Search Results - (Author, Cooperation:H. Okamura)
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1Latest Papers from Table of Contents or Articles in PressGoda, T., Doi, M., Umezaki, Y., Murai, I., Shimatani, H., Chu, M. L., Nguyen, V. H., Okamura, H., Hamada, F. N.
Cold Spring Harbor Laboratory Press
Published 2018Staff ViewPublication Date: 2018-02-16Publisher: Cold Spring Harbor Laboratory PressPrint ISSN: 0890-9369Topics: BiologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressY. Yamaguchi ; T. Suzuki ; Y. Mizoro ; H. Kori ; K. Okada ; Y. Chen ; J. M. Fustin ; F. Yamazaki ; N. Mizuguchi ; J. Zhang ; X. Dong ; G. Tsujimoto ; Y. Okuno ; M. Doi ; H. Okamura
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-10-05Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antidiuretic Hormone Receptor Antagonists ; Body Temperature/genetics ; CLOCK Proteins/genetics ; Cell Communication/drug effects/genetics ; Cells, Cultured ; Circadian Rhythm/genetics ; Gene Expression Regulation ; Jet Lag Syndrome/*genetics/physiopathology ; Mice ; Mice, Knockout ; Motor Activity/genetics ; Receptors, Vasopressin/*genetics ; Suprachiasmatic Nucleus/physiopathologyPublished by: -
3Latest Papers from Table of Contents or Articles in PressIshizuka, S., Kawamoto, Y., Sakamaki, T., Tokuyama, N., Toda, K., Okamura, H., Furuichi, T.
Royal Society
Published 2018Staff ViewPublication Date: 2018-02-01Publisher: Royal SocietyElectronic ISSN: 2054-5703Topics: Natural Sciences in GeneralKeywords: molecular biology, genetics, ecologyPublished by: -
4Articles: DFG German National LicensesStaff View
ISSN: 1469-8986Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicinePsychologyNotes: A sequential blanking paradigm was used to determine the effects of more intense, later appearing, stimuli upon the visual evoked potential (VEP) to earlier appearing stimuli. In sequential blanking the presentation of a sequence of visual stimuli at certain rates, and in certain orders, results in the perceptual blanking of approximately one-half of the stimuli. The precise timing and location requirements for this effect are conveniently produced with a digital computer and associated cathode ray tube display.Further evidence was found for the inhibiting effect of later occurring (more intense) stimuli on the VEP response to earlier occurring (less intense) stimuli. This effect revealed itself in the delayed appearance of the major components of the VEP. In addition, it was found that the amount of delay was related to the ratio of the intensity difference between the earlier (blanked) and later occurring (blanking) stimuli, i.e., the greater the intensity difference between them the greater the temporal displacement produced in the VEP components.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1469-8986Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicinePsychologyNotes: The averaged visual cortical evoked potential (VEP) was examined in two separate experiments us a function of stimulus location. The VEP was recorded from over left and right occipital hemispheres and stimuli were presented binocularly.The results of Experiment I, in which three stimulus locations were used, indicated that stimuli presented in the left visual field resulted in shorter VKP latencies at the right occipital area than the left, while for stimuli presented in the right visual field, the opposite occurred. In Experiment II, seven locations were used and similar VEP latency asymmetries were observed. White no hemispheric amplitude asymmetries were found, there was a trend toward a decrease of VEP amplitude with increasing distance of stimulation from the fovea.The latency asymmetries may he explained in terms of the angle at which the stimuli impinge upon the retinas of the two eyes from different locations. Direct stimulation is produced at the primary projection area, whereas indirect stimulation probably occurs at the secondary area, after crossover of impulses via the corpus callosum.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesIchimaru, T. ; Matsuyama, S. ; Ohkura, S. ; Mori, Y. ; Okamura, H.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2826Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: To clarify central actions of cholecystokinin-octapeptide (CCK-8) on reproduction, effects of an intracerebroventricular (i.c.v.) administration of CCK-8 on the activity of the gonadotropin-releasing hormone (GnRH) pulse generator were examined in ovariectomized (OVX) goats in the absence or presence of oestradiol. Goats were chronically fitted with recording electrodes in the mediobasal hypothalamus, and electrophysiological manifestations of the GnRH pulse generator were monitored as characteristic increases in the multiple-unit activity (MUA volleys). In OVX goats, a bolus i.c.v. injection of as little as 0.01 nmol of CCK-8 induced a MUA volley with a short latency, which resulted in a significant decrease in the post-treatment volley interval compared to that in the saline injected control. Administration of higher doses of CCK-8 (0.1 and 2 nmol) did not further accelerate the occurrence of the MUA volley, but stimulatory effects were observed for a longer period than that after the 0.01 nmol injection. When goats were treated with oestradiol, while a bolus i.c.v. injection of 0.01 nmol CCK-8 had no effect, an injection of 0.1 nmol of the peptide significantly decreased the post-treatment volley interval. On continuous i.c.v. infusion of CCK-8 at 3 nmol per 200 µl/h for 3 h, MUA volleys with shorter intervals than those in the control were successively induced without any apparent change in basal plasma luteinizing hormone levels in OVX goats. These results demonstrate that central CCK-8 strongly accelerates the activity of the GnRH pulse generator in goats.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesKuribayashi, K ; Kodama, T ; Okamura, H ; Sugita, M ; Matsuyama, T
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background Correcting Th1/Th2 imbalance with administration of IL-12 before and during antigen challenge holds therapeutic promise in asthma. However, the effects of IL-12 on the established asthmatic responses have not fully been examined.Objective We investigated whether IL-12 administered after antigen challenge could diminish airway hyper-reactivity (AHR) and eosinophilia in mice actively sensitized to ovalbumin. We also have investigated the ability of administered IL-12 to induce IL-18 receptor (IL-18R) expression that may lead possible synergic action of IL-12 with endogenous IL-18.Methods C57BL/6 mice immunized to ovalbumin (OVA) by intraperitoneal (i.p.) injection, were challenged three times with an aerosol of OVA every second day for 8 days. Recombinant IL-12 (500 ng) was intravenously administered on a single occasion 1 h after the final challenge of mice. Mice were analysed for effects of IL-12 on AHR, inflammatory cell infiltration and cytokine levels in lung tissue as well as serum immunoglobulin (Ig) E levels. Immunohistochemistry for IL-18R was performed using rat monoclonal antibody specific for murine IL-18Rα (IL-1 receptor related protein; IL-1Rrp).Results An intravenous IL-12 administration diminished AHR, pulmonary eosinophilia and T lymphocyte infiltration, serum IgE, IL-4 and IL-13 in lung tissue. Expression of IL-18R was induced in the mononuclear cells in the lung of mice exposed to OVA. IL-12 administration enhanced the IL-18R expression compared with the control.Conclusion These data indicate that IL-12 can attenuate established antigen-induced AHR and inflammation. In this mechanism it would be interpreted as follows: IL-12 administration in OVA-challenged mice decreased IL-4 production and IgE production thereafter through direct effect on inhibiting the activation of established Th2 cells response and also combined effect with up-regulation of IL-18R expression by inflammatory cells in the lung.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1460-2695Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract This paper presents a simple algorithm of hysteresis loop counting to make on-line data processing much easier. It involves a modification of the range pair counting method and the rain flow method and yields practically the same result as these methods. In addition, the applicability of the present method to cumulative damage estimation is examined in experiments on fatigue crack growth rates under stationary random loads and low cycle fatigue lives under stationary random loads together with non-stationary random loads such as seismically excited loads.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesOkamura, H. ; Kelly, P.A. ; Chabot, J.G. ; Morel, G. ; Belles-Isles, M. ; Heisler, S.
Amsterdam : ElsevierStaff ViewISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesKawaguchi-Nagata, K. ; Okamura, H. ; Tamura, T. ; Yamatodani, A. ; Watanabe, T. ; Wada, H. ; Taguchi, T. ; Kitamura, Y. ; Shoji, K.
Amsterdam : ElsevierStaff ViewISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0003-4916Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesKawaguchi-Nagata, K. ; Watanabe, T. ; Maeyama, K. ; Yamatodani, A. ; Okamura, H. ; Tamura, T. ; Shoji, K. ; Kitamura, Y.
Amsterdam : ElsevierStaff ViewISSN: 0005-2728Keywords: (Murine) ; Differentiation ; Histamine ; Histidine decarboxylase ; Macrophages ; Myelomonocytic leukemia cell ; [abr] HDC ; [abr] L-histidine decarboxylase (L-histidine carboxy-lyase, EC 4.1.1.22) ; [abr] post-endotoxin serum, the serum which was obtained from miceSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0011-2240Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0375-9601Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesJeandel, L. ; Okamura, H. ; Belles-Isles, M. ; Chabot, J.-G. ; Dihl, F. ; Morel, G. ; Kelly, P.A. ; Heisler, S.
Amsterdam : ElsevierStaff ViewISSN: 0303-7207Keywords: Adipocyte ; Atrial natriuretic peptide binding site ; Cyclic AMP ; Cyclic GMP ; Glycerol ; Immunocytochemistry ; Tri-glyceridesSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0921-4526Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0920-3796Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Energy, Environment Protection, Nuclear Power EngineeringPhysicsType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0022-1902Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyEnergy, Environment Protection, Nuclear Power EngineeringType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesMorimoto, S. ; Akiyama, H. ; Takoaka, M. ; Okamura, H. ; Imaoka, S. ; Funae, Y.
Amsterdam : ElsevierStaff ViewISSN: 0021-9673Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0022-1902Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyEnergy, Environment Protection, Nuclear Power EngineeringType of Medium: Electronic ResourceURL: