Search Results - (Author, Cooperation:G. J. Barker)
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1Latest Papers from Table of Contents or Articles in PressR. Whelan ; R. Watts ; C. A. Orr ; R. R. Althoff ; E. Artiges ; T. Banaschewski ; G. J. Barker ; A. L. Bokde ; C. Buchel ; F. M. Carvalho ; P. J. Conrod ; H. Flor ; M. Fauth-Buhler ; V. Frouin ; J. Gallinat ; G. Gan ; P. Gowland ; A. Heinz ; B. Ittermann ; C. Lawrence ; K. Mann ; J. L. Martinot ; F. Nees ; N. Ortiz ; M. L. Paillere-Martinot ; T. Paus ; Z. Pausova ; M. Rietschel ; T. W. Robbins ; M. N. Smolka ; A. Strohle ; G. Schumann ; H. Garavan
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-07-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adolescent ; Alcohol Drinking/*psychology ; Alcoholism/genetics/prevention & control/*psychology ; Artificial Intelligence ; Brain/physiology ; Cognition/physiology ; Environment ; Humans ; Life Change Events ; Longitudinal Studies ; *Models, Theoretical ; Personality/physiology ; Polymorphism, Single Nucleotide ; Psychology ; Reproducibility of Results ; Risk FactorsPublished by: -
2Latest Papers from Table of Contents or Articles in PressJ. Richiardi ; A. Altmann ; A. C. Milazzo ; C. Chang ; M. M. Chakravarty ; T. Banaschewski ; G. J. Barker ; A. L. Bokde ; U. Bromberg ; C. Buchel ; P. Conrod ; M. Fauth-Buhler ; H. Flor ; V. Frouin ; J. Gallinat ; H. Garavan ; P. Gowland ; A. Heinz ; H. Lemaitre ; K. F. Mann ; J. L. Martinot ; F. Nees ; T. Paus ; Z. Pausova ; M. Rietschel ; T. W. Robbins ; M. N. Smolka ; R. Spanagel ; A. Strohle ; G. Schumann ; M. Hawrylycz ; J. B. Poline ; M. D. Greicius
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-06-13Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adolescent ; Adult ; Animals ; Brain/metabolism/*physiology ; Female ; Gene Expression ; Humans ; Ion Channels/*genetics ; Magnetic Resonance Imaging ; Male ; Mice ; Nerve Net/metabolism/*physiology ; Neural Pathways/metabolism/physiology ; Polymorphism, Genetic ; Rest/*physiology ; Synapses/metabolism/physiology ; *Transcriptome ; Young AdultPublished by: -
3Articles: DFG German National LicensesAkrawy, M. Z. ; Alexander, G. ; Allison, J. ; Allport, P. P. ; Anderson, K. J. ; Armitage, J. C. ; Arnison, G. T. J. ; Ashton, P. ; Azuelos, G. ; Baines, J. T. M. ; Ball, A. H. ; Banks, J. ; Barker, G. J. ; Barlow, R. J. ; Batley, J. R. ; Beck, A. ; Becker, J. ; Behnke, T. ; Bell, K. W. ; Bella, G. ; Bethke, S. ; Biebel, O. ; Binder, U. ; Bloodworth, I. J. ; Bock, P.
Springer
Published 1991Staff ViewISSN: 1434-6052Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract Jet production rates in hadronicZ 0 decays are studied using four different recombination schemes to define resolvable jets. The strong coupling constant α s ( $$M_{Z^0 } $$ ) is determined in fits of the correspondingO(α s 2 ) QCD calculations to the differential 2-jet distributionsD 2(y). Hadronisation corrections and renormalisation scale uncertainties are found to be different for each recombination scheme. Within their overall systematic uncertainties, the four schemes yield consistent values of α s ( $$M_{Z^0 } $$ ), leading to a final result of $$\alpha _s (M_{Z^0 } ) = 0.118 \pm 0.008.$$ . The error includes the experimental uncertainties (±0.003), uncertainties of hadronisation corrections and of the degree of parton virtualities to which the data are corrected, as well as the uncertainty of choosing the renormalisation scale.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesActon, P. D. ; Alexander, G. ; Allison, J. ; Allport, P. P. ; Anderson, K. J. ; Arcelli, S. ; Ashton, P. ; Astbury, A. ; Axen, D. ; Azuelos, G. ; Bahan, G. A. ; Baines, J. T. M. ; Ball, A. H. ; Banks, J. ; Barker, G. J. ; Barlow, R. J. ; Batley, J. R. ; Beaudoin, G. ; Beck, A. ; Becker, J. ; Behnke, T. ; Bell, K. W. ; Bella, G. ; Berlich, P. ; Bethke, S.
Springer
Published 1992Staff ViewISSN: 1434-6052Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract We present an analysis of multiplicity distributions of charged particles produced inZ 0 hadronic decays. The results are based on the analysis of 82941 events collected within 100 MeV of theZ 0 peak energy with the OPAL detector at LEP. The charged particle multiplicity distribution, corrected for initial-state radiation and for detector acceptance and resolution, was found to have a mean 〈n ch〉=21.40±0.02(stat.)±0.43(syst.) and a dispersionD=6.49±0.02(stat.)±0.20(syst.). The shape is well described by the Lognormal and Gamma distributions. A negative binomial parameterisation was found to describe the shape of the multiplicity distribution less well. A comparison with results obtained at lower energies confirms the validity of KNO(-G) scaling up to LEP energies. A separate analysis of events with low sphericity, typically associated with two-jet final states, shows the presence of features expected for models based on a stochastic production mechanism for particles. In all cases, the features observed in the data are well described by the Lund parton shower model JETSET.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesActon, P. D. ; Alexander, G. ; Allison, J. ; Allport, P. P. ; Anderson, K. J. ; Arcelli, S. ; Ashton, P. ; Astbury, A. ; Axen, D. ; Azuelos, G. ; Bahan, G. A. ; Baines, J. T. M. ; Ball, A. H. ; Banks, J. ; Barker, G. J. ; Barlow, R. J. ; Batley, J. R. ; Beaudion, G. ; Beck, A. ; Becker, J. ; Behnke, T. ; Bell, K. W. ; Bella, G. ; Berlich, P. ; Bethke, S.
Springer
Published 1992Staff ViewISSN: 1434-6052Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract The value of the strong coupling constant, $$\alpha _s (M_{Z^0 } )$$ , is determined from a study of 15 different observables in hadronicZ 0 and τ decays. The study includes global event shape variables, jet production rates, energy correlations, theZ 0 line shape and decay asymmetries and the hadronic branching fraction of τ-leptons. Differences between the αs values from the different observables can be consistently attributed to unknown higher order contributions to the calculations. These uncertaities may be parametrized by variations of the renormalization scale and of the parton virtuality to which the data are corrected, separately for each observable, resulting in a consistent description of the event shapes, jet rates and energy correlations with the value $$\alpha _s (M_{Z^0 } ) = 0.122_{ - 0.005}^{ + 0.006} $$ in . The error is dominated by the theoretical uncertainties. Application of recent calculations which include the resummation of leading and next-to-leading logarithms to all orders for some observables confirm this result with a reduced sensitivity to renormalization scale variations. TheZ 0 line shapes and τ-lepton branching ratios yield $$\alpha _s (M_{Z^0 } ) = 0.148 \pm 0.021$$ and $$\alpha _s (M_{Z^0 } ) = 0.123_{ - 0.007}^{ + 0.006} $$ , respectively, in . These measurements and their uncertainties are entirely independent of each other and from event shape and jet observables; the good agreement of the resulting αs values thus constitutes an important consistency check of the reliability of perturbative QCD.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesAkrawy, M. Z. ; Alexander, G. ; Allison, J. ; Allport, P. P. ; Anderson, K. J. ; Armitage, J. C. ; Arnison, G. T. J. ; Ashton, P. ; Azuelos, G. ; Baines, J. T. M. ; Ball, A. H. ; Banks, J. ; Barker, G. J. ; Barlow, R. J. ; Batley, J. R. ; Beaudoin, G. ; Beck, A. ; Becker, J. ; Behnke, T. ; Bell, K. W. ; Bella, G. ; Bethke, S. ; Biebel, O. ; Binder, U. ; Boodworth, I. J.
Springer
Published 1991Staff ViewISSN: 1434-6052Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract The OPAL detector at LEP is used to measure the branching ratio of theZ 0 into invisible particles by measuring the cross section of single photon events ine + e − collisions at centre-of-mass energies near theZ 0 resonance. In a data sample of 5.3 pb−1, we observe 73 events with single photons depositing more than 1.5 GeV in the electromagnetic calorimeter, with an expected background of 8±2 events not associated with invisibleZ 0 decay. With this data we determine theZ 0 invisible width to be 0.50±0.07±0.03 GeV, where the first error is statistical and the second systematic. This corresponds to 3.0±0.4±0.2 light neutrino generations in the Standard Model.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesAlexander, G. ; Allison, J. ; Allport, P. P. ; Anderson, K. J. ; Arcelli, S. ; Armitage, J. C. ; Ashton, P. ; Astbury, A. ; Axen, D. ; Azuelos, G. ; Bahan, G. A. ; Baines, J. T. M. ; Ball, A. H. ; Banks, J. ; Barker, G. J. ; Barlow, R. J. ; Batley, J. R. ; Beaudoin, G. ; Beck, A. ; Becker, J. ; Behnke, T. ; Bell, K. W. ; Bella, G. ; Bethke, S. ; Biebel, O.
Springer
Published 1991Staff ViewISSN: 1434-6052Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract Three-jet variables constructed from multi-hadronic events produced byZ 0 decays are compared to theoretical calculations assuming a vector gluon or a hypothetical scalar gluon. The data yield conclusive direct evidence for the former case. The distributions of the reduced energy of the second-most energetic jet and of the cosine of the Ellis-Karliner angle are chosen to demonstrate this effect.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesAlexander, G. ; Allison, J. ; Allport, P. P. ; Anderson, K. J. ; Arcelli, S. ; Armitage, J. C. ; Ashton, P. ; Astbury, A. ; Axen, D. ; Azuelos, G. ; Bahan, G. A. ; Baines, J. T. M. ; Ball, A. H. ; Banks, J. ; Barker, G. J. ; Barlow, R. J. ; Batley, J. R. ; Beaudoin, G. ; Beck, A. ; Becker, J. ; Behnke, T. ; Bell, K. W. ; Bella, G. ; Bethke, S. ; Biebel, O.
Springer
Published 1991Staff ViewISSN: 1434-6052Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract We report on an improved measurement of the mass of theZ 0 boson, its total width and its partial decay widths into hadrons and leptons, as well as the effective axial vector and vector couplings to charged leptons. These measurements are based on a data set of approximately 160 000 hadronicZ 0 decays and 18 000 decays into electrons, muons and taus, recorded by the OPAL experiment at centre of mass energies near the mass of theZ 0. The total width and the partial widths to visible final states, derived from the measured cross sections, are used to extract the invisible width. The effective couplings of theZ 0 to charged leptons are studied using measurements of the lepton pair cross sections and forward-backward asymmetries at the different centre of mass energy points of theZ 0 scan. The implications of our results in the context of the Standard Model are discussed.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesAkrawy, M. Z. ; Alexander, G. ; Allison, J. ; Allport, P. P. ; Anderson, K. J. ; Armitage, J. C. ; Arnison, G. T. J. ; Ashton, P. ; Azuelos, G. ; Baines, J. T. M. ; Ball, A. H. ; Banks, J. ; Barker, G. J. ; Barlow, R. J. ; Batley, J. R. ; Becker, J. ; Behnke, T. ; Bell, K. W. ; Bella, G. ; Bethke, S. ; Biebel, O. ; Binder, U. ; Bloodworth, I. J. ; Bock, P. ; Breuker, H.
Springer
Published 1991Staff ViewISSN: 1434-6052Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract A search for minimal standard model (MSM) and minimal supersymmetric model (MSSM), Higgs bosons with masses larger than 3 GeV/c2 has been performed by the OPAL collaboration one + e − data from LEP corresponding to an integrated luminosity of 1.24 pb−1. The limits for MSM Higgs bosons have been obtained using the channelsZ 0→Z 0* H 0,Z 0*→(v $$\bar v$$ ore + e − or µ+, µ−. The search for MSSM Higgs bosons has been performed using the channelsZ 0→Z 0* H 0,v $$\bar v$$ ore + e − or µ+µ−),h 0 →q $$\bar q$$ andZ 0→h 0 A 0,h 0 A 0→(4 jet orτ + τ −→ or 4τ), whereh 0 andA 0 are the two lightest neutral MSSM Higgs bosons. No Higgs boson signal has been observed. The MSM Higgs boson is excluded in the mass range 3 GeV 〈 $$m_{H^0 }$$ 〈25.3 GeV/c2 at the 95% confidence level; limits on the masses of the two lightest neutral MSSM Higgs bosons are obtained forh 0 mases up to 40.5 GeV/c2.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1751-8466Topics: Linguistics and Literary StudiesURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1433-0407Keywords: Schlüsselwörter Multiple Sklerose ; Magnetresonanztomographie ; Protonenspektroskopie ; Magnetisation-Transfer ; Demyelinisierung ; Key words Magnetic resonance imaging ; Multiple sclerosis ; Proton spectroscopy ; Magnetisation transfer ; DemyelinationSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Summary We investigated a patient with secondary progressive Multiple Sclerosis during an acute relapse and after 6 months using several Magnetic Resonance methods. Conventional Magnetic Resonance images demonstrated at the time of relapse a large gadolinium enhancing lesion. Using proton spectroscopy and Magnetisation Transfer images heterogeneous changes suggestive of oedematous swelling peripherally, and active myelin destruction centrally were demonstrated in the acute phase. After clinical recovery there was marked resolution of acute inflammatory Magnetic Resonance abnormalities and recovery of MR tissue parameters. In comparison with conventional Magnetic Resonance Imaging Magnetisation Transfer Imaging and Proton Spectroscopy provide improved characterisation of pathological changes in MS.Notes: Zusammenfassung Wir untersuchten eine Patientin mit sekundär progressiver multipler Sklerose während eines akuten Schubes und im Verlauf nach 6 Monaten mit verschiedenen Magnetresonanztechniken. In der konventionellen Bildgebung fand sich zeitgleich zur klinischen Verschlechterung eine ausgedehnte kontrastmittelanreichernde Läsion. Mittels der Protonenspektroskopie und Magnetisation-Transfer-Bildern konnten heterogene pathologische Veränderungen mit wahrscheinlich ödematösen Gewebeveränderungen in der Peripherie und Demyelinisierung im Zentrum der Läsion in der akuten Phase dargestellt werden. Mit dem Abklingen der akuten Symptomatik zeigte sich eine Rückbildung der akut entzündlichen Aktivität und eine Erholung der MR-Gewebeparameter. Im Vergleich zur konventionellen Magnetresonanztomographie bieten Magnetisation Transfer Bildgebung und Protonen Spektroskopie spezifischere Informationen bei der Darstellung pathologischer Gewebeveränderungen der multiplen Sklerose.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1751-8466Topics: Linguistics and Literary StudiesURL: -
13Articles: DFG German National LicensesSilver, N. C. ; Barker, G. J. ; Losseff, N. A. ; Gawne-Cain, M. L. ; MacManus, D. G. ; Thompson, A. J. ; Miller, D. H.
Springer
Published 1997Staff ViewISSN: 1432-1920Keywords: Key words Magnetisation transfer ratio ; Cervical spinal cord ; Multiple sclerosisSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract MRI readily detects the lesions of multiple sclerosis (MS) in the brain and spinal cord. Conventional MRI sequences do not, however, permit distinction between the various pathological characteristics (oedema, demyelination, axonal loss and gliosis) of lesions in MS. Magnetisation transfer (MT) imaging may be more specific in distinguishing the pathologies responsible for disability in MS, namely demyelination and axonal loss, and therefore may have a potential role in monitoring treatment. We have applied MT imaging to the cervical spinal cord to see if it is feasible to measure MT ratios (MTR) in this region where pathological changes may result in considerable disability. We studied 12 patients with MS and 12 age- and sex-matched normal controls using a sagittal T2-weighted fast spin-echo sequence with and without an MT pulse. The median value for cervical cord mean MTR measurement in normal controls was 19.30 % units (interquartile range 19.05–19.55), whereas values were significantly lower in MS patients (median = 17.95 % units, interquartile range 17.25–19.00, P = 0.0004). There was a low intrarater variability for repeated mean MTR measurements. We conclude that it is possible to measure MTR in the cervical spinal cord, that a significant reduction occurs in patients with MS, and that there may be a role for this measure in future MS treatment trials.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesThorpe, J. W. ; Halpin, S. F. ; MacManus, D. G. ; Barker, G. J. ; Kendall, B. E. ; Miller, D. H.
Springer
Published 1994Staff ViewISSN: 1432-1920Keywords: Magnetic resonance imaging ; Fast spin-echo ; Multiple sclerosisSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Long repetition time (TR) spin-echo (SE) with T2- or proton density weighting is the sequence of choice to detect the brain lesions of multiple sclerosis (MS). Fast spin-echo (FSE) permits the generation of T2-weighted images with similar contrast to SE but in a fraction of the time. We compared the sensitivity of FSE and SE in the detection of the brain lesions of MS. Six patients with clinically definite MS underwent brain imaging with both dual echo (long TR, long and short echo time (TE) SE and dual echo FSE. The SE and FSE images were first reviewed independently and then compared. A total of 404 lesions was detected on SE and 398 on FSE. Slightly more periventricular lesions were detected using SE than FSE (145 vs 127), whereas more posterior cranial fossa lesions were detected by FSE (77 vs 57). With both SE and FSE the short TE images revealed more lesions than the long echo. These results suggest that FSE could replace SE as the long TR sequence of choice in the investigation of MS.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesGass, A. ; Moseley, I. F. ; Barker, G. J. ; Jones, S. ; MacManus, D. ; McDonald, W. I. ; Miller, D. H.
Springer
Published 1996Staff ViewISSN: 1432-1920Keywords: Magnetic resonance imaging ; Fast spin-echo ; STIR ; Fat suppression ; Optic neuritisSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Fast spin-echo (FSE) is a new sequence with acquisition times currently down to one-sixteenth of those obtained with conventional spin-echo sequences, which allows high-resolution (512×512 matrix) images to be acquired in an acceptable time. We compared the higher resolution of FSE with the medium resolution of a short inversion-time inversion-recovery (STIR) sequence in depicting the optic nerves of healthy controls and patients with optic neuritis. Optic nerve MRI examinations were performed in 18 patients with optic neuritis and 10 normal controls. Two sequences were obtained coronally: fat-suppressed FSE (FSE TR 3250 ms/TEef 68 ms, echo-train length 16, 4 excitations, 24 cm rectangular field of view, 3 mm interleaved contiguous slices, in-plane resolution 0.5×0.5 mm) and STIR (TR 2000 ms/TE 50 ms/TI 175 ms, inplane resolution 0.8×0.8 mm, slice thickness 5 mm). FSE demonstrated much more anatomical detail than STIR, e. g. distinction of optic nerve and sheath. Lesions were seen in 20 of 21 symptomatic nerves using FSE and in 18 of 21 using STIR. Nerve swelling or partial cross-sectional lesions of the optic nerve were each seen only on FSE in 3 cases. Fatsuppressed FSE imaging of the optic nerve improves anatomical definition and increases lesion detection in optic neuritis.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesGass, A. ; Moseley, I. F. ; Barker, G. J. ; Jones, S. ; MacManus, D. ; McDonald, W. I. ; Miller, D. H.
Springer
Published 1996Staff ViewISSN: 1432-1920Keywords: Key words Magnetic resonance imaging ; Fast spin-echo ; STIR ; Fat suppression ; Optic neuritisSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Fast spin-echo (FSE) is a new sequence with acquisition times currently down to one-sixteenth of those obtained with conventional spin-echo sequences, which allows high-resolution (512 × 512 matrix) images to be acquired in an acceptable time. We compared the higher resolution of FSE with the medium resolution of a short inversion-time inversion-recovery (STIR) sequence in depicting the optic nerves of healthy controls and patients with optic neuritis. Optic nerve MRI examinations were performed in 18 patients with optic neuritis and 10 normal controls. Two sequences were obtained coronally: fat-suppressed FSE (FSE TR 3250 ms/TEef 68 ms, echo-train length 16, 4 excitations, 24 cm rectangular field of view, 3 mm interleaved contiguous slices, in-plane resolution 0.5 × 0.5 mm) and STIR (TR 2000 ms/TE 50 ms/TI 175 ms, in-plane resolution 0.8 × 0.8 mm, slice thickness 5 mm). FSE demonstrated much more anatomical detail than STIR, e. g. distinction of optic nerve and sheath. Lesions were seen in 20 of 21 symptomatic nerves using FSE and in 18 of 21 using STIR. Nerve swelling or partial cross-sectional lesions of the optic nerve were each seen only on FSE in 3 cases. Fat-suppressed FSE imaging of the optic nerve improves anatomical definition and increases lesion detection in optic neuritis.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesWieshmann, U. C. ; Barker, G. J. ; Symms, M. R. ; Bartlett, P. A. ; Stevens, J. M. ; Shorvon, S. D.
Springer
Published 1998Staff ViewISSN: 1432-1920Keywords: Key words Fluid-attenuated inversion recovery ; Three-dimensional imaging ; Pulse sequencesSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We developed a 3D version of fast fluid-attenuated inversion-recovery imaging (FLAIR) which provides images with a slice thickness of 1.5 mm. We present our initial experience with 3D fast FLAIR in patients with epilepsy. We compared 3D fast FLAIR (slice thickness 1.5 mm), 2D fast FLAIR (slice thickness 5 mm) and a 3D spoiled GRASS (IRSPGR) sequence (slice thickness 1.5 mm) in 10 patients with lesional epilepsy (head injury 1, hippocampal sclerosis 2, low-grade glioma 2, dysembryoplastic neuroepithelial tumour 2, polymicrogyria 1, perinatal infarct 1 and presumed thrombosed aneurysm 1). Both 2D and 3D fast FLAIR sequences yielded higher conspicuity for lesions than the T1-weighted IRSPGR sequence, except in the patient with polymicrogyria. The extent of the lesion, in particular that of low-grade tumours, was best assessed on 3D fast FLAIR images. 3D fast FLAIR may be a useful additional tool especially for imaging low-grade tumours.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesGómez-Ansón, B. ; MacManus, D. G. ; Parker, G. J. M. ; Davie, C. A. ; Barker, G. J. ; Moseley, I. F. ; McDonald, W. I. ; Miller, D. H.
Springer
Published 2000Staff ViewISSN: 1432-1920Keywords: Key words Magnetic resonance spectroscopy ; Spinal cord ; Multiple sclerosisSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Magnetic resonance spectroscopy (MRS) has been used in a variety of conditions affecting the central nervous system. Until now, only the brain has been studied, and spectroscopy of the spinal cord has not been previously reported. During the past 12 months, we have been experimenting with MRS of the cervical spinal cord of healthy volunteers. We present this technique, its current limitations, and possible future technological improvements and potential applications.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesTubridy, N. ; Barker, G. J. ; MacManus, D. G. ; Moseley, I. F. ; Miller, D. H.
Springer
Published 1998Staff ViewISSN: 1432-1920Keywords: Key words Multiple sclerosis ; Magnetic resonance imaging ; Pulse sequences ; Echo-planar imagingSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We used five MRI sequences in six patients with multiple sclerosis (MS): conventional spin-echo (CSE) with 5-mm slices; 2D fast spin-echo (FSE) with 2-mm slices; multishot T2*-weighted echo-planar imaging (EPI) with 5-mm slices; fast fluid-attenuated inversion recovery (fFLAIR) with 2-mm slices; and 3D fast spin-echo with 1.5-mm-thick slices. A total of 225 lesions were detected on CSE, 274 on 2D FSE, 137 on EPI, 385 on fFLAIR and 320 on 3D FSE. The EPI sequence was clearly the least sensitive and susceptibility artefact was a problem, particularly in the brain stem and temporal lobes. Fast FLAIR displayed a much higher number of supratentorial lesions (380) than 3D FSE (297), 2D FSE (264) or CSE (211). However, in the posterior cranial fossa 3D FSE was the most sensitive sequence (23 lesions), followed by CSE (14) and 2D FSE (10), while fFLAIR (5) was extremely insensitive.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesGass, A. ; Barker, G. J. ; Riordan-Eva, P. ; MacManus, D. ; Sanders, M. ; Tofts, P. S. ; McDonald, W. I. ; Moseley, I. F. ; Miller, D. H.
Springer
Published 1996Staff ViewISSN: 1432-1920Keywords: Key words Magnetic resonance imaging ; Benign intracranial hypertension ; Papilloedema ; Optic nerveSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We investigated the MRI appearance of the optic nerve and its cerebrospinal-fluid-containing sheath in 17 patients with benign intracranial hypertension (BIH) and 15 normal controls. Using phased-array local coils, 3-mm coronal T2-weighted fat-suppressed fast spin-echo images were obtained with an in-plane resolution of 〈 0.39 mm. The optic nerve and its sheath were clearly differentiated. An enlarged, elongated subarachnoid space around the optic nerve was demonstrated in patients with BIH. High-resolution MRI of the optic nerve offers additional information which may be of value for diagnosis and in planning and monitoring treatment.Type of Medium: Electronic ResourceURL: