Search Results - (Author, Cooperation:H. Matsuno)

2018-10-09

American Physical Society (APS)

0556-2813

1089-490X

Physics

Nuclear Structure

2018-11-14

American Physical Society (APS)

0556-2813

1089-490X

Physics

Nuclear Structure

2018-07-24

The American Association of Immunologists (AAI)

0022-1767

1550-6606

Medicine

2016-03-31

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Bacterial Adhesion ; Caco-2 Cells ; Cell Line ; Colitis/chemically induced/drug therapy/genetics ; Colon/*microbiology ; Dextran Sulfate ; Epithelium/*microbiology ; Female ; *Flagella ; GPI-Linked Proteins/deficiency/genetics/*metabolism/secretion ; Gram-Negative Bacteria/drug effects/metabolism/pathogenicity/*physiology ; Homeostasis ; Humans ; Inflammation/chemically induced/drug therapy/genetics ; Intestinal Mucosa/cytology/metabolism/*microbiology/secretion ; Male ; Mice ; Proteus mirabilis/drug effects/metabolism/pathogenicity ; Symbiosis

1089-7550

AIP Digital Archive

Physics

Optical characteristics of LiNbO3 implanted with Au+ ions at energy of 23 keV were studied. The color of the surface of the LiNbO3 was changed to blue-green and a large absorption peak around 620 nm was observed. The surface morphology was also found to change with time. Metallic Au dots were observed on the surface after implantation and grew from day to day when the samples were held at room temperature. The absorption peak produced by Au+ implantation was relatively stable toward thermal treatment compared to that of Cu+ implantation into LiNbO3. But as the sample was heated at temperatures higher than about 500 °C, this peak gradually decreased and finally disappeared. These characteristics were explained fairly well by the behavior of Au colloids formed in the surface layer of LiNbO3. © 1996 American Institute of Physics.

Electronic Resource

0584-8547

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Physics

Electronic Resource

1420-908X

Key words: Rheumatoid arthritis — Hyaluronate — Intra-articular injection

Springer Online Journal Archives 1860-2000

Medicine

Abstract. Objective: The purpose of this study was to analyze the biochemical characteristics of synovial fluids after treatment of patients with rheumatoid arthritis (RA) with intra-articularly injected hyaluronate (HA).¶Treatment: In a double-blind study, 13 patients received intra-articular injections of 1% HA in phosphate buffered saline (PBS) while 13 other patients were injected 0.01% HA in PBS, as the control group. Injections were administered once a week for five weeks.¶Methods: Clinical efficacy and characteristics of synovial fluid were compared between groups.¶Results: Significant clinical improvement was observed in the HA-treated group compared to the control group. The viscosity of retained synovial fluid increased. Stringing and HA concentration increased significantly whereas the concentrations of protein and chondroitin sulfate 4 and 6 decreased significantly. The HA molecular weight remained the same in both groups.¶Conclusion: Intra-articular HA injection altered the properties of synovial fluid and proved efficacious for patients with RA.

Electronic Resource

1432-1041

Thromboxane synthase inhibitor ; CS-518 ; 11-dehydrothromboxane B2 ; enzyme immunoassay ; thromboxane B2

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Medicine

Summary When 50 mg CS-518, a novel thromboxane (TX) A2 synthase inhibitor, was orally administered to healthy male volunteers, the plasma concentration of CS-518 peaked after 0.5 h and then decreased with a half-life of 0.44 h. There was no significant change in the plasma concentration of circulating TXB2, whereas that of circulating 11-dehydrothromboxane B2 (11-dhTXB2), an enzymatic metabolite of TXB2, was significantly decreased from 0.5 h to 24 h after administration; the maximal decrease to about 25% of the pre-dose value was found at 6 h. After CS-518 100 mg b.d. for 4.5 days, plasma 11-dhTXB2 was suppressed to the same extent as after the single dose of 50 mg from 6 h after the initial dose throughout the administration period. The urinary excretion of 11-dhTXB2 corrected for the creatinine level was significantly decreased by 70–84% throughout the treatment. These results suggest that CS-518 causes long-lasting inhibition of TXA2 synthase despite its rapid elimination from plasma, and that circulating 11-dhTXB2 in plasma and its urinary excretion can serve as a quantitative index of TXA2 synthase inhibition in vivo by CS-518.

Electronic Resource

1432-1459

Medulloblastoma ; Syringomyelia ; Olfactory tract cyst

Springer Online Journal Archives 1860-2000

Medicine

Zusammenfassung In einem Fall von Kleinhirnmedulloblastom bei einem 9jährigen Knaben zeigte die Autopsie eine Syringomyelie im Lumbosakralmark und eine zystische Höhle des Tractus olfactorius. Es wird angenommen, daß beide Höhlenbildungen durch die subarachnoidale Tumorausbreitung sowie durch die Bestrahlung und die Chemotherapie verursacht wurden.

Summary In a 9-year-old boy with cerebellar medulloblastoma, lumbosacral syringomyelia and a cystic change in the olfactory tract were found at autopsy. The cause of the syringomyelia and the olfactory tract cyst was considered to be secondary to dissemination of the tumor and its treatment.

Electronic Resource

1432-5195

Springer Online Journal Archives 1860-2000

Medicine

Résumé  L’armature MC a été mis au point pour le traitement de patients souffrant d’une arthrite rhumatoide (AR) qui se présente avec une protrusion acétabulaire, en tant que bague de renforcement métallique acétabulaire d’une cavité articulaire à revêtement poreux sans ciment Harris-Galante (HG). Depuis 1991, cette nouvelle bague de support avec greffon osseux autogène à paroi médiale a été utilisé pour traiter la protrusion acétabulaire de patients ayant une AR. Nous avons réexaminé 15 hanches de 13 patients AR sur une moyenne de 53,6 mois, s’étalant sur une plage de 24 à 84 mois après l’opération. Les résultats cliniques de l’arthroplastie totale de la hanche utilisant cette bague de support furent satistaisants pour tous les cas. Aucun cas ne montra de radiotransparence entre le greffon osseux et la paroi acétabulaire. Tous les greffons osseux se présentaient comme étant tomographiquement réunis, et la protrusion n’a pas progressé

Abstract  The MC cup supporter is an acetabular reinforcement ring for the Harris-Galante (HG) cementless porous-coated socket. This supporting ring has been used with autogenous bone graft since 1991 in the management of protrusio acetabuli in patients with rheumatoid arthritis (RA). We have reviewed 15 hips in 13 patients at an average of 53.6 months (range 24–84 months) after operation. The clinical results of total hip arthroplasty (THA) in protrusio acetabuli using this ring were satisfactory. All grafts appeared to have united radiologically with no radiolucent lines between graft and acetabulum.

Electronic Resource

1434-4726

Inner ear microcirculation ; Photochemically induced vascular thrombosis ; Rose bengal ; Hearing loss

Springer Online Journal Archives 1860-2000

Medicine

Summary A new photochemical method was employed to cause disorders in the inner ear's microcirculation, using the rat as an animal model. Hearing loss was used as a measure for establishing the altered microcirculation. Under pentobarbital anesthesia, the middle ear was opened by a ventral approach. The lateral wall of the cochlea was then illuminated with a filtered xenon lamp (wavelength 540 nm) while rose bengal was infused intravenously. Photoactivated rose bengal produces oxygen radicals and oxygen singlets, which subsequently damage the vascular epithelium to cause the adhesion and aggregation of platelets in the small vessels. Disintegration of the inner ear hair cells at the irradiated site became evident 24 h after the illumination. These findings further suggest that the photochemical occlusion in the inner ear's microcirculation led to ischemic damage of the stria vascularis and the hair cells in the inner ear. When the action potential (AP) of the cochlea was measured with an electrocochleogram a gradual decrease occurred after the illumination. When acetylsalicylic acid was injected intravenously before treatment, the time required to completely suppress the AP was prolonged in a dose-dependent manner. Findings indicate that our method causes a photochemically induced occlusion in the inner ear's microcirculation and is therefore potentially useful for evaluating the various effects of drugs on the ear.

Electronic Resource