Search Results - (Author, Cooperation:G. Zamboni)

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  1. 1
    N. Waddell ; M. Pajic ; A. M. Patch ; D. K. Chang ; K. S. Kassahn ; P. Bailey ; A. L. Johns ; D. Miller ; K. Nones ; K. Quek ; M. C. Quinn ; A. J. Robertson ; M. Z. Fadlullah ; T. J. Bruxner ; A. N. Christ ; I. Harliwong ; S. Idrisoglu ; S. Manning ; C. Nourse ; E. Nourbakhsh ; S. Wani ; P. J. Wilson ; E. Markham ; N. Cloonan ; M. J. Anderson ; J. L. Fink ; O. Holmes ; S. H. Kazakoff ; C. Leonard ; F. Newell ; B. Poudel ; S. Song ; D. Taylor ; S. Wood ; Q. Xu ; J. Wu ; M. Pinese ; M. J. Cowley ; H. C. Lee ; M. D. Jones ; A. M. Nagrial ; J. Humphris ; L. A. Chantrill ; V. Chin ; A. M. Steinmann ; A. Mawson ; E. S. Humphrey ; E. K. Colvin ; A. Chou ; C. J. Scarlett ; A. V. Pinho ; M. Giry-Laterriere ; I. Rooman ; J. S. Samra ; J. G. Kench ; J. A. Pettitt ; N. D. Merrett ; C. Toon ; K. Epari ; N. Q. Nguyen ; A. Barbour ; N. Zeps ; N. B. Jamieson ; J. S. Graham ; S. P. Niclou ; R. Bjerkvig ; R. Grutzmann ; D. Aust ; R. H. Hruban ; A. Maitra ; C. A. Iacobuzio-Donahue ; C. L. Wolfgang ; R. A. Morgan ; R. T. Lawlor ; V. Corbo ; C. Bassi ; M. Falconi ; G. Zamboni ; G. Tortora ; M. A. Tempero ; A. J. Gill ; J. R. Eshleman ; C. Pilarsky ; A. Scarpa ; E. A. Musgrove ; J. V. Pearson ; A. V. Biankin ; S. M. Grimmond
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-02-27
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adenocarcinoma/drug therapy/genetics ; Animals ; Carcinoma, Pancreatic Ductal/drug therapy/genetics ; *DNA Mutational Analysis ; DNA Repair/genetics ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Markers/genetics ; Genome, Human/*genetics ; Genomic Instability/genetics ; *Genomics ; Genotype ; Humans ; Mice ; Mutation/*genetics ; Pancreatic Neoplasms/classification/drug therapy/*genetics ; Platinum/pharmacology ; Point Mutation/genetics ; Poly(ADP-ribose) Polymerase Inhibitors ; Xenograft Model Antitumor Assays
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    FRANZIN, G. ; ZAMBONI, G. ; DINA, R. ; SCARPA, A. ; FRATTON, A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1983
    Staff View
    ISSN:
    1365-2559
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    A light microscopy and histochemical study of 24 juvenile and 27 inflammatory polyps showed that both may derive from inflammatory processes. Granulation tissue, secondary to spontaneous local inflammation or due to surgical procedures may subsequently be covered by regenerating epithelium which lines haemorrhagic cavities and mucus lakes to form irregular, elongated and cystic glands, which are characteristic of juvenile polyps. Both juvenile and inflammatory polyps showed cystic, metaplastic and ‘transitional-type’ glands. The mucin distribution was identical in both types of polyps. All these findings suggest a common origin of the polyps. The presence of ‘transitional-type’ glands seems to confirm these as a secondary regenerative phenomenon rather than pre-neoplastic, although dysplastic changes in juvenile polyps have been described. It is suggested that both the juvenile and inflammatory polyps may undergo dysplasia only in genetically predisposed subjects. However, this event seems to be very rare.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2559.1983.tb02284.x

    Articles: DFG German National Licenses
  3. 3
    FRANZIN, G. ; GRIGIONI, W.F. ; DINA, R. ; SCARPA, A. ; ZAMBONI, G.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1983
    Staff View
    ISSN:
    1365-2559
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Changes in mucin secretion and increase in height of the colonic mucosa adjacent to colorectal carcinoma (transitional mucosa) have been considered pre-malignant. In this study similar changes (both morphological and histochemical) have been found in some cases of ulcerative colitis and ischaemic colitis, as well as in juvenile, inflammatory and hyperplastic (metaplastic) polyps. ‘Transitional’ patterns of mucin secretion also occur in some other cases of ulcerative colitis, colostomies and Crohn's disease of the colon in which the mucosa has a normal height, suggesting the changes in mucin secretion are independent of mucosal morphology. In all these pathological conditions, hyperplastic (metaplastic) mucosa also coexisted. These findings seem to suggest that: (1) ‘transitional’ changes more likely represent a secondary regenerative phenomenon rather than a premalignant one; (2) the pattern of mucin secretion is not selective enough to serve as a premalignant marker; therefore is not a valid prognostic indicator in colonic biopsies; (3) hyperplastic (metaplastic) changes might derive from ‘transitional’ mucosa as a result of a more mature phase of this exaggerated regenerative phenomenon. However, in some patients longstanding ‘transitional’ mucosa may lead to dysplasia under the influence of environmental and genetic factors.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2559.1983.tb02283.x

    Articles: DFG German National Licenses
  4. 4
    Zamboni, G. ; Jones, C.A. ; Hughes, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0003-2697
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0003-2697(83)90652-8

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    0028-3932
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0028-3932(74)90001-3

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    1436-0691
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Background. Extended pancreaticoduodenectomy (EPD) with retroperitoneal lymphatic, neural, and connective clearance has been proposed to improve survival in patients with carcinomas of the head of the pancreas. The open questions are: does EPD allow better staging of the tumor? Does it reduce local recurrences? And does it improve survival? Method. We treated 26 patients by EPD between January 1994 and September 1996. Eighteen patients had pancreatic ductal carcinoma, 7, periampullary carcinoma; and 1, intraductal papillary mucinous carcinoma. Results. The pancreatic cancers were International Union against Cancer (UICC) stage I in 3 patients, stage III in 14, and stage IV in 1. Two patients with stage III disease would have been considered as having stage I without EPD. Pancreatic cancer and periampullary carcinoma patients had a 3-year actuarial survival of 32% and 86%, respectively. At a mean follow-up time of 22.5 months (range, 6–39 months), 3 pancreatic cancer patients (16.6%) had loco-regional recurrences, 6 patients (33%) had distant metastases, and 1 (5.5%) had distant and loco-regional recurrences. Only 1 of 7 patients with periampullary carcinoma had distant metastasis 20 months after resection. Conclusion. EPD seems to decrease the rate of local recurrences and allows more correct staging. The intermediate survival results are encouraging but a definitive conclusion awaits longer follow-up.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s005340050086

    Articles: DFG German National Licenses
  7. 7
    Zamboni, G. ; Perez, E. ; Parmeggiani, P. L.
    Springer
    Published 1982
    Staff View
    ISSN:
    1420-9071
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Summary In rats adapted to a 12∶12 h light-dark (LD) schedule, cyclic AMP concentration in the preoptic region showed a L minimum and D maximum. No significant fluctuations were observed in the parietal cortex.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01959733

    Articles: DFG German National Licenses
  8. 8
    Amici, R. ; Perez, E. ; Zamboni, G. ; Parmeggiani, P. L.
    Springer
    Published 1990
    Staff View
    ISSN:
    1420-9071
    Keywords:
    cAMP ; sleep ; preoptic area
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Summary cAMP concentration was found to be significantly lower during desynchronized sleep than during synchronized sleep in the preoptic area of rats kept at normal laboratory temperature. No significant changes in cerebral cortex cAMP concentraion were observed in the same experimental conditions.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01955415

    Articles: DFG German National Licenses
  9. 9
    Jones, C.A. ; Zamboni, G. ; Hanley, M.R.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0167-0115
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0167-0115(85)90222-8

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1432-2307
    Keywords:
    Epithelial membrane antigen ; Immunohistochemistry ; Hepatic tumours
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Twenty-two cases of primary hepatic tumours (16 hepatocarcinoma and 6 cholangiocarcinoma) have been studied by immunoperoxidase technique, for the presence of Epithelial Membrane Antigen (EMA). All 6 cases of cholangiocarcinoma showed positive reaction for the presence of EMA while 14 out of 16 hepatocarcinomas were completely negative. In two cases of hepatocarcinoma focal positive cells were present. The results obtained suggest that EMA could be of valuable use, in surgical pathology, for discriminating hepatocarcinoma from cholangiocarcinoma.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00734847

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    1432-2307
    Keywords:
    Pancreas ; Solid-cystic tumour ; Progesterone receptor
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract A role for sex hormones in the pathogenesis of solid-cystic tumour (SCT) of the pancreas is suggested by its predilection for young fertile women. Controversial data have been provided for the presence of progesterone receptors (PR) and/or oestrogen receptors (ER) in SCT. We report the immunohistochemical detection of PR in ten cases of SCT. Eight were from young women. The remaining two were from a post-menopausal woman and a young boy. All cases showed PR immunoreactivity in the large majority of neoplastic cells, whereas none exhibited ER positivity. In one tumour two types of cell populations were noted, the more anaplastic invasivetype being PR negative, whereas the more typical was PR positive. PR immunoreactivity in the absence of ER may simply reflect a lower sensitivity of ER antibody failing to reveal the biochemically detectable ER, or that the PR in cells of SCT are constitutively synthesized in an oestrogen-independent way, as in T47D breast carcinoma cell line, meningioma cells and some gastric cancer cells. Our findings support the hypothesis of a possible pathogenetic role of progesterone in SCT, independent of the patient's sex and age.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01606531

    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1432-2307
    Keywords:
    Pancreatic intraductal tumours ; Grade of dysplasia ; Gastroenteropancreatic markers ; K-ras mutations ; p53 mutations
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Intraductal papillary growth of mucin producting hypersecreting, columnar cells characterizes a group of rare pancreatic exocrine neoplasms which we propose to call intraductal papillary-mucinous tumors (IPMT). We analysed the histopathology of 26 IPMT in relation to gastro-enteropancreatic marker expression, genetic changes and biology. Four IPMT showing only mild dysplasia were considered to be adenomas. Nine tumours displayed moderate dysplasia and were regarded as borderline. Severe dysplasia-carcinoma in situ changes were found in 13 IPMT which were therefore classified as intraductal carcinomas. Six of these carcinomas were frankly invasive and two of these had lymph node metastases. The invasive component resembled mucinous noncystic carcinoma in all but one tumour which showed a ductal invasion pattern. Immunohistochemically, an intestinal marker type was found in most carcinomas, while gastric type differentiation prevailed among adenomas or borderline tumours. K-ras mutations (seven at codon 12 and one at codon 13) were found in 31% of IPMT (2 adenomas, 1 borderline, 5 carcinomas). Nuclear p53 overexpression was detected in 31% of IPMT (6 carcinomas and 2 borderline IPMT) and correlated with p53 mutations (one at exon 8 and the other at exon 5) in two carcinomas. p53 abnormalities were unrelated to K-ras mutation. c-erbB-2 overexpression was observed in 65% of IPMT, with various grades of dysplasia. Twenty-two of 24 patients are alive and well after a mean post-operative follow-up of 41 months. Only two patients, both with invasive cancer at the time of surgery, died of tumour disease. It is concluded that pancreatic IPMT encompass neoplasms which, in general, have a favorable prognosis, but are heterogeneous in regard to grade of dysplasia and marker expression. Adenoma, borderline tumour, intraductal carcinoma and invasive carcinoma can be differentiated. p53 changes but not K-ras mutation or c-erbB-2 overexpression are related to the grade of malignancy. Most IPMT differ in histological structure, marker expression and behaviour from ductal adenocarcinoma.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00189573

    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1432-0509
    Keywords:
    Pancreas, neoplasm ; Pancreas, papillary cystic neoplasm ; Papillary cystic neoplasm, imaging
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract We report a series of 10 papillary cystic neoplasms of the pancreas evaluated in our institution. The lesions are analyzed in retrospect to define the existence of eventual specific imaging patterns as well as to point out the existing problems of differential diagnosis versus other pancreatic tumors.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01256710

    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    1432-1203
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    15q12→15pter or 15pter→15q11::15q13→15pter. Analysis with various techniques of the satellite regions of the bisatellited chromosomes demonstrated maternal derivation in six and paternal derivation in one of the seven families. A nonsister chromatid exchange between the two homologous chromosomes 15 is considered a likely origin of the inv dup(15) in the cases with maternal derivation; in the only case of paternal derivation, however, the abnormal chromosome originated from one single chromosome 15. The clinical findings confirm that patients with inv dup(15) have mental and developmental retardation and are frequently affected by seizures, while severe physical malformations are absent.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00281681

    Articles: DFG German National Licenses
  15. 15
    Zamboni, G. ; Perez, E. ; Amici, R. ; Parmeggiani, P. L.
    Springer
    Published 1990
    Staff View
    ISSN:
    1432-1106
    Keywords:
    Cyclic AMP ; dl-Propranolol ; Wake-sleep cycle ; Preoptic region ; Hypoxia ; Rat
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The short-term effects of the intraperitoneal administration of dl-propranolol on the wake-sleep cycle of the rat were studied in relation to the cyclic AMP concentration in the preoptic region and cerebral cortex. The results show that propranolol, but not saline, affected all stages of the wake-sleep cycle, increasing wakefulness, decreasing synchronized sleep and abolishing desynchronized sleep. These effects were associated with a decrement in cyclic AMP concentration both in wakefulness and synchronized sleep. However, this decrement was relatively larger in the preoptic region than in the cerebral cortex. The effects of the drug on cyclic AMP accumulation were also studied in hypoxia, a condition of unspecific brain stimulation. In this condition, the cyclic AMP concentration in both brain regions was found to be higher than that observed during either wakefulness or synchronized sleep. In the hypoxic condition propranolol was found to decrease the nucleotide concentration to the same levels observed in wakefulness and synchronized sleep following its administration. However, no difference in the relative magnitude of the decrement was found between the preoptic region and the cerebral cortex. These findings suggest that in both brain regions the drug acts on a cyclic AMP accumulating system, which may be defined as propranololsensitive. The activity of the propranolol-sensitive system in the preoptic region would appear to be related to wake-sleep processes.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00230106

    Articles: DFG German National Licenses
  16. 16
    Parmeggiani, P. L. ; Zamboni, G. ; Perez, E. ; Lenzi, P.
    Springer
    Published 1984
    Staff View
    ISSN:
    1432-1106
    Keywords:
    Hypothalamic temperature ; Blood flow ; Desynchronized sleep ; Heat loss ; Thermogenesis
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The influence of changes in heat loss at specific heat exchangers, appraised by recording ear skin temperature (Ts), on the hypothalamic temperature (Thy) rise during desynchronized sleep (DS) was studied in unrestrained cats at different ambient temperatures (Ta). The correlations of initial and final Thy changes (ΔiThy and ΔfThy) with initial and final Ts changes (ΔiTs and ΔfTs), respectively, are statistically not significant. However, a significant negative correlation was found between ΔfiThy, i.e. ΔfThy-ΔiThy, and ΔfiTs, i.e. ΔfTs-ΔiTs. The latter result shows that only after its initial rise is Thy affected by changes in heat loss at specific heat exchangers during DS. Accordingly, ΔfThy and ΔfiThy are positively correlated with Ta. However, also ΔiThy, although not affected by heat loss changes at specific heat exchangers, shows a positive correlation with Ta. On the basis of these results and of the data in the literature, it is concluded that three independent factors underlie Thy changes during DS, namely heat loss at specific heat exchangers, hypothalamic blood flow and thermogenesis.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00236232

    Articles: DFG German National Licenses
  17. 17
    Perez, E. ; Zamboni, G. ; Parmeggiani, P. L.
    Springer
    Published 1982
    Staff View
    ISSN:
    1432-1106
    Keywords:
    cAMP ; Preoptic region ; Cerebral cortex ; Thermoregulation ; Sleep
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary cAMP concentrations in the preoptic region and cerebral cortex were studied in rats during exposure to low ambient temperature (−10 ° C) and after return to control ambient temperature (22 ° C). Significant changes in cAMP concentration were found only in the preoptic region. On prolonged exposure to low ambient temperature the nucleotide concentration decreased and the circadian rhythm, observed in control conditions, disappeared. Return to control ambient temperature after exposure to low ambient temperature induced a steep increase and a long-lasting plateau in cAMP concentration. The results are discussed in terms of interaction between thermoregulatory and sleep-wakefulness processes.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00235892

    Articles: DFG German National Licenses
  18. 18
    Staff View
    ISSN:
    1432-1963
    Keywords:
    Schlüsselwörter Pankreastumoren ; Sarkome ; PNET ; Key words Pancreatic tumors ; Sarcomas
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Summary Nonepithelial malignant tumors of the pancreas are extremely rare neoplasms with a frequency of ∼0,6%. They are always explored because of a suspected diagnosis of pancreatic carcinoma. Amongst the more than 600 primary pancreatic neoplasms in our pancreatic tumor archive only 5 neoplasms were of nonepithelial origin (one was a malignant peripheral nerve sheath tumor [MPNST], one a leiomyosarcoma, one a malignant mesothelioma, and two were peripheral neuroectodermal tumors [PNET]. The differential diagnosis includes secondary infiltration of the pancreas by mesenchymal tumors of the retroperitoneum, undifferentiated pancreatic carcinoma and, especially in the case of PNET, malignant lymphoma. Preoperative chemotherapy and down-staging can improve the operability and prognosis, especially in PNET.
    Notes:
    Zusammenfassung Nichtepitheliale maligne Tumoren des Pankreas sind mit einer Häufigkeit von ∼0,6% eine Rarität unter Pankreasneoplasien. Sie werden immer unter der Verdachtsdiagnose eines Pankreaskarzinoms exploriert. Von über 600 primären Pankreasneoplasien des vorliegenden Pankreastumorarchivs waren lediglich 5 Malignome nichtepithelialer Genese: ein maligner peripherer Nervenscheidentumor [MPNST], ein Leiomyosarkom, ein malignes Mesotheliom, 2 periphere neuroektodermale Tumoren [PNET]. Die Differentialdiagnose umfaßt eine sekundäre Infiltration des Pankreas durch mesenchymale Tumoren des Retroperitoneums, undifferenzierte Pankreaskarzinome und speziell für den PNET maligne Lymphome. Durch eine präoperative Chemotherapie und Downstaging kann im Falle des PNET Operabilität und eine Verbesserung der Prognose erzielt werden.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002920050211

    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1432-1076
    Keywords:
    First feed ; Newborn ; Insulin ; Glucagon ; C-peptide
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Blood glucose, insulin, C-peptide and glucagon were evaluated in 36 newborn term infants at birth, and before and 60 min after the first feed during the first day of life. Under basal conditions glycaemia diminished during the first day of life and glucagon increased, while insulin and C-peptide did not show any variation. The C-peptide: insulin molar ratio was higher in the newborn than in adults because of the longer half-life of C-peptide, probably due to reduced renal function in the neonatal period. The subjects were divided into two groups: 18 newborn infants were given a feed of commercially available milk powder reconstituted in water at 10% (5 ml/kg); the other 18 were given a feed of 5 ml/kg 10% glucose solution. In each group 6 were given the first feed after a fast of 6 h, 6 after a fast of 12 h, and 6 after a fast of 24 h from birth. After the first feed with milk, the average increase of glycaemia was 19.83 mg%, of insulin 6.06 μU/ml, and of C-peptide 1.88 ng/ml. After the first feed with glucose the average increase of glycaemia was 13.59 mg%, of insulin 2.46 μU/ml, and of C-peptide 0.59 ng/ml. Glucagon did not show significant changes after the first feed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00442435

    Articles: DFG German National Licenses
  20. 20
    Zamboni, G. ; Cecchettin, M. ; Zoppi, G.
    Springer
    Published 1978
    Staff View
    ISSN:
    1432-1076
    Keywords:
    Chronic renal failure ; Parathyroid hormone ; Calcitonin ; Urinary hydroxyproline ; Urinary cyclic AMP
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract In six infants aged between 4 and 8 months with chronic renal failure, we have studied blood levels of calcium (Ca), phosphorus (P), alkaline phosphatase, immunoreactive parathyroid hormone (PTH), and calcitonin (CT), as well as urinary excretion of Ca, P, hydroxyproline and cyclic AMP under basal conditions and during an infusion of 20 mg/kg of 10% Ca gluconate in normal saline over 4 h. Under basal conditions four infants had normal serum Ca and P values, alkaline phosphatase levels at the upper limit of normal, and very high PTH (range: 1450–2550 pg Eq/ml) and CT (range: 700–1900 pg/ml) levels. The urinary Ca excretion was low, whereas the urinary excretion of P, hydroxyproline and cyclic AMP was high. During Ca infusion, the total serum Ca and CT levels increased, PTH fell without however reaching the normal upper limit, and urinary P and cyclic AMP excretion decreased. In two infants with osteodystrophy and the highest levels of PTH (2900 and 3500 pg Eq/ml respectively) there was no suppression of PTH during Ca infusion.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00442162

    Articles: DFG German National Licenses