Search Results - (Author, Cooperation:H. H. Tsai)

2012-06-30

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Astrocytes/*physiology ; Bacterial Proteins/metabolism ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Brain/abnormalities/*cytology/physiology ; Brain Injuries/physiopathology ; *Cell Movement ; Green Fluorescent Proteins ; Homeodomain Proteins/metabolism ; Integrases/genetics ; Luminescent Proteins/metabolism ; Mice ; Mice, Transgenic ; Motor Neurons/*physiology ; Nerve Tissue Proteins/genetics ; Proteins/metabolism ; RNA, Untranslated ; Spinal Cord/abnormalities/*cytology/physiology ; Spinal Cord Injuries/physiopathology ; Synapses/*physiology ; Transcription Factors/metabolism ; Transcription, Genetic

2016-01-23

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Blood Vessels/cytology/embryology ; *Cell Movement ; Cerebral Cortex/blood supply/*embryology ; Endothelium, Vascular/cytology ; Humans ; Mice ; Neural Stem Cells/cytology/*physiology ; *Neurogenesis ; Oligodendroglia/cytology/*physiology ; *Organogenesis ; Pericytes/cytology/physiology ; Receptors, CXCR4/metabolism ; Signal Transduction ; Spinal Cord/blood supply/cytology/*embryology ; Wnt Proteins/metabolism

2014-04-30

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Astrocytes/cytology/*physiology ; Axons/physiology ; Cell Polarity ; Cell Survival/drug effects ; Humans ; Mice ; Motor Neurons/cytology/drug effects/*physiology ; Neural Pathways/*physiology ; Semaphorin-3A/deficiency/genetics/metabolism/pharmacology ; Sensory Receptor Cells/cytology/*physiology ; Spinal Cord/cytology ; Synapses/metabolism

2011-10-04

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Adolescent ; Adult ; Aged ; Aged, 80 and over ; Brain/*cytology/*growth & development ; *Cell Movement ; Cell Proliferation ; Child ; Child, Preschool ; Humans ; Infant ; Infant, Newborn ; Middle Aged ; Neurons/*cytology ; Olfactory Pathways/cytology

1365-2036

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Twenty-four-hour intragastric acidity was measured in 10 patients with past history of duodenal ulcer on the fourth day of dosing with placebo, and either 150 mg ranitidine given twice or four times daily. The order the treatments was randomized and a double-blind design was employed. Ranitidine (150 mg) b.d. decreased median integrated 24-h intragastric acidity by 65.1%, nocturnal acidity by 89.1%, and daytime acidity by 54.6% (all P 〈 0.01 compared to placebo). The corresponding decreases with 150 mg ranitidine q.d.s. were 62.3, 89.9 and 48.8%, respectively (all P 〈 0.01 compared to placebo). There were no significant differences between the two dosage regimens of ranitidine (P 〉 0.05).This study shows that giving extra doses of 150 mg ranitidine during the day does not increase the degree of suppression of intragastric acidity.

Electronic Resource

1365-2036

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background : Symptom relief, through adherence to appropriate maintenance therapy, is the sole objective of treatment for patients with endoscopy-negative gastro-oesophageal reflux disease.Aim : To compare the efficacy of ‘on-demand’ treatment with esomeprazole 20 mg vs. continuous treatment with lansoprazole 15 mg daily in patients with endoscopy-negative gastro-oesophageal reflux disease.Methods : Endoscopy-negative gastro-oesophageal reflux disease patients who achieved complete resolution of heartburn after short-term (2–4 weeks) treatment with esomeprazole 20 mg (n = 774) were randomized to receive either esomeprazole 20 mg on-demand (n =311) or lansoprazole 15 mg continuous daily treatment (n = 311) for 6 months.Results : Significantly more patients were willing to continue taking esomeprazole on-demand than lansoprazole continuous therapy after 6 months (93% vs. 88%; P = 0.02). This superior outcome was achieved despite patients on esomeprazole requiring medication only 38% as often as those on lansoprazole, leading to direct cost savings of more than one-third (36%). Furthermore, patients receiving esomeprazole 20 mg on-demand were more satisfied with their treatment after 1 month compared with patients taking lansoprazole 15 mg continuously.Conclusions : In patients with endoscopy-negative gastro-oesophageal reflux disease, esomeprazole 20 mg on-demand is more acceptable to patients and is an economically more effective treatment than lansoprazole 15 mg continuously.

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

0887-6266

Chemistry ; Polymer and Materials Science

Wiley InterScience Backfile Collection 1832-2000

Chemistry and Pharmacology

Physics

Integrated-intensity light scattering data are reported for moderately concentrated solutions of polystyrene in benzene and in cyclopentane. The benzene system is one for which the second virial coefficient A2 is large; data obtained over the range 0.5 〈 A2Mc 〈 30, with c the polymer concentration, are analyzed in terms of the (extrapolated) intensity at zero angle and the angular dependence of the intensity. The former is discussed in terms of power law representations based on scaling relations, which are found to represent the data. The latter is discussed in terms of the dependence of the chain dimensions on concentration. With cyclopentane, the behavior is similar for temperatures for which A2 is near its maximum, but for T near either ΘU or ΘL, for which A2 is zero or small, the angular dependence of the scattering is distinctly different, with the intensity exhibiting a maximum as a function of scattering angle.

8 Ill.

Electronic Resource

0269-3879

Chemistry ; Analytical Chemistry and Spectroscopy

Wiley InterScience Backfile Collection 1832-2000

Medicine

High performance gel filtration on monodisperse cross-linked agarose (Superose 6) has been assessed as a system for purification of mucus glycoproteins. Comparison with the conventional two-step purification of mucus glycoprotein by Sepharose CL4B gel filtration followed by caesium chloride density gradient centrifugation shows that purification by high performance gel filtration is at least as thorough, yielding mucin that is free from non-mucin glycoproteins as defined by buoyant density, mobility on sodium dodecyl sulphate-polyacrylamide gel electrophoresis and absence of Concanavalin A binding (mannose-containing) material. This technique allows mucus glycoprotein to be purified from lyophilized crude mucin in 120 min compared with approximately 72 h using the conventional techniques. This makes the comparative study of mucus glycoprotein changes in disease states much more feasible.

8 Ill.

Electronic Resource