Search Results - (Author, Cooperation:H. Verkade)

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  1. 1
    D. B. Gurevich ; P. D. Nguyen ; A. L. Siegel ; O. V. Ehrlich ; C. Sonntag ; J. M. Phan ; S. Berger ; D. Ratnayake ; L. Hersey ; J. Berger ; H. Verkade ; T. E. Hall ; P. D. Currie
    American Association for the Advancement of Science (AAAS)
    Published 2016
    Staff View
    Publication Date:
    2016-05-21
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    ISSN:
    1432-1076
    Keywords:
    Fat absorption ; Premature infants ; Antibiotics ; Infant formula
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Fat absorption of an adapted cow's milk formula was studied in a randomized controlled trial involving two groups of 18 premature infants (mean gestational age±SD: 33.0±2.9 weeks, range 26.5–37.5 weeks). The triglyceride configuration was modified by the use of lard. This modification did not improve the absorption of fat or energy. Also no difference in serum concentrations of cholesterol and tridifference was found. Growth velocity during the study was similar in both groups. Detailed analysis of the data revealed that in infants who received (parenterally) antibiotics (mainly ampicillin and netilmicin) a higher coefficient of fat absorption (+20%,P〈0.01) and of energy absorption (+8%,P=0.03) was found. Based on these results, we find no support for the use of lard in adapted cow's milk infant formulas to improve fat absorption. In studies of fat and energy absorption the effects of antibiotics have to be taken into account.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01995863

    Articles: DFG German National Licenses
  3. 3
    Verkade, H. M. ; O'Connell, M. J.
    Springer
    Published 1998
    Staff View
    ISSN:
    1617-4623
    Keywords:
    Key words Cell cycle ; Checkpoint ; Fission yeast ; cut5 ; DNA damage
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Notes:
    Abstract A checkpoint responding to DNA damage in G2 results in a delay in the onset of mitosis through inhibition of p34cdc2 kinase activity via maintenance of inhibitory tyrosine phosphorylation. Genetic analyses of this checkpoint in fission yeast have identified single alleles of several genes, suggesting these screens are not yet saturating, and hence further genes await identification. To fully understand the complexity of this checkpoint it will be necessary to define all the genes involved. To this end we screened for new mutants defective in the ability to delay mitosis in the presence of DNA-damaging agents. Twenty-four mutants were isolated that were defective in UV-C and MMS-induced checkpoint delay. Amongst these mutants was an allele of cut5 that was also defective in the checkpoint responses. We show here, contrary to previous reports, that the UV-C induced checkpoint response is defective in cut5 mutants. Therefore, like all other checkpoint mutants, cut5 is required for G2 checkpoint arrest following DNA damage, regardless of the nature of the lesions involved.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004380050913

    Articles: DFG German National Licenses