Search Results - (Author, Cooperation:H. Wekerle)
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1Latest Papers from Table of Contents or Articles in PressK. Berer ; M. Mues ; M. Koutrolos ; Z. A. Rasbi ; M. Boziki ; C. Johner ; H. Wekerle ; G. Krishnamoorthy
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-10-28Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adoptive Transfer ; Animals ; Autoantigens/*immunology ; Autoimmunity/*immunology ; B-Lymphocytes/cytology/immunology ; Brain/immunology/pathology ; Cell Movement ; Cytokines/immunology ; Diet ; Encephalomyelitis, Autoimmune, Experimental/immunology/microbiology ; Germ-Free Life/immunology ; Germinal Center/cytology/immunology ; Lymph Nodes/cytology/immunology ; Lymphocyte Activation ; Metagenome/*immunology ; Mice ; Multiple Sclerosis, Relapsing-Remitting/etiology/*immunology/*pathology ; Myelin Proteins/immunology ; Myelin Sheath/*immunology/*pathology ; Myelin-Oligodendrocyte Glycoprotein ; Stomach/microbiology ; T-Lymphocytes/immunologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2013-10-11Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Benztropine/*therapeutic use ; Encephalomyelitis, Autoimmune, Experimental/*drug therapy ; Female ; *Models, Biological ; Multiple Sclerosis/*drug therapy ; Myelin Sheath/*drug effects ; Oligodendroglia/*drug effects ; Regeneration/*drug effectsPublished by: -
3Latest Papers from Table of Contents or Articles in PressF. Odoardi ; C. Sie ; K. Streyl ; V. K. Ulaganathan ; C. Schlager ; D. Lodygin ; K. Heckelsmiller ; W. Nietfeld ; J. Ellwart ; W. E. Klinkert ; C. Lottaz ; M. Nosov ; V. Brinkmann ; R. Spang ; H. Lehrach ; M. Vingron ; H. Wekerle ; C. Flugel-Koch ; A. Flugel
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-08-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adoptive Transfer ; Animals ; Autoimmunity/immunology ; Blood-Brain Barrier/immunology ; Brain/cytology/immunology/*pathology ; Cell Adhesion Molecules, Neuronal/metabolism ; *Cell Movement ; Cerebrovascular Circulation ; Disease Models, Animal ; Encephalomyelitis, Autoimmune, Experimental/*immunology/*pathology ; Gene Expression Profiling ; Immunologic Memory ; Lung/cytology/immunology/*pathology ; Lymphocyte Activation ; Myelin Sheath/immunology ; Nerve Growth Factors/metabolism ; Rats ; Rats, Inbred Lew ; T-Lymphocytes/cytology/immunology/metabolism/*pathologyPublished by: -
4Articles: DFG German National LicensesStaff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesNeumann, H. ; Boucraut, J. ; Hahnel, C. ; Misgeld, T. ; Wekerle, H.
Oxford, UK : Blackwell Publishing Ltd
Published 1996Staff ViewISSN: 1460-9568Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We analysed the inducibility of major histocompatibility complex (MHC) class II molecules of astrocytes and microglia in organotypic hippocampus slice cultures of Lewis rats. Treatment with interferon-γ (IFN-γ) resulted in the induction of MHC class II molecules on microglia preferentially in the injured marginal zones of the slice culture, but only sporadically in areas containing intact neuronal architecture. In astrocytes, inducibility of MHC class II molecules was even more strictly controlled. IFN-γ treatment induced MHC class II expression only in the slice culture zones containing degenerated neurons, and not in the presence of functional neurons. After suppression of spontaneous neuronal activity of the slice culture by the sodium channel blocker tetrodotoxin, MHC class II molecules on astrocytes could be induced by IFN-γ in areas with intact neuronal architecture, and microglia cells exhibited a higher level of expression. These data suggest that loss of neurons could result in MHC class II inducibility of glial cells, and thus in increased immune reactivity of nervous tissue.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesWEKERLE, H. ; PATERSON, B. ; KETELSEN, U.-P. ; FELDMAN, M.
[s.l.] : Nature Publishing Group
Published 1975Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] We have described a tissue culture method that allows growth in vitro of thymus reticulum monolayers derived from adult normal rats or mice7. These cultures at early stages consist of two main cell types, reticular and epithelial. In this communication we report the clonal differentiation of a ...Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesPilat, D. ; Fink, T. ; Obermaier-Skrobanek, B. ; Zimmer, M. ; Wekerle, H. ; Lichter, P. ; Jenne, D.E.
Amsterdam : ElsevierStaff ViewISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesGiegerich, G. ; Pette, M. ; Fujita, K. ; Wekerle, H. ; Epplen, J.T. ; Hinkkanen, A.
Amsterdam : ElsevierStaff ViewISSN: 0378-4347Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesWekerle, H. ; Hohlfeld, R. ; Ketelsen, U.-P. ; Kalden, J. R. ; Kalies, I.
Oxford, UK : Blackwell Publishing Ltd
Published 1981Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesSterz, R. ; Hohlfeld, R. ; Kalies, I. ; Wekerle, H. ; Peper, K.
Oxford, UK : Blackwell Publishing Ltd
Published 1981Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesZHANG, Y. ; TZARTOS, S. ; SCHALKE, B. C. G. ; MELMS, A. ; WEKERLE, H.
Oxford, UK : Blackwell Publishing Ltd
Published 1987Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesMELMS, A. ; ENDLER, B. ; KIRCHNER, TH. ; SCHALKE, B. C. G. ; MÜLLER-HERMELINK, H. K. ; WEKERLE, H.
Oxford, UK : Blackwell Publishing Ltd
Published 1987Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-0533Keywords: Ia antigen ; Central nervous system ; Experimental allergic encephalitis ; Immunohistochemistry ; Electron microscopySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Ia antigen, encoded within the major histocompatibility complex, plays an important role in the activation of T lymphocytes. Since experimental allergic encephalitis is an essentially T cell-mediated disease, Ia antigen in the central nervous system (CNS) may be pathogenetically relevant. The occurrence of Ia antigen in the CNS of normal rats and of rats with experimental allergic encephalitis was studied by light and electron microscope immunocytochemistry using the monoclonal anti-Ia antibodies Ox 4 and Ox 6. In normal, unsensitized animals a distict population of stellate cells in the meninges and some perivascular mononuclear cells in the nervous tissue carried Ia antigen. In rats with experimental allergic encephalitis a dramatic increase of Ia-positive cells was found. In addition to the positive cells found in normal animals, monocytes, macrophages and many lymphocytes in the meningeal perivascular and parenchymal inflammatory infiltrates as well as “activated microglia” stained for Ia antigen. We did not find evidence for Ia expression on endothelial cells, astrocytes or other components of the CNS in either normal or diseased rats.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesSchmid-Schönbein, H. ; Wekerle, H. ; Lohrmann, H. -P. ; Scharf, R. E. ; Brudler, O. ; Fischer, J. ; Löffler, H.
Springer
Published 1985Staff ViewISSN: 1432-0584Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] When rat T lymphocytes are seeded on syngeneic astrocyte monolayers, they immediately start to migrate to the top of the cell surfaces. They extend uropods, but show no morphological signs of activation such as blast transformation or proliferation. Induction of la antigen on the astrocyte ...Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1420-908XSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Conclusion Autoaggressive T cells specific for the PNS myelin P2 protein play a central role in the initiation of EAN in the Lewis rat, although there is as yet no direct experimental evidence that the T cells can themselves mediate demyelination in vivo. However, the striking similarities in the pathogenesis of EAN and the Guillain-Barré syndrome suggest that T cell mediated EAN provides an excellent model to study the immunological mechanisms of inflammation and demyelination that are relevant to human PNS disease.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1432-119XSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary The introduction of acrylate resins (Lowicryl K 4M, LR White) into electronmicroscopic immunocytochemistry applied to embedded tissue (post-embedding method) has improved the localization of antigens because of a satisfactory preservation of both ultrastructure and antigenicity of tissues. Here we describe a method that allows double staining of intracellular and membranous determinants in ultrathin sections of nervous tissue and cultures of peripheral nervous system cells. Ultrathin sections of the rat central nervous system fixed on uncoated grids were stained first for MBP selectively on the one face, then the opposite face was stained for GFAP using monoclonal antibodies and indirect immunogold staining method (IGS). Cultured Schwann cells induced to express major histocompatibility complex (MHC) class II antigens were stained for class. H antigens by pre-embedding method then followed by post-embedding IGS for the other intracytopasmic antigens.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesVoltz, R. ; Wick, M. ; Fateh-Moghadam, A. ; Witt, Th. N. ; Reimers, C. ; Siegele, B. ; Hohlfeld, R. ; Wekerle, H.
Springer
Published 1992Staff ViewISSN: 1618-2650Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: