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1Latest Papers from Table of Contents or Articles in PressL. M. Boyden ; M. Choi ; K. A. Choate ; C. J. Nelson-Williams ; A. Farhi ; H. R. Toka ; I. R. Tikhonova ; R. Bjornson ; S. M. Mane ; G. Colussi ; M. Lebel ; R. D. Gordon ; B. A. Semmekrot ; A. Poujol ; M. J. Valimaki ; M. E. De Ferrari ; S. A. Sanjad ; M. Gutkin ; F. E. Karet ; J. R. Tucci ; J. R. Stockigt ; K. M. Keppler-Noreuil ; C. C. Porter ; S. K. Anand ; M. L. Whiteford ; I. D. Davis ; S. B. Dewar ; A. Bettinelli ; J. J. Fadrowski ; C. W. Belsha ; T. E. Hunley ; R. D. Nelson ; H. Trachtman ; T. R. Cole ; M. Pinsk ; D. Bockenhauer ; M. Shenoy ; P. Vaidyanathan ; J. W. Foreman ; M. Rasoulpour ; F. Thameem ; H. Z. Al-Shahrouri ; J. Radhakrishnan ; A. G. Gharavi ; B. Goilav ; R. P. Lifton
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-01-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Animals ; Base Sequence ; Blood Pressure/genetics ; Carrier Proteins/chemistry/*genetics ; Cohort Studies ; Cullin Proteins/chemistry/*genetics ; Electrolytes ; Exons/genetics ; Female ; Gene Expression Profiling ; Genes, Dominant/genetics ; Genes, Recessive/genetics ; Genotype ; Homeostasis/genetics ; Humans ; Hydrogen-Ion Concentration ; Hypertension/complications/*genetics/physiopathology ; Male ; Mice ; Models, Molecular ; Molecular Sequence Data ; Mutation/*genetics ; Phenotype ; Potassium/metabolism ; Pseudohypoaldosteronism/complications/*genetics/physiopathology ; Sodium Chloride/metabolism ; Water-Electrolyte Imbalance/complications/*genetics/physiopathologyPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 0005-2736Keywords: Fluorescence anisotropy ; Hyperosmolality ; Lipid fluidity ; Synaptosome ; Taurine transportSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0026-2862Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1437-7799Keywords: Key words High glucose ; Rat mesangial cells ; Growth ; Vitamin ESource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Background. We aimed to examine both whether vitamin E prevented and whether it reversed the growth inhibitory effect of high glucose. Methods. For the preventive experiment, rat mesangial cells (RMC) were grown in control glucose medium with the addition of 100 μM of vitamin E. High glucose (27.5 mM) was added to the medium concurrent with the vitamin E addition. The 3-(4,5-di-methylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay was used to measure RMC proliferation. Our data confirmed the growth inhibitory effect of high glucose and showed that the growth inhibition was prevented by vitamin E. To examine whether vitamin E reversed the growth inhibitory effects of high glucose, RMC were grown in control and high glucose medium. Contrary to previous prevention type studies, vitamin E was not added to the medium until growth inhibition of the RMC by the high glucose was established. Results. Our data show that it took 5 days of vitamin E administration to reverse the growth inhibitory effect of high glucose. Conclusion. This is the first time that vitamin E has been shown to reverse this high-glucose-induced inhibition of RMC, suggesting that vitamin E reverses a potentially important pathogenetic process.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1432-198XKeywords: Hypertension ; Renovascular disease ; CaptoprilSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract A captopril challenge test (CCT) for renovascular disease in adults was described recently. We used it in 20 consecutive, untreated hypertensive children and adolescents. All had a normal urinalysis and glomerular filtration rate and non-diagnostic renal sonograms or intravenous urograms. Plasma renin activity (PRA) was measured before and 1 h after administration of captopril (0.76±0.17 mg/kg). The CCT was positive in 10 patients. Renal arteriograms were performed in 7 patients with a positive CCT and in 2 with a negative CCT. Renovascular disease was found in 4 patients, 1 of whom had a negative CCT. The PRA response to captopril was the same in patients with true- and the false-positive tests. The predictive value of the positive test was 43%. In conclusion, we did not find the CCT, as described for adults, to be of value in children and adolescents.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesSu, Irene H. ; Frank, Rachel ; Gauthier, Bernard G. ; Valderrama, Elsa ; Simon, David B. ; Lifton, Richard P. ; Trachtman, H.
Springer
Published 2000Staff ViewISSN: 1432-198XKeywords: Key words Bartter syndrome ; Focal segmental glomerulosclerosisSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We describe a patient with signs and symptoms of classic Bartter syndrome. The patient tested negative for all known genetic abnormalities associated with this tubular disorder. Proteinuria was found within 1 year after the diagnosis of Bartter syndrome. A renal biopsy performed 6 months later, when her kidney function was normal, revealed focal segmental glomerulosclerosis (FSGS). We propose a link between stimulation of the renin-angiotensin system and sclerotic changes in the glomerulus. This lesion may explain previous reports of kidney failure in patients with Bartter syndrome.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesGreenbaum, L. A. ; Simckes, A. M. ; McKenney, D. ; Kainer, G. ; Nagaraj, S. K. ; Trachtman, H. ; Alon, U. S.
Springer
Published 2000Staff ViewISSN: 1432-198XKeywords: Key words Biopsy ; Kidney ; Complications ; Percutaneous ; Internet ; e-mailSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Technological improvements have reduced the frequency of complications in children receiving a percutaneous renal biopsy. No study has systematically compared the safety of open and percutaneous kidney biopsy. Yet many nephrologists consider a single native kidney an absolute contraindication to percutaneous biopsy. We have established an international registry of single native kidney biopsies in children and we now report our early results. Eight biopsies are included. Seven patients had percutaneous biopsies and one an open biopsy. None of the patients had major complications, and adequate tissue was obtained from all. Our limited experience indicates that the presence of a single native kidney is not an absolute indication for an open approach. We encourage our colleagues to report to the international registry in order to further document the safety of percutaneous biopsy of the single native kidney in children.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesTahzib, Munirih ; Frank, Rachel ; Gauthier, Bernard ; Valderrama, Elsa ; Trachtman, H.
Springer
Published 1999Staff ViewISSN: 1432-198XKeywords: Key words Focal segmental glomerulosclerosis ; Antioxidants ; Vitamin E ; ProteinuriaSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Experimental data indicate that excessive production of reactive oxygen molecules contributes to progressive renal injury and that treatment with antioxidants attenuates this damage. Therefore, we investigated whether vitamin E supplementation could ameliorate renal disease and reduce proteinuria in children with a variety of kidney disorders. Vitamin E, 200 IU twice daily, was administered orally to 11 children with focal segmental glomerulosclerosis (FSGS) (group A) and 9 patients with miscellaneous kidney diseases (group B) [Henoch-Schönlein purpura nephritis (n=3), urinary tract anomalies (n=2), non-specific immune complex glomerulonephritis (n=2), IgA nephropathy (n=1), and reflux nephropathy (n=1)]. The duration of vitamin E treatment, when no other therapy was introduced, was 2.9±0.4 months. Proteinuria was determined by measuring the protein:creatinine ratio (mg/mg) in an early morning urine specimen. In children with FSGS, administration of vitamin E lowered the protein:creatinine ratio in 10 of 11 patients from 9.7±5.1 to 4.1±1.1 (P〈0.005). In contrast, among children with miscellaneous renal diseases, vitamin E had no beneficial impact on urinary protein excretion-protein:creatinine ratio 2.5±1.0 pre versus 2.4±1.2 post antioxidant. Vitamin E supplementation had no effect on glomerular filtration rate, serum albumin, or cholesterol concentration in either group of patients. These findings suggest that reactive oxygen molecules may play a more-prominent role in causing renal injury in patients with FSGS than in other kidney disorders. Antioxidant therapy may be a useful adjunct in the treatment of children with FSGS and proteinuria that is refractory to standard medical management.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1438-2199Keywords: Taurine ; Antioxidant ; Lipid peroxidation ; Puromycin aminonucleoside nephropathy ; Focal segmental glomerulosclerosis ; Diabetic nephropathy ; HypertensionSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Taurine is an abundant free amino acid in the plasma and cytosol. The kidney plays a pivotal role in maintaining taurine balance. Immunohistochemical studies reveal a unique localization pattern of the amino acid along the nephron. Taurine acts as an antioxidant in a variety ofin vitro andin vivo systems. It prevents lipid peroxidation of glomerular mesangial cells and renal tubular epithelial cells exposed to high glucose or hypoxic culture conditions. Dietary taurine supplementation ameliorates experimental renal disease including models of refractory nephrotic syndrome and diabetic nephropathy. The beneficial effects of taurine are mediated by its antioxidant action. It does not attenuate ischemic or nephrotoxic acute renal failure or chronic renal failure due to sub-total ablation of kidney mass. Additional work is required to fully explain the scope and mechanism of action of taurine as a renoprotective agent in experimental kidney disease. Clinical trials are warranted to determine the usefulness of this amino acid as an adjunctive treatment of progressive glomerular disease and diabetic nephropathy.Type of Medium: Electronic ResourceURL: