Search Results - (Author, Cooperation:G. Rossi)

2018-06-05

Nature Publishing Group (NPG)

2041-4889

Biology

Medicine

2018-05-26

BMJ Publishing Group

0022-2593

1468-6244

Medicine

Editor's choice

2018-02-10

Rockefeller University Press

0022-1007

1540-9538

Medicine

Leukemia & Lymphoma

2016-03-19

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Bacterial Infections/genetics/immunology ; Dinoprostone/*immunology ; Gene Expression ; Humans ; Immunity, Innate ; Inflammation/drug therapy/*immunology/microbiology ; Interleukins/*immunology ; Intestines/*immunology/microbiology ; Lymphocytes/*immunology ; Mice ; Receptors, Prostaglandin E, EP4 Subtype/antagonists & ; inhibitors/genetics/*immunology ; Signal Transduction

2012-04-21

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

*Altitude ; *Biodiversity ; Climate ; *Ecosystem ; Europe ; Geological Phenomena ; *Plants

2018-03-06

Oxford University Press

1525-2167

1532-2114

Medicine

2018-05-24

Royal Society

2054-5703

Natural Sciences in General

behaviour, psychology, cognition

2018-08-03

American Society of Hematology (ASH)

0006-4971

1528-0020

Biology

Medicine

Red Cells, Iron, and Erythropoiesis, Clinical Trials and Observations

2018-02-02

The American Association for Cancer Research (AACR)

1078-0432

1557-3265

Medicine

2018-04-26

The Company of Biologists

0950-1991

1477-9129

Biology

Cardiovascular development and regeneration, Neural development

2018-11-24

Institute of Physics Publishing (IOP)

1748-0221

Physics

1089-7690

AIP Digital Archive

Physics

Chemistry and Pharmacology

Conformational disorder plays an important role in determining the electronic properties of conjugated polymers. To obtain a better theoretical description of the role and extent of conformational disorder, we derive the π electron correlation length and the bond correlation length in terms of the effective torsional potential and geometry of the conjugated polymer chains. These quantites are related to the conjugation lengths and persistence lengths of the chain, which are computed for polyacetylene, polydiacetylene, polythiophene, and polypyrrole. In spite of uncertainties in the torsional potential parameters for these materials, good qualitative agreement is found between experiment and theory.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

In this article, a new dynamic calibration technique for sensors used to measure flow temperature is developed. The technique is based on laser heating of the sensor and allows one to operate in situ when optical access to the sensor is provided and the flow is transparent to laser light. It is possible to obtain both the time constant of the sensor and the convective heat exchange coefficient. Laboratory tests performed inside a wind tunnel, have shown the reliability and the advantage of such a technique. It is also possible to reduce the uncertainty on thermal exchange coefficient estimation (and therefore on the time constant) in order to obtain a more accurate model of the dynamic characteristics of the probes which are used for flow temperature measurements. © 1996 American Institute of Physics.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

In this article a new noncontact fiber optic probe, previously developed for bubble velocity measurements, is described. The sensing element is based on the optical interaction between the bubble and two focused laser beams. Not only the reflected but also the refracted beams are detected by the probe to perform bubble parameter measurements. The measurement principle is based on a transit-time technique, used, for example, in laser dual focus velocimetry or cross-correlation based measuring systems. The measurement system makes use of optical fiber components. The probe is designed for measurements on two-phase bubble flows without contact between the bubble and the probe tip and with minimal disturbance to the flow in the measurement region. The probe tip diameter is only 4 mm. No optical access to the flow is necessary because the probe can be installed inside the flow. Performances of the probe are theoretically and experimentally analyzed. Bubble-laser beam interaction has been analyzed by developing a special purpose simulation software. The probe was then tested in a hydraulic test rig circulated by a vertical air–water bubble flow at velocities up to 2 m/s and bubble diameter from 1 to 4 mm. The developed probe was calibrated by a laser Doppler velocimeter and classical photographic techniques. First results have shown uncertainty values of about 2% (one standard deviation) for velocity measurements. © 1996 American Institute of Physics.

Electronic Resource

1468-2494

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

The stability of the formaldehyde-releaser preservative Dowicil 200 has been investigated. The studies were carried out on cosmetic emulsions preserved with different concentrations of Dowicil 200, stored in the dark at 45°C or 25°C. The degree of microbiological activity was tested with respect to S. aureus, P. aeruginosa, E. coli and A. niger using the agar diffusion and challenge tests. The chemical stability was evaluated by HPLC in the reverse phase mode. A significant preservative instability was observed.

Electronic Resource

1468-2982

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Various open and controlled studies have confirmed the antimigraine action of flunarizine, while the antimigraine properties of nimodipine are still open to controversy. Moreover, only a few studies include an additional follow-up after discontinuation of migraine prophylaxis with either drug. We carried out a single blind evaluation of the efficacy and tolerance of flunarizine (25 patients) in comparison with nimodipine (25 patients) and the long-term effect after discontinuation of a 6-month treatment. Both medications significantly reduced migraine frequency and severity. Flunarizine was more efficacious than nimodipine in reducing migraine frequency (p 〈 0.001), pain severity (p 〈 0.05), migraine index (p 〈 0.05) and corrected migraine index (p 〈 0.05). The positive effect lasted 8.4 ± 4.0 months after discontinuation of flunarizine and 4.9 ± 3.5 months after nimodipine (p 〈 0.05). Our results suggest that flunarizine is more effective than nimodipine in the prophylactic treatment of migraine. The positive effect after drug discontinuation lasts longer with flunarizine, compared to nimodipine.

Electronic Resource

1398-9995

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background: In atopic individuals, exposure to allergens is followed by recruitment of blood eosinophils in the target tissue. We investigated whether allergen inhalation challenge could result in depletion of blood eosinophils overexpressing adhesion molecules involved in eosinophil migration.Methods: Blood eosinophils were isolated from seven atopic asthmatic patients and seven control subjects and the “at baseline” expression of lymphocyte function-associated antigen-1 (LFA-1), macrophage antigen-1 (Mac-1) and very late antigen-4 (VLA-4) was assessed by monoclonal antibody staining and flow cytometry analysis. Asthmatic patients underwent allergen challenge and the expression of LFA-1, Mac-1 and VLA-4 by blood eosinophils was again evaluated 3 h and 24 h after allergen challenge.Results: As compared to controls, eosinophils from atopics showed at baseline enhanced LFA-1 expression (P=0.0012), but similar Mac-1 or VLA-4 expression (P 〉 0.1, each comparison). In atopics, the percentage and absolute number of blood eosinophils were significantly decreased 3 h after allergen challenge (P=0.001 and P=0.022, respectively) but returned to similar values to prechallenge values after an additional 21 h (P 〉 0.1). Allergen challenge was also followed by a significant decrease in LFA-1 expression by eosinophils, at 3 h (P=0.002) and at 24 h (P=0.038), while no changes in Mac-1 and VLA-4 were observed. A significant correlation between postchallenge decrease in LFA-1 expression and in blood eosinophilia, both expressed as percentage (r=0.88; P 〈 0.01) or absolute number (r=0.87; P 〈 0.01) was demonstrated at 3 h (r=0.88; P 〈 0.01) but not at 24 h (r=0.64, P 〉 0.05 and r=0.11; P 〉 0.05, respectively).Conclusion: In allergic asthma, an early recruitment of blood eosinophils overexpressing LFA-1 occurs in the first hours after allergen challenge.

Electronic Resource

1749-6632

Blackwell Publishing Journal Backfiles 1879-2005

Natural Sciences in General

Electronic Resource

1365-3040

Blackwell Publishing Journal Backfiles 1879-2005

Biology

Abstract Watermelon (Citrullus vulgaris Schrad.) cotyledons were excised from the seed after 24 h of imbibition and incubated for different times (ranging from 1 to 240 min) on filter paper saturated with 0.1 mM BA (benzyladenine) solution. After the incubation in BA the cotyledons were thoroughly rinsed in water and grown for 5 days in darkness on filter paper saturated with distilled water.Continuous presence of BA is not a prerequisite for optimal growth. Several effects of the hormone (stimulation of expansion growth, acceleration of lipid breakdown, enhancement of hydroxypyruvate reductase activity, increase in carotenoid content) are more intensive if the cotyledons are treated with BA for a relatively short time and then grown in water. Maximal effects are observed after a 4 h exposure to BA. A single 1 min exposure is sufficient to elicit measurable effects on growth, hydroxypyruvate reductase and carotenoid content. The sensitivity to very short exposures is considerably different for different hormone effects. Carotenoid content and hydroxypyruvate reductase activity are enhanced much more than expansion growth.

Electronic Resource

1365-2559

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

The p24 protein is the major core protein of LAV/HTLV III which is the putative agent of the lymphadenopathy syndrome. By the use of an anti-p24 monoclonal antibody we have studied the presence of LAV/HTLV III infected cells in 20 lymph nodes obtained from lymphadenopathy syndrome patients: 14 lymph nodes were characterized by prominent follicular hyperplasia consistent with the early phase of the syndrome and six lymph nodes presented marked regressive changes. Cells positive for p24 were detected in 8/14 lymph nodes with hyperplastic changes and in 1/6 lymph nodes with regressive changes. Positive cells were most often located in germinal centres and were mainly characterized by a lymphoid morphology. However, immunoreactivity for p24 protein was also occasionally observed in some histiocytic-like cells and in high endothelial cells of post-capillary venules, suggesting that these ‘accessory cells’ also play a role in the early phases of the lymphadenopathy syndrome.

Electronic Resource