Dale ; G. E. Davies ; N. Delanty ; C. Depondt ; S. Djurovic ; W. C. Drevets ; T. Espeseth ; R. L. Gollub ; B. C. Ho ; W. Hoffmann ; N. Hosten ; R. S. Kahn ; S. Le Hellard ; A. Meyer-Lindenberg ; B. Muller-Myhsok ; M. Nauck ; L. Nyberg ; M. Pandolfo ; B. W. Penninx ; J. L. Roffman ; S. M. Sisodiya ; J. W. Smoller ; H. van Bokhoven ; N. E. van Haren ; H. Volzke ; H. Walter ; M. W. Weiner ; W. Wen ; T. White ; I. Agartz ; O. A. Andreassen ; J. Blangero ; D. I. Boomsma ; R. M. Brouwer ; D. M. Cannon ; M. R. Cookson ; E. J. de Geus ; I. J. Deary ; G. Donohoe ; G. Fernandez ; S. E. Fisher ; C. Francks ; D. C. Glahn ; H. J. Grabe ; O. Gruber ; J. Hardy ; R. Hashimoto ; H. E. Hulshoff Pol ; E. G. Jonsson ; I. Kloszewska ; S. Lovestone ; V. S. Mattay ; P. Mecocci ; C. McDonald ; A. M. McIntosh ; R. A. Ophoff ; T. Paus ; Z. Pausova ; M. Ryten ; P. S. Sachdev ; A. J. Saykin ; A. Simmons ; A. Singleton ; H. Soininen ; J. M. Wardlaw ; M. E. Weale ; D. R. Weinberger ; H. H. Adams ; L. J. Launer ; S. Seiler ; R. Schmidt ; G. Chauhan ; C. L. Satizabal ; J. T. Becker ; L. Yanek ; S. J. van der Lee ; M. Ebling ; B. Fischl ; W. T. Longstreth, Jr. ; D. Greve ; H. Schmidt ; P. Nyquist ; L. N. Vinke ; C. M. van Duijn ; L. Xue ; B. Mazoyer ; J. C. Bis ; V. Gudnason ; S. Seshadri ; M. A. Ikram ; N. G. Martin ; M. J. Wright ; G. Schumann ; B. Franke ; P. M. Thompson ; S. E. Medland
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Published 2015Staff ViewPublication Date: 2015-01-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging/genetics ; Apoptosis/genetics ; Brain/*anatomy & histology ; Caudate Nucleus/anatomy & histology ; Child ; Female ; Gene Expression Regulation, Developmental/genetics ; Genetic Loci/genetics ; Genetic Variation/*genetics ; *Genome-Wide Association Study ; Hippocampus/anatomy & histology ; Humans ; Magnetic Resonance Imaging ; Male ; Membrane Proteins/genetics ; Middle Aged ; Organ Size/genetics ; Putamen/anatomy & histology ; Sex Characteristics ; Skull/anatomy & histology ; Young AdultPublished by: -
2P. K. Joshi ; T. Esko ; H. Mattsson ; N. Eklund ; I. Gandin ; T. Nutile ; A. U. Jackson ; C. Schurmann ; A. V. Smith ; W. Zhang ; Y. Okada ; A. Stancakova ; J. D. Faul ; W. Zhao ; T. M. Bartz ; M. P. Concas ; N. Franceschini ; S. Enroth ; V. Vitart ; S. Trompet ; X. Guo ; D. I. Chasman ; J. R. O'Connel ; T. Corre ; S. S. Nongmaithem ; Y. Chen ; M. Mangino ; D. Ruggiero ; M. Traglia ; A. E. Farmaki ; T. Kacprowski ; A. Bjonnes ; A. van der Spek ; Y. Wu ; A. K. Giri ; L. R. Yanek ; L. Wang ; E. Hofer ; C. A. Rietveld ; O. McLeod ; M. C. Cornelis ; C. Pattaro ; N. Verweij ; C. Baumbach ; A. Abdellaoui ; H. R. Warren ; D. Vuckovic ; H. Mei ; C. Bouchard ; J. R. Perry ; S. Cappellani ; S. S. Mirza ; M. C. Benton ; U. Broeckel ; S. E. Medland ; P. A. Lind ; G. Malerba ; A. Drong ; L. Yengo ; L. F. Bielak ; D. Zhi ; P. J. van der Most ; D. Shriner ; R. Magi ; G. Hemani ; T. Karaderi ; Z. Wang ; T. Liu ; I. Demuth ; J. H. Zhao ; W. Meng ; L. Lataniotis ; S. W. van der Laan ; J. P. 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Seshadri ; P. Sever ; S. Shrestha ; B. H. Smith ; J. A. Smith ; N. Soranzo ; N. Sotoodehnia ; L. Southam ; A. V. Stanton ; M. G. Stathopoulou ; K. Strauch ; R. J. Strawbridge ; M. J. Suderman ; N. Tandon ; S. T. Tang ; K. D. Taylor ; B. O. Tayo ; A. M. Toglhofer ; M. Tomaszewski ; N. Tsernikova ; J. Tuomilehto ; A. G. Uitterlinden ; D. Vaidya ; A. van Hylckama Vlieg ; J. van Setten ; T. Vasankari ; S. Vedantam ; E. Vlachopoulou ; D. Vozzi ; E. Vuoksimaa ; M. Waldenberger ; E. B. Ware ; W. Wentworth-Shields ; J. B. Whitfield ; S. Wild ; G. Willemsen ; C. S. Yajnik ; J. Yao ; G. Zaza ; X. Zhu ; R. M. Salem ; M. Melbye ; H. Bisgaard ; N. J. Samani ; D. Cusi ; D. A. Mackey ; R. S. Cooper ; P. Froguel ; G. Pasterkamp ; S. F. Grant ; H. Hakonarson ; L. Ferrucci ; R. A. Scott ; A. D. Morris ; C. N. Palmer ; G. Dedoussis ; P. Deloukas ; L. Bertram ; U. Lindenberger ; S. I. Berndt ; C. M. Lindgren ; N. J. Timpson ; A. Tonjes ; P. B. Munroe ; T. I. Sorensen ; C. N. Rotimi ; D. K. Arnett ; A. J. Oldehinkel ; S. L. Kardia ; B. Balkau ; G. Gambaro ; A. P. Morris ; J. G. Eriksson ; M. J. Wright ; N. G. Martin ; S. C. Hunt ; J. M. Starr ; I. J. Deary ; L. R. Griffiths ; H. Tiemeier ; N. Pirastu ; J. Kaprio ; N. J. Wareham ; L. Perusse ; J. G. Wilson ; G. Girotto ; M. J. Caulfield ; O. Raitakari ; D. I. Boomsma ; C. Gieger ; P. van der Harst ; A. A. Hicks ; P. Kraft ; J. Sinisalo ; P. Knekt ; M. Johannesson ; P. K. Magnusson ; A. Hamsten ; R. Schmidt ; I. B. Borecki ; E. Vartiainen ; D. M. Becker ; D. Bharadwaj ; K. L. Mohlke ; M. Boehnke ; C. M. van Duijn ; D. K. Sanghera ; A. Teumer ; E. Zeggini ; A. Metspalu ; P. Gasparini ; S. Ulivi ; C. Ober ; D. Toniolo ; I. Rudan ; D. J. Porteous ; M. Ciullo ; T. D. Spector ; C. Hayward ; J. Dupuis ; R. J. Loos ; A. F. Wright ; G. R. Chandak ; P. Vollenweider ; A. R. Shuldiner ; P. M. Ridker ; J. I. Rotter ; N. Sattar ; U. Gyllensten ; K. E. North ; M. Pirastu ; B. M. Psaty ; D. R. Weir ; M. Laakso ; V. Gudnason ; A. Takahashi ; J. C. 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3C. A. Rietveld ; S. E. Medland ; J. Derringer ; J. Yang ; T. Esko ; N. W. Martin ; H. J. Westra ; K. Shakhbazov ; A. Abdellaoui ; A. Agrawal ; E. Albrecht ; B. Z. Alizadeh ; N. Amin ; J. Barnard ; S. E. Baumeister ; K. S. Benke ; L. F. Bielak ; J. A. Boatman ; P. A. Boyle ; G. Davies ; C. de Leeuw ; N. Eklund ; D. S. Evans ; R. Ferhmann ; K. Fischer ; C. Gieger ; H. K. Gjessing ; S. Hagg ; J. R. Harris ; C. Hayward ; C. Holzapfel ; C. A. Ibrahim-Verbaas ; E. Ingelsson ; B. Jacobsson ; P. K. Joshi ; A. Jugessur ; M. Kaakinen ; S. Kanoni ; J. Karjalainen ; I. Kolcic ; K. Kristiansson ; Z. Kutalik ; J. Lahti ; S. H. Lee ; P. Lin ; P. A. Lind ; Y. Liu ; K. Lohman ; M. Loitfelder ; G. McMahon ; P. M. Vidal ; O. Meirelles ; L. Milani ; R. Myhre ; M. L. Nuotio ; C. J. Oldmeadow ; K. E. Petrovic ; W. J. Peyrot ; O. Polasek ; L. Quaye ; E. Reinmaa ; J. P. Rice ; T. S. Rizzi ; H. Schmidt ; R. Schmidt ; A. V. Smith ; J. A. Smith ; T. Tanaka ; A. Terracciano ; M. J. van der Loos ; V. Vitart ; H. Volzke ; J. Wellmann ; L. Yu ; W. Zhao ; J. Allik ; J. R. Attia ; S. Bandinelli ; F. Bastardot ; J. Beauchamp ; D. A. Bennett ; K. Berger ; L. J. Bierut ; D. I. Boomsma ; U. Bultmann ; H. Campbell ; C. F. Chabris ; L. Cherkas ; M. K. Chung ; F. Cucca ; M. de Andrade ; P. L. De Jager ; J. E. De Neve ; I. J. Deary ; G. V. Dedoussis ; P. Deloukas ; M. Dimitriou ; G. Eiriksdottir ; M. F. Elderson ; J. G. Eriksson ; D. M. Evans ; J. D. Faul ; L. Ferrucci ; M. E. Garcia ; H. Gronberg ; V. Guethnason ; P. Hall ; J. M. Harris ; T. B. Harris ; N. D. Hastie ; A. C. Heath ; D. G. Hernandez ; W. Hoffmann ; A. Hofman ; R. Holle ; E. G. Holliday ; J. J. Hottenga ; W. G. Iacono ; T. Illig ; M. R. Jarvelin ; M. Kahonen ; J. Kaprio ; R. M. Kirkpatrick ; M. Kowgier ; A. Latvala ; L. J. Launer ; D. A. Lawlor ; T. Lehtimaki ; J. Li ; P. Lichtenstein ; P. Lichtner ; D. C. Liewald ; P. A. Madden ; P. K. Magnusson ; T. E. Makinen ; M. Masala ; M. McGue ; A. Metspalu ; A. Mielck ; M. B. Miller ; G. W. Montgomery ; S. Mukherjee ; D. R. Nyholt ; B. A. Oostra ; L. J. Palmer ; A. Palotie ; B. W. Penninx ; M. Perola ; P. A. Peyser ; M. Preisig ; K. Raikkonen ; O. T. Raitakari ; A. Realo ; S. M. Ring ; S. Ripatti ; F. Rivadeneira ; I. Rudan ; A. Rustichini ; V. Salomaa ; A. P. Sarin ; D. Schlessinger ; R. J. Scott ; H. Snieder ; B. St Pourcain ; J. M. Starr ; J. H. Sul ; I. Surakka ; R. Svento ; A. Teumer ; H. Tiemeier ; F. J. van Rooij ; D. R. Van Wagoner ; E. Vartiainen ; J. Viikari ; P. Vollenweider ; J. M. Vonk ; G. Waeber ; D. R. Weir ; H. E. Wichmann ; E. Widen ; G. Willemsen ; J. F. Wilson ; A. F. Wright ; D. Conley ; G. Davey-Smith ; L. Franke ; P. J. Groenen ; M. Johannesson ; S. L. Kardia ; R. F. Krueger ; D. Laibson ; N. G. Martin ; M. N. Meyer ; D. Posthuma ; A. R. Thurik ; N. J. Timpson ; A. G. Uitterlinden ; C. M. van Duijn ; P. M. Visscher ; D. J. Benjamin ; D. Cesarini ; P. D. Koellinger
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4A. Okbay ; J. P. Beauchamp ; M. A. Fontana ; J. J. Lee ; T. H. Pers ; C. A. Rietveld ; P. Turley ; G. B. Chen ; V. Emilsson ; S. F. Meddens ; S. Oskarsson ; J. K. Pickrell ; K. Thom ; P. Timshel ; R. de Vlaming ; A. Abdellaoui ; T. S. Ahluwalia ; J. Bacelis ; C. Baumbach ; G. Bjornsdottir ; J. H. Brandsma ; M. Pina Concas ; J. Derringer ; N. A. Furlotte ; T. E. Galesloot ; G. Girotto ; R. Gupta ; L. M. Hall ; S. E. Harris ; E. Hofer ; M. Horikoshi ; J. E. Huffman ; K. Kaasik ; I. P. Kalafati ; R. Karlsson ; A. Kong ; J. Lahti ; S. J. van der Lee ; C. deLeeuw ; P. A. Lind ; K. O. Lindgren ; T. Liu ; M. Mangino ; J. Marten ; E. Mihailov ; M. B. Miller ; P. J. van der Most ; C. Oldmeadow ; A. Payton ; N. Pervjakova ; W. J. Peyrot ; Y. Qian ; O. Raitakari ; R. Rueedi ; E. Salvi ; B. Schmidt ; K. E. Schraut ; J. Shi ; A. V. Smith ; R. A. Poot ; B. St Pourcain ; A. Teumer ; G. Thorleifsson ; N. Verweij ; D. Vuckovic ; J. Wellmann ; H. J. Westra ; J. Yang ; W. Zhao ; Z. Zhu ; B. Z. Alizadeh ; N. Amin ; A. Bakshi ; S. E. Baumeister ; G. Biino ; K. Bonnelykke ; P. A. Boyle ; H. Campbell ; F. P. Cappuccio ; G. Davies ; J. E. De Neve ; P. Deloukas ; I. Demuth ; J. Ding ; P. Eibich ; L. Eisele ; N. Eklund ; D. M. Evans ; J. D. Faul ; M. F. Feitosa ; A. J. Forstner ; I. Gandin ; B. Gunnarsson ; B. V. Halldorsson ; T. B. Harris ; A. C. Heath ; L. J. Hocking ; E. G. Holliday ; G. Homuth ; M. A. Horan ; J. J. Hottenga ; P. L. de Jager ; P. K. Joshi ; A. Jugessur ; M. A. Kaakinen ; M. Kahonen ; S. Kanoni ; L. Keltigangas-Jarvinen ; L. A. Kiemeney ; I. Kolcic ; S. Koskinen ; A. T. Kraja ; M. Kroh ; Z. Kutalik ; A. Latvala ; L. J. Launer ; M. P. Lebreton ; D. F. Levinson ; P. Lichtenstein ; P. Lichtner ; D. C. Liewald ; A. Loukola ; P. A. Madden ; R. Magi ; T. Maki-Opas ; R. E. Marioni ; P. Marques-Vidal ; G. A. Meddens ; G. McMahon ; C. Meisinger ; T. Meitinger ; Y. Milaneschi ; L. Milani ; G. W. Montgomery ; R. Myhre ; C. P. Nelson ; D. R. Nyholt ; W. E. Ollier ; A. Palotie ; L. Paternoster ; N. L. Pedersen ; K. E. Petrovic ; D. J. Porteous ; K. Raikkonen ; S. M. Ring ; A. Robino ; O. Rostapshova ; I. Rudan ; A. Rustichini ; V. Salomaa ; A. R. Sanders ; A. P. Sarin ; H. Schmidt ; R. J. Scott ; B. H. Smith ; J. A. Smith ; J. A. Staessen ; E. Steinhagen-Thiessen ; K. Strauch ; A. Terracciano ; M. D. Tobin ; S. Ulivi ; S. Vaccargiu ; L. Quaye ; F. J. van Rooij ; C. Venturini ; A. A. Vinkhuyzen ; U. Volker ; H. Volzke ; J. M. Vonk ; D. Vozzi ; J. Waage ; E. B. Ware ; G. Willemsen ; J. R. Attia ; D. A. Bennett ; K. Berger ; L. Bertram ; H. Bisgaard ; D. I. Boomsma ; I. B. Borecki ; U. Bultmann ; C. F. Chabris ; F. Cucca ; D. Cusi ; I. J. Deary ; G. V. Dedoussis ; C. M. van Duijn ; J. G. Eriksson ; B. Franke ; L. Franke ; P. Gasparini ; P. V. Gejman ; C. Gieger ; H. J. Grabe ; J. Gratten ; P. J. Groenen ; V. Gudnason ; P. van der Harst ; C. Hayward ; D. A. Hinds ; W. Hoffmann ; E. Hypponen ; W. G. Iacono ; B. Jacobsson ; M. R. Jarvelin ; K. H. Jockel ; J. Kaprio ; S. L. Kardia ; T. Lehtimaki ; S. F. Lehrer ; P. K. Magnusson ; N. G. Martin ; M. McGue ; A. Metspalu ; N. Pendleton ; B. W. Penninx ; M. Perola ; N. Pirastu ; M. Pirastu ; O. Polasek ; D. Posthuma ; C. Power ; M. A. Province ; N. J. Samani ; D. Schlessinger ; R. Schmidt ; T. I. Sorensen ; T. D. Spector ; K. Stefansson ; U. Thorsteinsdottir ; A. R. Thurik ; N. J. Timpson ; H. Tiemeier ; J. Y. Tung ; A. G. Uitterlinden ; V. Vitart ; P. Vollenweider ; D. R. Weir ; J. F. Wilson ; A. F. Wright ; D. C. Conley ; R. F. Krueger ; G. Davey Smith ; A. Hofman ; D. I. Laibson ; S. E. Medland ; M. N. Meyer ; M. Johannesson ; P. M. Visscher ; T. Esko ; P. D. Koellinger ; D. Cesarini ; D. J. Benjamin
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Published 2016Staff ViewPublication Date: 2016-05-27Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
5C. Gieger ; A. Radhakrishnan ; A. Cvejic ; W. Tang ; E. Porcu ; G. Pistis ; J. Serbanovic-Canic ; U. Elling ; A. H. Goodall ; Y. Labrune ; L. M. Lopez ; R. Magi ; S. Meacham ; Y. Okada ; N. Pirastu ; R. Sorice ; A. Teumer ; K. Voss ; W. Zhang ; R. Ramirez-Solis ; J. C. Bis ; D. Ellinghaus ; M. Gogele ; J. J. Hottenga ; C. Langenberg ; P. Kovacs ; P. F. O'Reilly ; S. Y. Shin ; T. Esko ; J. Hartiala ; S. Kanoni ; F. Murgia ; A. Parsa ; J. Stephens ; P. van der Harst ; C. Ellen van der Schoot ; H. Allayee ; A. Attwood ; B. Balkau ; F. Bastardot ; S. Basu ; S. E. Baumeister ; G. Biino ; L. Bomba ; A. Bonnefond ; F. Cambien ; J. C. Chambers ; F. Cucca ; P. D'Adamo ; G. Davies ; R. A. de Boer ; E. J. de Geus ; A. Doring ; P. Elliott ; J. Erdmann ; D. M. Evans ; M. Falchi ; W. Feng ; A. R. Folsom ; I. H. Frazer ; Q. D. Gibson ; N. L. Glazer ; C. Hammond ; A. L. Hartikainen ; S. R. Heckbert ; C. Hengstenberg ; M. Hersch ; T. Illig ; R. J. Loos ; J. Jolley ; K. T. Khaw ; B. Kuhnel ; M. C. Kyrtsonis ; V. Lagou ; H. Lloyd-Jones ; T. Lumley ; M. Mangino ; A. Maschio ; I. Mateo Leach ; B. McKnight ; Y. Memari ; B. D. Mitchell ; G. W. Montgomery ; Y. Nakamura ; M. Nauck ; G. Navis ; U. Nothlings ; I. M. Nolte ; D. J. Porteous ; A. Pouta ; P. P. Pramstaller ; J. Pullat ; S. M. Ring ; J. I. Rotter ; D. Ruggiero ; A. Ruokonen ; C. Sala ; N. J. Samani ; J. Sambrook ; D. Schlessinger ; S. Schreiber ; H. Schunkert ; J. Scott ; N. L. Smith ; H. Snieder ; J. M. Starr ; M. Stumvoll ; A. Takahashi ; W. H. Tang ; K. Taylor ; A. Tenesa ; S. Lay Thein ; A. Tonjes ; M. Uda ; S. Ulivi ; D. J. van Veldhuisen ; P. M. Visscher ; U. Volker ; H. E. Wichmann ; K. L. Wiggins ; G. Willemsen ; T. P. Yang ; J. Hua Zhao ; P. Zitting ; J. R. Bradley ; G. V. Dedoussis ; P. Gasparini ; S. L. Hazen ; A. Metspalu ; M. Pirastu ; A. R. Shuldiner ; L. Joost van Pelt ; J. J. Zwaginga ; D. I. Boomsma ; I. J. Deary ; A. Franke ; P. Froguel ; S. K. Ganesh ; M. R. Jarvelin ; N. G. Martin ; C. Meisinger ; B. M. Psaty ; T. D. Spector ; N. J. Wareham ; J. W. Akkerman ; M. Ciullo ; P. Deloukas ; A. Greinacher ; S. Jupe ; N. Kamatani ; J. Khadake ; J. S. Kooner ; J. Penninger ; I. Prokopenko ; D. Stemple ; D. Toniolo ; L. Wernisch ; S. Sanna ; A. A. Hicks ; A. Rendon ; M. A. Ferreira ; W. H. Ouwehand ; N. Soranzo
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Published 2011Staff ViewPublication Date: 2011-12-06Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Blood Platelets/*cytology/metabolism ; Cell Size ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Europe ; Gene Expression Profiling ; Gene Silencing ; Genome, Human/genetics ; Genome-Wide Association Study ; Hematopoiesis/*genetics ; Humans ; Megakaryocytes/*cytology/metabolism ; Platelet Count ; Protein Interaction Maps ; Transcription, Genetic/genetics ; Zebrafish/genetics ; Zebrafish Proteins/geneticsPublished by: -
6P. van der Harst ; W. Zhang ; I. Mateo Leach ; A. Rendon ; N. Verweij ; J. Sehmi ; D. S. Paul ; U. Elling ; H. Allayee ; X. Li ; A. Radhakrishnan ; S. T. Tan ; K. Voss ; C. X. Weichenberger ; C. A. Albers ; A. Al-Hussani ; F. W. Asselbergs ; M. Ciullo ; F. Danjou ; C. Dina ; T. Esko ; D. M. Evans ; L. Franke ; M. Gogele ; J. Hartiala ; M. Hersch ; H. Holm ; J. J. Hottenga ; S. Kanoni ; M. E. Kleber ; V. Lagou ; C. Langenberg ; L. M. Lopez ; L. P. Lyytikainen ; O. Melander ; F. Murgia ; I. M. Nolte ; P. F. O'Reilly ; S. Padmanabhan ; A. Parsa ; N. Pirastu ; E. Porcu ; L. Portas ; I. Prokopenko ; J. S. Ried ; S. Y. Shin ; C. S. Tang ; A. Teumer ; M. Traglia ; S. Ulivi ; H. J. Westra ; J. Yang ; J. H. Zhao ; F. Anni ; A. Abdellaoui ; A. Attwood ; B. Balkau ; S. Bandinelli ; F. Bastardot ; B. Benyamin ; B. O. Boehm ; W. O. Cookson ; D. Das ; P. I. de Bakker ; R. A. de Boer ; E. J. de Geus ; M. H. de Moor ; M. Dimitriou ; F. S. Domingues ; A. Doring ; G. Engstrom ; G. I. Eyjolfsson ; L. Ferrucci ; K. Fischer ; R. Galanello ; S. F. Garner ; B. Genser ; Q. D. Gibson ; G. Girotto ; D. F. Gudbjartsson ; S. E. Harris ; A. L. Hartikainen ; C. E. Hastie ; B. Hedblad ; T. Illig ; J. Jolley ; M. Kahonen ; I. P. Kema ; J. P. Kemp ; L. Liang ; H. Lloyd-Jones ; R. J. Loos ; S. Meacham ; S. E. Medland ; C. Meisinger ; Y. Memari ; E. Mihailov ; K. Miller ; M. F. Moffatt ; M. Nauck ; M. Novatchkova ; T. Nutile ; I. Olafsson ; P. T. Onundarson ; D. Parracciani ; B. W. Penninx ; L. Perseu ; A. Piga ; G. Pistis ; A. Pouta ; U. Puc ; O. Raitakari ; S. M. Ring ; A. Robino ; D. Ruggiero ; A. Ruokonen ; A. Saint-Pierre ; C. Sala ; A. Salumets ; J. Sambrook ; H. Schepers ; C. O. Schmidt ; H. H. Sillje ; R. Sladek ; J. H. Smit ; J. M. Starr ; J. Stephens ; P. Sulem ; T. Tanaka ; U. Thorsteinsdottir ; V. Tragante ; W. H. van Gilst ; L. J. van Pelt ; D. J. van Veldhuisen ; U. Volker ; J. B. Whitfield ; G. Willemsen ; B. R. Winkelmann ; G. Wirnsberger ; A. Algra ; F. Cucca ; A. P. d'Adamo ; J. Danesh ; I. J. Deary ; A. F. Dominiczak ; P. Elliott ; P. Fortina ; P. Froguel ; P. Gasparini ; A. Greinacher ; S. L. Hazen ; M. R. Jarvelin ; K. T. Khaw ; T. Lehtimaki ; W. Maerz ; N. G. Martin ; A. Metspalu ; B. D. Mitchell ; G. W. Montgomery ; C. Moore ; G. Navis ; M. Pirastu ; P. P. Pramstaller ; R. Ramirez-Solis ; E. Schadt ; J. Scott ; A. R. Shuldiner ; G. D. Smith ; J. G. Smith ; H. Snieder ; R. Sorice ; T. D. Spector ; K. Stefansson ; M. Stumvoll ; W. H. Tang ; D. Toniolo ; A. Tonjes ; P. M. Visscher ; P. Vollenweider ; N. J. Wareham ; B. H. Wolffenbuttel ; D. I. Boomsma ; J. S. Beckmann ; G. V. Dedoussis ; P. Deloukas ; M. A. Ferreira ; S. Sanna ; M. Uda ; A. A. Hicks ; J. M. Penninger ; C. Gieger ; J. S. Kooner ; W. H. Ouwehand ; N. Soranzo ; J. C. Chambers
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Published 2012Staff ViewPublication Date: 2012-12-12Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Cycle/genetics ; Cytokines/metabolism ; Drosophila melanogaster/genetics ; Erythrocytes/cytology/*metabolism ; Female ; Gene Expression Regulation/genetics ; *Genetic Loci ; *Genome-Wide Association Study ; Hematopoiesis/genetics ; Hemoglobins/genetics ; Humans ; Male ; Mice ; Organ Specificity ; *Phenotype ; Polymorphism, Single Nucleotide/genetics ; RNA Interference ; Signal Transduction/geneticsPublished by: -
7I. J. Deary ; J. Yang ; G. Davies ; S. E. Harris ; A. Tenesa ; D. Liewald ; M. Luciano ; L. M. Lopez ; A. J. Gow ; J. Corley ; P. Redmond ; H. C. Fox ; S. J. Rowe ; P. Haggarty ; G. McNeill ; M. E. Goddard ; D. J. Porteous ; L. J. Whalley ; J. M. Starr ; P. M. Visscher
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Published 2012Staff ViewPublication Date: 2012-01-20Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Aged ; Aging/*genetics/physiology/*psychology ; Child ; Cognition/physiology ; Gene-Environment Interaction ; Genetic Association Studies ; Genome, Human/genetics ; Genotype ; Humans ; Intelligence/*genetics/*physiology ; Intelligence Tests ; Models, Genetic ; Phenotype ; Polymorphism, Single Nucleotide/*geneticsPublished by: -
8Staff View
Publication Date: 2018-10-26Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Thrombosis and HemostasisPublished by: -
9Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] SIR - We welcome the fact that Christopher Brand's book The g Factor: General Intelligence and its Applications, has been reviewed in Nature1, and we regret its withdrawal by the publishers, John Wiley & Sons. As departmental colleagues of the author we should like to make the following ...Type of Medium: Electronic ResourceURL: -
10MacLeod, K. M. ; Hepburn, D. A. ; Deary, I. J. ; Goodwin, G. M. ; Dougall, N. ; Ebmeier, K. P. ; Frier, B. M.
Springer
Published 1994Staff ViewISSN: 1432-0428Keywords: Diabetes mellitus ; hypoglycaemia ; cerebral blood flow ; SPECTSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Chronic hyperglycaemia and recurrent severe hypoglycaemia have both been implicated as causing cerebral damage in patients with diabetes. Although cognitive dysfunction and intellectual impairment have been demonstrated in patients with recurrent severe hypoglycaemia, structural correlates have not been described, and it is not known whether specific functional changes occur in the brains of affected patients. Regional cerebral blood flow was estimated by SPECT with 99mTechnetium Exametazime in 20 patients with IDDM. Ten patients had never experienced severe hypoglycaemia and 10 had a history of recurrent severe hypoglycaemia. Patient results were compared with 20 age- and sex-matched healthy volunteers. We observed differences between the two patient groups and the control group. Tracer uptake was greater in diabetic patients in the superior pre-frontal cortex. This effect was particularly pronounced in the group who had a history of previous severe hypoglycaemia. Patients with a history of recurrent hypoglycaemia also had a relative reduction in tracer uptake to the calcarine cortex. This suggests an alteration in the pattern of baseline regional cerebral blood flow in diabetic patients with frontal excess and relative posterior reduction in cerebral blood flow.Type of Medium: Electronic ResourceURL: -
11Staff View
ISSN: 1432-0428Keywords: Hypoglycaemia ; insulin ; diabetes mellitus ; cognitive function ; intelligence ; reaction time ; inspection timeSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary To examine the hypothesis that episodes of severe hypoglycaemia may cause cumulative cognitive impairment, 100 Type 1 (insulin-dependent) diabetic patients were examined. Their age range was 25–52 years, and the onset of diabetes had occurred after the age of 19 years. Patients with evidence of organic brain disease, including cerebrovascular disease, were excluded. A questionnaire was used to assess the number, frequency and severity of hypoglycaemic episodes experienced during treatment with insulin and the accuracy of this retrospective information was verified from general practice and hospital case-notes. A detailed neuropsychological assessment was undertaken, including tests of pre-morbid and present IQ (Wechsler-Revised), memory and information-processing speed. Significant correlations were observed between the frequency of severe hypoglycaemia and the magnitude of intellectual decline, Performance IQ, inspection time and reaction time (patients with the more frequent hypoglycaemia had poorer performance). Two sub-groups of patients were identified on the basis of their experience of severe hypoglycaemia, and were balanced for pre-morbid IQ, age and duration of diabetes. One sub-group (n=23) had never experienced severe hypoglycaemia (Group A), whilst the other sub-group (n=24) had suffered at least five episodes of severe hypoglycaemia (Group B). Group B had greater intellectual impairment than Group A, and Group B also had a significantly slower mean reaction time and higher reaction time variance when compared with Group A. It is concluded that recurrent severe hypoglycaemia is associated with cumulative cognitive impairment in adult diabetic patients treated with insulin.Type of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 1432-0428Keywords: Hypoglycaemia ; neuroglycopenia ; autonomic ; factor analysis ; insulinSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The allocation of hypoglycaemic symptoms to autonomie or neuroglycopenic groups tends to occur on an a priori basis. In view of the practical need for clear symptom markers of hypoglycaemia more scientific approaches must be pursued. Substantial evidence is presented from two large scale studies we performed which support a three factor model of hypoglycaemic symptomatology, based on the statistical associations discovered among symptoms reported by diabetic patients. Study 1 involved 295 insulin-treated outpatients and found that 11 key hypoglycaemic symptoms segregated into three clear factors: autonomie (sweating, palpitation, shaking and hunger) neuroglycopenic (confusion, drowsiness, odd behaviour, speech difficulty and incoordination), and malaise (nausea and headache). The three factors were validated on a separate group of 303 insulin-treated diabetic out-patients. Confirmatory factor analyses showed that the three factor model was the optimal model for explaining symptom covariance in each group. A multi-sample confirmatory factor analysis tested the rigorous assumptions that the relative loadings of symptoms on factors across groups were equal, and that the residual variance for each symptom was identical across groups. These assumptions were successful, indicating that the three factor model was replicated in detail across these two large samples. It is suggested that the results indicate valid groupings of symptoms that may be used in future research and in clinical practice.Type of Medium: Electronic ResourceURL: -
13MacLeod, K. M. ; Hepburn, D. A. ; Deary, I. J. ; Goodwin, G. M. ; Dougall, N. ; Ebmeier, K. P. ; Frier, B. M.
Springer
Published 1994Staff ViewISSN: 1432-0428Keywords: Key words Diabetes mellitus, hypoglycaemia, cerebral blood flow, SPECT.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Chronic hyperglycaemia and recurrent severe hypoglycaemia have both been implicated as causing cerebral damage in patients with diabetes. Although cognitive dysfunction and intellectual impairment have been demonstrated in patients with recurrent severe hypoglycaemia, structural correlates have not been described, and it is not known whether specific functional changes occur in the brains of affected patients. Regional cerebral blood flow was estimated by SPECT with 99mTechnetium Exametazime in 20 patients with IDDM. Ten patients had never experienced severe hypoglycaemia and 10 had a history of recurrent severe hypoglycaemia. Patient results were compared with 20 age- and sex-matched healthy volunteers. We observed differences between the two patient groups and the control group. Tracer uptake was greater in diabetic patients in the superior pre-frontal cortex. This effect was particularly pronounced in the group who had a history of previous severe hypoglycaemia. Patients with a history of recurrent hypoglycaemia also had a relative reduction in tracer uptake to the calcarine cortex. This suggests an alteration in the pattern of baseline regional cerebral blood flow in diabetic patients with frontal excess and relative posterior reduction in cerebral blood flow. [Diabetologia (1994) 37: 257–263]Type of Medium: Electronic ResourceURL: -
14Staff View
ISSN: 1432-2072Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
15Staff View
ISSN: 1432-2072Keywords: Hypoglycemia ; Cognitive function ; Adaptation ; Type 1 diabetes ; Neuroglycopenia ; Symptoms of hypoglycemiaSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract It has been suggested that cerebral adaptation may occur in response to short-term hypoglycemia. This was examined in the present study by measuring serial changes in cognitive function and symptoms after 60 min of continuous hypoglycemia. Hypoglycemia was induced with a hyperinsulinemic glucose clamp on two separate occasions in 24 non-diabetic human subjects. Cognitive function was assessed using the following cognitive test battery: Paced Auditory Serial Addition Test (PASAT), Rapid Visual Information Processing (RVIP), Trail-Making B (TMB), Digit Symbol Substitution Test (DSST) and Four Choice Reaction Time (CRT). In condition A the blood glucose was maintained at 4.5 mmol/l throughout. On two separate occasions (condition B and condition C) the blood glucose was stabilised at 4.5 mmol/l for 30 min, lowered to 2.5 mmol/l for 60 min and restored to 4.5 mmol/l for 30 min. In each condition the cognitive test battery was performed immediately after stabilisation of blood glucose at 4.5 mmol/l and the subsequent battery was repeated at different time intervals: condition A — after a further 40 min of euglycemia; condition B — after 5 min of hypoglycemia; condition C — after 40 min of hypoglycemia. Acute hypoglycemia induced a significant deterioration in cognitive function which was manifest in all tests except TMB (P〈0.05), but performance ability did not differ between conditions B and C. Symptom scores, assessed by a scaled questionnaire, increased significantly during hypoglycemia (P〈0.001) but no differences were detected between the scores at 30 min and 60 min. In non-diabetic humans, no improvement appears to occur either in cognitive function or in symptom score after 40–60 min of hypoglycemia (2.5 mmol/l), suggesting that cerebral adaptation does not occur during this period of time.Type of Medium: Electronic ResourceURL: -
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ISSN: 1824-310XKeywords: Intelligence ; inspection time ; reaction time ; evoked potentialsSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract Despite the ubiquitous nature of Spearman's g in mental test performance, the charge «intelligence is what intelligence tests test» has not been countered in a satisfactory way. It is proposed that there are two ways to answer this complaint. The first concerns the new hypothesis testing models in factor analysis. The second involves studying the ‘biology of intelligence’. The biology of intelligence has various meanings and four are discussed: biology as theory; biology as race and genetics; biology as neurobiology; and biology as basic psychological processes. The last of these is considered in some detail and it is found that reaction time, evoked potentials and inspection time offer bright prospects for further research on the biology of psychometric intelligence.Type of Medium: Electronic ResourceURL: