Search Results - (Author, Cooperation:H. Goto)
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1Latest Papers from Table of Contents or Articles in PressSegawa, S., Kondo, Y., Nakai, Y., Iizuka, A., Kaneko, S., Yokosawa, M., Furuyama, K., Tsuboi, H., Goto, D., Matsumoto, I., Sumida, T.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-12-11Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressO. Simakov ; T. Kawashima ; F. Marletaz ; J. Jenkins ; R. Koyanagi ; T. Mitros ; K. Hisata ; J. Bredeson ; E. Shoguchi ; F. Gyoja ; J. X. Yue ; Y. C. Chen ; R. M. Freeman, Jr. ; A. Sasaki ; T. Hikosaka-Katayama ; A. Sato ; M. Fujie ; K. W. Baughman ; J. Levine ; P. Gonzalez ; C. Cameron ; J. H. Fritzenwanker ; A. M. Pani ; H. Goto ; M. Kanda ; N. Arakaki ; S. Yamasaki ; J. Qu ; A. Cree ; Y. Ding ; H. H. Dinh ; S. Dugan ; M. Holder ; S. N. Jhangiani ; C. L. Kovar ; S. L. Lee ; L. R. Lewis ; D. Morton ; L. V. Nazareth ; G. Okwuonu ; J. Santibanez ; R. Chen ; S. Richards ; D. M. Muzny ; A. Gillis ; L. Peshkin ; M. Wu ; T. Humphreys ; Y. H. Su ; N. H. Putnam ; J. Schmutz ; A. Fujiyama ; J. K. Yu ; K. Tagawa ; K. C. Worley ; R. A. Gibbs ; M. W. Kirschner ; C. J. Lowe ; N. Satoh ; D. S. Rokhsar ; J. Gerhart
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-11-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Chordata, Nonvertebrate/classification/*genetics ; Conserved Sequence/genetics ; Echinodermata/classification/genetics ; *Evolution, Molecular ; Genome/*genetics ; Multigene Family/genetics ; Phylogeny ; Signal Transduction ; Synteny/genetics ; Transforming Growth Factor betaPublished by: -
3Latest Papers from Table of Contents or Articles in PressGoto, H., Nishio, M., To, Y., Oishi, T., Miyachi, Y., Maehama, T., Nishina, H., Akiyama, H., Mak, T. W., Makii, Y., Saito, T., Yasoda, A., Tsumaki, N., Suzuki, A.
The Company of Biologists
Published 2018Staff ViewPublication Date: 2018-03-29Publisher: The Company of BiologistsPrint ISSN: 0950-1991Electronic ISSN: 1477-9129Topics: BiologyKeywords: Musculoskeletal systemPublished by: -
4Articles: DFG German National LicensesKashiwai, T. ; Sugiyama, T. ; Toki, I. ; Nagashima, S. ; Goto, H. ; Iida, N. ; Yamagata, Y.
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1468-2494Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We developed a non-water gel product comprising HPC and PEG, reacting hydration with water. We investigated the gelation mechanism of HPC/PEG gel by means of a stress-controlled rheometer and an X-ray diffractometer. According to the results, the mechanism has two factors: entanglement of the HPC polymer chain and cross-linkage of the microcrystal domain of the HPC main chain. The HPC/PEG gel is useful as the basic material of the cosmetic plaster that causes skin surface temperature to rise and the blood stream to accelerate.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The CD4 molecule is an important cell surface molecule expressed on many cell types including T-helper cells. CD4 can be shed from cells, and the truncated soluble form of CD4 (sCD4) has been found elevated in serum in several diseases. In this study the authors show that migration of polymorphonuclear neutrophils (PMN) is induced by sCD4. Histopathology of the site of injection of recombinant sCD4 in the skin shows local infiltration of PMN. In vitro, in Boyden chamber, sCD4 can rapidly give rise to a dose-dependent migration of PMN. The authors speculate that sCD4 can be another chemotactic factor and, as such, constitutes a link within the immune system between specific and non-specific elements of inflammation.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesCARVALHO, L. J. M. ; DANIEL-RIBEIRO, C. T. ; GOTO, H.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: More than 30 years after the first report of successful vaccination against malaria using radiation-attenuated sporozoites, an effective malaria vaccine is not yet available. However, field and experimental data indicate that it can be developed. An astonishing amount of data has accumulated concerning parasite biology, host–parasite interactions, immunity and escape mechanisms, targets and modulators of immune responses. Nevertheless, so far this knowledge has not been enough to make us understand how to properly manipulate the whole system to build an effective vaccine. In this article, we describe candidate antigens, mechanisms, targets and trials performed with potential malaria vaccines and discuss the approaches, in vivo and in vitro models, constraints and how technologies such as DNA vaccination, genomics/proteomics and reverse immunogenetics are providing exciting results and opening new doors to make malaria vaccine a reality.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesArai, H. ; Nomura, Y. ; Kinoshita, M. ; Shimizu, H. ; Ono, K. ; Goto, H. ; Takigawa, M. ; Nishimura, F. ; Washio, N. ; Kurihara, H. ; Murayama, Y.
Oxford, UK : Blackwell Publishing Ltd
Published 1995Staff ViewISSN: 1600-0765Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The effects of various prostaglandins (PGs) on the functions of human gingival fibroblasts (Gin-1 cells; ATCC CRL 1292) were examined by phase-contrast microscopy, cell-counting and radioautographic experiments. Tested PGs were PGA1, PGA2, PGB1, PGB2, PGD2, PGE1, PGE2, PGF1α, PGF2α, PGI2, 6-keto-PGF1α, 9α-11α-methanoepoxy-PGF2α, and thromboxane (TX) B2. PGA1, and PGD2 at 30 μM caused morphological deformation of Gin-1 cells. All the PGs tested at 30 μM suppressed the proliferation of Gin-1 cells in the logarithmic growth phase. Furthermore, all the PGs tested at 10 μM suppressed DNA synthesis, collagen synthesis, and noncollagenous protein synthesis in confluent Gin-1 cells, while exerting no effect on GAG synthesis. The concentrations of PGs used are beyond those found in healthy gingiva. However, in periodontitis the local concentrations of some PGs within the gingiva are expected to be extremely elevated beyond the physiological level. These results suggest that PGs may play an important role as a negative regulator in metabolism and some pathologic gingival conditions by suppressing the functions of gingival fibroblasts.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesHayasaki, N ; Ito, M ; Suzuki, T ; Ina, K ; Ando, T ; Kusugami, K ; Goto, H
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aim : To characterize the histological features of intestinal Behçet's disease and simple ulcer syndrome and to clarify the possible mechanisms involved in their development by analysing the type of inflammatory infiltrates in the diseased intestine and the expression of adhesion molecules on endothelial cells.Methods and results : Tissue samples from 10 patients diagnosed as having intestinal Behçet's disease or simple ulcer syndrome were studied. Immunohistochemical studies were performed on paraffin-embedded tissue using a labelled streptavidin–biotin method. In all cases, phlebitis was remarkably seen in submucosal inflammatory lesions, but the adjacent arteries were not affected. Inflammatory infiltrates around the affected vessels consisted of neutrophils and mononuclear cells, and neutrophils predominated over CD68+ macrophages and lymphocytes. The majority of mononuclear cells were CD3+ T cells, and CD4+ cells were more frequent than CD8+ T cells. As for adhesion molecule expression, intercellular adhesion molecule-1, but not vascular cell adhesion molecule-1, was expressed in most endothelial cells of the vessels with phlebitis, some of which were also positive for HLA-DR.Conclusion : Neutrophilic phlebitis may be involved in the pathogenesis of intestinal Behçet's disease and simple ulcer syndrome.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesTACHI, K. ; GOTO, H. ; HAYAKAWA, T. ; SUGIYAMA, S.
Oxford, UK : Blackwell Publishing Ltd
Published 1996Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background: Gastric mucosal microcirculation is an important factor in the protection of gastric mucosa, and nitric oxide (NO) plays a crucial role in the regulation of regional blood flow. This study was designed to evaluate the effect of cetraxate, an anti-ulcer drug, on water immersion stress-induced gastric lesions in relation to the changes in NO synthase activity. Methods: Gastric lesions were induced in rats by water immersion stress. The effects of cetraxate on NO synthase activity with or without stress was determined enzymatically. Changes in gastric mucosal prostaglandin (PG) contents with or without stress were also determined using high-performance liquid chromatography. Gastric mucosal blood flow was measured by hydrogen gas clearance technique. Results: Water immersion stress-induced gastric lesions. Cetraxate significantly mitigated the lesions but NG-monomethyl-l-arginine (l-NMMA), a specific inhibitor of NO synthase, exacerbated the lesions. The favourable effect of cetraxate was remarkably diminished by administration of l-NMMA. NO synthase activity decreased significantly by 6 h after stress. Cetraxate treatment increased NO synthase activity throughout the experiment in rats with or without stress treatment. Water immersion stress decreased all PGs detected, i.e. 6-keto-PGF1α, PGF2α PGE2 and PGD2. Cetraxate prevented stress-induced decreases in PG contents. l-NMMA showed no significant effect on PG contents. Cetraxate increased gastric mucosal blood flow significantly and l-NMMA cancelled out cetraxate-induced increase in blood flow. Conclusions: The pharmacological efficacy of anti-ulcer drugs such as cetraxate might be attributable to the enhancement of NO synthase activity resulting in an increase in gastric mucosal blood flow.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesNada, T. ; Ando, T. ; Nobata, K. ; Tsuzuki, T. ; Minami, M. ; Ina, K. ; Iinuma, Y. ; Ichiyama, S. ; Ohta, M. ; El-Omar, E. ; Kusugami, K. ; Goto, H.
Oxford, UK : Blackwell Publishing Ltd
Published 2004Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background : Failure of Helicobacter pylori eradication occurs frequently despite use of multiple microbial agents.Aim : We aimed to study differences between H. pylori strains isolated before and after eradication failure.Methods : We treated 87 patients with peptic ulcer using triple therapy consisting of omeprazole plus combinations of clarithromycin, amoxicillin, or metronidazole. We studied the status of cagA, vacA, and iceA by PCR, and examined the differences in H. pylori isolates by pulsed-field gel electrophoresis and arbitrary primer polymerase chain reaction. The minimum inhibitory concentration of clarithromycin, amoxicillin, or metronidazole was determined by an agar dilution method.Results : Eradication therapy failed in 12 patients (14%); H. pylori isolates were obtained from all of these both before and after therapy. After eradication therapy, 10 patients were colonized with the same strain as before therapy, while the other two patients were colonized with different strains from those before therapy. In the former group, one isolate changed from metronidazole-sensitive to -resistant, one changed from clarithromycin- and metronidazole-sensitive to -resistant, and four were resistant to clarithromycin or metronidazole both before and after therapy. The other four isolates remained sensitive to clarithromycin and metronidazole after therapy. In the two patients who yielded apparently different isolates after therapy, they changed from clarithromycin- and metronidazole-sensitive to -resistant.Conclusion : Eradication of H. pylori by first-line therapy is an important goal in the treatment of H. pylori-positive peptic ulcer, and that appropriate antimicrobial sensitivity testing should be conducted in patients with eradication failure.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesTSUKAMOTO, Y. ; TSUCHIDA, T. ; GOTO, H. ; HASE, S. ; ARISAWA, T. ; NIWA, Y.
Oxford, UK : Blackwell Publishing Ltd
Published 1993Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We investigated the effect of sucralfate on angiogenesis in granulation tissue of gastric ulcers induced by acetic acid in rats using the carmine dye method. Intragastric administration of sucralfate at a dose of 500 mg/kg twice daily for 9 days significantly accelerated ulcer healing and significantly increased the extent of angiogenesis in the ulcer base on the tenth day after ulcer induction. As we reported previously, intragastric administration of cimetidine at a dose of 100 mg/kg once daily for 9 days decreased the extent of angiogenesis on the tenth day. However, combination treatment using sucralfate and cimetidine accelerated ulcer healing significantly, without altering the extent of angiogenesis. It is concluded, therefore, that the treatment with sucralfate may be effective in peptic ulcer disease from the standpoint of angiogenesis in the ulcer base.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesHOSHINO, H. ; GOTO, H. ; SUGIYAMA, S. ; HAYAKAWA, T. ; OZAWA, T.
Oxford, UK : Blackwell Publishing Ltd
Published 1995Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aim: To assess the effects of FK506, a newly developed immunosuppressant, on experimental colitis in rats. Methods: Experimental colitis was induced by a single colonic instillation of hapten 2,4,6-trinitrobenzene sulphonic acid (TNB) in anaesthetized rats. Rats received 30 mg TNB dissolved in 0.25 mL of 50% ethanol, and were sacrificed on day 5 following 4 days dosing with FK506 (0.25, 0.5, 1.0, 2.0 mg/kg, s.c.) or vehicle. Mucosal prostanoid concentrations were determined using high performance liquid chromotography. Tissue myeloperoxidase activities were measured. The effects of FK506 on superoxide radical formation by neutrophils in both rats and humans were also estimated in vitro.Results: Administration of FK506 significantly reduced the colonic damage in a dose-dependent manner. Activities of myeloperoxidase and concentrations of 6-keto-prostaglandin Fl1α (6-keto-PGF1α, PGF2α and PGE2 in colonic tissue increased significantly following induction of experimental colitis, however, FK506 did not affect these changes. FK506 reduced stimulant-induced superoxide radical formation by neutrophils in rats and humans. Conclusion: FK506 decreased superoxide radical generation by neutrophils, which might contribute to the lessening of colonic damage in this model.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesHISANAGA, Y. ; GOTO, H. ; TACHI, K. ; HAYAKAWA, T. ; SUGIYAMA, S.
Oxford BSL : Blackwell Science
Published 1996Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background: Nitric oxide (NO) is a potent cytoprotective substance of gastric mucosa. FK506, an immunosuppressive drug, shows anti-gastric ulcer effects equivalent to famotidine, an H2 blocker, in rats. This study was designed to evaluate the cytoprotective mechanism of FK506 on gastric mucosa in relation to the changes in NO synthase activity. Methods: Gastric lesions were induced in rats by water immersion stress. Changes in NO synthase activity during water immersion stress treatment, and effects of FK506 on NO synthase activity were determined enzymatically. Gastric mucosal interleukin (IL)-1β and IL-2 were measured by immunoradiometric assay. Gastric mucosal blood flow was measured by hydrogen gas clearance technique. Results: FK506 mitigated gastric lesions developed by water immersion stress. Stress-induced lesions were exacerbated by NG-monomethyl-L-arginine (L-NMMA), a specific inhibitor of NO synthase, while sodium nitroprusside, a NO donor, mitigated the lesions. Water immersion stress increased NO synthase activity in the early phase (0.5 h after stress treatment) and decreased it in the late phase (6 h after). Decrease in NO synthase activity in the late phase was significantly mitigated by FK506, though it did not affect changes in NO synthase activity in the early phase. Water immersion stress increased gastric mucosal IL-1β and IL-2 contents 6 h after stress treatment, and these increases were prevented by FK506. FK506 itself did not affect gastric mucosal blood flow. L-NMMA treatment significantly decreased gastric mucosal blood flow. In contrast, gastric mucosal blood flow was significantly increased by sodium nitroprusside. Conclusions: Increase in NO synthase activity might contribute to cytoprotection, and a decrease in activity might be a harmful factor for the gastric mucosa. Preservation of NO synthase activity by FK506 might be involved in FK506's protective effects on the gastric mucosa.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesGoto, H. ; Matsui-Yuasa, I. ; Otani, S. ; Morisawa, S. ; Nishizawa, Y. ; Morii, H.
Amsterdam : ElsevierStaff ViewISSN: 0003-9861Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0003-9861Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesGoto, H. ; Sugiyama, S. ; Ohara, A. ; Hoshino, H. ; Hamajima, E. ; Kanamori, S.i. ; Tsukamoto, Y. ; Ozawa, T.
Amsterdam : ElsevierStaff ViewISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] A number of species of Collembola have been reared in this Department during the past ten years. Among these are two species of the isotomid genus Folsomia (F. candida Willem and F. cavicola Delamare). In both these species, males and females have been found in wild populations in approximately ...Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0167-4781Keywords: Cloning ; Erythrocyte AMP deaminase ; Sequence ; cDNASource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0167-4781Keywords: Calcium ; Leukemia ; Promyelocyte ; Vitamin D ; Vitamin D receptorSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0891-5849Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicineType of Medium: Electronic ResourceURL: