Search Results - (Author, Cooperation:H. Nagase)
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1Latest Papers from Table of Contents or Articles in PressS. Porazinski ; H. Wang ; Y. Asaoka ; M. Behrndt ; T. Miyamoto ; H. Morita ; S. Hata ; T. Sasaki ; S. F. Krens ; Y. Osada ; S. Asaka ; A. Momoi ; S. Linton ; J. B. Miesfeld ; B. A. Link ; T. Senga ; A. Castillo-Morales ; A. O. Urrutia ; N. Shimizu ; H. Nagase ; S. Matsuura ; S. Bagby ; H. Kondoh ; H. Nishina ; C. P. Heisenberg ; M. Furutani-Seiki
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-03-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Actomyosin/metabolism ; Adaptor Proteins, Signal Transducing/genetics/metabolism ; Animals ; Body Size/*genetics ; Embryo, Nonmammalian/anatomy & histology/embryology/metabolism ; Fish Proteins/genetics/*metabolism ; GTPase-Activating Proteins/metabolism ; Genes, Essential/genetics ; Gravitation ; Humans ; Morphogenesis/*genetics ; Mutation/genetics ; Organ Size/genetics ; Oryzias/*anatomy & histology/*embryology/genetics ; Phenotype ; Protein-Serine-Threonine Kinases/genetics/metabolism ; Signal Transduction ; Spheroids, Cellular/cytology/metabolismPublished by: -
2Articles: DFG German National LicensesKozawa, T. ; Kachi, T. ; Kano, H. ; Nagase, H. ; Koide, N. ; Manabe, K.
[S.l.] : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Thermal stress in GaN epitaxial layers with different thicknesses grown on sapphire substrates by metalorganic vapor phase epitaxy using an AlN buffer layer was investigated. Biaxial compressive stress in the GaN layer, due to the difference in the thermal expansion coefficients between GaN and sapphire, was obtained by measuring the curvature of wafer bending, and the observed stress agreed with the calculated stress. In Raman measurements, the E2 phonon peak of GaN was found to shift and broaden with the stress as a consequence of the change of the elastic constants with strain. The frequency shift Δω (in cm−1) was obtained for the first time, given by the relation: Δω=6.2 σ, where the biaxial stress σ is expressed in GPa. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesMatsuzawa, A. ; Yasuda, T. ; Sakamoto, S. ; Nagase, H. ; Nakano, H. ; Yoshimoto, T.
Oxford, UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We previously found that Mtv-2+ lymph nodes (LN) implanted into Mtv-2− mice underwent marked hyperplasia owing to the influx of lymphocytes. LN grafts infected with exogenous mouse mammary tumour viruses (MMTV), MMTV(FM) transmitted by FM mice and MMTV-2 produced by Mtv-2, also swelled in MMTV-free recipients. Mtv-3 and Mtv-7 also displayed this capability. Mtv-2-induced LN hyperplasia was earlier in onset and greater in extent when major histocompatibility complex (MHC) class II I-E was expressed than unexpressed. Mtv-3-induced LN hyperplasia was suppressed completely by Mtv-3 from a different mouse strain and partially by Mtv-6 slightly different from Mtv-3 in superantigen (SAg) Vβ specificity. LN hyperplasia occurred bidirectionally in LN transplantation between mice carrying Mtv-2 and Mtv-3, which are different SAg Vβ specificity. LN hyperplasia induced by MMTV-2 carrying SAg responsive to Vβ14 alone and MMTV(FM) carrying SAg responsive to Vβ14 and Vβ8.2 was completely but partially suppressed by MMTV(FM) and MMTV-2, respectively. CD4+ T cells were essential for MMTV-induced LN hyperplasia. LN in situ also underwent significant hyperplasia when infected with MMTV. Thus, MMTV SAg may entice circulating lymphocytes into lymphoid organs and contribute to more efficient dissemination MMTV in vivo. Secondary lymphoid tissue chemokine (SLC) may not be directly involved in this event.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesYoshimura-Uchiyama, C. ; Iikura, M. ; Yamaguchi, M. ; Nagase, H. ; Ishii, A. ; Matsushima, K. ; Yamamoto, K. ; Shichijo, M. ; Bacon, K. B. ; Hirai, K.
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background Both prostaglandin (PG) D receptor (DP) and CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells)/DP2 are high-affinity receptors for PGD2. Previous studies have demonstrated that PGD2 enhances releasability and induces CRTH2/DP2-mediated migration in human basophils, but the precise effects of PGD2 on basophils as well as receptor usage have not been fully clarified.Objective We comprehensively explored the roles of DP and CRTH2/DP2 in basophil functions by using selective agonists and antagonists for each receptor.Methods DP and CRTH2/DP2 transcripts were quantified by real-time PCR. We studied the effects of selective agonists (DP: BW245C; CRTH2/DP2: 13,14-dihydro-15-keto (DK)-PGD2) and/or antagonists (DP: BWA868C; CRTH2/DP2: ramatroban) on Ca2+ mobilization, migration, degranulation, CD11b expression and survival of human basophils.Results Basophils expressed transcripts of both DP and CRTH2/DP2, but the levels of CRTH2/DP2 transcripts were ca. 100-fold higher compared with DP transcripts. Ca2+ influx was induced in basophils by either PGD2 or DK-PGD2/CRTH2 agonist but not by BW245C/DP agonist. Basophils treated with PGD2 were completely desensitized to subsequent stimulation with DK-PGD2, but not vice versa. DK-PGD2 as well as PGD2 up-regulated CD11b expression, induced migration and enhanced degranulation, and those effects were completely antagonized by ramatroban/CRTH2 antagonist. In contrast, BW245C/DP agonist exhibited an inhibitory effect on basophil migration and IgE-mediated degranulation, and the migration inhibitory effect was effectively antagonized by BWA868C/DP antagonist. On the other hand, while PGD2 significantly shortened the basophil life-span, neither DK-PGD2/CRTH2 agonist nor BW245C/DP agonist did.Conclusion CRTH2/DP2 is primarily responsible for the pro-inflammatory effects of PGD2 on human basophils, while DP introduces negative signals capable of antagonizing the effects of CRTH2/DP2 in these cells. The effects of PGD2 on longevity imply a mechanism(s) other than via DP or CRTH2/DP2. CRTH2/DP2 on basophils may afford opportunities for therapeutic targeting in allergic inflammation.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesNagase, H. ; Morita, Y. ; Yamaguchi, M. ; Yamada, H. ; Yamamoto, K. ; Jibiki, S. ; Hirai, K. ; Ohta, K. ; Kawasaki, H. ; Yoshie, O.
Copenhagen : Munksgaard International Publishers
Published 1999Staff ViewISSN: 1398-9995Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background: The effects of a panel of 15 chemokines on eosinophil chemotaxis were studied by a new photometric assay which is both less tedious and less laborious than the conventional manual counting methods. Approximately 40 chemokines have been identified to date, but there is little information on the eosinophil migration-inducing ability of chemokines other than CC chemokine receptor (CCR) 3 ligands. Methods: Eosinophil migration was measured by the Boyden chamber technique with a 96-well multiwell chamber and polycarbonate membrane filter. Eosinophil migration was assessed by determination of the eosinophil peroxidase (EPO) activity, and photometric measurement was performed with a microtiter plate reader. Results: The assay was sensitive enough to detect 200 eosinophils, and the time required was within 4 h. CCR3 ligands, i.e., regulated on activation normal T-cell expressed and secreted (RANTES), eotaxin, eotaxin-2, and monocyte chemoattractant protein (MCP)-3, induced significant migration, while other chemokines showed no significant migration-inducing ability. Although the chemotaxis induction by these chemokines was efficiently inhibited by anti-CCR3 mAb, anti-CCR1 mAb failed to show any inhibitory effects. Conclusions: The photometric assay is suitable for analyzing a large number of samples. CCR3 ligands are the most important chemokines inducing eosinophil chemotaxis; thus, CCR3 represents a possible therapeutic target for the treatment of allergic diseases.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0003-9861Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesArakawa, H. ; Nagase, H. ; Hayashi, N. ; Fujiwara, T. ; Ogawa, M. ; Shin, S. ; Nakamura, Y.
Amsterdam : ElsevierStaff ViewISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0925-4005Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyElectrical Engineering, Measurement and Control TechnologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesNetzel-Arnett, S. ; Mallya, S.K. ; Nagase, H. ; Birkedal-Hansen, H. ; Van Wart, H.E.
Amsterdam : ElsevierStaff ViewISSN: 0003-2697Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0003-2697Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0014-4827Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesInhibitory effect of calmodulin inhibitors on palytoxin-induced K^+ release from rabbit erythrocytesStaff View
ISSN: 0014-5793Keywords: Calmodulin inhibitor ; Erythrocyte ; K^+ release ; PalytoxinSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: Degradation ; Extracellular matrix ; ProteinaseSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesOkada, Y. ; Watanabe, S. ; Nakanishi, I. ; Kishi, J.-i. ; Hayakawa, T. ; Watorek, W. ; Travis, J. ; Nagase, H.
Amsterdam : ElsevierStaff ViewISSN: 0014-5793Keywords: Extracellular matrix ; Metalloproteinase ; Neutrophil elastase ; Tissue inhibitor of metalloproteinasesSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: (Na^+ + K^+)-ATPase ; Cardiac glycoside ; K^+ release ; Palytoxin ; Red blood cellSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: Gelatinase A ; Matrix metalloproteinase ; Progesterone ; TIMP-2 ; Uterine cervixSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesIto, A. ; Goshowaki, H. ; Sato, T. ; Mori, Y. ; Yamashita, K. ; Hayakawa, T. ; Nagase, H.
Amsterdam : ElsevierStaff ViewISSN: 0014-5793Keywords: (Rabbit uterine cervix) ; Estradiol-17β ; Procollagenase ; Recombinant interleukin-1α ; Tissue inhibitor of metalloproteinaseSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: Amino acid sequence ; Ovostatin ; Thiol ester ; α"2-MacroglobulinSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0027-5107Keywords: Antimutagenicity ; Comutagenicity ; Salmonella typhimurium ; Salvia miltiorrhiza ; TanshinonesSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0027-5107Keywords: Antimutagenic factors ; Aquatic plants ; Curled pondweed ; European cut-grass ; SmartweedSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: