Search Results - (Author, Cooperation:H. Stark)
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1Latest Papers from Table of Contents or Articles in PressD. E. Agafonov ; B. Kastner ; O. Dybkov ; R. V. Hofele ; W. T. Liu ; H. Urlaub ; R. Luhrmann ; H. Stark
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-02-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Cryoelectron Microscopy ; Crystallography, X-Ray ; DEAD-box RNA Helicases/chemistry ; Enzyme Activation ; HeLa Cells ; Humans ; Models, Molecular ; Peptide Elongation Factors/chemistry ; Protein Conformation ; RNA Helicases/chemistry ; RNA-Binding Proteins/chemistry ; Ribonucleoprotein, U4-U6 Small Nuclear/*chemistry ; Ribonucleoprotein, U5 Small Nuclear/*chemistry ; Ribonucleoproteins, Small Nuclear/chemistry ; Saccharomyces cerevisiae Proteins/chemistry ; Schizosaccharomyces/metabolism ; Ubiquitin Thiolesterase/chemistryPublished by: -
2Latest Papers from Table of Contents or Articles in PressTang, W., Wallace, T. A., Yi, M., Magi-Galluzzi, C., Dorsey, T. H., Onabajo, O. O., Obajemu, A., Jordan, S. V., Loffredo, C. A., Stephens, R. M., Silverman, R. H., Stark, G. R., Klein, E. A., Prokunina-Olsson, L., Ambs, S.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-11-02Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
3Latest Papers from Table of Contents or Articles in PressN. Fischer ; P. Neumann ; A. L. Konevega ; L. V. Bock ; R. Ficner ; M. V. Rodnina ; H. Stark
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-02-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Anti-Bacterial Agents/chemistry/metabolism ; *Cryoelectron Microscopy/methods ; Escherichia coli/*chemistry/*ultrastructure ; Ligands ; Models, Molecular ; Peptide Elongation Factor Tu/*chemistry/metabolism/*ultrastructure ; Pyridones/chemistry/metabolism ; RNA, Bacterial/chemistry/metabolism/ultrastructure ; RNA, Ribosomal/chemistry/metabolism/ultrastructure ; RNA, Transfer/chemistry/metabolism/ultrastructure ; Ribosomes/*chemistry/metabolism/*ultrastructurePublished by: -
4FIS Bildung LiteraturdatenbankStaff View
Type of Medium: articlePublication Date: 1992Keywords: Sachinformation ; Chemie ; Zellstoff ; Produktionstechnik ; Gesetzgebung ; Recycling ; Umweltschutz ; Papier ; Forstwirtschaft ; ÖsterreichIn: Praxis der Naturwissenschaften. Chemie, Bd. 41 (1992) H. 7, S. 40-41, 0177-95160342-8745Language: German -
5Articles: DFG German National LicensesStaff View
ISSN: 1744-6570Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: PsychologyType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1744-6570Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: PsychologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesWOLFART, S. ; HEYDECKE, G. ; LUTHARDT, R. G. ; MARRÉ, B. ; FREESMEYER, W. B. ; STARK, H. ; WÖSTMANN, B. ; MUNDT, T. ; POSPIECH, P. ; JAHN, F. ; GITT, I. ; SCHÄDLER, M. ; AGGSTALLER, H. ; TALEBPUR, F. ; BUSCHE, E. ; BELL, M.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2842Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: abstract A multi-centre randomized clinical trial is under way at 14 university dental schools in Germany to compare prosthodontic treatments for the shortened dental arch (SDA). One of the aims of this pilot-study was to measure the effect of two treatment options of the SDA on oral health-related quality of life and on the Research Diagnostic Criteria (RDC) for temporomandibular disorders (TMD). Thirty-four patients participated in the pilot-study. Inclusion criteria were: all molars were missing and the presence of at least both canines and one premolar in each quadrant. Participants were randomly assigned to receive either removable partial dentures including molar replacement (RPD_group) or retain a premolar occlusion (PROC_group). The Oral Health Impact Profile (OHIP-49) and the RDC for TMD were completed by participants before treatment (pre-treatment), 6 weeks (6wks), 6 months (6m) and 12 months (12m) after treatment. At the 12-month follow up, data of 10 women and 11 men (mean age: 62 ± 10 years) were available. Medians of the OHIP total-scores were as follows: RPD (n = 10), 43·5 (pre-treatment), 18·2 (6wks), 13·3 (6m), 14·7 (12m). PROC (n = 11): 31·8 (pre-treatment), 27·1 (6wks), 8·8 (6m), 8·3 (12m). Significant differences were shown for RPD_group between pre-treatment and 6m/12m and for PROC_group between pre-treatment and 6m. There were no significant differences between treatment groups at any time. Within each group, an improvement of life-quality was observed. No significant difference could be reported between the two therapy concepts. This may be due to the low sample size within the pilot study.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0003-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0920-5632Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0029-554XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Energy, Environment Protection, Nuclear Power EngineeringPhysicsType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStark, H. ; Krause, M. ; Arrang, J.-M. ; Ligneau, X. ; Schwartz, J.-C. ; Schunack, W.
Amsterdam : ElsevierStaff ViewISSN: 0960-894XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyMedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0375-9601Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0196-9781Keywords: Aminopeptidase ; Brain microinjection ; In vivo metabolism ; Neuropeptides ; Vasopressin ; Vasopressin fragmentsSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0196-9781Keywords: Blood-brain barrier ; Brain ; Endothelial cells ; In vitro ; Metabolism ; Neuropeptides ; Peptides ; TransportSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0223-5234Keywords: N^α-acylated histamine ; N^α-alkylated histamine ; N^α-histamine-γ-cyclohexylbutyramide ; histamine ; histamine H"3-receptor antagonistSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyMedicineType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1432-1440Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesSchlicker, E. ; Kathmann, M. ; Bitschnau, H. ; Marr, I. ; Reidemeister, S. ; Stark, H. ; Schunack, W.
Springer
Published 1996Staff ViewISSN: 1432-1912Keywords: Key words3H-Nα-Methylhistamine binding ; Mouse brain cortex slices ; Guinea-pig ileum strips ; Histamine H3 receptors ; Iodoproxyfan ; Noradrenaline release ; Acetylcholine releaseSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We determined the affinities of 16 newly synthesized H3 receptor antagonists in an H3 receptor binding assay and the potencies of 12 of these compounds at functional H3 receptors in the mouse brain cortex and guinea-pig ileum. The compounds differ from histamine in that the C-C-N side chain is replaced by a chain of the structure C-C-C-O. The two major aims of the study were (1) to investigate whether the two functional H3 receptors are pharmacologically different and (2) to derive structure-activity relationships. The specific binding of 3H-Nα-methylhistamine to rat brain cortex membranes was monophasically displaced by each of the 16 compounds at pKi values ranging from 7.30 to 9.48. In superfused mouse brain cortex slices preincubated with 3H-noradrenaline, the electrically evoked tritium overflow was slightly decreased by iodoproxyfan and its deiodo analogue; this effect was counteracted by the H3 receptor antagonist clobenpropit. The other compounds did not affect the evoked tritium overflow by themselves. The concentration-response curve of histamine for its inhibitory effect on the electrically evoked tritium overflow was shifted to the right by the 12 compounds with apparent pA2 values ranging from 7.02 to 9.00. The 12 compounds also shifted to the right the concentration-response curve of R-α-methylhistamine for its inhibitory effect on the electrically induced contraction in guinea-pig ileum strips; the apparent pA2 values ranged from 5.97 to 9.00. Iodoproxyfan decreased the electrically induced contraction by itself and this effect was counteracted by the H3 receptor antagonist thioperamide. The apparent pA2 values in the two functional H3 receptor models showed a highly significant correlation (r=0.882; P〈0.001). Highly significant correlations were also obtained when the pKi values of the compounds in the binding assay were compared to their apparent pA2 values in the mouse brain (r=0.799; P〈0.004) and in the guinea-pig ileum (r=0.851; P〈0.001). In each of the three experimental models, iodoproxyfan was the most potent compound; its deiodo analogue was less potent by more than 1.1 log units. The present results show that the compounds under study possess moderate to high affinity and/or (partial) H3 receptor antagonist potency. The two functional H3 receptors in the mouse brain cortex and the guinea-pig ileum may be slightly different; further studies are necessary to clarify whether this difference is due to H3 receptor heterogeneity, species variants or differences in the efficiency of receptor coupling. The marked difference in the affinity/potency between iodoproxyfan and its deiodo analogue may suggest that a highly lipophilic residue in that part of the molecule favours a high affinity/antagonistic potency at H3 receptors.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesMatthies, H. ; Stark, H. ; Hartrodt, B. ; Ruethrich, H.-L. ; Spieler, H.-T. ; Barth, A. ; Neubert, K.
Amsterdam : ElsevierStaff ViewISSN: 0196-9781Keywords: Analgesic action ; Deproceptin ; Deprolorphin ; Isoreceptors ; β-Casomorphin ; μ-ReceptorsSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesHistamine H3-receptor activation inhibits acetylcholine release from the guinea pig myenteric plexusStaff View
ISSN: 1420-908XSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The role of histamine H3-receptors in the control of acetylcholine release from peripheral cholinergic neurons was evaluated in the isolated guinea pig ileum, previously loaded with3H-choline. When tested in the presence of H1- and H2-blockade, histamine (0.1–100 μmol/l) and (R)α-methylhistamine (0.01–1 μmol/l) dose-dependently reduced the electrically-evoked choline outflow, with (R)α-methylhistamine being a partial agonist. Selective H3-receptor blocking drugs, thioperamide (0.1 μmol/l) and impromidine (0.1 μmol/l) reversed the histamine-induced inhibitory, effect. These data suggest that intestinal cholinergic nerves are endowed with histamine H3-receptors whose activation produces an inhibitory effect upon acetylcholine release. The practical implications of these findings are obvious.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesSchneebeli, H. R. ; Schweitzer, G. ; Stark, H. -G. ; Rau, F. ; Struwe, Michael ; Bangert, V. ; Schwarz, H. R. ; Eckmann, B. ; Spirig, F. ; Straumann, N. ; Sperb, R. ; Scheurle, J. ; Bayer-Flückiger, Eva ; Aebi, Robert ; Renardy, Michael ; Amick, C. J. ; Josten, G. ; Heij, C. ; Eichler, R.
Springer
Published 1990Staff ViewISSN: 1420-9039Source: Springer Online Journal Archives 1860-2000Topics: MathematicsPhysicsType of Medium: Electronic ResourceURL: