Search Results - (Author, Cooperation:G. Stoll)
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1Latest Papers from Table of Contents or Articles in PressE. Vacchelli ; Y. Ma ; E. E. Baracco ; A. Sistigu ; D. P. Enot ; F. Pietrocola ; H. Yang ; S. Adjemian ; K. Chaba ; M. Semeraro ; M. Signore ; A. De Ninno ; V. Lucarini ; F. Peschiaroli ; L. Businaro ; A. Gerardino ; G. Manic ; T. Ulas ; P. Gunther ; J. L. Schultze ; O. Kepp ; G. Stoll ; C. Lefebvre ; C. Mulot ; F. Castoldi ; S. Rusakiewicz ; S. Ladoire ; L. Apetoh ; J. M. Bravo-San Pedro ; M. Lucattelli ; C. Delarasse ; V. Boige ; M. Ducreux ; S. Delaloge ; C. Borg ; F. Andre ; G. Schiavoni ; I. Vitale ; P. Laurent-Puig ; F. Mattei ; L. Zitvogel ; G. Kroemer
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-10-31Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Animals ; Annexin A1/metabolism/pharmacology ; Anthracyclines/*therapeutic use ; Breast Neoplasms/drug therapy/immunology ; Cell Line, Tumor ; Chemotherapy, Adjuvant ; Colorectal Neoplasms/drug therapy/immunology ; Dendritic Cells/drug effects/immunology ; Female ; Humans ; Immunity, Innate/genetics ; Leukocytes/drug effects/immunology ; Mice ; Neoplasms/*drug therapy/*immunology ; Polymorphism, Single Nucleotide ; Receptors, Formyl Peptide/genetics/*physiology ; T-Lymphocytes/immunologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressMöhrmann, L., Huang, H. J., Hong, D. S., Tsimberidou, A. M., Fu, S., Piha-Paul, S. A., Subbiah, V., Karp, D. D., Naing, A., Krug, A., Enderle, D., Priewasser, T., Noerholm, M., Eitan, E., Coticchia, C., Stoll, G., Jordan, L.-M., Eng, C., Kopetz, E. S., Skog, J., Meric-Bernstam, F., Janku, F.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-01-04Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
3Articles: DFG German National LicensesGranet, M. ; Stoll, G. ; Dorel, J. ; Achauer, U. ; Poupinet, G. ; Fuchs, K.
Oxford, UK : Blackwell Publishing Ltd
Published 1995Staff ViewISSN: 1365-246XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: GeosciencesNotes: The Massif Central, the most significant geomorphological unit of the Hercynian belt in France, is characterized by graben structures which are part of the European Cenozoic Rift System (ECRIS) and also by distinct volcanic episodes, the most recent dated at 20 Ma to 4000 years BP. In order to study the lithosphere-asthenosphere system beneath this volcanic area, we performed a teleseismic field experiment.During a six-month period, a joint French-German team operated a network of 79 mobile short-period seismic stations in addition to the 14 permanent stations. Inversion of P-wave traveltime residuals of teleseismic events recorded by this dense array yielded a detailed image of the 3-D velocity structure beneath the Massif Central down to 180 km depth. The upper 60 km of the lithosphere displays strong lateral heterogeneities and shows a remarkable correlation between the volcanic provinces and the negative velocity perturbations. The 3-D model reveals two channels of low velocities, interpreted as the remaining thermal signature of magma ascent following large lithospheric fractures inherited from Hercynian time and reactivated during Oligocene times. The teleseismic inversion model yields no indication of a low-velocity zone in the mantle associated with the graben structures proper. The observation of smaller velocity perturbations and a change in the shape of the velocity pattern in the 60–100 km depth range indicates a smooth transition from the lithosphere to the asthenosphere, thus giving an idea of the lithosphere thickness. A broad volume of low velocities having a diameter of about 200 km from 100 km depth to the bottom of the model is present beneath the Massif Central. This body is likely to be the source responsible for the volcanism. It could be interpreted as the top of a plume-type structure which is now in its cooling phase.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1752-1688Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Architecture, Civil Engineering, SurveyingGeographyNotes: Aerial photogrammetric techniques were developed and tested for identifying and classifying river-based recreation sites. A classification system was designed to describe the nature of the land itself, the land use, or the vegetation on the landscape. The Connecticut, a large river running through four states, was examined and classified using the system. Analysis of two sets of aerial photographs taken with a time lapse of ten to thirteen years enabled determination of past use and development trends. A catalogue of maps classifying strips of land adjacent to the river was prepared and reproduced for use by interested planning agencies. Statistics on land area by types for the river as it now is and as it was ten to thirteen years previously have been prepared by towns, counties, and states. The aerial photographs proved invaluable for analyzing the recreational potential of the Connecticut River.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStoll, G. ; Jander, S. ; Sitzer, M. ; Müller, W. ; Sandmann, W. ; Siebler, M.
Springer
Published 2000Staff ViewISSN: 1433-0407Keywords: Schlüsselwörter Karotisstenose ; Mikroembolien ; T-Zellen ; Tissue-Faktor ; Matrixmetalloproteinase ; Keywords Carotid artery stenosis ; Microemboli ; T cells ; Tissue factorSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Summary Arterioarterial thromboembolism from extracranial internal carotid artery (ICA) stenosis is an important pathogenic mechanism of ischemic stroke. However, even a high-grade ICA stenosis carries a greatly variable annual risk of stroke, as high as 13% following a recent occurrence of transient or minor cerebral ischemia or as low as 1–2% in clinically asymptomatic patients. There is increasing evidence that inflammatory processes play a central role in atherosclerosis and particularly in plaque destabilization converting chronic atherosclerosis into an acute neurological disorder. In thromboendarterectomy specimens from patients with high-grade ICA stenoses, the extent of inflammatory infiltration and the expression of matrixmetalloproteinase-9 correlated to clinical and ultrasonic features of plaque destabilization such as cerebral microembolism. Inflammation might become a new therapeutic target in symptomatic carotid artery disease.Notes: Zusammenfassung Arterioarterielle Thrombembolien aus extrakraniellen Stenosen der A. carotis interna (ACI) stellen eine häufige Ursache zerebraler Ischämien dar. Dabei ist das Schlaganfallrisiko nicht ausschließlich vom Stenosegrad abhängig: Hochgradige (〉70%ige) ACI-Stenosen haben ein jährliches Schlaganfallrisiko von 13%, wenn sie innerhalb von 6 Monaten symptomatisch waren, gegenüber nur 1–2% bei zuvor asymptomatischen Stenosen. Die Pathomechanismen, die aus einem chronischen arteriosklerotischen Karotisplaque eine akute neurologische Erkrankung im Sinne der Plaquedestabilisierung machen, sind weitgehend unklar. Es gibt zunehmende Hinweise darauf, dass Entzündungsprozesse an der Entstehung der Arteriosklerose generell und der Plaquedestablisierung im Besonderen beteiligt sind. Anhand von Gefäßpräparaten nach Karotisthrombendarteriektomien konnte gezeigt werden, dass das Ausmaß der T-Zell- und Makrophageninfiltration in der Gefäßwand und die Expression von Matrixmetalloproteinasen mit klinischen und sonologischen Zeichen der Plaquedestabilisierung im Sinne von Mikroembolien korreliert. Damit ergeben sich möglicherweise neue antiinflammatorische Therapieansätze bei symptomatischen Karotisprozessen.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0931-8658Topics: EconomicsNotes: BuchbesprechungenURL: -
7Articles: DFG German National LicensesBraun, J. S. ; Jander, Sebastian ; Schroeter, Michael ; Witte, Otto W. ; Stoll, G.
Springer
Published 1996Staff ViewISSN: 1432-0533Keywords: Key words Focal ischemia ; Apoptosis ; Necrosis ; Inflammation ; T cellsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract In this study we examined the time course of apoptotic cell death after photochemically induced focal ischemia of the rat cerebral cortex. For unequivocal differentiation between apoptosis and necrosis two criteria of programmed cell death were used: terminal deoxyribonucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) and morphological evidence of fragmentation and marginalization of nuclei. After photothrombosis, many TUNEL-positive cells were found within the infarct region from 12 h to 3 days. By day 6 they were preferentially located in the boundary zone of the infarct, and by day 14 they had disappeared. A high proportion of TUNEL-positive cells displayed fragmentation or marginalization of their nuclei, indicating apoptosis. Neurons, but not T cells and macrophages, were apoptotic. Inflammatory infiltrates were in close contact to apoptotic neurons throughout the infarct areas at day 1 and in the boundary zone between days 2 and 6 after photothrombosis. In summary, our study shows that neuronal apoptosis after cerebral ischemia is a prolonged process to which leukocyte-derived cytokines may contribute. In contrast to autoimmune diseases of the nervous system, termination of the local inflammatory response after cerebral ischemia does not involve apoptosis.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1573-7381Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Nerve growth factor receptor, expressed in Schwann cells during early development of the PNS, is rarely found in the normal mature PNS. Following nerve transection nerve growth factor receptor is re-expressed at high levels in the Schwann cells of the denervated nerve fibres. In this study we asked if demyelination caused by an immune-mediated process or by physical destruction of myelin is associated with expression of nerve growth factor receptor, and if so, what cells are positive. We examined spinal roots and sciatic nerves from rats with experimental autoimmune neuritis and sciatic nerves from rats with focal demyelination produced by local application of lysolecithin. Both in 1 μm serial cryosections and in immunostained teased nerve fibres we found that the Schwann cells that were associated with demyelinated internodes expressed nerve growth factor receptor. Immunoreactivity for nerve growth factor receptor appeared first in a perinuclear ring, probably corresponding to the Golgi complex. In completely demyelinated internodes the postmitotic Schwann cells ensheathing the axons expressed nerve growth factor receptor on their plasmalemmae. Neighbouring Schwann cells with intact myelin sheaths remained nerve growth factor receptor negative. In contrast, Schwann cells of neighbouring unmyelinated fibres expressed prominent nerve growth factor receptor immunoreactivity. These data further indicate that expression of nerve growth factor receptor by Schwann cells does not require axonal degeneration, but can be stimulated by some factor associated with acute demyelination.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1573-7381Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary This study examined the role of Schwann cells and hematogenous macrophages in myelin degradation and Ia antigen expression during Wallerian degeneration of rodent sciatic nerve. To identify and distinguish between macrophages and Schwann cells we used, in addition to electron microscopy, immunocytochemical staining of teased nerve fibres and 1 μm thick cryosections. Before the appearance of adherent macrophages the myelin sheath fragmented into ovoids, small whorls of myelin debris appeared within Schwann cell cytoplasm and the Schwann cell displayed numerous lipid droplets. However, at least in large fibres most myelin degradation and removal was accomplished or assisted by macrophages, identified by their expression of the ED1 marker. These cells began entering the nerve from blood vessels by day 2, migrated to degenerating nerve fibres and adhered to nerve fibres in the regions of the ovoids. There they penetrated the Schwann cell basal lamina to occupy an intratubal position and phagocytose myelin. During Wallerian degeneration a subpopulation of ED1-positive monocytes/macrophages expressed Ia antigen; Schwann cells were Ia-negative. Ia expression by monocytes/macrophages appeared to be a transient event and was not seen in post-phagocytic macrophages, as indicated by the fact that ED1-positive phagocytes with large vacuoles were Ia-negative. Our data show that both Schwann cells and macrophages play important roles in degrading and removing myelin during Wallerian degeneration. The expression of Ia antigen during Wallerian degeneration indicates that Ia expression need not necessarily reflect specific immune events but in some instances can represent a nonspecific response to PNS damage.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1435-1463Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung 1. Wir haben versucht, eine Methode zu entwickeln, die uns gestattet, gültige Calcium-Bilanzen auszustellen. Die erworbene Erfahrung hat uns das Interesse gezeigt, welches an unserer Verfahrensweise genommen wird. 2. Das Studium der Calcium-Bilanz scheint uns angezeigt, um die Hyperparathyreose klarzustellen, wenn sie, was häufig der Fall ist, einer einfachen Blut-Calcium- und-Phosphor-Probe ausweicht. 3. Eine einwandfrei negative Calcium-Bilanz stellt dann die hyperparathyroide Natur der gegenständlichen Affektion fest. 4. Bei derLithiasis urinaria scheint uns die mittels Studium der Calcium-Bilanzen festgestellte Hyperparathyreose nach einer Erfahrung von 7 Fällen häufig (4 auf 7) aber nicht konstant. 5. Bei derPolyarthritis chronica deformans et ankylotica haben wir in 4 Fällen 2 einwandfrei positive Bilanzen beobachtet; eine war praktisch normal (9,2%) und eine leicht negativ (−17,2%). 6. Mehr oder weniger positive Bilanzen wurden in 2 Fällen Raynaudscher Krankheit und bei der Lobsteinschen Krankheit gefunden. 7. Eine ganze Reihe anderer, genügend verschiedener Fälle wurde mittels der Bilanzen, die teils negativ, teils positiv, teils normal waren, studiert. 8. Es ist zu früh, um daraus eine definitive Schlußfolgerung zu ziehen; aber vorläufig wollten wir die Aufmerksamkeit auf eine Methode zur Exploration der parathyroiden Funktion lenken, die, trotz der Kompliziertheit der Messungen, welche sie mit sich bringt, in größerem Maßstab versucht zu werden verdient.Abstract: Summary 1. We have attempted to develop a method which permits us to draw up valid calcium balances. The experience made has shown to us the interest taken in our proceedings. 2. In our opinion, the study of the calcium balance is indicated for the purpose of revealing hyperparathyreosis, when it evades the simple examination of blood calcium and phosphor, which is frequently the case. 3. Then a clearly negative calcium balance establishes the hyperparathyroid nature of the affection in question. 4. In the case ofurinary lithiasis the hyperparathyreosis revealed by the study of calcium balances seems to us after an experience made in 7 cases, to be frequent (in 4 cases out of 7) but not constant. 5. In 4 cases ofchronic deforming and ankylotic polyarthritis we have found 2 clearly positive balances. One was practically normal (9,2%) and one slightly negative (−17,2%). 6. More or less positive balances have been observed in 2 cases of Raynaud disease and in the Lobstein disease. 7. A whole series of other sufficiently different cases has been studied with the aid of balances which were partly negative, partly positive, and partly practically normal. 8. It is too soon for drawing a definite conclusion, but for the present we wanted to call the reader's attention to a method which is apt to reveal the parathyroid function which, in spite of the complexity of measurements required, seems to deserve to be attempted on a larger scale.Notes: Conclusions 1. Nous avons essayé de mettre au point une méthode nous permettant de dresser des bilans calciques valables. L'expérience acquise nous a démontré l'intérêt qui s'attache à notre façon de procéder. 2. L'étude du bilan calcique nous semble indiquée pour déceler l'hyperparathyroïdie lorsque celle-ci échappe, ce qui est fréquent, à l'examen simple du calcium et du phosphore sanguin. 3. Un bilan calcique franchement négatif établit alors la nature hyperparathyroïdienne de l'affection en cause. 4. Dans la lithiase urinaire, l'hyperparathyroïdie relevée par l'étude des bilans calciques nous paraît après une expérience de 7 cas fréquente (4 fois sur 7), mais non constante. 5. Dans la polyathrite chronique déformante et ankylosante, nous avons trouvé sur 4 cas, 2 bilans franchement positifs; 1 pratiquement normal (9,2%) et 1 légèrement négatif (−17,2%). 6. Des bilans plus ou moins positifs ont été observés, dans deux cas de maladie de Raynaud et dans la maladie de Lobstein. 7. Toute une série d'autres cas, assez disparates ont été étudiés avec des bilans tontôt négatifs, tantôt positifs, tantôt pratiquement normaux. 8. Il est trop tôt pour en tirer une conclusion définitive; mais dès maintement nous avons voulu attirer l'attention sur une méthode d'exploration de la fonction parathyroïdienne qui, malgré la complexité des dosages qu'elle comporte, paraît mériter d'être essayée sur une plus vaste échelle.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesHäusler, K. G. ; Hobisch, G. ; Hummel, K. ; Stoll, G. ; Reinhold, G. ; Wartewig, S.
Weinheim : Wiley-Blackwell
Published 1991Staff ViewISSN: 0323-7648Keywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyPhysicsDescription / Table of Contents: Examination of 1,4-cis-polybutadiene crosslinked by irradiation yielded a decrease of the cleavage products 1,4-butadiene and 4-vinylcyclohexene in the pyrograms, which was up to ten times greater than expected from the reaction mechanism assumed so far and from results obtained by measurements of the modulus of compression. This drastical reduction of the main cleavage products can only be attributed to a correspondingly large reduction of the double bonds in the polybutadiene with increasing crosslinking. It could be demonstrated by metathesis degradation combined with GC/MS coupling and examination by Raman spectroscopy that the degree of degradation and the number of C—C double bonds decrease in the same way with increasing dosis of irradiation and network density. The crosslinking of 1,4-cis-polybutadiene thus proceeds by the splitting of the double bonds with subsequent short-chain polymerization and leads to the formation of junction points with f 〉 10.Notes: Pyrolysegaschromatographische Untersuchungen von mit β-Strahlen vernetztem 1,4-cis-Polybutadien ergaben eine bis zu zehnfach größere Abnahme der Spaltprodukte 1,4-Butadien und 4-Vinylcyclohexen als sie nach Ablauf eines bisher angenommenen Reaktionsmechanismus und den Ergebnissen der Kompressionsmodulmessungen auftreten dürfte. Diese drastische Verringerung der Hauptspaltprodukte kann nur auf eine entsprechend große Abnahme der Doppelbindungen im Polybutadien mit zunehmender Vernetzung zurückgeführt werden. Durch Metatheseabbau in Kombination mit einer GC/MS-Kopplung und ramanspektroskopische Untersuchungen konnte gezeigt werden, daß der Abbaugrad und die C=C-Doppelbindungen in gleicher Weise mit zunchmender Strahlendosis und Netzwerkdichte abnehmen. Die strahlenchemische Vernetzung von 1,4-cis-Polybutadien erfolgt damit über die Aufspaltung der Doppelbindungen mit einer sich anschließenden Kurzkettenpolymerisation und führt zur Bildung von Netzknoten mit einer Funktionalität f 〉 10.Additional Material: 10 Ill.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesSchick, C. ; Fabry, F. ; Schnell, U. ; Stoll, G. ; Deutschbein, L. ; Mischok, W.
Weinheim : Wiley-Blackwell
Published 1988Staff ViewISSN: 0323-7648Keywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyPhysicsDescription / Table of Contents: PETP samples were crystallized in different manner, and the resulting lamellar structures were investigated by X-ray diffraction, DSC, NMR, und Raman spectroscopy. In dependence on the crystallization conditions, lamellar thicknesses between 1.5nm and 2.5nm, rigid amorphous regions (interface) of about 2nm, and mobile amorphous regions with 1 nm to 3 nm were obtained. In the latter ones the rearrangement processes take place which are connected with the thermal glass transition. The thicknesses of these regions are related to the correlation length of the rearrangement processes determined via the glass transitions.Notes: Mit Röntgenbeugungs-, kalorimetrischen, NMR- und ramanspektroskopischen Untersuchungen werden Aussagen zur lamellaren Struktur von unterschiedlich kristallisierten PETP-Proben gemacht. Die verwendeten Kristallisations-regime ergeben Lamellendicken von 1,5 nm bis 2,5 nm, starre amorphe Bereiche (Randschichten) von etwa 2 nm und beweglich amorphe Bereiche von 1 nm bis 3 nm, in denen die mit dem thermischen Glasübergang verknüpften Umlagerungsprozesse ablaufen. Die Dicke dieser Bereiche entspricht den aus den Glasübergängen ermittelten Korrelationslängen der Umlagerungsprozesse.Additional Material: 6 Ill.Type of Medium: Electronic ResourceURL: