Search Results - (Author, Cooperation:H. Mizuguchi)
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1Latest Papers from Table of Contents or Articles in PressT. Olszak ; J. F. Neves ; C. M. Dowds ; K. Baker ; J. Glickman ; N. O. Davidson ; C. S. Lin ; C. Jobin ; S. Brand ; K. Sotlar ; K. Wada ; K. Katayama ; A. Nakajima ; H. Mizuguchi ; K. Kawasaki ; K. Nagata ; W. Muller ; S. B. Snapper ; S. Schreiber ; A. Kaser ; S. Zeissig ; R. S. Blumberg
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-04-11Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antigens, CD1d/*immunology ; Carrier Proteins/metabolism ; Colitis/immunology/pathology ; Disease Models, Animal ; Epithelial Cells/*immunology/metabolism ; Female ; HSP110 Heat-Shock Proteins/genetics/metabolism ; Humans ; Immunity, Mucosal/*immunology ; Inflammation/immunology/pathology ; Inflammatory Bowel Diseases/immunology/pathology ; Interleukin-10/genetics/*immunology ; Intestinal Mucosa/*cytology/*immunology ; Male ; Mice ; Natural Killer T-Cells/immunology/metabolism ; Oxazolone ; STAT3 Transcription Factor/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressKatayama, Y., Tachibana, M., Kurisu, N., Oya, Y., Terasawa, Y., Goda, H., Kobiyama, K., Ishii, K. J., Akira, S., Mizuguchi, H., Sakurai, F.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-04-10Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 0005-2760Keywords: (Rat liver) ; Clofibric acid ; Peroxisome proliferator ; PhosphatidylcholineSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0005-2760Keywords: (Rat) ; Arachidonic acid content ; Clofibric acid ; Dietary oil ; Kidney ; Liver ; Phosphatidylcholine ; Prostaglandin formationSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesOhta, K. ; Hayashi, H. ; Mizuguchi, H. ; Kagamiyama, H. ; Fujimoto, K. ; Fukui, H.
Amsterdam : ElsevierStaff ViewISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesFukui, H. ; Fujimoto, K. ; Mizuguchi, H. ; Sakamoto, K. ; Horio, Y. ; Takai, S. ; Yamada, K. ; Ito, S.
Amsterdam : ElsevierStaff ViewISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesYe Qi Liu ; Horio, Y. ; Mizuguchi, H. ; Fujimoto, K. ; Imamura, I. ; Abe, Y. ; Fukui, H.
Amsterdam : ElsevierStaff ViewISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0040-4039Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0040-4039Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-0428Keywords: Insulin ; hepatic clearance ; receptor recycling ; receptor-mediated endocytosis ; physiological model ; mouse liver perfusionSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary After perfusion of mouse livers with A14-125I-insulin for designated intervals, an acid-wash technique was employed to separately measure the surface-bound (Xs) and intracellular (Xi) A14-125I-insulin, as well as intracellular degradation products (Xdeg) of labelled insulin. From the perfusate concentrations (Cp) of A14-125I-insulin, the apparent intrinsic hepatic clearance of labelled insulin at a high dose (0.2 nmol/l) was shown to be 60% smaller than that at a low dose (0.018 nmol/l), indicating that the cellular uptake of insulin is remarkably nonlinear at the concentration range examined. From the time courses of Cp, Xs, Xi and Xdeg, the hepatic insulin disposition was shown to be largely accounted for by the receptor-mediated endocytosis. The observed data at the low dose were analysed to estimate biochemical parameters, (i.e., total receptor number, endocytotic rate constant and intracellular degradation rate constant) according to “receptor-recycling” and “non-receptor-recycling” models, using a computer-aided optimization procedure. The “receptor-recycling” model could not only adequately explain the Cp, Xs, Xi and Xdeg at the low dose, but also predict the Cp at the high dose. On the other hand, a “non-receptor-recycling” model, in which recycling of receptors was not assumed, could also explain the observed data at the low dose, but failed to predict the Cp at the high dose, indicating that the receptor recycling process is necessary to explain the hepatic insulin clearance at high insulin concentrations, at which hepatic insulin clearance should be limited by the rate of receptor recycling. However, the applicability of our model might be limited within the physiologic insulin concentrations, because of the negative co-operativity of insulin-receptor interaction and a high-capacity, non-degradative and more rapidly recycling pathway for receptors that may occur at high concentrations of insulin. In conclusion, we have developed a mathematical model of hepatic insulin clearance and distribution under physiological conditions, including receptor binding, receptor-mediated endocytosis and receptor recycling, which has been so far demonstrated using isolated hepatocytes.Type of Medium: Electronic ResourceURL: