Search Results - (Author, Cooperation:H. A. Pasolli)
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1Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2011-02-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Carrier Proteins/genetics/metabolism ; *Cell Differentiation ; *Cell Division ; Cells, Cultured ; Epidermis/*cytology ; Female ; Gene Knockdown Techniques ; Keratinocytes/cytology ; Male ; Mice ; Microtubule-Associated Proteins/deficiency/genetics/metabolism ; Nuclear Proteins/deficiency/genetics/metabolism ; Receptors, Notch/genetics/*metabolism ; Signal Transduction ; Skin/cytology/embryology ; Spindle Apparatus/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressC. Y. Chang ; H. A. Pasolli ; E. G. Giannopoulou ; G. Guasch ; R. M. Gronostajski ; O. Elemento ; E. Fuchs
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-02-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Apoptosis ; Cell Differentiation ; Cell Proliferation ; Chromatin Immunoprecipitation ; Endothelin-2/genetics/metabolism ; Epithelial Cells/cytology/metabolism ; Hair/cytology/growth & development ; Hair Color ; Hair Follicle/*cytology/metabolism ; Melanocytes/*cytology/metabolism ; Mice ; NFI Transcription Factors/deficiency/genetics/*metabolism ; Sequence Analysis ; Stem Cell Factor/metabolism ; *Stem Cell Niche ; Stem Cells/*cytology/*metabolismPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 1573-6865Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary The populations of cells which produce immunoreactive growth hormone (GH) and thyroid stimulating hormone (TSH) in the rat pituitary gland do not occur in fixed percentages but vary greatly under different physiological and experimental conditions. These variations can be directly correlated to the levels of stimulation and/or inhibition of the specific secretory activity. In both types of cell, sustained stimulation with trophic hormones or blockage of the feedback mechanisms induces remarkable growth in the specific cell population. Conversely, the interruption or inhibition of the stimulus thwarted the hormonal secretion and caused a massive degeneration of redundant cells. The stimulation of both GH and TSH cells is accompanied by an enhanced secretory activity as judged by their higher concentrations in serum and hypertrophy of the cytoplasmic organelles involved in synthesis and intracellular processing of the hormones. By contrast, interruption of the stimulus is followed by a variable degree of disruption of the cytoplasmic organization, including a sizable degeneration of cells. In stimulated rats, the concentrations of both GH and TSH decreased significantly in pituitary tissue due to mobilization of the hormonal stores contained in secretory granules. On the other hand, the withdrawal of stimuli blocked the hormonal release; this is reflected by the accumulation of both hormones and secretory granules in pituitary tissue. The strict correlation between the size of the GH and TSH populations with stimulation and inhibition of hormonal secretory activity reported in this investigation further supports the critical role played by the cell renewal process in endocrine secretion.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1573-6865Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary The populations of cells which produce immunoreactive growth hormone (GH) and thyroid stimulating hormone (TSH) in the rat pituitary gland do not occur in fixed percentages but vary greatly under different physiological and experimental conditions. These variations can be directly correlated to the levels of stimulation and/or inhibition of the specific secretory activity. In both types of cell, sustained stimulation with trophic hormones or blockage of the feedback mechanisms induces remarkable growth in the specific cell population. Conversely, the interruption or inhibition of the stimulus thwarted the hormonal secretion and caused a massive degeneration of redundant cells. The stimulation of both GH and TSH cells is accompanied by an enhanced secretory activity as judged by their higher concentrations in serum and hypertrophy of the cytoplasmic organelles involved in synthesis and intracellular processing of the hormones. By contrast, interruption of the stimulus is followed by a variable degree of disruption of the cytoplasmic organization, including a sizable degeneration of cells. In stimulated rats, the concentrations of both GH and TSH decreased significantly in pituitary tissue due to mobilization of the hormonal stores contained in secretory granules. On the other hand, the withdrawal of stimuli blocked the hormonal release; this is reflected by the accumulation of both hormones and secretory granules in pituitary tissue. The strict correlation between the size of the GH and TSH populations with stimulation and inhibition of hormonal secretory activity reported in this investigation further supports the critical role played by the cell renewal process in endocrine secretion.Type of Medium: Electronic ResourceURL: