Search Results - (Author, Cooperation:H. Lam)
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1Latest Papers from Table of Contents or Articles in PressYim, D., Nagata, H., Lam, C. Z., Grosse-Wortmann, L., Seed, M., Jaeggi, E., Yoo, S.-J.
American Heart Association (AHA)
Published 2018Staff ViewPublication Date: 2018-02-21Publisher: American Heart Association (AHA)Print ISSN: 1941-9651Electronic ISSN: 1942-0080Topics: MedicineKeywords: Pediatrics, Congenital Heart Disease, Computerized Tomography (CT), Imaging, Magnetic Resonance Imaging (MRI)Published by: -
2Latest Papers from Table of Contents or Articles in PressYoo, S.-J., Yim, D., Nagata, H., Lam, C. Z., Grosse-Wortmann, L., Seed, M., Jaeggi, E.
American Heart Association (AHA)
Published 2018Staff ViewPublication Date: 2018-06-20Publisher: American Heart Association (AHA)Print ISSN: 1941-9651Electronic ISSN: 1942-0080Topics: MedicineKeywords: Computerized Tomography (CT), Magnetic Resonance Imaging (MRI)Published by: -
3Latest Papers from Table of Contents or Articles in PressZuo, T., Wong, S. H., Lam, K., Lui, R., Cheung, K., Tang, W., Ching, J. Y. L., Chan, P. K. S., Chan, M. C. W., Wu, J. C. Y., Chan, F. K. L., Yu, J., Sung, J. J. Y., Ng, S. C.
BMJ Publishing Group
Published 2018Staff ViewPublication Date: 2018-03-09Publisher: BMJ Publishing GroupPrint ISSN: 0017-5749Electronic ISSN: 1468-3288Topics: MedicineKeywords: Open access, Editor's choicePublished by: -
4Latest Papers from Table of Contents or Articles in PressLenzini, F., Janousek, J., Thearle, O., Villa, M., Haylock, B., Kasture, S., Cui, L., Phan, H.-P., Dao, D. V., Yonezawa, H., Lam, P. K., Huntington, E. H., Lobino, M.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-12-08Publisher: American Association for the Advancement of Science (AAAS)Electronic ISSN: 2375-2548Topics: Natural Sciences in GeneralPublished by: -
5Latest Papers from Table of Contents or Articles in PressF. Chen ; C. H. Lam ; O. K. Tsui
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-03-01Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
6Latest Papers from Table of Contents or Articles in PressP. Picotti ; M. Clement-Ziza ; H. Lam ; D. S. Campbell ; A. Schmidt ; E. W. Deutsch ; H. Rost ; Z. Sun ; O. Rinner ; L. Reiter ; Q. Shen ; J. J. Michaelson ; A. Frei ; S. Alberti ; U. Kusebauch ; B. Wollscheid ; R. L. Moritz ; A. Beyer ; R. Aebersold
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-01-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: *Mass Spectrometry ; Peptide Library ; Polymorphism, Genetic ; Proteome/*analysis/genetics ; Proteomics/*methods ; Quantitative Trait Loci/*genetics ; Reference Values ; Saccharomyces cerevisiae/*chemistry/*genetics ; Saccharomyces cerevisiae Proteins/*analysis/genetics ; Selection, GeneticPublished by: -
7Latest Papers from Table of Contents or Articles in PressF. H. Lam ; A. Ghaderi ; G. R. Fink ; G. Stephanopoulos
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-10-04Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: *Biofuels ; Cation Transport Proteins/genetics ; Cell Culture Techniques ; Cell Membrane/metabolism ; Chemical Engineering ; *Drug Resistance, Fungal/genetics ; Ethanol/*metabolism/pharmacology ; Fermentation ; Genetic Engineering ; Glucose/metabolism ; Hydrogen-Ion Concentration ; Phosphates/*metabolism ; Potassium Compounds/*metabolism ; Proton Pumps/genetics ; Proton-Translocating ATPases/genetics ; Saccharomyces cerevisiae/drug effects/genetics/*metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Up-Regulation ; Xylose/metabolismPublished by: -
8Latest Papers from Table of Contents or Articles in PressM. S. Kim ; S. M. Pinto ; D. Getnet ; R. S. Nirujogi ; S. S. Manda ; R. Chaerkady ; A. K. Madugundu ; D. S. Kelkar ; R. Isserlin ; S. Jain ; J. K. Thomas ; B. Muthusamy ; P. Leal-Rojas ; P. Kumar ; N. A. Sahasrabuddhe ; L. Balakrishnan ; J. Advani ; B. George ; S. Renuse ; L. D. Selvan ; A. H. Patil ; V. Nanjappa ; A. Radhakrishnan ; S. Prasad ; T. Subbannayya ; R. Raju ; M. Kumar ; S. K. Sreenivasamurthy ; A. Marimuthu ; G. J. Sathe ; S. Chavan ; K. K. Datta ; Y. Subbannayya ; A. Sahu ; S. D. Yelamanchi ; S. Jayaram ; P. Rajagopalan ; J. Sharma ; K. R. Murthy ; N. Syed ; R. Goel ; A. A. Khan ; S. Ahmad ; G. Dey ; K. Mudgal ; A. Chatterjee ; T. C. Huang ; J. Zhong ; X. Wu ; P. G. Shaw ; D. Freed ; M. S. Zahari ; K. K. Mukherjee ; S. Shankar ; A. Mahadevan ; H. Lam ; C. J. Mitchell ; S. K. Shankar ; P. Satishchandra ; J. T. Schroeder ; R. Sirdeshmukh ; A. Maitra ; S. D. Leach ; C. G. Drake ; M. K. Halushka ; T. S. Prasad ; R. H. Hruban ; C. L. Kerr ; G. D. Bader ; C. A. Iacobuzio-Donahue ; H. Gowda ; A. Pandey
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-05-30Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adult ; Cells, Cultured ; Databases, Protein ; Fetus/metabolism ; Fourier Analysis ; Gene Expression Profiling ; Genome, Human/genetics ; Hematopoietic Stem Cells/cytology/metabolism ; Humans ; Internet ; Mass Spectrometry ; Molecular Sequence Annotation ; Open Reading Frames/genetics ; Organ Specificity ; Protein Biosynthesis ; Protein Isoforms/analysis/genetics/metabolism ; Protein Sorting Signals ; Protein Transport ; Proteome/analysis/chemistry/genetics/*metabolism ; *Proteomics ; Pseudogenes/genetics ; RNA, Untranslated/genetics ; Reproducibility of Results ; Untranslated Regions/geneticsPublished by: -
9FIS Bildung LiteraturdatenbankStaff View
Type of Medium: bookPublication Date: 1985Keywords: Computerunterstützter Unterricht ; ErwachsenenbildungLanguage: DutchNote: Literaturangaben S. 44 - 45 -
10Articles: DFG German National LicensesRieger, François ; Goudou, Danièle ; Tran, Lam H.
Oxford, UK : Blackwell Publishing Ltd
Published 1984Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: Acetylcholinesterase (AChE) is found both in motor end-plate (MEP)-free and MEP-rich regions of rat or mouse muscle. We studied the developmental aspects of the localization of asymmetric 16S AChE in both regions of the sternocleidomastoid muscle, which has a well-defined zone of motor innervation. In the rat, the proportion of 16S AChE to total AChE increases in the MEP-rich region, and becomes significantly higher than in the MEP-free regions between the first and the second weeks after birth. In the mouse, at birth, the MEP-rich region already has a higher relative content in 16S AChE than the MEP-free regions. Total 16S AChE amounts increase during postnatal development, not only in the MEP-rich region but also in the MEP-free regions. Thus, 16S AChE is not eliminated from MEP-free regions during muscle maturation and growth. Two distinct pools of 16S AChE are distinguished in the muscles, both of which increase during postnatal development: junctional and background 16S AChE.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesLEBLANC, Y. ; LAM, H-L. ; PASCOE, L. J. ; JONES, F. W.
Oxford, UK : Blackwell Publishing Ltd
Published 1982Staff ViewISSN: 1365-2478Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: GeosciencesPhysicsNotes: Two methods for estimating the true formation temperature from well logs are compared. One method requires knowledge of the circulation time, whereas the other requires an estimate of the thermal diffusivity of the contents of the well. Both methods require three or more successive bottom-hole temperature measurements. Data from 157 wells have been analyzed, and the calculated formation temperatures from the two methods agree well. By an analysis of best matching of the two methods, it is found that 0.35 × 10-6 m2 s-1 is a good estimate for the thermal diffusivity of the well contents.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesO'Driscoll, J. ; Muston, G. C. ; McGrath, J. A. ; Lam, H. M. ; Ashworth, J. ; Christiano, A. M.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-2230Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary Vohwinkel syndrome (VS) is a family of genodermatoses which exhibits extensive clinical and genetic heterogeneity. Here, we studied a pedigree originating from the UK with typical features of the ichthyotic variant of VS and identified a recurrent insertion mutation in the loricrin gene resulting in a mutant polypeptide with an unusual C terminus. Functional studies in transgenic mice have shown that the accumulation of mutant loricrin in the nucleus appears to interfere with the later stages of epidermal differentiation, thereby explaining the clinical manifestations of ichthyosis, keratoderma and pseudoainhum. Our findings extend the body of evidence implicating mutations in the loricrin gene as the underlying cause of VS.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesMao, B.-Y. ; Chang, P.-H. ; Chen, C.-E. ; Lam, H. W.
[S.l.] : American Institute of Physics (AIP)
Published 1987Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The effects of the oxygen dose on the microstructure and the dielectric properties of the buried oxide in oxygen implanted silicon-on-insulator (SOI) structures have been studied. Cross-sectional transmission electron microscopy analyses show that the density of oxygen precipitates at the silicon/buried-oxide interface increases with a decreasing oxygen dose when identical annealing processes are employed. Annealing studies reveal that 1275 °C anneals annihilate the oxygen precipitates. A longer annealing time is required to achieve an oxygen-precipitate-free silicon layer in an SOI substrate implanted with a lower oxygen dose. The inverse relationship between oxygen content in the silicon film and oxygen dose is attributed to the redistribution of oxygen during implantation. In the oxygen dose range studied, the thickness and the breakdown voltage of the buried oxide layer increase with increasing oxygen dose. Higher postimplant annealing temperature improves the isolation properties of the buried oxide layer.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesChang, P.-H. ; Slawinski, C. ; Mao, B.-Y. ; Lam, H. W.
[S.l.] : American Institute of Physics (AIP)
Published 1987Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The effects of implant dose and postimplant annealing treatment on the microstructure of nitrogen-implanted silicon-on-insulator were studied by cross-sectional transmission electron microscopy techniques. In the lower dose case (0.75×1018/cm2) an amorphous silicon layer forms after implantation. Annealing at 1200 °C or higher results in a buried polycrystalline α-Si3N4 layer containing many randomly oriented silicon particles. Higher dose implantation results in an amorphous silicon-nitride layer. A porous layer also forms in the middle of the amorphous layer if the implant dose is 1.2×1018/cm2 or higher. The crystallization of the amorphous layer in the higher dose cases is shown to happen in two steps. In the first step nucleation and growth of α-Si3N4 grains occur in the amorphous nitride region to form a spherulitic polycrystalline structure. The second step is the cellular growth of the spherulitic nitride grains into the crystalline silicon regions. Silicon particles are trapped at the cell walls as the cellular reaction advances. These particles are conglomerated and sphereodized but retain the same orientation as the substrate silicon at higher temperatures. The quality of the top silicon film is excellent after annealing at 1200 °C or higher, irrespective of the implant dose.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesNeill, F. ; Sear, J. W. ; French, G. ; Lam, H. ; Kemp, M. ; Hooper, R. J. L. ; Foex, P.
Oxford, UK : Blackwell Science Ltd
Published 2000Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We investigated the use of measurements of serum concentrations of the cardiac proteins troponins I and T as biochemical markers of myocardial cell damage in 80 patients undergoing vascular or major orthopaedic surgery. Holter electrocardiographic monitoring was carried out before surgery and for 3 days after surgery. Blood samples for troponins I and T and creatine kinase-MB isoenzyme were taken on each of these 4 days. Outcome was assessed at 3 months using a patient questionnaire, general practitioner follow-up and case notes review. Silent postoperative myocardial ischaemia was detected in 21 patients; increases in troponins I and T and creatine kinase-MB occurred in four, six and 17 of these patients, respectively. Eight patients suffered major postoperative complications (cardiac death, myocardial ischaemia, congestive cardiac failure, unstable angina and cerebrovascular accident) and 21 minor complications (poorly controlled hypertension needing increased or new additional treatment, palpitations, increased tiredness or shortness of breath in the absence of known respiratory disease). There were no associations between postoperative ischaemia and cardiac protein concentrations. The relative odds for the associations of major adverse outcome at 3 months after surgery and postoperative ischaemia or increased serum concentrations of the three proteins were 5.39 [95% confidence intervals 1.16–27.67] for postoperative ischaemia; 5.64 [1.07–31.00] for creatine kinase-MB isoenzyme; 17.00 [2.20–116.54] for troponin T and 13.20 [1.12–135.00] for troponin I. We found troponin T to be the only prospective marker for both major and minor cardiovascular complications (relative odds 10.65 [1.26–252.88]).Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: A viscous jet is not usually observed to separate from a sharp edge in the manner expected theoretically. In the present paper the separation of a creeping jet emerging from a tube with a rounded exit is considered. As a separation criterion, in the absence of surface tension, we propose that the traction normal to the nozzle surface drops to zero at the separation point. Boundary-element calculations then show a behavior that agrees with experimental data and with previous finite-element computations. They also permit the Michael condition to be observed at separation, so that the discrepancy between finite-element calculations and theory is removed.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesSkoubis, P. D. ; Lam, H. A. ; Shoblock, J. ; Narayanan, S. ; Maidment, N. T.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1460-9568Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The aversive response to naloxone administration observed in human and animal studies suggests the presence of an endogenous opioid tone regulating hedonic state but the class(es) of opioid peptides mediating such opioid hedonic tone is uncertain. We sought to address this question using mice deficient in either beta-endorphin or pro-enkephalin in a naloxone-conditioned place aversion paradigm. Mice received saline in the morning in one chamber and either saline or naloxone (0.1, 1 or 10 mg/kg, s.c.) in the afternoon in another chamber, each day for 3 days. On the test day they were given free access to the testing chambers in the afternoon and the time spent in each chamber was recorded. Whereas wild-type and beta-endorphin-deficient mice exhibited a robust conditioned place aversion to naloxone, pro-enkephalin knockout mice failed to show aversion to naloxone at any dose tested. In contrast, these mice showed a normal conditioned aversion to the kappa opioid receptor agonist, U50,488 (5 mg/kg), and to LiCl (100 mg/kg) indicating that these mice are capable of associative learning. In a separate experiment, pro-enkephalin knockout mice, similar to wild-type and beta-endorphin-deficient mice, demonstrated a significant conditioned place preference to morphine (2.5, 5 and 10 mg/kg s.c.). These data suggest that enkephalins, but not endorphins, may mediate an endogenous opioid component of basal affective state and also indicate that release of neither endogenous enkephalins nor endorphins is critical for the acquisition or expression of the association between contextual cues and the rewarding effect of exogenously administered opiates.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesMassé, M. ; Martinez-Mir, A. ; Lam, H. ; Geraghty, M. T. ; Christiano, A. M.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2230Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Identification of mutations in the hairless (HR) gene in patients with atrichia with papular lesions (APL) has proven of critical importance, as it provides a basis for the differentiation between APL and alopecia universalis. The establishment of the diagnostic criteria for APL has triggered the identification of a large number of APL patients among those suspected to suffer from alopecia universalis. This advancement has resulted in the discovery of an increasing number of hairless mutations in both consanguineous and nonconsanguineous APL families. Here, we report the identification of a homozygous mutation, 3434delC, in an APL patient of Arab--Palestinian descent. The proband is a 23-year-old female with generalized scalp and body alopecia. To confirm the diagnosis of APL and to identify the specific mutation, we sequenced the hairless gene. Sequencing of all exons of the hairless gene revealed a homozygous frameshift mutation, 3434delC, in exon 18. Interestingly, the same mutation was previously identified in an Arab--Israeli family. Our data suggest that the 3434delC mutation most likely represents a founder mutation in this geographical region.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesKUSHIGBOR, C. ; LAM, H. L. ; MAJOROWICZ, J. A. ; RAHMAN, M.
Oxford, UK : Blackwell Publishing Ltd
Published 1984Staff ViewISSN: 1365-2478Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: GeosciencesPhysicsNotes: There is a significant increase in terrestrial heat flow with depth in the Hinton-Edson area of the deep part of the western Canadian sedimentary basin in Alberta. This is especially true near the Rocky Mountain foothills which is an area of high relief, high hydraulic head and regional water recharge. Gravity-imposed downward movement of meteoric water through the thick sedimentary strata with velocities as low as 10–10 m/s to 0.5 × 10–9 m/s may cause an increase of heat flow with depth. Such disturbance of heat flow with depth on a regional scale in the sedimentary strata means that it is not possible to determine the background conductive steady-state heat flow associated with crustal or upper mantle heat sources in such an area from measurement of conductive heat flow in the part of the sedimentary column where water movement occurs. This is because the convective portion cannot be determined, particularly when measurements are made in only part of the regional hydrodynamic system of the basin.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesTok, J. ; Garzon, M. C. ; Cserhalmi-Friedman, P. ; Lam, H. M. ; Spitz, J. L. ; Christiano, A. M.
Oxford, UK : Blackwell Publishing Ltd
Published 1999Staff ViewISSN: 1600-0625Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: Lamellar ichthyosis (LI) is an autosomal recessive disorder of cornification. Mutations in the transglutaminase 1 gene (TGM1) have been identified in several families with this disorder. We analyzed two unrelated families with offspring affected with LI. Family 1 included affected monozygotic twins, in which a homozygous G-to-T transversion was identified in exon 6 at amino acid residue R315L. This mutation was also identified in the unaffected mother. In family 2, which consisted of one affected infant, a T-to-G transversion in exon 8 resulted in a change of phenylalanine to valine, F400V, and a C-to-T transition in exon 4 resulted in a change of proline to leucine, P248L. In this family, the mutation F400V was found in the unaffected father, and the mutation P248L was identified in the unaffected mother. These findings extend the growing body of literature documenting mutations in the TGM1 gene as the molecular basis of certain cases of lamellar ichthyosis.Type of Medium: Electronic ResourceURL: