Search Results - (Author, Cooperation:G. Ira)
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1Latest Papers from Table of Contents or Articles in PressR. Mayle ; I. M. Campbell ; C. R. Beck ; Y. Yu ; M. Wilson ; C. A. Shaw ; L. Bjergbaek ; J. R. Lupski ; G. Ira
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-08-15Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Alu Elements ; Base Sequence ; *DNA Breaks, Double-Stranded ; DNA Repair/*genetics ; DNA Replication/*genetics ; DNA-Binding Proteins/genetics/*metabolism ; DNA-Directed DNA Polymerase/metabolism ; Endonucleases/genetics/*metabolism ; *Genomic Instability ; Humans ; Molecular Sequence Data ; Neoplasms/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics/*metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressX. Chen ; D. Cui ; A. Papusha ; X. Zhang ; C. D. Chu ; J. Tang ; K. Chen ; X. Pan ; G. Ira
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-09-11Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Cell Cycle Proteins/metabolism ; *Chromatin Assembly and Disassembly ; *DNA Breaks, Double-Stranded ; *DNA Repair ; DNA, Fungal/genetics/*metabolism ; Exodeoxyribonucleases/metabolism ; Genes, Fungal/genetics ; Genome, Fungal/genetics ; Histones/metabolism ; Homologous Recombination ; Methylation ; Nucleosomes/genetics/*metabolism ; RecQ Helicases/metabolism ; Saccharomyces cerevisiae/*genetics/metabolism ; Saccharomyces cerevisiae Proteins/genetics/*metabolism ; Transcription Factors/deficiency/genetics/*metabolismPublished by: -
3Latest Papers from Table of Contents or Articles in PressM. A. Wilson ; Y. Kwon ; Y. Xu ; W. H. Chung ; P. Chi ; H. Niu ; R. Mayle ; X. Chen ; A. Malkova ; P. Sung ; G. Ira
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-09-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: *Crossing Over, Genetic ; DNA Helicases/deficiency/genetics/*metabolism ; DNA Polymerase III/*metabolism ; DNA Repair ; *DNA Replication ; DNA, Fungal/*biosynthesis/chemistry/metabolism ; Nucleic Acid Conformation ; Rad51 Recombinase/metabolism ; Saccharomyces cerevisiae/*enzymology/*genetics/metabolism ; Saccharomyces cerevisiae Proteins/genetics/*metabolismPublished by: -
4Latest Papers from Table of Contents or Articles in PressN. Saini ; S. Ramakrishnan ; R. Elango ; S. Ayyar ; Y. Zhang ; A. Deem ; G. Ira ; J. E. Haber ; K. S. Lobachev ; A. Malkova
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-09-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: *Chromosome Breakage ; *DNA Breaks, Double-Stranded ; DNA Helicases/metabolism ; DNA Repair/genetics ; DNA Replication/*genetics ; DNA, Fungal/*biosynthesis/genetics ; Genomic Instability/genetics ; Mutagenesis/genetics ; S Phase/genetics ; Saccharomyces cerevisiae/cytology/enzymology/*genetics/metabolism ; Saccharomyces cerevisiae Proteins/metabolismPublished by: -
5Latest Papers from Table of Contents or Articles in PressSamantha E. Adamson, Renata Polanowska-Grabowska, Kathryn Marqueen, Rachael Griffiths, Jerry Angdisen, Sarah R. Breevoort, Ira G. Schulman, Norbert Leitinger
American Heart Association (AHA)
Published 2018Staff ViewPublication Date: 2018-04-26Publisher: American Heart Association (AHA)Print ISSN: 1079-5642Electronic ISSN: 1524-4636Topics: MedicineKeywords: Cell Biology/Structural Biology, Inflammation, AtherosclerosisPublished by: -
6Articles: DFG German National LicensesStaff View
ISSN: 1540-6229Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: EconomicsNotes: The multifamily component of residential construction has received relatively little attention in the existing literature on macro-economic housing markets. In those studies where single and multifamily starts have been treated separately [Kawaller (1976), Arcelus and Meltzer (1973), Brady (1973), Kalchbrenner (1972)Smith (1969), the greater share of attention and background discussion has been directed toward the singlefamily sector. Such treatment probably is due to the fact that multifamily starts have traditionally accounted for the smaller fraction of total private starts. Since the Census Bureau began recording the starts breakdown in 1959, however, this fraction has not fallen much below a fifth in any quarter, and it has been as high as 48 percent. Moreover, with a growing acceptance of the condominium and cooperative housing concepts, expanding Federal rental assistance initiatives, and changing life style preferences, it would appear that increased attention given to the multifamily sector, may significantly enhance our understanding of housing markets in general.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Diabetes caused a 3.5-fold increase in the 32P-radio-activity associated with liver SOS ribosomes (Table 1); the administration of insulin (5 units per 100 g body weight) to diabetic animals reduced the radioactivity associated with the particles by about one-half in 90 min; phosphorylation, ...Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] We have isolated EIF-3 from mouse Krebs II ascites cells by chromatography of a 0.25M KC1 ribosomal salt wash on DEAE-^Sephadex and hydroxylapatite (details of the isolation of EIF-3 will be presented elsewhere). EIF-3, like initiation factor IF-2 from E. co//n12, forms a ternary complex with GTP ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The following details of the experiments have been described before: the source of the materials, the nature of the rats (80100 g males), and the method of making them diabetic with alloxan1,2; the preparation and the conditions of incubation of hemidiaphragm muscle5; the isolation of ribosomes ...Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Samples were prepared for analysis in the following manner : Non-fasting male Sprague-Dawley rats (400 g) were anaesthetized with 0-2 ml./100 g of a mixture of pentobarbital (15 mg/ml.) and heparin (750 units /ml.) and blood taken from the abdominal aorta. To 2 ml. of clear plasma was added 1 ml. ...Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesEffect of Insulin on Accumulation of Radioactivity from Amino-acids by Isolated Intact Rat DiaphragmStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] In circumstances similar to that in which it increases amino-acid incorporation into protein, insulin will also increase accumulation of 14C-a-aminoisobutyric acid, a non-utilized amino-acid, and of some, but not all, of the utilized amino-acids (cf. Table 2 for a summary and for references). This ...Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesChakravarti, Debabrata ; LaMorte, Vickie J. ; Nelson, Michael C. ; Nakajima, Toshihiro ; Schulman, Ira G. ; Juguilon, Henry ; Montminy, Marc ; Evans, Ronald M.
[s.l.] : Nature Publishing Group
Published 1996Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The retinoid X receptors (RXRs) and their heterodimeric partners possess a characteristic DNA-binding domain followed by a carboxy-terminal ligand-binding domain (LED) which is a complex region that includes subdomains for dimerization functions, transcriptional activation and, in some cases, ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesLala, Deepak S. ; Mukherjee, Ranjan ; Schulman, Ira G. ; Koch, Stacie S. Canan ; Dardashti, Laura J. ; Nadzan, Alex M. ; Croston, Glenn E. ; Evans, Ronald M. ; Heyman, Richard A.
[s.l.] : Nature Publishing Group
Published 1996Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Studies of the mechanisms by which intracellular receptors regulate transcription have been facilitated by synthetic ligands with different properties to naturally occurring hormones. For example, synthetic oestrogens and progestins with partial agonist/ antagonist activities have helped to ...Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] INSULIN in vitro has been shown to enhance the incorporation of labelled amino-acids into the protein of isolated diaphragm1-4, epididymal fat pad5'6, liver slices7 and bone marrow cells8'9. Particularly in the case of diaphragm, stimulation of amino-acid incorporation appears to take place ...Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Adrenalectomy increased, and cortisone depressed, the incorporation of amino-acids into myocardial slices in a way, qualitatively and quantitatively, similar to their effects on skeletal muscle1'8 (Table 1). There is no reason to believe, then, that there is a fundamental difference in the effect ...Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Table 1. EFFECT OF ADRENALECTOMY AND CORTISONE ON THE ACCUMULATION OF CARBON-14 LABELLED SUBSTRATE BY ISOLATED 'INTACT' BAT DIAPHRAGM Substrate added to the medium Counts/min./ml. intracellular water Counts/mi Q./ml. incubation medium Normal Adrenal-ectomized Cortisone ...Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0038-4941Topics: SociologyURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The method adopted was to divorce penetration and incorporation by effecting amino-acid accumulation before adding insulin. The amino-acid labelled with carbon-14, instead of being added in vitro, was injected intraperitoneally into the diaphragm donor; 10 min. later the rat was killed and the ...Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Table 119.8 ?? photometry Ring position flux Sky position flux Net ring flux Ring brightness Corrected ring brightness* Ring brightness temperature 56.0 ± 0.9 K 5.75 ±0.22x10" 3.57 ±0.18 x IO'19 W cm'2 ?G1 2.18±0.40xlO' 5.88±1.08xlO_. 9.06 ± ...Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1432-5233Keywords: Aminoacyltransferase II ; Diabetes ; GTPase ; Muscle ; RibosomesSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Résumé L'aminoacyltransférase II catalise l'hydrolyse du GTP en présence de ribosomes non lavés de muscle, mais l'hydrolyse du nucléoside triphosphate se vérifie même en l'absence de l'enzyme. L'hydrolyse du GTP en l'absence d'aminoacyltransférase II est réduite, sinon pas éliminée, par le lavage des ribosomes en NH4Cl 0,5 M. Une réduction ultérieure est obtenue par l'addition de ATP (0,01 mM). L'hydrolyse du GTP ribosomo-dépendant, catalisée par l'aminoacyltransférase II, augmente d'une façon linéaire pendant 15 min et est proportionnelle à la concentration de ribosomes; 4–7 moles de nucléoside triphosphate par mole de ribosomes sont hydrolysées. Les ribosomes incubés avec puromycine, dans le but d'éloigner le peptidyl-tRNA, ne montrent aucune réduction de l'hydrolyse du GTP catalisée par l'aminoacyltransférase II. Les ribosomes provénant du muscle des rats alloxano-diabétiques agissent moins activement, dans la synthèse protéique, que ceux des rats normaux. Cependant, il n'existe pas de différences en ce qui concerne la capacité des ribosomes de maintenir l'hydrolyse du GTP même quand l'aminoacyltransférase II est présente en concentrations saturantes. En conclusion, la capacité réduite des ribosomes diabétiques de cataliser la synthèse protéique n'est pas la conséquence d'une incapacité d'utilisation de l'aminoacyltransférase II pour l'hydrolyse du GTP.Abstract: Resumen La aminoaciltransferasa II cataliza la hidrólisis del GTP en presencia de ribosomas de músculo esquelético no lavados, pero la hidrólisis del trifosfato nucleosídico se verifica también en ausencia de la enzima. La hidrólisis del GTP en ausencia de aminoaciltransferasa II se reduce, aunque no se llega a eliminar, lavando los ribosomas con NH4Cl 0,5 M. Una reducción ulterior se obtiene añadienco ATP (0,01 mM). La hidrólisis del GTP ribosoma-dependiente, catalizada por la aminoaciltransferasa II, aumenta de manera lineal durante 15 min, y es proporcional a la concentración de ribosomas; se hidrolizan de 4 a 7 moles de trifosfato nucleosídico por mole de ribosomas. Los ribosomas incubados con puromicina, con la finalidad de eliminar el peptidil-tRNA, no acusan reducción alguna de la hidrólisis del GTP catalizada por la aminoaciltransferasa II. Los ribosomas procedentes de músculos de ratas aloxandiabéticas actúan menos activamente en la síntesis proteica que los de ratas normales. No obstante, no existen diferencias por lo que se refiere a la capacidad de los ribosomas para sostener la hidrólisis del GTP incluso cuando la aminoaciltransferasa II se presenta en cantidades de saturación. En conclusión, la capacidad reducida de los ribosomas diabéticos de catalizar la síntesis proteica, no es la consecuencia de una incapacidad de utilizar la aminoaciltransferasa II para la hidrólisis del GTP.Notes: Riassunto L'aminoaciltransferasi II catalizza l'idrolisi del GTP in presenza di ribosomi non lavati di muscolo scheletrico, ma l'idrolisi del nucleoside trifosfato si verifica anche in assenza dell'enzima. L'idrolisi del GTP in assenza di aminoaciltransferasi II viene ridotta, anche se non eliminata, dal lavaggio dei ribosomi in NH4Cl 0,5 M. Un'ulteriore riduzione si ottiene aggiungendo ATP (0,01 mM). L'idrolisi del GTP ribosomo-dipendente, catalizzata dalla aminoaciltransferasi II, aumenta in maniera lineare durante 15 min ed è proporzionale alla concentrazione di ribosomi; da 4 a 7 moli di nucleoside trifosfato per mole di ribosomi vengono idrolizzate. I ribosomi incubati con puromicina, allo scopo di rimuovere il peptidil-tRNA, non dimostrano alcuna riduzione dell'idrolisi del GTP catalizzata dalla aminoaciltransferasi II. I ribosomi provenienti dal muscolo di ratti con diabete da allossana agiscono meno attivamente, nella sintesi proteica, di quelli di ratti normali. Tuttavia, non esistono differenze per quanto riguarda la capacità dei ribosomi di sostenere l'idrolisi del GTP anche quando l'aminoaciltransferasi II sia presente in quantità saturanti. In conclusione, la ridotta capacità dei ribosomi diabetici di catalizzare la sintesi proteica non è la conseguenza di un'incapacità di utilizzare l'aminoaciltransferasi II per l'idrolisi del GTP.Type of Medium: Electronic ResourceURL: