Search Results - (Author, Cooperation:H. T. Orr)
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1Latest Papers from Table of Contents or Articles in PressJ. D. Fryer ; P. Yu ; H. Kang ; C. Mandel-Brehm ; A. N. Carter ; J. Crespo-Barreto ; Y. Gao ; A. Flora ; C. Shaw ; H. T. Orr ; H. Y. Zoghbi
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-11-05Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Ataxin-1 ; Ataxins ; Cerebellum/metabolism ; Disease Models, Animal ; *Exercise Therapy ; Gene Knock-In Techniques ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/genetics ; Repressor Proteins/genetics/*physiology ; Spinocerebellar Ataxias/genetics/*therapyPublished by: -
2Latest Papers from Table of Contents or Articles in PressJ. Park ; I. Al-Ramahi ; Q. Tan ; N. Mollema ; J. R. Diaz-Garcia ; T. Gallego-Flores ; H. C. Lu ; S. Lagalwar ; L. Duvick ; H. Kang ; Y. Lee ; P. Jafar-Nejad ; L. S. Sayegh ; R. Richman ; X. Liu ; Y. Gao ; C. A. Shaw ; J. S. Arthur ; H. T. Orr ; T. F. Westbrook ; J. Botas ; H. Y. Zoghbi
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-05-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Animals ; Animals, Genetically Modified ; Ataxin-1 ; Ataxins ; Cell Line, Tumor ; Disease Models, Animal ; Down-Regulation/drug effects ; Drosophila melanogaster/genetics/*metabolism ; Female ; Humans ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Mitogen-Activated Protein Kinases/*metabolism ; Molecular Sequence Data ; Molecular Targeted Therapy ; Nerve Tissue Proteins/chemistry/genetics/*metabolism/*toxicity ; Nuclear Proteins/chemistry/genetics/*metabolism/*toxicity ; Phosphorylation ; Protein Stability/drug effects ; Ribosomal Protein S6 Kinases, 90-kDa/deficiency/genetics/*metabolism ; Spinocerebellar Ataxias/*metabolism/*pathology ; Transgenes ; ras Proteins/*metabolismPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesSTROMINGER, J. L. ; ORR, H. T. ; PARHAM, P. ; PLOEGH, H. L. ; MANN, D. L. ; BILOFSKY, H. ; SAROFF, H. A. ; WU, T. T. ; KABAT, E. A.
Oxford, UK : Blackwell Publishing Ltd
Published 1980Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A computer search was carried out for homologies between HLA-A and HLA-B antigen sequences and the sequences of constant and variable regions of immunoglobulins and of all other sequenced proteins. Searches were made both with relatively short peptide sequences from the HLA antigens and with those longer peptide sequences which were available in 1978. Significant homology of HLA antigen sequences to immunoglobulin constant region sequences was found in two cases: (1) a short decapeptide sequence which includes the fourth cysteine residue of HLA-B7 and (2) an 89-amino-acid residue (Ac-2) C-terminal fragment of the papain-solubilized HLA-B7 molecule. The difficulty of establishing statistically significant sequence homology with relatively short peptide sequences is emphasized by computer-based comparisons of the decapeptide sequence with randomly generated peptide sequences. It is concluded that statistically significant homology with short sequences can be assured only when extraordinarily high degrees of homology are present and additional constraints are included in the matches, for example, matches at relatively rare amino acid residues such as Cys, His and Trp. The homology of the 89-amino-acid residue sequence to constant region sequences of immunoglobulins is as great as or greater than that of β2-microglobulin. These findings and the unique domain structure involving a disulphide loop of comparable size strongly favour a common evolutionary origin for this region of HLA-A and -B, β2-microglobulin and immunoglobulin constant regions.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesKrangel, M. S. ; Orr, H. T. ; Strominger, J. L.
Oxford, UK : Blackwell Publishing Ltd
Published 1980Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: SummaryIn summary, the complete primary structure of one HLA antigen (HLA-B7) has now been determined, and sufficient information is available about other HLA-A and -B and H-2 molecules to begin to assess the location of the variable regions within these molecules. It is these regions of the molecules which have evolved to give rise to the extensive polymorphism in human populations, and they most likely define functionally important regions of the molecule. Thus, this information may help us to elucidate the natural biological function of these molecules, as, for example, in the recognition of allogeneic or virally infected syngeneic cells by cytotoxic T cells. Some functional studies, using purified HLA-A and -B antigens inserted in liposomes, have been initiated, and studies of the biosynthesis of these antigens are of great interest in their own right. Further, using cDNA probes, they are being extended to permit us ultimately to underScand the organization of the genes on the sixth human chromosome which encode HLA-A and -B antigens. Finally, such probes may permit the rapid accumulation of sequence information, which would allow us to underScand more completely the structure of these extremely important cell surface molecules.Type of Medium: Electronic ResourceURL: