Search Results - (Author, Cooperation:H. Ngan)
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1Latest Papers from Table of Contents or Articles in PressA. Gould ; A. Udalski ; I. G. Shin ; I. Porritt ; J. Skowron ; C. Han ; J. C. Yee ; S. Kozlowski ; J. Y. Choi ; R. Poleski ; L. Wyrzykowski ; K. Ulaczyk ; P. Pietrukowicz ; P. Mroz ; M. K. Szymanski ; M. Kubiak ; I. Soszynski ; G. Pietrzynski ; B. S. Gaudi ; G. W. Christie ; J. Drummond ; J. McCormick ; T. Natusch ; H. Ngan ; T. G. Tan ; M. Albrow ; D. L. DePoy ; K. H. Hwang ; Y. K. Jung ; C. U. Lee ; H. Park ; R. W. Pogge ; F. Abe ; D. P. Bennett ; I. A. Bond ; C. S. Botzler ; M. Freeman ; A. Fukui ; D. Fukunaga ; Y. Itow ; N. Koshimoto ; P. Larsen ; C. H. Ling ; K. Masuda ; Y. Matsubara ; Y. Muraki ; S. Namba ; K. Ohnishi ; L. Philpott ; N. J. Rattenbury ; T. Saito ; D. J. Sullivan ; T. Sumi ; D. Suzuki ; P. J. Tristram ; N. Tsurumi ; K. Wada ; N. Yamai ; P. C. Yock ; A. Yonehara ; Y. Shvartzvald ; D. Maoz ; S. Kaspi ; M. Friedmann
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-07-06Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Articles: DFG German National LicensesKING, P. A. ; LI, D. F. H. ; NGAN, H. Y. S. ; MA, H. K.
Oxford, UK : Blackwell Publishing Ltd
Published 1989Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesChan, F. Y. ; Chau, M. T. ; Pun, T. C. ; Lam, C. ; Ngan, H. Y. S. ; Wong, R. L. C.
Oxford, UK : Blackwell Publishing Ltd
Published 1995Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Objective To assess whether colour Doppler sonography can replace pelvic arteriography in the assessment of patients with gestational trophoblastic disease.Design An observational study in which patients with gestational trophoblastic disease were assessed with both pelvic arteriography and colour Doppler sonography.Setting The oncology unit of the Department of Obstetrics and Gynaecology, University of Hong Kong. The unit is the main tertiary referral centre for treatment of trophoblastic diseases in Hong Kong.Subjects Thirty-two consecutive women referred over an 18 month period.Main outcome measures The site of localisation of the tumour and the size of the tumour as assessed by both methods.Results Eleven patients had a spontaneous fall of β-hCGtitres and did not have pelvic arteriograms performed. The remaining 21 patients had both investigations performed. Four patients had no evidence of abnormal pelvic vessels either on colour Doppler sonography or on pelvic arteriography. Their raised P hCG titres were due to metastatic disease elsewhere. In the remaining patients the location of the tumour vessels was found to be concordant between the two methods of imaging. Measurements of the mean diameter of tumour bulk by the two methods also agreed well (r = 0.93, P 〈 0–0001). Pelvic arteriogram over-estimated the size of the tumour in two patients by 2 and 3 cm, respectively, but this did not alter the risk categories of the patients.Conclusion Colour Doppler sonography is a noninvasive technique that can replace pelvic arteriography in the assessment of patients with trophoblastic diseases.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesXue, W C ; Feng, H C ; Chan, K Y K ; Chiu, P M ; Ngan, H Y S ; Khoo, U S ; Tsao, S W ; Chan, K W ; Cheung, A N Y
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aims : To assess the expression of Id proteins in trophoblastic tissues and to correlate this with clinical parameters, proliferative and apoptotic indices as well as to related oncogene expression.Methods and results : Immunohistochemistry for Id1, Id2, Id3 and Id4 was performed on 83 trophoblastic tissues including 17 normal first-trimester placentas, seven term placentas, 47 hydatidiform moles (HM), and 12 spontaneous miscarriages. The four Id proteins were predominantly expressed in the villous and implantation site intermediate trophoblast. Expression of Id1 in HM was significantly higher than that in normal placenta (P = 0.0006) and spontaneous miscarriage (P = 0.0001) but did not correlate with subsequent development of gestational trophoblastic neoplasia (GTN). Id1 expression correlated with the proliferation index as assessed by MCM7 (P = 0.003) and Ki67 (P = 0.017) and with the apoptotic activity assessed by TUNEL (P = 0.001) and M30 CytoDeath antibody (P = 0.013). Moreover, the expression of Id1 correlated with the expression of p53 (P = 0.004), p21WAF1/CIP1 (P = 0.003) but not with p16 (P = 0.107).Conclusions : Id proteins may play a role in the regulation of proliferative and apoptotic activity in trophoblastic tissue and are potentially useful in differentiating molar and non-molar gestation, but are not helpful in predicting GTN.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesXue, W C ; Khoo, U S ; Ngan, H Y S ; Chan, K Y K ; Chiu, P M ; Tsao, S W ; Cheung, A N Y
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aims: To assess the proliferative activity of gestational trophoblastic disease (GTD) using one of the novel proliferation markers (MCM7) and to determine its prognostic value in hydatidiform mole (HM).Methods and results: Immunohistochemical staining for MCM7 was performed on 122 samples of paraffin-embedded trophoblastic tissues including 22 normal first-trimester placentas, 12 term placentas, 12 spontaneous miscarriages (SM), 21 partial moles (PM), 44 complete hydatidiform moles (CM), and 11 choriocarcinomas (CCA). The correlations between the proliferative indices assessed by MCM7, proliferating cell nuclear antigen (PCNA) and Ki67 (MIB1) immunoreactivity as well as clinical progress were assessed. MCM7 immunoreactivity was found predominantly in the nuclei of cytotrophoblast and intermediate trophoblast and decreased with placental maturation. MCM7 expression was highest in CCA, followed by CM, PM, normal first-trimester placenta, SM and term placenta. MCM7 index was significantly higher in PM and CM than in SM (P = 0.007, P 〈 0.001) but not between PM and CM themselves (P = 0.560). Eighteen of the 65 patients with HM developed persistent trophoblastic disease (PTD) requiring chemotherapy. There was no significant difference in MCM7 indices between the patients who developed PTD and those who did not (P = 0.312). MCM7 indices correlated well with Ki67 (P = 0.002) but not with PCNA (P = 0.054) indices. MCM7 indices demonstrated less variability than PCNA and Ki67 and may be a better proliferation marker than the latter two.Conclusions: We conclude that MCM7 is useful in differentiating molar and non-molar gestations but is not helpful in discriminating PM from CM or in predicting PTD.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0045-2068Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0045-2068Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesLi, S S ; Xue, W C ; Khoo, U S ; Ngan, H Y S ; Chan, K Y K ; Tam, I Y S ; Chiu, P M ; Ip, P P C ; Tam, K F ; Cheung, A N Y
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aims : To assess, in tissue microarray (TMA), the proliferative activity of endometrial carcinoma using one of the minichromosome maintenance (MCM) proteins (MCM7), and to explore its potential value for prognosis. MCM proteins are essential for eukaryotic DNA replication and have recently been used to define the proliferative compartments in human tissues.Methods and results : Immunohistochemistry for MCM7 and Ki67 was performed on TMAs constructed from 212 cases of endometrial carcinoma. MCM7 and Ki67 expression was quantified according to the extent of nuclear staining. An analysis was carried out of the association between MCM7 expression and that of Ki67 and the clinicopathological characteristics of endometrial carcinoma. MCM7 and Ki67 immunoreactivity was clearly evident in the nuclei of tumour cells. MCM7 and Ki67 labelling indices in endometrial carcinomas correlated with each other (P 〈 0.001). A significant correlation existed between the MCM7 labelling index and histological grade (P = 0.008) and patients' age at diagnosis (P 〈 0.001). Well-differentiated carcinomas and younger patients had a lower MCM7 index. Poor survival was observed in patients with endometrial carcinoma with a high MCM7 index (P = 0.03) and MCM7 was found to be an independent prognostic factor by multivariate analysis (P = 0.04). The Ki67 labelling index correlated with histological grade (P = 0.01) but had no significant prognostic impact (P = 0.50).Conclusions : In this TMA study on endometrial carcinoma, MCM7 was found to be a more reliable and useful marker than Ki67 in assessing tumour proliferation and in the prognosis of patients.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesCheung, N. Y. A. ; Collins, R. J. ; Ngan, H. Y. S. ; Wong, L. C. ; Ma, H. K.
Springer
Published 1992Staff ViewISSN: 1432-0711Keywords: Irradiation ; Carcinoma of cervix ; Mucin ; PrognosisSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Histological sections from 50 patients with clinical stage Ib to stage IIb squamous cell carcinoma of the cervix, initially treated by radiotherapy and followed by Wertheim hysterectomy, were reviewed and stained for mucin. The tissues from 17 (34%) of the patients contained no residual carcinoma. Mucin production was demonstrated in tumour tissue from 18 (55%) of the patients with residual tumour, none of who died of disease during the 5 to 10 years of follow up. Two patients who died of recurrent carcinoma had no mucin production in the post-irradiated tumour tissues. The presence of mucin in irradiated carcinoma of cervix seems to infer a better prognosis and this may prove useful in the follow-up of irradiated carcinomas.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-0509Keywords: Key words: Choriocarcinoma—Metastases—MR imaging.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract. Choriocarcinoma is the most malignant tumor of gestational trophoblastic neoplasia. It grows rapidly and metastasizes to the lung, liver, and, less frequently, to the brain. Renal involvement is rare. Magnetic resonance imaging (MRI) is a useful modality to image the affected tissues; it contributes to the evaluation and management of the disease. One case of renal choriocarcinoma with MRI evaluation is reported.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1432-0843Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Subclinical and clinical bleomycin-induced pulmary toxicity (BIP) were investigated retrospectively in 9 patients with non-Hodgkin's lymphoma treated by mbination chemotherapy containing bleomycin. A crease in carbon monoxide diffusing capacity (DLCO) is found in 12.8% of patients. The cumulative risk of normal DLCO increased with the increasing total cumulive dose of bleomycin. No significant difference in the e of BIP was observed between patients receiving bleovein/Adriamycin/cyclophosphamide/vincristine/prednine (BACOP; bleomycin given at 10 mg/m2 for 4 weeks) d bleomycin/Adriamycin/cyclophosphamide/vincrise/dexamethasone/methotrexate/folinic acid (mACOD; bleomycin given at 4 mg/m2 for 3 weeks, ethotrexate given at 200 mg/m2. Monitoring for subclinil BIP should be considered in patients with non-Hodg lymphoma even if only a low dose of bleomycin was ven in the presence of other chemotherapeutic agents.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesCollins, R. J. ; Cheung, A. ; Ngan, H. Y. S. ; Wong, L. C. ; Chan, S. Y. W. ; Ma, H. K.
Springer
Published 1991Staff ViewISSN: 1432-0711Keywords: Ovarian tumor ; Neuroendocrine and mucinous carcinoma ; TransitionSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary A rare case of mixed carcinoma of ovary with a predominant malignant neuroendocrine and a lesser mucinous tumor component is described. Extensive areas of enteric-type epithelium containing endocrine cells were present in both the mucinous borderline tumor element and in the small foci of mucinous adenocarcinoma. Transition from the mucinous tumor to the malignant neuroendocrine component provides evidence for the derivation of some neuroendocrine or carcinoid tumors direct from mucinous tumors without necessarily being a component of a teratoma. Contrary to reported examples of mucinous carcinoid, the overgrowth and spread of the neuroendocrine component characterised the aggressive and lethal nature of this tumor.Type of Medium: Electronic ResourceURL: