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1Latest Papers from Table of Contents or Articles in PressJiacong Wei; Anthonie van der Wekken; Ali Saber; Miente Terpstra; Ed Schuuring; Wim Timens; T. Hiltermann; Harry Groen; Anke van den Berg; Klaas Kok
Molecular Diversity Preservation International (MPDI)
Published 2018Staff ViewPublication Date: 2018-01-05Publisher: Molecular Diversity Preservation International (MPDI)Electronic ISSN: 2072-6694Topics: MedicinePublished by: -
2Articles: DFG German National LicensesGrünberg ; Sharon ; Hiltermann ; Brahim ; Dick ; Sterk ; Van Krieken, J. Han J. M.
Oxford BSL : Blackwell Science Ltd
Published 2000Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Rhinovirus infections in airway epithelial cells in vitro have been shown to upregulate intercellular adhesion molecule-1 (ICAM-1) expression. Epithelial ICAM-1, in its dual role as the major rhinovirus receptor and as adhesion molecule for inflammatory cells may be involved in the pathogenesis of rhinovirus-induced exacerbations of asthma.〈section xml:id="abs1-2"〉〈title type="main"〉ObjectiveWe aimed to investigate the effect of experimental rhinovirus 16 (RV16) infection on ICAM-1 expression in bronchial mucosal biopsies in asthma. In addition, the effect of 2 weeks pretreatment with inhaled budesonide (800 μg b.d.) on RV16-associated changes in ICAM-1 expression was studied.〈section xml:id="abs1-3"〉〈title type="main"〉MethodsThe study had a parallel, placebo-controlled design in 25 steroid-naive nonsmoking atopic asthmatic subjects. After 2 weeks budesonide (BUD) or placebo (PLAC) pretreatment bronchoscopy was performed 2 days before (day −2) and 6 days after (day 6) RV16 inoculation (on days 0 and 1). Immunohistochemical staining for ICAM-1 was performed on snap-frozen bronchial biopsies. ICAM-1 staining intensity on the basal epithelial cells was scored semiquantitatively from 1 (weak) to 3 (intense). Similarly, epithelial intactness was noted (1 = basal cells only, 2 = basal and parabasal cells, 3 = intact epithelium).〈section xml:id="abs1-4"〉〈title type="main"〉ResultsICAM-1 scores were not significantly different between the groups at day −2 (P ≥ 0.08). Subsequent RV16 infection was associated with a trend towards an increase in ICAM-1 expression in the BUD-group (P = 0.07), whereas the increase was significant in the PLAC-group (P = 0.03). However, the increase was not significantly different between the groups (P = 0.74). Epithelial intactness score was not different between the groups before RV16 infection (P ≥ 0.07), and no significant changes were observed in either group (P ≥ 0.59). Moreover, ICAM-1 score did not correlate significantly with epithelium score in either group, at any time-point (P ≥ 0.27).〈section xml:id="abs1-5"〉〈title type="main"〉ConclusionWe conclude that an RV16 common cold in atopic asthmatic subjects is associated with increased ICAM-1 expression in the bronchial epithelium, which is not related to epithelial intactness. Glucocorticoid treatment does not appear to prevent the RV16-associated increased ICAM-1 expression. This suggests that other treatment modalities are required to protect against the spreading of infection during rhinovirus-induced exacerbations in asthma.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1432-069XSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung 1. 357, zum überwiegenden Teil gesunde Kinder im Alter zwischen 1. Lebensmonat und 14. Lebensjahr wurden mittels Läppchentests auf ihre Reagibilität gegenüber sechs Substanzen geprüft, die bei Erwachsenen häufig kontaktallergische Ekzeme verursachen (Kaliumbichromat 0,5%, Sublimat 0,1%, Formalin 1,2%, Nickelsulfat 2%, Terpentin 5%, Benzocain 5%). 2. Die Häufigkeit der beobachteten Reaktionen war abhängig a) von der Testsubstanz und b) von Lebensalter. a) In absteigender Reihenfolge erzeugten Reaktionen: Kaliumbichromat (29,7%), Sublimat (13,2%), Formalin (9,5%), Nickelsulfat (2,5%), Terpentin (2,2%) und Benzocain (0,8%). b) Säuglinge im 2.–4. Trimenon reagieren am häufigsten (72,8%), im 1. Trimenon am seltensten (15,4%); vom 2. Lebensjahr an sinkt die Reagibilität: 1-3-jährige: 56,4%; 4–9 jährige: 32,6%; 10–14 jährige: 19,7%. 3. Die makroskopisch-klinisch und histologisch ekzematösen Reaktionen sind toxischer Natur. 4. Erwachsenengerechte Testkonzentrationen eignen sich nicht, um bei Kindern eine Kontaktallergie aufzudecken.Notes: Summary 1. 357, mostly healthy children in the age of 1 month to 14 years were tested with 6 substances often causing allergic eczemas in adults (potassium dichromate 0.5%, bichloride of mercury 0.1%, formalin 1.2%, nickel sulfate 2%, turpentine 5%, benzocaine 5%). 2. The percentage of positive reactions depends a) on the testsubstance and b) on the age of the children. a) Reactions were produced by potassium dichromate in 29.7%, by bichloride of mercury in 13.2%, by formalin in 9.5%, by nickel sulfate in 2.5%, by turpentine in 2% and by benzocaine in 0.8% of the children. b) Most frequently reactions were observed in infants 4–12 month old (72.8%), seldom in newborns till to the third month of life (15.4%). From the second year onwards the reagibility decreases: 56.4% in 1–3 year, 32.6% in 4–9 year and 19.7% in 10–14 year old children. 3. The macroscopic-clinically and histologically eczematous test reactions are toxie (=primary irritant) reactions. 4. Concentrations adaequate for patch testing in adults are not suitable for the detection of epidermal hypersensitiveness in children.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0026-3141Topics: Ethnic SciencesHistoryPolitical ScienceSociologyEconomicsDescription / Table of Contents: KURDS AND KURDISTANNotes: BOOK REVIEWSURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0026-3141Topics: Ethnic SciencesHistoryPolitical ScienceSociologyEconomicsDescription / Table of Contents: ARAB-ISRAELI CONFLICTNotes: "BOOK REVIEWS"URL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0026-3141Topics: Ethnic SciencesHistoryPolitical ScienceSociologyEconomicsDescription / Table of Contents: KURDS AND KURDISTANNotes: BOOK REVIEWSURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1432-1904Source: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1432-1904Source: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesGrünwald, Frank ; Kälicke, Thomas ; Feine, Ulrich ; Lietzenmayer, Roland ; Scheidhauer, Klemens ; Dietlein, Markus ; Schober, Otmar ; Lerch, Hartmut ; Brandt-Mainz, Katja ; Burchert, Wolfgang ; Hiltermann, Gerhard ; Cremerius, Uwe ; Biersack, Hans-Jürgen
Springer
Published 1999Staff ViewISSN: 1619-7089Keywords: Key words: Thyroid cancer ; Fluorine-18 fluorodeoxyglucose ; Positron emission tomography ; Sestamibi ; RadioiodineSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: n =222) and the group with negative radioiodine scan (n=166), respectively. Specificity was 90% in the whole patient group. Sensitivity and specificity of WBS were 50% and 99%, respectively. When the results of FDG-PET and WBS were considered in combination, tumour tissue was missed in only 7%. Sensitivity and specificity of MIBI/Tl were 53% and 92%, respectively (n=117). We conclude that FDG-PET is a sensitive method in the follow-up of thyroid cancer which should be considered in all patients suffering from differentiated thyroid cancer with suspected recurrence and/or metastases, and particularly in those with elevated thyroglobulin values and negative WBS.Type of Medium: Electronic ResourceURL: