Search Results - (Author, Cooperation:H. A. Young)
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1Latest Papers from Table of Contents or Articles in PressChahoud, J., Sui, D., Erwin, W. D., Gulbis, A. M., Korbling, M., Zhang, M., Ahmed, S., Alatrash, G., Anderlini, P., Ciurea, S. O., Oran, B., Fayad, L. E., Bassett, R. L., Jabbour, E. J., Medeiros, L. J., Macapinlac, H. A., Young, K. H., Khouri, I. F.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-05-16Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressS. Kulkarni ; R. Savan ; Y. Qi ; X. Gao ; Y. Yuki ; S. E. Bass ; M. P. Martin ; P. Hunt ; S. G. Deeks ; A. Telenti ; F. Pereyra ; D. Goldstein ; S. Wolinsky ; B. Walker ; H. A. Young ; M. Carrington
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-04-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: 3' Untranslated Regions/genetics ; Alleles ; Base Sequence ; Cell Line ; *Gene Expression Regulation/genetics/immunology ; Genes, Reporter/genetics ; HIV/*immunology ; HIV Infections/*genetics/*immunology/therapy ; HLA-C Antigens/*genetics ; Humans ; MicroRNAs/*genetics ; Polymorphism, Single Nucleotide/genetics ; Viral LoadPublished by: -
3Latest Papers from Table of Contents or Articles in PressM. R. Zaidi ; S. Davis ; F. P. Noonan ; C. Graff-Cherry ; T. S. Hawley ; R. L. Walker ; L. Feigenbaum ; E. Fuchs ; L. Lyakh ; H. A. Young ; T. J. Hornyak ; H. Arnheiter ; G. Trinchieri ; P. S. Meltzer ; E. C. De Fabo ; G. Merlino
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-01-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Disease Models, Animal ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Developmental/radiation effects ; Humans ; Interferon-gamma/*metabolism ; Macrophages/metabolism/radiation effects ; Male ; Melanocytes/*metabolism/radiation effects ; Melanoma/*physiopathology ; Mice ; *Ultraviolet RaysPublished by: -
4Articles: DFG German National LicensesYoung, H. A. 〈Brigadier-General, CIE, CBE(RA, retired)〉
London : Periodicals Archive Online (PAO)
Published 1924Staff ViewISSN: 0958-0433Topics: Art HistoryDescription / Table of Contents: Indian SectionNotes: PROCEEDINGS OF THE SOCIETYURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0307-1847Topics: Political ScienceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1751-8482Topics: General, InterdisciplinaryEnglish, American StudiesURL: -
7Articles: DFG German National LicensesBream, J. H. ; Carrington, M. ; O'Toole, S. ; Dean, M. ; Gerrard, B. ; Shin, H. D. ; Kosack, D. ; Modi, W. ; Young, H. A. ; Smith, M. W.
Springer
Published 2000Staff ViewISSN: 1432-1211Keywords: Key words Interferon gamma ; Polymorphism ; Promoter ; AIOS ; 3′UTRSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Interferon gamma (IFN-gamma) is a multifunctional cytokine that is essential in the development of Th1 cells and in cellular responses to a variety of intracellular pathogens including human immunodeficiency virus (HIV-1). We screened genomic DNA samples from a predominately Caucasian male population of HIV-infected and healthy donors for polymorphisms in the human IFNG gene from –777 to +5608 by single-stranded conformational polymorphism. Surprisingly, the proximal promoter (–777 to transcription start) is invariant as no polymorphisms were found in over 100 samples tested. However, further screening revealed polymorphisms in other regions of the gene including a single base insertion in a poly-T tract in the first intron, three single base pair substitutions in the third intron, and another single base pair substitution in the 3′ untranslated region (UTR). Electrophoretic mobility shift assay was used to investigate whether these variants have altered DNA-binding abilities, since intronic enhancer elements have been reported for the IFNG gene. Oligonucleotides constructed for two third intron variants showed no difference in DNA-binding abilities as compared with wild-type sequences. However, the 3′UTR variant showed the formation of unique DNA-binding complexes to radiolabeled oligonucleotide probes as compared with the wild-type sequence. The influence of a CA-repeat microsatellite on AIDS disease progression in HIV-1 seroconverters was tested by a Cox proportional hazards model. There is no evidence of an association between alleles and infection with HIV-1 or progression to AIDS. We report an invariant proximal human IFNG promoter and the existence of multiple intronic variants and a potentially functional 3′UTR polymorphism.Type of Medium: Electronic ResourceURL: