Search Results - (Author, Cooperation:I. Ishikawa)
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1Staff View
Publication Date: 2018-12-21Publisher: American Physical Society (APS)Print ISSN: 0556-2821Electronic ISSN: 1089-4918Topics: PhysicsKeywords: Lattice field theories, lattice QCDPublished by: -
2T. Watanabe ; M. Kiso ; S. Fukuyama ; N. Nakajima ; M. Imai ; S. Yamada ; S. Murakami ; S. Yamayoshi ; K. Iwatsuki-Horimoto ; Y. Sakoda ; E. Takashita ; R. McBride ; T. Noda ; M. Hatta ; H. Imai ; D. Zhao ; N. Kishida ; M. Shirakura ; R. P. de Vries ; S. Shichinohe ; M. Okamatsu ; T. Tamura ; Y. Tomita ; N. Fujimoto ; K. Goto ; H. Katsura ; E. Kawakami ; I. Ishikawa ; S. Watanabe ; M. Ito ; Y. Sakai-Tagawa ; Y. Sugita ; R. Uraki ; R. Yamaji ; A. J. Eisfeld ; G. Zhong ; S. Fan ; J. Ping ; E. A. Maher ; A. Hanson ; Y. Uchida ; T. Saito ; M. Ozawa ; G. Neumann ; H. Kida ; T. Odagiri ; J. C. Paulson ; H. Hasegawa ; M. Tashiro ; Y. Kawaoka
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-07-12Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antiviral Agents/pharmacology ; Cells, Cultured ; Chickens/virology ; DNA-Directed RNA Polymerases/antagonists & inhibitors ; Dogs ; Enzyme Inhibitors/pharmacology ; Female ; Ferrets/virology ; Humans ; Influenza A Virus, H1N1 Subtype/drug effects/enzymology ; *Influenza A virus/chemistry/drug effects/isolation & purification/pathogenicity ; Influenza, Human/drug therapy/*virology ; Macaca fascicularis/virology ; Madin Darby Canine Kidney Cells ; Male ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Monkey Diseases/pathology/virology ; Neuraminidase/antagonists & inhibitors ; Orthomyxoviridae Infections/pathology/transmission/*virology ; Quail/virology ; Swine/virology ; Swine, Miniature/virology ; *Virus Replication/drug effectsPublished by: -
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ISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: A radial pattern is found to form in the polycarbonate (PC) substratum of a recordable compact disk. Characteristic features of the pattern are that it is composed of about 80 needle-like regions, the shape of which closely resembles a thin film. In addition, white light is found to scatter at the needle-like region/matrix boundaries. This suggests that the PC substratum may have inferior transparency due to the formation of this pattern. Thus, it is important to understand the bifurcation of the radial-pattern formation from the viewpoint of materials science and engineering. Based on the mechanics of the PC viscous fluid, it has been found that the bifurcation of the pattern formation has a Reynolds number of about 10−3. © 2001 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
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ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Papillary and nonpapillary renal cell tumours can be differentiated according to their genetic constitution. In this study, their incidence in end stage kidney disease has been investigated histologically. Nonpapillary renal cell carcinoma was observed in 22 cases (51.2%) whereas papillary renal cell tumours were diagnosed in 21 (48.8%) of the 43 patients with end stage kidney disease. The incidence of papillary renal cell tumours in end stage kidney disease is significantly higher (χ2= 31.9; P〈0.001) than in the general population (4.8%). Haemodialysis patients with nonpapillary and papillary renal cell tumours did not show significant differences in age, sex or size of tumour. However, patients with papillary renal cell tumours had received longer duration of haemodialysis than patients with nonpapillary renal cell carcinomas. These data suggest that not only different genetic events but also different aetiological factors are involved in the development of the two types of tumour in end stage kidney disease.Type of Medium: Electronic ResourceURL: -
5Pourzarandian, A. ; Watanabe, H. ; Ruwanpura, S. M. P. M. ; Aoki, A. ; Noguchi, K. ; Ishikawa, I.
Oxford, UK : Munksgaard International Publishers
Published 2005Staff ViewISSN: 1600-0765Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background and objectives: It has been reported that both prostaglandin E2 (PGE2) and Er:YAG laser irradiation accelerate wound healing. The stimulatory action of laser seems to occur during the proliferative stage of healing by stimulation of prostaglandin E2 and cyclooxygenase-2 (COX-2), which are crucial early mediators in the natural healing process. We have then investigated the effect of Er:YAG laser irradiation on PGE2 production and COX-2 gene expression in human gingival fibroblast in vitro.Material and methods: Cultured fibroblasts were exposed to low-power Er:YAG laser irradiation with an energy density of 3.37 J/cm2. The amount of PGE2 production was measured by enzyme-linked immunosorbent assay (ELISA). COX-2 mRNA level, which is a critical enzyme for PGE2 production, was analyzed by reverse transcriptase–polymerase chain reaction (RT–PCR).Results: Er:YAG laser significantly increased PGE2 production by human gingival fibroblasts. COX-2 mRNA, which was hardly detectable in control, increased dramatically after irradiation. COX-2 inhibitor, NS398, completely inhibited the PGE2 synthesis stimulated by Er:YAG laser irradiation.Conclusion: Our results showed that Er:YAG laser irradiation appears to exert its stimulative action on gingival fibroblasts proliferation through the production of PGE2 via the expression of COX-2. This should be considered as one of the important regulatory pathways to accelerate wound healing after Er:YAG laser irradiation.Type of Medium: Electronic ResourceURL: -
6Sasaki, K. M. ; Aoki, A. ; Masuno, H. ; Ichinose, S. ; Yamada, S. ; Ishikawa, I.
Copenhagen : Munksgaard International Publishers
Published 2002Staff ViewISSN: 1600-0765Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The present study examines the dental root after Er:YAG laser irradiation, compared with CO2 lased and non-treated surfaces, using Fourier Transformed Infrared (FTIR) spectroscopy. Freshly extracted human teeth were irradiated by Er:YAG laser at an energy output of 40 mJ/pulse, 10 Hz(0.4 watts), with or without water coolant, and by CO2 laser at an energy output of 0.5 watts in continuous wave mode without coolant. The surfaces were chalky and smooth after irradiation by Er:YAG laser with water coolant, were charred and irregular after irradiation by Er:YAG laser without water coolant, and were completely carbonized after CO2 laser irradiation. The FTIR profiles from samples of the surfaces that were irradiated by Er:YAG laser with water coolant were similar to those from non-treated samples, except for a slight decrease on the OH and amide bands, which are mainly related to organic components. This decrease was observed to be extreme after CO2 laser irradiation and moderate after Er:YAG laser irradiation without coolant. The formation of new bands showing toxic substances was observed to a large extent after CO2 laser irradiation and to a smaller extent after Er:YAG laser irradiation without water coolant. In contrast, no such bands were detected after Er:YAG laser irradiation with water coolant. The present results show that these laser treatments selectively ablated more organic components than inorganic components and that Er:YAG laser irradiation with water coolant did not cause major compositional changes or chemically deleterious changes in either root cementum or dentin.Type of Medium: Electronic ResourceURL: -
7Hashimoto-Uoshima, M. ; Noguchi, K. ; Suzuki, M. ; Murata, A. ; Yanagishita, M. ; Ishikawa, I.
Copenhagen : Munksgaard International Publishers
Published 2002Staff ViewISSN: 1600-0765Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: In inflammatory gingival diseases, cytokines have been demonstrated to play critical roles by coordinating the stimulation of immunological and connective tissue cells. The activities of these cells, degrading and remodeling extracellular matrices, constitute the major pathological and repair processes. Thus, elucidating cellular and molecular events occurring in inflamed connective tissues is crucial for the understanding and treatment of inflammation. In order to test a hypothesis that proinflammatory cytokines affect metabolism of major extracellular matrix molecules, we studied metabolism of proteoglycans (PGs) by human gingival fibroblasts (HGF) under the influence of interleukin-4 (IL-4) as a model of gingivitis. HGF in cell culture were metabolically radiolabeled using [3H]glucosamine and [35S]sulfate in the presence or absence of IL-4, and the labeled PGs were analyzed by chromatographic techniques. The incorporation of 35S into PGs increased with IL-4 both in media and cell layer. At 100 ng/ml of IL-4, the increment of 35S incorporation over control culture was 16–39% (p〈0.001) in media and 12–35% (p=0.01) in cell layer. The 35S-labeled macromolecules were PGs containing heparan sulfate (HS) and chondroitin sulfate (CS) chains. From the molecular weight and glycosaminoglycan composition analyses, versican and jrelecan-type and biglycan and decorin-type were very likely to be the major PG constituents both in media and cell layer. IL-4 stimulated synthesis of versican and jrelecan-type more potently than biglycan and decorin-type. With IL-4 treatment, the ratio of CSPG/HSPG decreased in media and increased in cell layer. This ratio suggested that syndecan family HSPGs were also present in HGF. In conclusion, IL-4 stimulated accumulation of CS/HSPGs in human gingival fibroblasts.Type of Medium: Electronic ResourceURL: -
8Aoki, A. ; Miura, M. ; Akiyama, F. ; Nakagawa, N. ; Tanaka, J. ; Oda, S. ; Watanabe, H. ; Ishikawa, I.
Copenhagen : Munksgaard International Publishers
Published 2000Staff ViewISSN: 1600-0765Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The purpose of the present study was to evaluate the effectiveness of Er:YAG laser scaling and the morphological and histological changes of the laser-scaled root surface in comparison with the effectiveness and root surface changes produced by conventional ultrasonic scaling. Fifty-three periodontally involved human extracted teeth with a band of subgingival calculus were used. The teeth were divided randomly into 2 groups for laser scaling and ultrasonic scaling. Laser irradiation was performed at an energy output of 40 mJ/pulse and 10 pulses/s under water spray, with the probe tip contacted obliquely to the root surface. Ultrasonic scaling was performed at a clinically standard power setting. The time required for scaling, the scaled area and the temperature changes were determined using both methods of treatment. The features of the scaled surfaces were examined by histological and scanning electron microscope (s.e.m.) observations. The Er:YAG laser provided subgingival calculus removal on a level equivalent to that provided by the ultrasonic scaler, without major thermal elevation. Macroscopically, the laser-treated root surface was somewhat rougher than or similar to the ultrasonically scaled root. However, the efficiency of the laser scaling was lower than that of the ultrasonic scaling. In addition, histological examination revealed a thin deeply stained zone on the lased root surface, and s.e.m. analysis revealed a characteristic microroughness on the lased surface. The laser scaling provided a level of calculus removal that was similar to that provided by the ultrasonic scaling. However, the Er:YAG laser produced superficial, structural and thermal microchanges on the root cementum.Type of Medium: Electronic ResourceURL: -
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ISSN: 0005-2744Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
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ISSN: 0020-708XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Energy, Environment Protection, Nuclear Power EngineeringPhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0020-708XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Energy, Environment Protection, Nuclear Power EngineeringPhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0883-2889Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Energy, Environment Protection, Nuclear Power EngineeringType of Medium: Electronic ResourceURL: -
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ISSN: 0006-3002Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0375-9601Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0375-9601Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0375-9601Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0375-9601Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0167-5087Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Energy, Environment Protection, Nuclear Power EngineeringPhysicsType of Medium: Electronic ResourceURL: -
19Makishima, M. ; Honma, Y. ; Hozumi, M. ; Sampi, K. ; Hattori, M. ; Ishikawa, I. ; Ogura, H. ; Kawahara, N. ; Motoyoshi, K. ; Kanaiwa, T.
Amsterdam : ElsevierStaff ViewISSN: 0167-4889Keywords: (HL-60 cell) ; Differentiation ; Growth regulation ; Myeloid leukemia cell ; Pyrimidine nucleoside ; StaurosporinSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
20Nagasawa, T. ; Aramaki, M. ; Takamatsu, N. ; Koseki, T. ; Kobayashi, H. ; Ishikawa, I.
Oxford, UK : Blackwell Publishing Ltd
Published 1999Staff ViewISSN: 1600-0765Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: