Search Results - (Author, Cooperation:H. W. Chang)

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  1. 1
    S. A. Sievers ; J. Karanicolas ; H. W. Chang ; A. Zhao ; L. Jiang ; O. Zirafi ; J. T. Stevens ; J. Munch ; D. Baker ; D. Eisenberg
    Nature Publishing Group (NPG)
    Published 2011
    Staff View
    Publication Date:
    2011-06-17
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Amino Acid Sequence ; Amino Acids/*chemistry/*pharmacology ; Amyloid/*antagonists & inhibitors/*chemistry/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors/chemistry/metabolism ; Computer-Aided Design ; *Drug Design ; HIV Infections/virology ; Hydrogen Bonding ; Kinetics ; Models, Molecular ; Peptides/*chemistry/*pharmacology ; Polylysine/pharmacology ; Protein Conformation ; tau Proteins/antagonists & inhibitors
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2013-11-01
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Antibodies, Monoclonal/*therapeutic use ; Antibodies, Neutralizing/*therapeutic use ; DNA, Viral/blood ; HIV Antibodies/immunology ; HIV-1/*immunology ; Macaca mulatta ; Simian Acquired Immunodeficiency Syndrome/*therapy ; Simian Immunodeficiency Virus/*physiology ; T-Lymphocytes/immunology ; Viremia/therapy
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    M. Y. Li ; Y. Shi ; C. C. Cheng ; L. S. Lu ; Y. C. Lin ; H. L. Tang ; M. L. Tsai ; C. W. Chu ; K. H. Wei ; J. H. He ; W. H. Chang ; K. Suenaga ; L. J. Li
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-08-01
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Y. J. Lu ; J. Kim ; H. Y. Chen ; C. Wu ; N. Dabidian ; C. E. Sanders ; C. Y. Wang ; M. Y. Lu ; B. H. Li ; X. Qiu ; W. H. Chang ; L. J. Chen ; G. Shvets ; C. K. Shih ; S. Gwo
    American Association for the Advancement of Science (AAAS)
    Published 2012
    Staff View
    Publication Date:
    2012-07-28
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    Publication Date:
    2018-11-08
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Electronic ISSN:
    2375-2548
    Topics:
    Natural Sciences in General
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Chang, H.-W. ; Trehub, S.E.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0022-0965
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0022-0965(77)90010-8

    Articles: DFG German National Licenses
  7. 7
    Wang, T.-K. ; Chang, H.-W.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0969-8043
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0969-8043(94)90214-3

    Articles: DFG German National Licenses
  8. 8
    Loong, W.-a. ; Chang, H.-w.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0167-9317
    Keywords:
    Poly(butene-1 sulfone) ; positive resist ; triphenylsulfonium hexafluoroarsenate
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Electrical Engineering, Measurement and Control Technology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0167-9317(91)90157-9

    Articles: DFG German National Licenses
  9. 9
    Niemi, W. D. ; Nastuk, W. L. ; Chang, H. W. ; Plescia, O. J. ; Plescia, A. M.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1981
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1981.tb33735.x

    Articles: DFG German National Licenses
  10. 10
    Lai, W. T. ; Chang, H. -W. ; Chu, A. K.
    Springer
    Published 1996
    Staff View
    ISSN:
    1572-817X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Electrical Engineering, Measurement and Control Technology
    Physics
    Notes:
    Abstract The amplitude reflectivity spectrum and the associated finesse of a microcavity with quarter-wave dielectric mirrors have been theoretically analysed. Triangular-shaped antiresonances were obtained when the radius of the incident beam was not much larger than a wavelength. This was due to the dispersion caused by high spatial frequency components of the incident beam. The dispersion resulted in an increase of the width of the high-transmission region, and therefore greatly degraded the finesse of the cavity.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00326204

    Articles: DFG German National Licenses
  11. 11
    Burridge, R. ; Chang, H.-W.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0165-2125
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Geosciences
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0165-2125(89)90003-6

    Articles: DFG German National Licenses
  12. 12
    de Hoop, M.V. ; Burridge, R. ; Chang, H.-W.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0165-2125
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Geosciences
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0165-2125(91)90067-X

    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1420-908X
    Keywords:
    Key words: Rutaecarpine —Evodia rutaecarpa— Cyclooxygenase-2 inhibitor — Bone marrow-derived mast cells (BMMC) — Anti-inflammation
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract. Objective and Design: We investigated the effect of a new class of COX-2 inhibitor, rutaecarpine, on the production of PGD2 in bone marrow derived mast cells (BMMC) and PGE2 in COX-2 transfected HEK293 cells. Inflammation was induced by γ-carrageenan in male Splague-Dawley (SD) rats.¶Material: Rutaecarpine (8,13-Dihydroindolo[2',3':3,4]pyridol[2,1-b]quinazolin-5(7H)-one) was isolated from the fruits of Evodia rutaecarpa. BMMC were cultured with WEHI-3 conditioned medium. c-Kit ligand and IL-10 were obtained by their expression in baculovirus.¶Methods: The generation of PGD2 and PGE2 were determined by their assay kit. COX-1 and COX-2 protein and mRNA expression was determined by BMMC in the presence of KL, LPS and IL-10.¶Treatment: Rutaecarpine and indomethacin dissolved in 0.1% carboxymethyl cellulose was administered intraperitoneally and, 1h later, γ-carrageenan solution was injected to right hind paw of rats. Paw volumes were measured using plethysmometer 5h after γ-carrageenan injection.¶Results: Rutaecarpine inhibited COX-2 and COX-1 dependent phases of PGD2 generation in BMMC in a concentration-dependent manner with an IC50 of 0.28 μM and 8.7 μM, respectively. It inhibited COX-2-dependent conversion of exogenous arachidonic acid to PGE2 in a dose-dependent manner by the COX-2-transfected HEK293 cells. However, rutaecarpine inhibited neither PLA2 and COX-1 activity nor COX-2 protein and mRNA expression up to the concentration of 30 μM in BMMC, indicating that rutaecarpine directly inhibited COX-2 activity. Furthermore, rutaecarpine showed in vivo anti-inflammatory activity on rat γ-carrageenan induced paw edema by intraperitoneal administration.¶Conclusion: Anti-inflammatory activity of Evodia rutaecarpa could be attributed at least in part by inhibition of COS-2.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s000110050512

    Articles: DFG German National Licenses
  14. 14
    Yanoshita, R. ; Chang, H. W. ; Son, K. H. ; Kudo, I. ; Samejima, Y.
    Springer
    Published 1996
    Staff View
    ISSN:
    1420-908X
    Keywords:
    Platelet-activating factor ; LysoPAF acetyltransferase ; Choline acetyltransferase ; Flavonoid ; RBL-2H3 cell
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Objective and Design: Several kinds of flavonoids, widely distributed natural products of the vegetable kingdom which possess anti-inflammatory activity, were examined for inhibitory effects on the acetyl-CoA: 1-alkyl-2-lyso-sn-glycero-3-phosphocholine (lysoPAF) acetyltransferase activity. Methods: Acetyl-CoA:lysoPAF acetyltransferase activity was determined using homogenates of a rat mucosal-type mastcytoma cell line, RBL-2H3 as an enzyme source. The production of platelet-activating factor (PAF) in rat peripheral white blood cells stimulated with the calcium ionophore A23187 was studied. Results: Of the flavonoids tested, luteolin and quercetin exhibited significant inhibitory effects (IC50, 45μM and 80μM, respectively), whereas other structurally-related flavonoids failed to affect the lysoPAF acetyltransferase activity. Luteolin did not suppress the activity of choline acetyltransferase, suggesting that the inhibition observed here was specific. Luteolin also inhibited the production of PAF in rat peripheral white blood cells. Conclusions: These results indicate that luteolin could become a leading compound for developing a novel type of anti-inflammatory, anti-allergic drugs that target lysoPAF acetyltransferase.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02342225

    Articles: DFG German National Licenses
  15. 15
    Lee, K. K. ; Kim, Y. Y. ; Chang, H. W. ; Chung, S. Y.
    Springer
    Published 1997
    Staff View
    ISSN:
    1432-0495
    Keywords:
    Key words Nanjido Landfill ; Landfill leachate ; Landfill gas ; Environmental impact
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Geosciences
    Notes:
    Abstract  The Nanjido Landfill is the largest uncontrolled landfill in Korea and it causes various kinds of environmental problems. Landfill gases and leachate are recognized as the most serious environmental problems associated with the landfill. This study employs a series of numerical models and uses test data to interpret the distribution and flow of landfill gases and leachate. Leachate seepage appears about 40–60 m higher than the estimated basal groundwater table. Thus, seepage data indicate that perched or floating leachate layers are formed in the unsaturated zone of the landfill. The leachate production rate is estimated using infiltration test data and a model for unsaturated groundwater flow. Geochemical data indicate that the landfill leachate degrades the basal groundwater quality along the downgradient zone. The environmental impact of the leachate on river water is estimated.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002540050179

    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    1432-1076
    Keywords:
    Myoglobinuria ; Dystrophinopathy ; Becker muscular dystrophy
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Two young boys were referred for evaluation of metabolic myopathy because of elevated serum levels of creatine kinase, cramps and pigmenturia. Immunohistochemical studies of dystrophin in muscle biopsies showed reduced intensity of the stain with a patchy and discontinous pattern in most fibers. In both patients dystrophin was undetectable by immunoblotting. DNA analysis of the dystrophin gene was not informative in one patient; in the other it revealed an in-frame deletion comprising exons 3–6. These observations suggest that the two patients are affected with an unusual phenotype of Becker muscular dystrophy. Dystrophin analysis should be included in the evaluation of patients with childhood-onset of recurrent myoglobinuria.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02073385

    Articles: DFG German National Licenses
  17. 17
    Lei, H. C. ; Chang, H. W.
    Springer
    Published 1996
    Staff View
    ISSN:
    1573-2703
    Keywords:
    void formation ; Blatz-Ko material ; compressible elastic solids ; bifurcation
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Mathematics
    Technology
    Notes:
    Abstract A new class of compressible elastic solids, which includes the Blatz-Ko material as a special case, is proposed. A closed-form solution is constructed and studied for a bifurcation problem modeling void formation in this class of compressible elastic solids. The relation between the void-formation condition and the material parameters is obtained analytically. An energy comparison of the void-formation deformation and the homogeneous expansion deformation is carried out.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00042789

    Articles: DFG German National Licenses