Search Results - (Author, Cooperation:Herholz)

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  1. 1
    Mosler, Bettina [Verfasser] ; Herholz, Gerd [Verfasser]
    Essen : Neue Deutsche Schule
    Published 1991
    Staff View
    Type of Medium:
    book
    Publication Date:
    1991
    Keywords:
    Spiel ; Sprachgebrauch ; Kulturelle Bildung
    Language:
    German
    Note:
    Literaturangaben

    FIS Bildung Literaturdatenbank
  2. 2
    HEISS, W. D. ; KESSLER, J. ; SLANSKY, I. ; MIELKE, R. ; SZELIES, B. ; HERHOLZ, K.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1993
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Notes:
    Forty patients with probable Alzheimer's disease (AD) were selected from a pool of 80 patients and assigned to 4 groups. Each received either social support, cognitive training only, or cognitive training in combination with pyritinol or phosphatidylserine. Treatment duration was 6 months. Before and after treatment the patients underwent neuropsychological testing as well as measurement of the regional cerebral metabolic rate for glucose using positron emission tomography (PET) and 2[18F]-fluoro-2-deoxy-D-glucose (FDG). Before treatment, the groups were comparable in respect to resting and activated glucose pattern achieved by a visual recognition task. They did not differ in scores of a neuropsychological test battery. After the treatment period the group with cognitive training + phosphatidylserine showed a significant glucose enhancement during the stimulation tasks in various brain regions, and an improvement in cognitive functioning compared to the other groups. The group with cognitive training + pyritinol had better stimulation effect as that of the social support group indicating that a combination of cognitive training + pharmacological intervention was superior than that of cognitive training alone.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1993.tb23078.x

    Articles: DFG German National Licenses
  3. 3
    Kessler, J. ; Herholz, K. ; Grond, M. ; Heiss, W.-D.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0028-3932
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0028-3932(91)90084-L

    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    0028-3932
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0028-3932(86)90048-5

    Articles: DFG German National Licenses
  5. 5
    Braun, Martin ; Herholz, Cornelia ; Straub, Reto ; Choisat, Béatrice ; Frey, Joachim ; Nicolet, Jacques ; Kuhnert, Peter

    Oxford, UK : Blackwell Publishing Ltd
    Published 2000
    Staff View
    ISSN:
    1574-6968
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Notes:
    Clostridium difficile is an antibiotic-associated emerging pathogen of humans and animals. Thus far three toxins of C. difficile have been described: an enterotoxin (ToxA), a cytotoxin (ToxB) and an ADP-ribosyltransferase (CDT). In the present work we describe the first isolation of CDT producing C. difficile from Equidae with gastro-intestinal disease. Out of 17 C. difficile strains isolated from Equidae, 11 were positive for the genes tcdA and tcdB encoding ToxA and ToxB. In addition four of these 11 isolates were positive for the cdtA gene encoding the catalytic subunit of the ADP-ribosyltransferase CDT. Interestingly none of the isolates derived from canines (41 isolates) and felines (4 isolates) harboured the cdtA gene. In C. difficile field isolates which contained the cdtA gene, ADP-ribosyltransferase activity could also be detected in culture supernatants indicating expression and secretion of CDT. All strains were associated with intestinal disorders, but no association was found for the occurrence of toxins with a specific clinical diagnosis.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1574-6968.2000.tb08985.x

    Articles: DFG German National Licenses
  6. 6
    KESSLER, J. ; GHAEMI, M. ; MIELKE, R. ; HERHOLZ, K. ; HEISS, W. D.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1996
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Notes:
    Patients with probable Alzheimer's disease were either stimulated with a continuous visual recognition task (n = 18) or with a continuous auditory recognition task during PET measurement with 18 FDG. The PET scanner was a Siemens CTI, ECAT EXACT with 5 mm transaxial and 6 mm axial resolution. The global stimulation effects were nearly identical in both groups and increased of 4.17 ± 8.14% in the auditory stimulated group and of 4.03 ± 11.78% in the visual stimulated group. Beyond regional stimulation effects in both groups a common cerebellar stimulation effect was measured. It is concluded that the cerebellar stimulation effect reflects a modality independent cognitive process and that the only small enhancement of global glucose metabolism indicates disturbed stimuli processes and finally explained the patient's failure in memory tasks.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1996.tb34424.x

    Articles: DFG German National Licenses
  7. 7
    Ghaemi, Mehran ; Rudolf, Jobst ; Hilker, Rüdiger ; Herholz, Karl ; Heiss, Wolf-Dieter

    Copenhagen : Munksgaard
    Published 2001
    Staff View
    ISSN:
    1600-079X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    We investigated regional L-3,4-dihydroxy-6-[18F]fluoro-phenylalanine (Fdopa) uptake within the pineal gland using co-registration of Fdopa PET and MRI images. Data from 12 early Parkinson's disease (PD) and 9 advanced PD patients were compared with those from 13 age-matched healthy controls. We found a significant increase of Fdopa influx constants (Ki) and relative Fdopa tracer activity in the pineal gland of PD patients. Additionally, significant correlations were found between Ki and the Hoehn and Yahr (H&Y) scores, and between the relative Fdopa activity and the parameters disease duration, H&Y disease score and Unified Parkinson's Disease Rating Scale (UPDRS). Our studies in patients with PD indicate a participation of extrastriatal dopaminergic structures within the scope of pathophysiological processes in PD. The result may be explained as a compensatory upregulation of monoaminergic transmitter systems outside the basal ganglia. Increased Fdopa uptake in the pineal gland may reflect pineal dysfunction in PD patients.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1034/j.1600-079X.2001.300404.x

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    1435-1463
    Keywords:
    Keywords: Dementia ; cholinergic system ; acetylcholine esterase ; positron emission tomography ; cerebral blood flow ; cerebral glucose metabolism.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary. Memory and attention are cognitive functions that depend heavily on the cholinergic system. Local activity of acetylcholine esterase (AChE) is an indicator of its integrity. Using a recently developed tracer for positron emission tomography (PET), C-11-labeled N-methyl-4-piperidyl-acetate (C-11-MP4A), we measured regional AChE activity in 4 non-demented subjects, 4 patients with dementia of Alzheimer type (DAT) and 1 patient with senile dementia of Lewy body type (SDLT), and compared the findings with measurements of blood flow (CBF) and glucose metabolism (CMRGlc). Initial tracer extraction was closely related to CBF. AChE activity was reduced significantly in all brain regions in demented subjects, whereas reduction of CMRGlc and CBF was more limited to temporo-parietal association areas. AChE activity in SDLT was in the lower range of values in DAT. Our results indicate that, compared to non-demented controls, there is a global reduction of cortical AChE activity in dementia.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s007020070009

    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    1435-1463
    Keywords:
    Positron emission tomography ; (18F)methylspiperone ; clozapine ; haloperidol ; D2 dopamine receptors ; schizophrenia
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Four schizophrenic patients were investigated with dynamic positron emission tomography (PET) using (18F)fluorodeoxyglucose (FDG) and (18F)methylspiperone (MSP) as tracers. Two schizophrenics were on haloperidol therapy at the time of MSP PET. The other two schizophrenics were treated with clozapine, in one of them MSP PET was carried out twice with different daily doses (100 mg and 450 mg respectively). Neuroleptic serum levels were measured in all patients. Results were compared with MSP PET of two drug-free male control subjects and with a previous fluoroethylspiperone (FESP) study of normals. Three hours after tracer injection specific binding of MSP was observed in the striatum in all cases. The striatum to cerebellum ratio was used to estimate the degree of neuroleptic-caused striatal D2 dopamine receptor occupancy. In the haloperidol treated patients MSP binding was significantly decreased, whereas in the clozapine treated patients striatum to cerebellum ratio was normal. Even the increase of clozapine dose in the same patient had no influence on this ratio. Despite the smaller number of patients the study shows for the first time in humans that striatal MSP binding reflects the different D2 dopamine receptor affinities of clozapine and haloperidol.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01250702

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1432-1440
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01757689

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    1432-1440
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02156932

    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1432-1440
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01784744

    Articles: DFG German National Licenses
  13. 13
    Klose ; Schmidt ; Fischer, W. ; Fuchs ; Dinkler ; Herholz ; Holthusen ; Zorn ; Boeters
    Springer
    Published 1935
    Staff View
    ISSN:
    1432-1440
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01779998

    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    1432-1440
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01778966

    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    1432-1440
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01778671

    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    1432-1440
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01761288

    Articles: DFG German National Licenses
  17. 17
    Staff View
    ISSN:
    1432-1440
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01779275

    Articles: DFG German National Licenses
  18. 18
    Mündel ; Mader ; Herholz ; Dinkler ; Zinn ; Schleckat ; Schmidt ; Fuchs ; Rosenhagen ; Stefan
    Springer
    Published 1935
    Staff View
    ISSN:
    1432-1440
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01779071

    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1432-1440
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01779203

    Articles: DFG German National Licenses
  20. 20
    Staff View
    ISSN:
    1432-1440
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01771769

    Articles: DFG German National Licenses