Search Results - (Author, Cooperation:G. Tsujimoto)

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  1. 1
    Y. Yamaguchi ; T. Suzuki ; Y. Mizoro ; H. Kori ; K. Okada ; Y. Chen ; J. M. Fustin ; F. Yamazaki ; N. Mizuguchi ; J. Zhang ; X. Dong ; G. Tsujimoto ; Y. Okuno ; M. Doi ; H. Okamura
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-10-05
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Antidiuretic Hormone Receptor Antagonists ; Body Temperature/genetics ; CLOCK Proteins/genetics ; Cell Communication/drug effects/genetics ; Cells, Cultured ; Circadian Rhythm/genetics ; Gene Expression Regulation ; Jet Lag Syndrome/*genetics/physiopathology ; Mice ; Mice, Knockout ; Motor Activity/genetics ; Receptors, Vasopressin/*genetics ; Suprachiasmatic Nucleus/physiopathology
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2012-02-22
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adipocytes/metabolism/pathology ; Adipogenesis ; Adipose Tissue/metabolism/pathology ; Animals ; Calcium Signaling ; Cell Differentiation ; DNA Mutational Analysis ; Diet, High-Fat ; Energy Metabolism ; Europe/ethnology ; European Continental Ancestry Group/genetics ; Exons/genetics ; Fatty Liver/complications/genetics ; Gene Expression Regulation ; Glucagon-Like Peptide 1/secretion ; Glucose/metabolism ; Glucose Intolerance/complications ; Humans ; Insulin/metabolism ; Insulin Resistance ; Lipogenesis ; Liver/metabolism ; Macrophages/metabolism ; Mice ; Mutation/genetics ; Obesity/complications/genetics/*metabolism/pathology ; Receptors, G-Protein-Coupled/deficiency/genetics/*metabolism ; Signal Transduction/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    ISSN:
    1474-8673
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Chemistry and Pharmacology
    Medicine
    Notes:
    1 We have characterized the α1-adrenoceptor subtypes present in isolated aorta of the α1D-adrenoceptor knockout (KO) mice, by chloroethylclonidine (CEC)-induced alkylation and their protection by selective α1-adrenoceptor antagonists. 2 The α1D-adrenoceptor is involved in the contractile response to noradrenaline in wild type (WT) mouse aorta. 3 In WT mice 5-methylurapidil (5-MU, an α1A-adrenoceptor antagonist) or BMY 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl]-8-azaspiro[4.5] decane-7,9 dione, a selective α1D-adrenoceptor antagonist), protected the receptors from CEC-induced (α1B/D-adrenoceptor) alkylation, the combination of both antagonists resulted in complete protection, while AH11110A (1-[biphenyl-2-yloxy]-4-imino-4-piperidin-1-yl-butan-2-ol, an α1B-adrenoceptor antagonist) did not protect. 4 In aorta of KO mice there was a 19-fold rightward shift in noradrenaline effective concentration (EC50) compared with WT; while 5-MU alone or in combination with AH11110A protected α1-adrenoceptors to the same extent. 5 The data indicate that α1A-adrenoceptors mediate contraction and suggest their role in maintaining homeostasis in the α1D-adrenoceptors KO mice.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1474-8673.2005.00348.x

    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/bbrc.1994.1504

    Articles: DFG German National Licenses
  5. 5
    Hirasawa, A. ; Shibata, K. ; Kotosai, K. ; Tsujimoto, G.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/bbrc.1994.2150

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/bbrc.1993.2130

    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/bbrc.1994.2864

    Articles: DFG German National Licenses
  8. 8
    Tsujimoto, A. ; Tsujimoto, G. ; Hoffman, B.B.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0047-6374
    Keywords:
    Adrenergc receptors ; Aging ; Glycogen phosphorylase ; Liver
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0047-6374(86)90025-4

    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    1432-1041
    Keywords:
    theophylline ; smoking ; sustained release formulation ; dosage forms ; multidose pharmacokinetics ; bioavailability ; circadian variation in kinetics
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Medicine
    Notes:
    Summary The pharmacokinetics and bioavailability of theophylline following 10 days of multiple doses of a plain uncoated (640 mg, q.i.d.) and a sustained-release tablet formulation (600 mg, b.i.d.) were related to habitual smoking in 11 healthy adult male volunteers, who had previously taken part in a single-dose study of an intravenous preparation of theophylline and of the same oral dosage form. There were significant differences (p〈0.05 to 0.01) in the steady-state mean and minimum theophylline concentration and AUC between the groups (6 smokers versus 5 nonsmokers), but not between other variables. A difference (p〈0.05) in peak time was also found between the dosage forms. The mean elimination t1/2 was significantly (p〈0.05) shorter in smokers than in nonsmokers. The intersubject variability in plasma theophylline concentration observed on the final trial day in the smoking group was larger and diverged more from simulation curves generated from the mean pharmacokinetic parameters of the single-dose study of the same formulations as compared to that of the nonsmoking group. There was no significant difference between the two groups in the mean accumulation ratio and absolute bioavailability of the two dosage forms. The mean morning (7 a.m.) trough theophylline concentrations after both formulations were significantly (p〈0.05 to 0.01) greater than the evening (7 p.m.) values within the same group. The average number of reported side-effects was significantly (p〈0.001) greater during the earlier period (Days 1 to 3) than the later period of the trial. A trend was observed suggesting that the incidence of side-effects was less in smokers than in nonsmokers. The results indicate that smoking is a determinant not only of enhanced elimination of theophylline but that it also produces more variability in the plasma level, irrespective of the dosage form administered or the dosing scheme employed. There may be circadian variation in theophylline kinetics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00610056

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1435-232X
    Keywords:
    Key words PEPD ; Prolidase deficiency ; Mutation ; Polymorphism ; Nonsense mutation
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract A nonsense mutation at amino acid residue 184 in the human peptidase D (PEPD) gene caused the production of a truncated polypeptide. Characterizing molecular defects in patients provides clues to elucidate the relationship between the phenotype and the genotype.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s100380050023

    Articles: DFG German National Licenses