Search Results - (Author, Cooperation:H. Wekerle)

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  1. 1
    K. Berer ; M. Mues ; M. Koutrolos ; Z. A. Rasbi ; M. Boziki ; C. Johner ; H. Wekerle ; G. Krishnamoorthy
    Nature Publishing Group (NPG)
    Published 2011
    Staff View
    Publication Date:
    2011-10-28
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adoptive Transfer ; Animals ; Autoantigens/*immunology ; Autoimmunity/*immunology ; B-Lymphocytes/cytology/immunology ; Brain/immunology/pathology ; Cell Movement ; Cytokines/immunology ; Diet ; Encephalomyelitis, Autoimmune, Experimental/immunology/microbiology ; Germ-Free Life/immunology ; Germinal Center/cytology/immunology ; Lymph Nodes/cytology/immunology ; Lymphocyte Activation ; Metagenome/*immunology ; Mice ; Multiple Sclerosis, Relapsing-Remitting/etiology/*immunology/*pathology ; Myelin Proteins/immunology ; Myelin Sheath/*immunology/*pathology ; Myelin-Oligodendrocyte Glycoprotein ; Stomach/microbiology ; T-Lymphocytes/immunology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    H. Wekerle ; E. Meinl
    Nature Publishing Group (NPG)
    Published 2013
    Staff View
    Publication Date:
    2013-10-11
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Benztropine/*therapeutic use ; Encephalomyelitis, Autoimmune, Experimental/*drug therapy ; Female ; *Models, Biological ; Multiple Sclerosis/*drug therapy ; Myelin Sheath/*drug effects ; Oligodendroglia/*drug effects ; Regeneration/*drug effects
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2012-08-24
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adoptive Transfer ; Animals ; Autoimmunity/immunology ; Blood-Brain Barrier/immunology ; Brain/cytology/immunology/*pathology ; Cell Adhesion Molecules, Neuronal/metabolism ; *Cell Movement ; Cerebrovascular Circulation ; Disease Models, Animal ; Encephalomyelitis, Autoimmune, Experimental/*immunology/*pathology ; Gene Expression Profiling ; Immunologic Memory ; Lung/cytology/immunology/*pathology ; Lymphocyte Activation ; Myelin Sheath/immunology ; Nerve Growth Factors/metabolism ; Rats ; Rats, Inbred Lew ; T-Lymphocytes/cytology/immunology/metabolism/*pathology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  4. 4
    SUN, D. ; MEYERMANN, R. ; WEKERLE, H.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1988
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  5. 5
    Neumann, H. ; Boucraut, J. ; Hahnel, C. ; Misgeld, T. ; Wekerle, H.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1996
    Staff View
    ISSN:
    1460-9568
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    We analysed the inducibility of major histocompatibility complex (MHC) class II molecules of astrocytes and microglia in organotypic hippocampus slice cultures of Lewis rats. Treatment with interferon-γ (IFN-γ) resulted in the induction of MHC class II molecules on microglia preferentially in the injured marginal zones of the slice culture, but only sporadically in areas containing intact neuronal architecture. In astrocytes, inducibility of MHC class II molecules was even more strictly controlled. IFN-γ treatment induced MHC class II expression only in the slice culture zones containing degenerated neurons, and not in the presence of functional neurons. After suppression of spontaneous neuronal activity of the slice culture by the sodium channel blocker tetrodotoxin, MHC class II molecules on astrocytes could be induced by IFN-γ in areas with intact neuronal architecture, and microglia cells exhibited a higher level of expression. These data suggest that loss of neurons could result in MHC class II inducibility of glial cells, and thus in increased immune reactivity of nervous tissue.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  6. 6
    WEKERLE, H. ; PATERSON, B. ; KETELSEN, U.-P. ; FELDMAN, M.

    [s.l.] : Nature Publishing Group
    Published 1975
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] We have described a tissue culture method that allows growth in vitro of thymus reticulum monolayers derived from adult normal rats or mice7. These cultures at early stages consist of two main cell types, reticular and epithelial. In this communication we report the clonal differentiation of a ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    0888-7543
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    0888-7543
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
  10. 10
    Wekerle, H. ; Hohlfeld, R. ; Ketelsen, U.-P. ; Kalden, J. R. ; Kalies, I.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1981
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    Sterz, R. ; Hohlfeld, R. ; Kalies, I. ; Wekerle, H. ; Peper, K.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1981
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    ZHANG, Y. ; TZARTOS, S. ; SCHALKE, B. C. G. ; MELMS, A. ; WEKERLE, H.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1987
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  13. 13
    MELMS, A. ; ENDLER, B. ; KIRCHNER, TH. ; SCHALKE, B. C. G. ; MÜLLER-HERMELINK, H. K. ; WEKERLE, H.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1987
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    Vass, K. ; Lassmann, H. ; Wekerle, H. ; Wisniewski, H. M.
    Springer
    Published 1986
    Staff View
    ISSN:
    1432-0533
    Keywords:
    Ia antigen ; Central nervous system ; Experimental allergic encephalitis ; Immunohistochemistry ; Electron microscopy
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Ia antigen, encoded within the major histocompatibility complex, plays an important role in the activation of T lymphocytes. Since experimental allergic encephalitis is an essentially T cell-mediated disease, Ia antigen in the central nervous system (CNS) may be pathogenetically relevant. The occurrence of Ia antigen in the CNS of normal rats and of rats with experimental allergic encephalitis was studied by light and electron microscope immunocytochemistry using the monoclonal anti-Ia antibodies Ox 4 and Ox 6. In normal, unsensitized animals a distict population of stellate cells in the meninges and some perivascular mononuclear cells in the nervous tissue carried Ia antigen. In rats with experimental allergic encephalitis a dramatic increase of Ia-positive cells was found. In addition to the positive cells found in normal animals, monocytes, macrophages and many lymphocytes in the meningeal perivascular and parenchymal inflammatory infiltrates as well as “activated microglia” stained for Ia antigen. We did not find evidence for Ia expression on endothelial cells, astrocytes or other components of the CNS in either normal or diseased rats.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    1432-0584
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  16. 16
    Sun, D. ; Wekerle, H.

    [s.l.] : Nature Publishing Group
    Published 1986
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] When rat T lymphocytes are seeded on syngeneic astrocyte monolayers, they immediately start to migrate to the top of the cell surfaces. They extend uropods, but show no morphological signs of activation such as blast transformation or proliferation. Induction of la antigen on the astrocyte ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  17. 17
    Linington, C. ; Wekerle, H. ; Meyermann, R.
    Springer
    Published 1986
    Staff View
    ISSN:
    1420-908X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Conclusion Autoaggressive T cells specific for the PNS myelin P2 protein play a central role in the initiation of EAN in the Lewis rat, although there is as yet no direct experimental evidence that the T cells can themselves mediate demyelination in vivo. However, the striking similarities in the pathogenesis of EAN and the Guillain-Barré syndrome suggest that T cell mediated EAN provides an excellent model to study the immunological mechanisms of inflammation and demyelination that are relevant to human PNS disease.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  18. 18
    Goto, M. ; Meyermann, R. ; Wekerle, H.
    Springer
    Published 1987
    Staff View
    ISSN:
    1432-119X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Summary The introduction of acrylate resins (Lowicryl K 4M, LR White) into electronmicroscopic immunocytochemistry applied to embedded tissue (post-embedding method) has improved the localization of antigens because of a satisfactory preservation of both ultrastructure and antigenicity of tissues. Here we describe a method that allows double staining of intracellular and membranous determinants in ultrathin sections of nervous tissue and cultures of peripheral nervous system cells. Ultrathin sections of the rat central nervous system fixed on uncoated grids were stained first for MBP selectively on the one face, then the opposite face was stained for GFAP using monoclonal antibodies and indirect immunogold staining method (IGS). Cultured Schwann cells induced to express major histocompatibility complex (MHC) class II antigens were stained for class. H antigens by pre-embedding method then followed by post-embedding IGS for the other intracytopasmic antigens.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1618-2650
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses