Search Results - (Author, Cooperation:G. McGranahan)

Showing 1 - 7 results of 7, query time: 0.14s Refine Results
  1. 1
    Staff View
    Publication Date:
    2012-03-01
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    *Conservation of Natural Resources ; Demography ; *Human Activities ; Humans ; *Policy Making
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Comstock, S. S. ; McGranahan, G. ; Peterson, W. R. ; Teuber, S. S.

    Oxford, UK : Blackwell Science Ltd
    Published 2004
    Staff View
    ISSN:
    1365-2222
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Background Tree nuts, including English walnuts (Juglans regia), are sources of food allergens often associated with life-threatening allergic reactions. It is unknown if seed storage proteins from other Juglans species have IgE epitopes similar to those of the important English walnut allergens, Jug r 1 (2S albumin) and Jug r 2 (vicilin-like).Objective To screen for potential germplasm sources of hypoallergenic seed storage proteins of relevance in walnut food allergy. We sought to identify English walnut cultivars (cvs) or other Juglans species that showed decreased IgE binding to major seed storage proteins or an inability to cross-react with Jug r 1 or Jug r 2.Methods We determined if IgE in sera of patients who have had life-threatening systemic reactions to English walnut bound protein extracts from all tested walnut cvs (57 cvs total) or species (six) by Western immunoblot. Further, we used immunoblot inhibition to determine the in vitro cross-reactivity of Jug r 1 and Jug r 2, native and recombinant, with several walnut species.Results All walnut cvs and species contain allergenic proteins. Furthermore, as shown by in vitro immunoblot inhibition, the major walnut allergens in the species tested cross-reacted with those in J. regia cv. Chandler and J. nigra cv. Thomas extracts.Conclusions Based on our findings, it is unlikely that a composite hypoallergenic walnut could be bred from available germplasm. In addition, patients with severe allergy to English walnut are likely to be clinically allergic to all commercial English walnut cvs and other closely related Juglans species.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2222.2004.02049.x

    Articles: DFG German National Licenses
  3. 3
    MAHONEY, N. ; MOLYNEUX, R.J. ; MCKENNA, J. ; LESLIE, C.A. ; MCGRANAHAN, G.

    Oxford, UK : Blackwell Publishing Ltd
    Published 2003
    Staff View
    ISSN:
    1750-3841
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Process Engineering, Biotechnology, Nutrition Technology
    Notes:
    : The ability of tree nuts to inhibit production of aflatoxins by Aspergillus flavus was investigated in vitro. Walnuts were much more resistant to aflatoxin formation than almonds or pistachios. The walnut cultivar ‘Tulare’ showed complete suppression of toxin production. Kernel without seed coat had no activity and the inhibitory factor(s) were shown to be specifically located in seed coat tissue. When seed coat was added back to ‘Tulare’ kernel media, aflatoxin was decreased to the detection limit or below. Aflatoxin production declined rapidly with seed coat maturity and was independent of growing location and rootstock. Breeding programs could increase resistance, enhancing marketability and safety of walnuts for human consumption.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2621.2003.tb05720.x

    Articles: DFG German National Licenses
  4. 4
    McGranahan, G.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0197-3975
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Geography
    Sociology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0197-3975(93)90034-A

    Articles: DFG German National Licenses
  5. 5
    McGranahan, G.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0197-3975
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Geography
    Sociology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0197-3975(93)90008-Z

    Articles: DFG German National Licenses
  6. 6
    McGranahan, G.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0305-750X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Geography
    Political Science
    Sociology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0305-750X(91)90073-Q

    Articles: DFG German National Licenses
  7. 7
    Tulecke, W. ; McGranahan, G.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0168-9452
    Keywords:
    Juglans ; Pterocarya ; cotyledons ; somatic embryogenesis ; walnut
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0168-9452(85)90163-3

    Articles: DFG German National Licenses