Search Results - (Author, Cooperation:H. Clevers)

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  1. 1
    L. Lum ; H. Clevers
    American Association for the Advancement of Science (AAAS)
    Published 2012
    Staff View
    Publication Date:
    2012-08-28
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Antineoplastic Agents/pharmacology/*therapeutic use ; Clinical Trials, Phase I as Topic ; DNA-Binding Proteins/genetics ; Drug Discovery ; Enzyme Inhibitors/pharmacology/*therapeutic use ; Humans ; Membrane Proteins/*antagonists & inhibitors/genetics/*metabolism ; Molecular Targeted Therapy ; Mutation ; Neoplasms/*drug therapy/genetics/metabolism ; Oncogene Proteins/genetics ; Palmitic Acid/metabolism ; Protein-Serine-Threonine Kinases/genetics ; Wnt Proteins/*metabolism ; Wnt Signaling Pathway/*drug effects
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    T. Sato ; H. Clevers
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-06-08
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adult Stem Cells/*physiology ; Animals ; Cell Count ; *Cell Culture Techniques ; Disease Models, Animal ; Ephrin-B1/metabolism ; Humans ; Intestinal Mucosa/physiology ; Intestine, Small/*growth & development ; Mice ; *Morphogenesis ; Receptors, G-Protein-Coupled/genetics ; *Regenerative Medicine ; Stem Cell Niche ; Wnt Proteins/metabolism
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    H. Clevers ; K. M. Loh ; R. Nusse
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-10-04
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Brain/physiology ; Cell Division ; Hair Follicle/physiology ; Humans ; Intestines/physiology ; Mammary Glands, Human/physiology ; Regeneration/genetics/*physiology ; Signal Transduction ; Stem Cell Niche/physiology ; Stem Cells/cytology/metabolism/*physiology ; Transcription, Genetic ; Wnt Proteins/*metabolism
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    H. Clevers
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-12-15
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adult Stem Cells/*cytology/*physiology ; Cell Culture Techniques ; *Cell Differentiation ; Cell Proliferation ; Hematopoietic Stem Cells/cytology/physiology ; Humans ; Intestines/physiology ; *Regeneration
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    A. G. Schepers ; H. J. Snippert ; D. E. Stange ; M. van den Born ; J. H. van Es ; M. van de Wetering ; H. Clevers
    American Association for the Advancement of Science (AAAS)
    Published 2012
    Staff View
    Publication Date:
    2012-08-03
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adenoma/genetics/metabolism/*pathology ; Animals ; Biomarkers/analysis ; Cell Lineage ; Cell Transformation, Neoplastic ; Gene Expression Profiling ; Gene Knock-In Techniques ; Genes, Reporter ; Intestinal Mucosa/metabolism/pathology ; Intestinal Neoplasms/genetics/*pathology ; Mice ; Multipotent Stem Cells/pathology/physiology ; Neoplastic Stem Cells/*pathology/*physiology ; Paneth Cells/pathology ; Receptors, G-Protein-Coupled/*analysis ; Stem Cell Niche ; Tamoxifen/pharmacology ; Tumor Stem Cell Assay
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Staff View
    Publication Date:
    2014-08-01
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; *Cell Differentiation ; *Cell Lineage ; Cell Tracking ; Clone Cells/cytology ; Dental Pulp/cytology ; Female ; Incisor/*cytology/embryology ; Male ; Mesenchymal Stromal Cells/*cytology ; Mice ; Models, Biological ; Neural Crest/cytology ; Neuroglia/*cytology ; Odontoblasts/cytology ; Regeneration ; Schwann Cells/cytology
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  7. 7
    D. Grun ; A. Lyubimova ; L. Kester ; K. Wiebrands ; O. Basak ; N. Sasaki ; H. Clevers ; A. van Oudenaarden
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-08-20
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Algorithms ; Animals ; Biomarkers/analysis ; Cell Differentiation/genetics ; Cell Lineage ; Cell Separation/*methods ; In Situ Hybridization, Fluorescence ; Intestine, Small/*cytology ; Mice ; Neoplasm Proteins/genetics ; Organoids/cytology ; Paneth Cells/cytology/metabolism ; RNA, Messenger/*genetics ; Receptors, G-Protein-Coupled/genetics ; Reproducibility of Results ; *Sequence Analysis, RNA ; *Single-Cell Analysis ; Stem Cells/cytology/metabolism ; Transcriptome/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  8. 8
    Staff View
    Publication Date:
    2012-08-17
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adenoma/metabolism/pathology ; Animals ; Cell Proliferation ; Colorectal Neoplasms/metabolism/pathology ; DNA-Binding Proteins/deficiency/genetics/*metabolism ; *Endocytosis ; Frizzled Receptors/metabolism ; HEK293 Cells ; Humans ; Lysosomes/metabolism ; Mice ; Oncogene Proteins/deficiency/genetics/*metabolism ; Organoids/cytology/metabolism/pathology ; Paneth Cells/metabolism/pathology ; Receptors, G-Protein-Coupled/genetics/metabolism ; Receptors, Wnt/antagonists & inhibitors/*metabolism ; Stem Cells/cytology/*enzymology/metabolism ; Tumor Suppressor Proteins/deficiency/genetics/*metabolism ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/deficiency/genetics/*metabolism ; Ubiquitination ; *Wnt Signaling Pathway/drug effects ; beta Catenin/metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  9. 9
    Staff View
    Publication Date:
    2015-04-30
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  10. 10
    M. Karin ; H. Clevers
    Nature Publishing Group (NPG)
    Published 2016
    Staff View
    Publication Date:
    2016-01-23
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  11. 11
    L. Ritsma ; S. I. Ellenbroek ; A. Zomer ; H. J. Snippert ; F. J. de Sauvage ; B. D. Simons ; H. Clevers ; J. van Rheenen
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-02-18
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Cell Division ; Cell Lineage ; Cell Survival ; Clone Cells/cytology ; Female ; *Homeostasis ; Intestinal Mucosa/*cytology ; Male ; Mice ; Models, Biological ; Molecular Imaging ; Receptors, G-Protein-Coupled/genetics/metabolism ; *Single-Cell Analysis ; Stem Cells/*cytology
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  12. 12
    Staff View
    Publication Date:
    2014-01-28
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Basic Helix-Loop-Helix Transcription Factors/antagonists & ; inhibitors/deficiency/genetics/*metabolism ; *Cell Differentiation/genetics ; Cell Movement ; DNA-Binding Proteins/metabolism ; Down-Regulation ; Germinal Center/*cytology/immunology ; Humans ; Inhibitor of Differentiation Proteins/genetics/metabolism ; Mice ; Mutation/genetics ; Receptors, CCR7/metabolism ; Receptors, CXCR5/metabolism ; T-Lymphocytes, Helper-Inducer/*cytology/immunology/*metabolism ; Th17 Cells/cytology/immunology/metabolism ; Transcription, Genetic/genetics ; Up-Regulation
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  13. 13
    Staff View
    Publication Date:
    2014-07-22
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Biological Clocks/genetics ; Cell Division ; Cell Lineage/*genetics ; Cells, Cultured ; Clone Cells/*cytology/*metabolism ; Embryo, Mammalian/cytology ; Genome/*genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mutagenesis/*genetics ; Mutation/*genetics ; Mutation Rate ; Organoids/cytology/metabolism ; Phylogeny ; Sequence Analysis, DNA ; Tail/cytology
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  14. 14
    H. Clevers ; E. Bender
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-05-15
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adult Stem Cells/metabolism/pathology ; Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology/therapeutic use ; Cell Line, Tumor ; Clinical Trials as Topic ; Colorectal Neoplasms/*drug therapy/genetics/*pathology ; Drug Evaluation, Preclinical/*methods ; Humans ; Mice ; *Models, Biological ; Organoids/*drug effects/metabolism/*pathology ; Precision Medicine/*methods ; Xenograft Model Antitumor Assays
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  15. 15
    Staff View
    Publication Date:
    2016-02-11
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alleles ; Animals ; Cell Adhesion ; Cell Division ; Cell Membrane/*metabolism ; Diffusion ; Female ; Frizzled Receptors/metabolism ; Gene Knock-In Techniques ; Intercellular Signaling Peptides and Proteins/metabolism ; Intestinal Mucosa/*cytology ; Male ; Mice ; Organoids/cytology/metabolism ; Paneth Cells/cytology/metabolism ; Receptors, G-Protein-Coupled/metabolism ; *Stem Cell Niche ; Stem Cells/*cytology/*metabolism ; Ubiquitin-Protein Ligases/metabolism ; *Wnt Signaling Pathway ; Wnt3 Protein/genetics/*metabolism/secretion
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  16. 16
    Staff View
    Publication Date:
    2010-11-30
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Antigens, CD24/metabolism ; Cell Count ; Cell Proliferation ; Coculture Techniques ; Humans ; Intestines/*cytology ; Mice ; Multipotent Stem Cells/*cytology/*metabolism ; Paneth Cells/*cytology/secretion ; Receptors, G-Protein-Coupled/*metabolism ; Stem Cell Niche/*cytology/secretion ; Wnt Proteins/metabolism/secretion ; Wnt3 Protein
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  17. 17
    Staff View
    Publication Date:
    2011-07-06
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adult Stem Cells/metabolism ; Animals ; Cells, Cultured ; Epithelial Cells/cytology/metabolism ; Frizzled Receptors/metabolism ; Gene Deletion ; HEK293 Cells ; Humans ; Mice ; Protein Binding ; Protein Structure, Tertiary ; Receptors, G-Protein-Coupled/chemistry/deficiency/genetics/*metabolism ; Regeneration ; *Signal Transduction/genetics ; Thrombospondins/*metabolism ; Wnt Proteins/genetics/*metabolism ; Wnt3 Protein ; Wnt3A Protein
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  18. 18
    Staff View
    Publication Date:
    2012-07-28
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Biocatalysis ; Colitis/drug therapy/*etiology/*microbiology/pathology ; Dextran Sulfate ; Diarrhea/complications ; Dietary Proteins/metabolism/pharmacology ; Female ; Gene Deletion ; Genetic Predisposition to Disease ; Germ-Free Life ; Homeostasis ; Immunity, Innate ; Intestines/*microbiology/pathology ; Male ; Malnutrition/*complications/metabolism ; *Metagenome ; Mice ; Models, Biological ; Niacinamide/metabolism/pharmacology/therapeutic use ; Peptidyl-Dipeptidase A/deficiency/genetics/*metabolism ; Renin-Angiotensin System/physiology ; TOR Serine-Threonine Kinases/metabolism ; Trinitrobenzenesulfonic Acid ; Tryptophan/*metabolism/pharmacology/therapeutic use
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  19. 19
    Staff View
    Publication Date:
    2013-01-29
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alleles ; Animals ; Bile Ducts/cytology/metabolism ; Cell Lineage ; Clone Cells/cytology/metabolism ; Culture Media/chemistry/metabolism ; Disease Models, Animal ; Female ; Gene Knock-In Techniques ; Hepatocytes/*cytology/*metabolism/pathology ; Hydrolases/deficiency/genetics ; Liver/cytology/metabolism/pathology ; Liver Diseases/metabolism/pathology ; Male ; Mice ; Multipotent Stem Cells/cytology/metabolism ; Organoids/cytology/transplantation ; Receptors, G-Protein-Coupled/agonists/deficiency/genetics/*metabolism ; *Regeneration ; Stem Cells/*cytology/*metabolism ; Thrombospondins/deficiency/genetics/metabolism ; Tyrosinemias/metabolism/pathology ; *Wnt Signaling Pathway
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  20. 20
    H. Clevers
    Nature Publishing Group (NPG)
    Published 2013
    Staff View
    Publication Date:
    2013-03-01
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; *Cell Lineage ; Multipotent Stem Cells/*cytology/*secretion ; Paneth Cells/*cytology/*metabolism ; Receptors, G-Protein-Coupled/*metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press