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1Staff View
Publication Date: 2018-05-10Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
2Staff View
Publication Date: 2018-06-26Publisher: American Physical Society (APS)Print ISSN: 0556-2813Electronic ISSN: 1089-490XTopics: PhysicsKeywords: Nuclear StructurePublished by: -
3W.-Z. Wei, X.-H. Meng, Y.-Y. Li, J. Liu, G.-J. Wang, H. Mei, G. Yang, D.-M. Mei and C. Zhang
Institute of Physics Publishing (IOP)
Published 2018Staff ViewPublication Date: 2018-12-20Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
4Staff View
Publication Date: 2018-10-03Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
5P. K. Joshi ; T. Esko ; H. Mattsson ; N. Eklund ; I. Gandin ; T. Nutile ; A. U. Jackson ; C. Schurmann ; A. V. Smith ; W. Zhang ; Y. Okada ; A. Stancakova ; J. D. Faul ; W. Zhao ; T. M. Bartz ; M. P. Concas ; N. Franceschini ; S. Enroth ; V. Vitart ; S. Trompet ; X. Guo ; D. I. Chasman ; J. R. O'Connel ; T. Corre ; S. S. Nongmaithem ; Y. Chen ; M. Mangino ; D. Ruggiero ; M. Traglia ; A. E. Farmaki ; T. Kacprowski ; A. Bjonnes ; A. van der Spek ; Y. Wu ; A. K. Giri ; L. R. Yanek ; L. Wang ; E. Hofer ; C. A. Rietveld ; O. McLeod ; M. C. Cornelis ; C. Pattaro ; N. Verweij ; C. Baumbach ; A. Abdellaoui ; H. R. Warren ; D. Vuckovic ; H. Mei ; C. Bouchard ; J. R. Perry ; S. Cappellani ; S. S. Mirza ; M. C. Benton ; U. Broeckel ; S. E. Medland ; P. A. Lind ; G. Malerba ; A. Drong ; L. Yengo ; L. F. Bielak ; D. Zhi ; P. J. van der Most ; D. Shriner ; R. Magi ; G. Hemani ; T. Karaderi ; Z. Wang ; T. Liu ; I. Demuth ; J. H. Zhao ; W. Meng ; L. Lataniotis ; S. W. van der Laan ; J. P. Bradfield ; A. R. Wood ; A. Bonnefond ; T. S. Ahluwalia ; L. M. Hall ; E. Salvi ; S. Yazar ; L. Carstensen ; H. G. de Haan ; M. Abney ; U. Afzal ; M. A. Allison ; N. Amin ; F. W. Asselbergs ; S. J. Bakker ; R. G. Barr ; S. E. Baumeister ; D. J. Benjamin ; S. Bergmann ; E. Boerwinkle ; E. P. Bottinger ; A. Campbell ; A. Chakravarti ; Y. Chan ; S. J. Chanock ; C. Chen ; Y. D. Chen ; F. S. Collins ; J. Connell ; A. Correa ; L. A. Cupples ; G. D. Smith ; G. Davies ; M. Dorr ; G. Ehret ; S. B. Ellis ; B. Feenstra ; M. F. Feitosa ; I. Ford ; C. S. Fox ; T. M. Frayling ; N. Friedrich ; F. Geller ; G. Scotland ; I. Gillham-Nasenya ; O. Gottesman ; M. Graff ; F. Grodstein ; C. Gu ; C. Haley ; C. J. Hammond ; S. E. Harris ; T. B. Harris ; N. D. Hastie ; N. L. Heard-Costa ; K. Heikkila ; L. J. Hocking ; G. Homuth ; J. J. Hottenga ; J. Huang ; J. E. Huffman ; P. G. Hysi ; M. A. Ikram ; E. Ingelsson ; A. Joensuu ; A. Johansson ; P. Jousilahti ; J. W. Jukema ; M. Kahonen ; Y. Kamatani ; S. Kanoni ; S. M. Kerr ; N. M. Khan ; P. Koellinger ; H. A. Koistinen ; M. K. Kooner ; M. Kubo ; J. Kuusisto ; J. Lahti ; L. J. Launer ; R. A. Lea ; B. Lehne ; T. Lehtimaki ; D. C. Liewald ; L. Lind ; M. Loh ; M. L. Lokki ; S. J. London ; S. J. Loomis ; A. Loukola ; Y. Lu ; T. Lumley ; A. Lundqvist ; S. Mannisto ; P. Marques-Vidal ; C. Masciullo ; A. Matchan ; R. A. Mathias ; K. Matsuda ; J. B. Meigs ; C. Meisinger ; T. Meitinger ; C. Menni ; F. D. Mentch ; E. Mihailov ; L. Milani ; M. E. Montasser ; G. W. Montgomery ; A. Morrison ; R. H. Myers ; R. Nadukuru ; P. Navarro ; M. Nelis ; M. S. Nieminen ; I. M. Nolte ; G. T. O'Connor ; A. Ogunniyi ; S. Padmanabhan ; W. R. Palmas ; J. S. Pankow ; I. Patarcic ; F. Pavani ; P. A. Peyser ; K. Pietilainen ; N. Poulter ; I. Prokopenko ; S. Ralhan ; P. Redmond ; S. S. Rich ; H. Rissanen ; A. Robino ; L. M. Rose ; R. Rose ; C. Sala ; B. Salako ; V. Salomaa ; A. P. Sarin ; R. Saxena ; H. Schmidt ; L. J. Scott ; W. R. Scott ; B. Sennblad ; S. Seshadri ; P. Sever ; S. Shrestha ; B. H. Smith ; J. A. Smith ; N. Soranzo ; N. Sotoodehnia ; L. Southam ; A. V. Stanton ; M. G. Stathopoulou ; K. Strauch ; R. J. Strawbridge ; M. J. Suderman ; N. Tandon ; S. T. Tang ; K. D. Taylor ; B. O. Tayo ; A. M. Toglhofer ; M. Tomaszewski ; N. Tsernikova ; J. Tuomilehto ; A. G. Uitterlinden ; D. Vaidya ; A. van Hylckama Vlieg ; J. van Setten ; T. Vasankari ; S. Vedantam ; E. Vlachopoulou ; D. Vozzi ; E. Vuoksimaa ; M. Waldenberger ; E. B. Ware ; W. Wentworth-Shields ; J. B. Whitfield ; S. Wild ; G. Willemsen ; C. S. Yajnik ; J. Yao ; G. Zaza ; X. Zhu ; R. M. Salem ; M. Melbye ; H. Bisgaard ; N. J. Samani ; D. Cusi ; D. A. Mackey ; R. S. Cooper ; P. Froguel ; G. Pasterkamp ; S. F. Grant ; H. Hakonarson ; L. Ferrucci ; R. A. Scott ; A. D. Morris ; C. N. Palmer ; G. Dedoussis ; P. Deloukas ; L. Bertram ; U. Lindenberger ; S. I. Berndt ; C. M. Lindgren ; N. J. Timpson ; A. Tonjes ; P. B. Munroe ; T. I. Sorensen ; C. N. Rotimi ; D. K. Arnett ; A. J. Oldehinkel ; S. L. Kardia ; B. Balkau ; G. Gambaro ; A. P. Morris ; J. G. Eriksson ; M. J. Wright ; N. G. Martin ; S. C. Hunt ; J. M. Starr ; I. J. Deary ; L. R. Griffiths ; H. Tiemeier ; N. Pirastu ; J. Kaprio ; N. J. Wareham ; L. Perusse ; J. G. Wilson ; G. Girotto ; M. J. Caulfield ; O. Raitakari ; D. I. Boomsma ; C. Gieger ; P. van der Harst ; A. A. Hicks ; P. Kraft ; J. Sinisalo ; P. Knekt ; M. Johannesson ; P. K. Magnusson ; A. Hamsten ; R. Schmidt ; I. B. Borecki ; E. Vartiainen ; D. M. Becker ; D. Bharadwaj ; K. L. Mohlke ; M. Boehnke ; C. M. van Duijn ; D. K. Sanghera ; A. Teumer ; E. Zeggini ; A. Metspalu ; P. Gasparini ; S. Ulivi ; C. Ober ; D. Toniolo ; I. Rudan ; D. J. Porteous ; M. Ciullo ; T. D. Spector ; C. Hayward ; J. Dupuis ; R. J. Loos ; A. F. Wright ; G. R. Chandak ; P. Vollenweider ; A. R. Shuldiner ; P. M. Ridker ; J. I. Rotter ; N. Sattar ; U. Gyllensten ; K. E. North ; M. Pirastu ; B. M. Psaty ; D. R. Weir ; M. Laakso ; V. Gudnason ; A. Takahashi ; J. C. Chambers ; J. S. Kooner ; D. P. Strachan ; H. Campbell ; J. N. Hirschhorn ; M. Perola ; O. Polasek ; J. F. Wilson
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-07-02Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Biological Evolution ; Blood Pressure/genetics ; Body Height/*genetics ; Cholesterol, LDL/genetics ; *Cognition ; Cohort Studies ; Educational Status ; Female ; Forced Expiratory Volume/genetics ; Genome, Human/genetics ; *Homozygote ; Humans ; Lung Volume Measurements ; Male ; PhenotypePublished by: -
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ISSN: 1468-2850Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: PsychologyNotes: The Diagnostic and Statistical Manual of Mental Disorders (DSM) states that individuals with a dependent personality are at increased risk for anxiety disorders. Meta-analysis of 53 studies examining the comorbidity of dependent personality disorder (DPD) and one or more anxiety disorders (ADs) revealed that the overall DPD-AD relationship is modest in magnitude (mean r = .11) and holds for some ADs but not others. Follow-up analyses indicated that the DPD-AD link was not moderated by diagnostic system, assessment method, or comparison group (other personality-disordered patients versus non-personality-disordered controls). Given these findings, future versions of the DSM may need a more tentative and qualified description of DPD-AD comorbidity.Type of Medium: Electronic ResourceURL: -
7Bornstein, Robert F. ; Ng, H. Mei ; Gallagher, Heather A. ; Kloss, Deanna M. ; Regier, Natalie G.
Oxford, UK : Blackwell Publishing
Published 2005Staff ViewISSN: 1467-6494Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: PsychologyNotes: Abstract Four experiments tested a key tenet of Bornstein's (1992, 1993) cognitive/interactionist (C/I) model of interpersonal dependency: that priming the helpless self-schema (HSS) alters processing of dependency-related information in dependent—but not nondependent—individuals. Experiments 1 and 2 assessed the effects of subliminal lexical priming and an emotional priming manipulation on lexical decision (LD) judgments for dependency-related words and control words. Experiments 3 and 4 assessed the effects of these same priming procedures on Interpersonal Stroop Task (IST) performance. As predicted, priming the HSS produced contrasting effects on different outcome measures, decreasing LD latencies, but increasing IST response times. Results are discussed in the context of the C/I model, and suggestions for future studies are offered.Type of Medium: Electronic ResourceURL: -
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ISSN: 1432-0533Keywords: Brain infarct ; Blood-brain barrier ; Brain edema ; Cerebral blood vessels ; Serum proteinSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The cellular events occurring in ischemic brain infarcts of 1 day to 8 weeks duration were investigated. The material consisted of 17 human postmortem brains with anemic infarcts caused by occlusive vascular diseases. Using antiserum against human plasma albumin as a marker for the breakdown of blood-brain barrier and ammoniacal silver nitrate stain to demonstrate the vasculature, the onset and distribution of the extravasated plasma protein was compared with histological changes in the blood vessels. It was observed that extravasation occurred in several separate regions of the infarct during different time periods. During the first few days, plasma proteins exudated from the vessels located at the marginal zone surrounding the infarct. This was followed by a prolonged phase of intense extravasation that coincided with the production of new capillaries originating from the blood vessels at the margin of the infarct and from pial vessels. It is postulated that the actively proliferative and migratory activities of the endothelial cells and pericytes in the neovasculature may be responsible for the extravasation which is reflected in the contrast enhancement of the infarct observed clinically during the recovery phase.Type of Medium: Electronic ResourceURL: -
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ISSN: 1432-0533Keywords: Brain abscess ; Fibroblast growth factor ; Nerve growth factor ; Platelet-derived growth factor ; Transforming growth factor-betaSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We correlated the histopathological findings of six human brain abscesses with the expression of basic fibroblast growth factor (bFGF), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGFβ). The clinical courses ranged from 1 month to 1 year and viridans streptoccus was the major pathogen. In early abscesses, we demonstrated strong bFGF and moderate NGF and PDGF immunoreactivities in neutrophils and monocytes/macrophages infiltrating the abscess wall and in the fibrin layer lining the abscess center. In the subacute cases, growth of capillaries and fibroblasts into the fibrin layer and deposition of collagen resulted in the formation of a mesodermal layer between the abscess center and the outer gliotic layer. The proliferative non-neural cells (endothelial cells, fibroblasts and glial cells) expressed mild to strong bFGF, NGF and PDGF immunoreactivities, while strong TGFβ staining was seen in the extracellular matrix. A loss of growth factor expression and increased fibrosis was seen in the chronic case. These findings suggest that bFGF, NGF, PDGF and TGFβ produced by the continued influx of leukocytes and by the proliferating non-neural cells may mediate various steps of defense mechanisms and wound healing such as angiogenesis, fibrogenesis and gliosis.Type of Medium: Electronic ResourceURL: -
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ISSN: 1432-0533Keywords: Metachromatic Leukodystrophy ; Neuronal Inclusions ; Laminated Bodies ; Mucopolysaecharides ; Electron MicroscopySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The ultrastructural findings of the metachromatic granules in the anterior horn cells of the spinal cord in a case of metachromatic leukodystrophy are presented. The typical neuronal inclusions are concentrically laminated bodies of approximately 1 μ. In addition various morphological variations of the abnormal inclusions are seen side by side in the same neuron and give the impression that the highly organized laminated bodies are formed as a result of progressive deposition of membranous material upon a nidas which is initially amorphous, which then becomes granular, fibrillar or horizontally striped and finally multilaminated. Material capable of binding colloidal iron particles is demonstrated in these inclusions, and suggests the presence of mucopolysaccharides.Type of Medium: Electronic ResourceURL: -
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ISSN: 1432-0533Keywords: Cerebro-hepato-renal syndrome ; Zellweger's Syndrome ; Polymicrogyria ; Dysmyelination ; Axonal dystrophy ; Metabolic abnormalitySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The nervous system in patients with cerebro-hepato-renal syndrome appeared to be affected at various tissue levels. There was evidence of a migrational disorder manifested by polymicrogyria and lack of normal neuronal maturation. There was dysmyelination of the white matter associated with accumulation of neutral fat in astrocytes. Within the peripheral nerves, masses of tangled neurofilaments producing dystrophic axons were demonstrated by electron microscopy. These findings could be explained on the basis of a genetic metabolic defect, one that involved particularly the amino acids. The defect may have interfered with the normal intercellular reaction during embryogenesis resulting in the malformation of multiple organs. The same metabolic abnormality could have caused the hepatic damage and disturbance in normal myelination during the neonatal period.Type of Medium: Electronic ResourceURL: -
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ISSN: 1432-0533Keywords: Remyelination ; Landry-Guillain-Barré-SyndromeSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung Die ultrastrukturelle untersuchung der peripheren Nerven eines Falles von Landry-Guillain-Barré Syndrom, der während einer kurzen Erholungsphase starb, ergibt charakteristische Befunde, die als regenerative Veränderung gedeutet werden. Um jedes Axon sieht man geschlossene Lagen von Vesikeln und Tubuli; das Verschmelzen dieser Vesikeln scheint von der Bildung der Myelinlamellen gefolgt zu werden. Es drängt sich die Annahme auf, daß die Vesikeln vom endoplasmischen Reticulum der Axone gebildet werden.Notes: Summary Ultrastructural study of peripheral nerves in a case of Landry-Guillain-Barré syndrome dying during early recovery phase reveals characteristic findings which are inter preted as being regenerative changes. Layers of compact vesicles and tubules are seen around each axon and coalescence of these vesicles appears to be followed by formation of myelin lamella. There is suggestive evidence that the vesicles may be produced by the endoplasmic reticulum of the axon.Type of Medium: Electronic ResourceURL: -
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ISSN: 1432-0533Keywords: Neuroaxonal dystrophySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The aim of the present study was to determine the frequency and etiological factors of neuroaxonal dystrophy (N.D.) in brainstem and spinal cord of children with various non-neurological diseases. The material used in this study consisted of 266 consecutive autopsies from 1974–1976 and an additional 13 cases from previous years. By far, the most common cause of N.D. in children was chemotherapeutic drugs, particularly vincristine, used for the treatment of malignant tumors. Approximately 90% of these children developed N.D. and the changes ranged from mild to severe. Approximately two-thirds of children with cystic fibrosis, congestive heart failure and chronic renal failure developed N.D. and the changes were mostly mild. Only one-third of patients with congenital biliary atresia and malnutrition developed N.D. and the changes were always mild. The frequency and severity of N.D. increased in patients who had prolonged clinical courses; no N.D. was seen in patients who died from acute causes such as trauma, acute infection, intoxication, acute renal failure or prematurity. This type of N.D. may be considered as reactive to a wide variety of injurious factors such as drug toxicity, malnutrition, chronic hypoxia and chronic renal failure, either alone or in combination. In contrast to previous reports of a low incidence of N.D. in children, there has been a sharp increase in recent years due to the advent of chemotherapy.Type of Medium: Electronic ResourceURL: -
14Staff View
ISSN: 1432-119XSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Cerebral ischemia/hypoxia induces ischemic neuronal changes characterized by nuclear pyknosis, cytoplasmic shrinkage, and basophilia. The ischemic neurons were shown to exhibit strong and persistent c-fos proto-oncogene. The ischemic neuronal changes and c-fos expression are thought to be the consequence of release of excessive glutamate by the ischemic neurons. In the present study, we investigated with immunohistochemistry the subcellular distribution of Fos and Jun/AP-1, the protein products of c-fos and c-jun proto-oncogenes, and compared them with histological changes show by hematoxylin-eosin and by EA 50 stains. The latter is a stain mixture used traditionally in the Papanicolaou procedure and has a specific affinity for ischemic neurons. The active ingredient is eosin Y, a tetrabrominated derivative of fluorescein. With EA 50, the ischemic neurons stain red and emit a yellow fluorescence, while the non-ischemic neurons are green and non-fluorescent. The subcellular site of cosin Y binding corresponds with Fos and Jun/AP-1; all are concentrated in the nuclei and spread into the perikaryon, dendrites, and axons. The eosin Y-binding appears in neurons that have shown advanced ischemic changes. The dye is thus a good histological marker for damaged neurons, but requires freshly fixed tissues and paraffin sections of less than 4 μm thick. Preincubation of tissue sections in antibodies against Fos and Jun abolishes the eosin Y binding, suggesting that the dye may interact with Fos/Jun/AP-1 protein or other protein products in the ischemic neurons.Type of Medium: Electronic ResourceURL: -
15Staff View
Publication Date: 2018-05-11Publisher: American Heart Association (AHA)Print ISSN: 1942-325XElectronic ISSN: 1942-3268Topics: MedicineKeywords: Electrophysiology, Epidemiology, Genetic, Association StudiesPublished by: -
16Staff View
Publication Date: 2018-01-12Publisher: American Heart Association (AHA)Print ISSN: 1942-325XElectronic ISSN: 1942-3268Topics: MedicineKeywords: Electrophysiology, Genetic, Association StudiesPublished by: -
17Gusnaniar, , Hizal, F., Choi, C.-H., Sjollema, J., Nuryastuti, T., Rustema-Abbing, M., Rozenbaum, R. T., van der Mei, H. C., Busscher, H. J., Wessel, S. W.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-07-18Publisher: The American Society for Microbiology (ASM)Print ISSN: 0099-2240Electronic ISSN: 1098-5336Topics: BiologyPublished by: -
18Staff View
Publication Date: 2018-06-20Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, PaediatricsPublished by: -
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ISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The transport of H2 in liquid water is studied using adiabatic, nonadiabatic, and classical molecular dynamics methods in an attempt to understand the influence of transitions between translational states of the H2 molecule driven by solvent fluctuations. Quantum autocorrelation functions of the H2 center-of-mass velocity are computed in various dynamical limits. We find that there are strong nonadiabatic couplings between the instantaneous adiabatic translational states of H2 in water which result in rapid decorrelation of the H2 center-of-mass velocity for the time evolving translational mixed state. Transitions to excited translational states reduce the effects of caging dynamics in the velocity autocorrelation function dramatically. Classical and adiabatic descriptions of the dynamics predict that caging is much more important than we find nonadiabatically. Diffusion constants and frequency spectra are compared for the different limits and with experiment. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
20Mei, H. S. ; Xiao, L. ; Coker, D. F.
College Park, Md. : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Calculation of the rotational Raman spectrum of H2 in ice Ih is reported using previously developed nonadiabatic correlation function methods and accurate potentials. We explore the importance of the quantal treatment of the H2 center-of-mass translational motion. Calculated rotational Raman linewidths quantitatively reproduce experimental results. Observed differences in trends in bandwidth for liquid and solid phases are understood in terms of time scale and strength of dynamical mixing of rotational states. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: