ILSE | Search Results - (Author, Cooperation:G. Getz)

1

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

Filbin, M. G., Tirosh, I., Hovestadt, V., Shaw, M. L., Escalante, L. E., Mathewson, N. D., Neftel, C., Frank, N., Pelton, K., Hebert, C. M., Haberler, C., Yizhak, K., Gojo, J., Egervari, K., Mount, C., van Galen, P., Bonal, D. M., Nguyen, Q.-D., Beck, A., Sinai, C., Czech, T., Dorfer, C., Goumnerova, L., Lavarino, C., Carcaboso, A. M., Mora, J., Mylvaganam, R., Luo, C. C., Peyrl, A., Popovic, M., Azizi, A., Batchelor, T. T., Frosch, M. P., Martinez-Lage, M., Kieran, M. W., Bandopadhayay, P., Beroukhim, R., Fritsch, G., Getz, G., Rozenblatt-Rosen, O., Wucherpfennig, K. W., Louis, D. N., Monje, M., Slavc, I., Ligon, K. L., Golub, T. R., Regev, A., Bernstein, B. E., Suva, M. L.
American Association for the Advancement of Science (AAAS)
Published 2018

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Publication Date:	2018-04-20
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Geosciences Computer Science Medicine Natural Sciences in General Physics
Keywords:	Genetics, Medicine, Diseases
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

2

Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma

S. Manier; J. Park; M. Capelletti; M. Bustoros; S. S. Freeman; G. Ha; J. Rhoades; C. J. Liu; D. Huynh; S. C. Reed; G. Gydush; K. Z. Salem; D. Rotem; C. Freymond; A. Yosef; A. Perilla-Glen; L. Garderet; E. M. Van Allen; S. Kumar; J. C. Love; G. Getz; V. A. Adalsteinsson; I. M. Ghobrial
Nature Publishing Group (NPG)
Published 2018

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Publication Date:	2018-04-28
Publisher:	Nature Publishing Group (NPG)
Electronic ISSN:	2041-1723
Topics:	Biology Chemistry and Pharmacology Natural Sciences in General Physics
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

3

Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

M. Yu ; A. Bardia ; N. Aceto ; F. Bersani ; M. W. Madden ; M. C. Donaldson ; R. Desai ; H. Zhu ; V. Comaills ; Z. Zheng ; B. S. Wittner ; P. Stojanov ; E. Brachtel ; D. Sgroi ; R. Kapur ; T. Shioda ; D. T. Ting ; S. Ramaswamy ; G. Getz ; A. J. Iafrate ; C. Benes ; M. Toner ; S. Maheswaran ; D. A. Haber
American Association for the Advancement of Science (AAAS)
Published 2014

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Publication Date:	2014-07-12
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Animals ; Antineoplastic Agents/pharmacology/therapeutic use ; Breast Neoplasms/drug therapy/genetics ; Cell Culture Techniques ; Cell Separation ; Culture ; Drug Resistance, Neoplasm/genetics ; Drug Screening Assays, Antitumor/methods ; Estrogen Receptor alpha/genetics ; Female ; Gene Frequency ; Humans ; Mice ; Microfluidics/methods ; Molecular Targeted Therapy ; Mutation ; Neoplastic Cells, Circulating/*drug effects/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Sequence Analysis, DNA ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

4

Human genomics. The human transcriptome across tissues and individuals

M. Mele ; P. G. Ferreira ; F. Reverter ; D. S. DeLuca ; J. Monlong ; M. Sammeth ; T. R. Young ; J. M. Goldmann ; D. D. Pervouchine ; T. J. Sullivan ; R. Johnson ; A. V. Segre ; S. Djebali ; A. Niarchou ; F. A. Wright ; T. Lappalainen ; M. Calvo ; G. Getz ; E. T. Dermitzakis ; K. G. Ardlie ; R. Guigo
American Association for the Advancement of Science (AAAS)
Published 2015

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Publication Date:	2015-05-09
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Alternative Splicing ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Genome, Human/genetics ; Humans ; Male ; Organ Specificity/genetics ; Phenotype ; Polymorphism, Single Nucleotide ; Sequence Analysis, RNA ; Sex Factors ; *Transcriptome
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

5

Landscape of genomic alterations in cervical carcinomas

A. I. Ojesina ; L. Lichtenstein ; S. S. Freeman ; C. S. Pedamallu ; I. Imaz-Rosshandler ; T. J. Pugh ; A. D. Cherniack ; L. Ambrogio ; K. Cibulskis ; B. Bertelsen ; S. Romero-Cordoba ; V. Trevino ; K. Vazquez-Santillan ; A. S. Guadarrama ; A. A. Wright ; M. W. Rosenberg ; F. Duke ; B. Kaplan ; R. Wang ; E. Nickerson ; H. M. Walline ; M. S. Lawrence ; C. Stewart ; S. L. Carter ; A. McKenna ; I. P. Rodriguez-Sanchez ; M. Espinosa-Castilla ; K. Woie ; L. Bjorge ; E. Wik ; M. K. Halle ; E. A. Hoivik ; C. Krakstad ; N. B. Gabino ; G. S. Gomez-Macias ; L. D. Valdez-Chapa ; M. L. Garza-Rodriguez ; G. Maytorena ; J. Vazquez ; C. Rodea ; A. Cravioto ; M. L. Cortes ; H. Greulich ; C. P. Crum ; D. S. Neuberg ; A. Hidalgo-Miranda ; C. R. Escareno ; L. A. Akslen ; T. E. Carey ; O. K. Vintermyr ; S. B. Gabriel ; H. A. Barrera-Saldana ; J. Melendez-Zajgla ; G. Getz ; H. B. Salvesen ; M. Meyerson
Nature Publishing Group (NPG)
Published 2014

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Publication Date:	2014-01-07
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Adenocarcinoma/genetics/virology ; Carcinoma, Squamous Cell/genetics/virology ; Case-Control Studies ; Cell Cycle Proteins/genetics ; Core Binding Factor beta Subunit/genetics ; DNA Copy Number Variations/genetics ; DNA Mutational Analysis ; DNA-Binding Proteins/genetics ; E1A-Associated p300 Protein/genetics ; Exome/genetics ; F-Box Proteins/genetics ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Genome, Human/genetics ; Genomics ; HLA-B Antigens/genetics ; Humans ; Mitogen-Activated Protein Kinase 1/genetics ; Mutation/genetics ; NF-E2-Related Factor 2/genetics ; Papillomaviridae/genetics/physiology ; Papillomavirus Infections/genetics ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-ets ; Receptor, ErbB-2/genetics ; Transcription Factors/genetics ; Transcriptome/genetics ; Tumor Suppressor Protein p53/genetics ; Ubiquitin-Protein Ligases/genetics ; Uterine Cervical Neoplasms/*genetics/virology ; Virus Integration/genetics
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

6

The genomic complexity of primary human prostate cancer

M. F. Berger ; M. S. Lawrence ; F. Demichelis ; Y. Drier ; K. Cibulskis ; A. Y. Sivachenko ; A. Sboner ; R. Esgueva ; D. Pflueger ; C. Sougnez ; R. Onofrio ; S. L. Carter ; K. Park ; L. Habegger ; L. Ambrogio ; T. Fennell ; M. Parkin ; G. Saksena ; D. Voet ; A. H. Ramos ; T. J. Pugh ; J. Wilkinson ; S. Fisher ; W. Winckler ; S. Mahan ; K. Ardlie ; J. Baldwin ; J. W. Simons ; N. Kitabayashi ; T. Y. MacDonald ; P. W. Kantoff ; L. Chin ; S. B. Gabriel ; M. B. Gerstein ; T. R. Golub ; M. Meyerson ; A. Tewari ; E. S. Lander ; G. Getz ; M. A. Rubin ; L. A. Garraway
Nature Publishing Group (NPG)
Published 2011

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Publication Date:	2011-02-11
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Carrier Proteins/genetics ; Case-Control Studies ; Cell Adhesion Molecules/genetics ; Chromatin/genetics/metabolism ; Chromosome Aberrations ; Chromosome Breakpoints ; Epigenesis, Genetic/genetics ; Gene Expression Regulation, Neoplastic ; Genome, Human/genetics ; Humans ; Male ; PTEN Phosphohydrolase/genetics/metabolism ; Prostatic Neoplasms/genetics ; Recombination, Genetic/genetics ; Signal Transduction/genetics ; Transcription, Genetic
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

7

Sequence analysis of mutations and translocations across breast cancer subtypes

S. Banerji ; K. Cibulskis ; C. Rangel-Escareno ; K. K. Brown ; S. L. Carter ; A. M. Frederick ; M. S. Lawrence ; A. Y. Sivachenko ; C. Sougnez ; L. Zou ; M. L. Cortes ; J. C. Fernandez-Lopez ; S. Peng ; K. G. Ardlie ; D. Auclair ; V. Bautista-Pina ; F. Duke ; J. Francis ; J. Jung ; A. Maffuz-Aziz ; R. C. Onofrio ; M. Parkin ; N. H. Pho ; V. Quintanar-Jurado ; A. H. Ramos ; R. Rebollar-Vega ; S. Rodriguez-Cuevas ; S. L. Romero-Cordoba ; S. E. Schumacher ; N. Stransky ; K. M. Thompson ; L. Uribe-Figueroa ; J. Baselga ; R. Beroukhim ; K. Polyak ; D. C. Sgroi ; A. L. Richardson ; G. Jimenez-Sanchez ; E. S. Lander ; S. B. Gabriel ; L. A. Garraway ; T. R. Golub ; J. Melendez-Zajgla ; A. Toker ; G. Getz ; A. Hidalgo-Miranda ; M. Meyerson
Nature Publishing Group (NPG)
Published 2012

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Publication Date:	2012-06-23
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Algorithms ; Breast Neoplasms/classification/genetics/pathology ; Core Binding Factor Alpha 2 Subunit/genetics ; Core Binding Factor beta Subunit/genetics ; DNA Mutational Analysis ; Exome/genetics ; Female ; Gene Fusion/genetics ; Humans ; Membrane Proteins/genetics ; Mexico ; Mutation/genetics ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors/genetics/metabolism ; Translocation, Genetic/genetics ; Vietnam
Published by:	http://www.nature.com/

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8

Melanoma genome sequencing reveals frequent PREX2 mutations

M. F. Berger ; E. Hodis ; T. P. Heffernan ; Y. L. Deribe ; M. S. Lawrence ; A. Protopopov ; E. Ivanova ; I. R. Watson ; E. Nickerson ; P. Ghosh ; H. Zhang ; R. Zeid ; X. Ren ; K. Cibulskis ; A. Y. Sivachenko ; N. Wagle ; A. Sucker ; C. Sougnez ; R. Onofrio ; L. Ambrogio ; D. Auclair ; T. Fennell ; S. L. Carter ; Y. Drier ; P. Stojanov ; M. A. Singer ; D. Voet ; R. Jing ; G. Saksena ; J. Barretina ; A. H. Ramos ; T. J. Pugh ; N. Stransky ; M. Parkin ; W. Winckler ; S. Mahan ; K. Ardlie ; J. Baldwin ; J. Wargo ; D. Schadendorf ; M. Meyerson ; S. B. Gabriel ; T. R. Golub ; S. N. Wagner ; E. S. Lander ; G. Getz ; L. Chin ; L. A. Garraway
Nature Publishing Group (NPG)
Published 2012

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Publication Date:	2012-05-25
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Chromosome Breakpoints/radiation effects ; DNA Damage ; DNA Mutational Analysis ; Gene Expression Regulation, Neoplastic ; Genome, Human/genetics ; Guanine Nucleotide Exchange Factors/genetics/metabolism ; Humans ; Melanocytes/metabolism/pathology ; Melanoma/genetics/pathology ; Mutagenesis/radiation effects ; Mutation/genetics/radiation effects ; Oncogenes/genetics ; Sunlight/*adverse effects ; Ultraviolet Rays/adverse effects
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

9

Discovery and saturation analysis of cancer genes across 21 tumour types

M. S. Lawrence ; P. Stojanov ; C. H. Mermel ; J. T. Robinson ; L. A. Garraway ; T. R. Golub ; M. Meyerson ; S. B. Gabriel ; E. S. Lander ; G. Getz
Nature Publishing Group (NPG)
Published 2014

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Publication Date:	2014-01-07
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Apoptosis/genetics ; Case-Control Studies ; Cell Proliferation ; Chromatin/genetics ; DNA Mutational Analysis ; Exome/genetics ; Genes, Neoplasm/genetics ; Genome, Human/genetics ; Genomic Instability/genetics ; Genomics ; Humans ; Immune Evasion/genetics ; Mutation Rate ; Neoplasms/classification/*genetics/pathology ; Point Mutation/genetics ; RNA Processing, Post-Transcriptional/genetics ; Sample Size
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

10

Data analysis: Create a cloud commons

L. D. Stein ; B. M. Knoppers ; P. Campbell ; G. Getz ; J. O. Korbel
Nature Publishing Group (NPG)
Published 2015

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Publication Date:	2015-07-15
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Access to Information ; Databases, Genetic/economics/standards/trends ; Information Storage and Retrieval/economics/standards/trends ; National Institutes of Health (U.S.) ; United States
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

11

The mutational landscape of head and neck squamous cell carcinoma

N. Stransky ; A. M. Egloff ; A. D. Tward ; A. D. Kostic ; K. Cibulskis ; A. Sivachenko ; G. V. Kryukov ; M. S. Lawrence ; C. Sougnez ; A. McKenna ; E. Shefler ; A. H. Ramos ; P. Stojanov ; S. L. Carter ; D. Voet ; M. L. Cortes ; D. Auclair ; M. F. Berger ; G. Saksena ; C. Guiducci ; R. C. Onofrio ; M. Parkin ; M. Romkes ; J. L. Weissfeld ; R. R. Seethala ; L. Wang ; C. Rangel-Escareno ; J. C. Fernandez-Lopez ; A. Hidalgo-Miranda ; J. Melendez-Zajgla ; W. Winckler ; K. Ardlie ; S. B. Gabriel ; M. Meyerson ; E. S. Lander ; G. Getz ; T. R. Golub ; L. A. Garraway ; J. R. Grandis
American Association for the Advancement of Science (AAAS)
Published 2011

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Publication Date:	2011-07-30
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Algorithms ; Apoptosis ; Carcinoma/genetics/metabolism/virology ; Carcinoma, Squamous Cell ; Cell Differentiation ; Exons ; Head and Neck Neoplasms/genetics/metabolism/virology ; Humans ; Mutation ; Neoplasms, Squamous Cell/genetics/metabolism/virology ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/virology ; Point Mutation ; Receptor, Notch1/genetics/metabolism ; Sequence Analysis, DNA ; Sequence Deletion ; Signal Transduction ; Smoking ; Tobacco
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

12

Mutations driving CLL and their evolution in progression and relapse

D. A. Landau ; E. Tausch ; A. N. Taylor-Weiner ; C. Stewart ; J. G. Reiter ; J. Bahlo ; S. Kluth ; I. Bozic ; M. Lawrence ; S. Bottcher ; S. L. Carter ; K. Cibulskis ; D. Mertens ; C. L. Sougnez ; M. Rosenberg ; J. M. Hess ; J. Edelmann ; S. Kless ; M. Kneba ; M. Ritgen ; A. Fink ; K. Fischer ; S. Gabriel ; E. S. Lander ; M. A. Nowak ; H. Dohner ; M. Hallek ; D. Neuberg ; G. Getz ; S. Stilgenbauer ; C. J. Wu
Nature Publishing Group (NPG)
Published 2015

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Publication Date:	2015-10-16
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Cell Transformation, Neoplastic/genetics ; Clone Cells/metabolism/pathology ; DNA Copy Number Variations/genetics ; Disease Progression ; Evolution, Molecular ; Exome/genetics ; Genes, myc/genetics ; Humans ; Ikaros Transcription Factor/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis/genetics/pathology/therapy ; MAP Kinase Signaling System/genetics ; Mutation/genetics ; Neoplasm Recurrence, Local/*genetics ; Prognosis ; RNA Processing, Post-Transcriptional/genetics ; RNA Transport/genetics ; Ribosomal Proteins/genetics ; Treatment Outcome
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

13

Initial genome sequencing and analysis of multiple myeloma

M. A. Chapman ; M. S. Lawrence ; J. J. Keats ; K. Cibulskis ; C. Sougnez ; A. C. Schinzel ; C. L. Harview ; J. P. Brunet ; G. J. Ahmann ; M. Adli ; K. C. Anderson ; K. G. Ardlie ; D. Auclair ; A. Baker ; P. L. Bergsagel ; B. E. Bernstein ; Y. Drier ; R. Fonseca ; S. B. Gabriel ; C. C. Hofmeister ; S. Jagannath ; A. J. Jakubowiak ; A. Krishnan ; J. Levy ; T. Liefeld ; S. Lonial ; S. Mahan ; B. Mfuko ; S. Monti ; L. M. Perkins ; R. Onofrio ; T. J. Pugh ; S. V. Rajkumar ; A. H. Ramos ; D. S. Siegel ; A. Sivachenko ; A. K. Stewart ; S. Trudel ; R. Vij ; D. Voet ; W. Winckler ; T. Zimmerman ; J. Carpten ; J. Trent ; W. C. Hahn ; L. A. Garraway ; M. Meyerson ; E. S. Lander ; G. Getz ; T. R. Golub
Nature Publishing Group (NPG)
Published 2011

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Publication Date:	2011-03-25
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Amino Acid Sequence ; Blood Coagulation/genetics ; CpG Islands/genetics ; DNA Mutational Analysis ; DNA Repair/genetics ; Exons/genetics ; Exosome Multienzyme Ribonuclease Complex ; Genome, Human/genetics ; Genomics ; Histones/metabolism ; Homeodomain Proteins/genetics ; Homeostasis/genetics ; Humans ; Methylation ; Models, Molecular ; Molecular Sequence Data ; Multiple Myeloma/drug therapy/enzymology/genetics/metabolism ; Mutation/*genetics ; NF-kappa B/metabolism ; Oncogenes/genetics ; Open Reading Frames/genetics ; Protein Biosynthesis/genetics ; Protein Conformation ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors/genetics/metabolism ; RNA Processing, Post-Transcriptional/genetics ; Ribonucleases/chemistry/genetics ; Signal Transduction/genetics ; Transcription, Genetic/genetics
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

14

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

J. Barretina ; G. Caponigro ; N. Stransky ; K. Venkatesan ; A. A. Margolin ; S. Kim ; C. J. Wilson ; J. Lehar ; G. V. Kryukov ; D. Sonkin ; A. Reddy ; M. Liu ; L. Murray ; M. F. Berger ; J. E. Monahan ; P. Morais ; J. Meltzer ; A. Korejwa ; J. Jane-Valbuena ; F. A. Mapa ; J. Thibault ; E. Bric-Furlong ; P. Raman ; A. Shipway ; I. H. Engels ; J. Cheng ; G. K. Yu ; J. Yu ; P. Aspesi, Jr. ; M. de Silva ; K. Jagtap ; M. D. Jones ; L. Wang ; C. Hatton ; E. Palescandolo ; S. Gupta ; S. Mahan ; C. Sougnez ; R. C. Onofrio ; T. Liefeld ; L. MacConaill ; W. Winckler ; M. Reich ; N. Li ; J. P. Mesirov ; S. B. Gabriel ; G. Getz ; K. Ardlie ; V. Chan ; V. E. Myer ; B. L. Weber ; J. Porter ; M. Warmuth ; P. Finan ; J. L. Harris ; M. Meyerson ; T. R. Golub ; M. P. Morrissey ; W. R. Sellers ; R. Schlegel ; L. A. Garraway
Nature Publishing Group (NPG)
Published 2012

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Publication Date:	2012-03-31
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Lineage ; Chromosomes, Human/genetics ; Clinical Trials as Topic/methods ; Databases, Factual ; Drug Screening Assays, Antitumor/methods ; Encyclopedias as Topic ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genes, ras/genetics ; Genome, Human/genetics ; Genomics ; Humans ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors/metabolism ; Models, Biological ; Neoplasms/drug therapy/genetics/metabolism/pathology ; Pharmacogenetics ; Plasma Cells/cytology/drug effects/metabolism ; Precision Medicine/methods ; Receptor, IGF Type 1/antagonists & inhibitors/metabolism ; Receptors, Aryl Hydrocarbon/genetics/metabolism ; Sequence Analysis, DNA ; Topoisomerase Inhibitors/pharmacology
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

15

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

T. J. Pugh ; S. D. Weeraratne ; T. C. Archer ; D. A. Pomeranz Krummel ; D. Auclair ; J. Bochicchio ; M. O. Carneiro ; S. L. Carter ; K. Cibulskis ; R. L. Erlich ; H. Greulich ; M. S. Lawrence ; N. J. Lennon ; A. McKenna ; J. Meldrim ; A. H. Ramos ; M. G. Ross ; C. Russ ; E. Shefler ; A. Sivachenko ; B. Sogoloff ; P. Stojanov ; P. Tamayo ; J. P. Mesirov ; V. Amani ; N. Teider ; S. Sengupta ; J. P. Francois ; P. A. Northcott ; M. D. Taylor ; F. Yu ; G. R. Crabtree ; A. G. Kautzman ; S. B. Gabriel ; G. Getz ; N. Jager ; D. T. Jones ; P. Lichter ; S. M. Pfister ; T. M. Roberts ; M. Meyerson ; S. L. Pomeroy ; Y. J. Cho
Nature Publishing Group (NPG)
Published 2012

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Publication Date:	2012-07-24
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Cerebellar Neoplasms/classification/genetics ; Child ; DEAD-box RNA Helicases/chemistry/genetics/metabolism ; DNA Helicases/chemistry/genetics ; DNA-Binding Proteins/genetics ; Exome/genetics ; Genome, Human/genetics ; Hedgehog Proteins/metabolism ; Histone-Lysine N-Methyltransferase/genetics/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; LIM Domain Proteins/genetics ; Medulloblastoma/classification/genetics ; Models, Molecular ; Mutation/*genetics ; Neoplasm Proteins/genetics ; Nuclear Proteins/chemistry/genetics ; Promoter Regions, Genetic/genetics ; Protein Structure, Tertiary/genetics ; Proto-Oncogene Proteins/genetics ; Receptors, Cell Surface/genetics ; Repressor Proteins/genetics ; Signal Transduction ; TCF Transcription Factors/metabolism ; Transcription Factors/chemistry/genetics ; Tumor Suppressor Protein p53/genetics ; Wnt Proteins/metabolism ; beta Catenin/genetics/metabolism
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

16

Mutational heterogeneity in cancer and the search for new cancer-associated genes

M. S. Lawrence ; P. Stojanov ; P. Polak ; G. V. Kryukov ; K. Cibulskis ; A. Sivachenko ; S. L. Carter ; C. Stewart ; C. H. Mermel ; S. A. Roberts ; A. Kiezun ; P. S. Hammerman ; A. McKenna ; Y. Drier ; L. Zou ; A. H. Ramos ; T. J. Pugh ; N. Stransky ; E. Helman ; J. Kim ; C. Sougnez ; L. Ambrogio ; E. Nickerson ; E. Shefler ; M. L. Cortes ; D. Auclair ; G. Saksena ; D. Voet ; M. Noble ; D. DiCara ; P. Lin ; L. Lichtenstein ; D. I. Heiman ; T. Fennell ; M. Imielinski ; B. Hernandez ; E. Hodis ; S. Baca ; A. M. Dulak ; J. Lohr ; D. A. Landau ; C. J. Wu ; J. Melendez-Zajgla ; A. Hidalgo-Miranda ; A. Koren ; S. A. McCarroll ; J. Mora ; R. S. Lee ; B. Crompton ; R. Onofrio ; M. Parkin ; W. Winckler ; K. Ardlie ; S. B. Gabriel ; C. W. Roberts ; J. A. Biegel ; K. Stegmaier ; A. J. Bass ; L. A. Garraway ; M. Meyerson ; T. R. Golub ; D. A. Gordenin ; S. Sunyaev ; E. S. Lander ; G. Getz
Nature Publishing Group (NPG)
Published 2013

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Publication Date:	2013-06-19
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Artifacts ; DNA Replication Timing ; Exome/genetics ; False Positive Reactions ; Gene Expression ; Genetic Heterogeneity ; Genome, Human/genetics ; Humans ; Lung Neoplasms/genetics ; Mutation/genetics ; Mutation Rate ; Neoplasms/classification/genetics/pathology ; Neoplasms, Squamous Cell/genetics ; Oncogenes/genetics ; Reproducibility of Results ; Sample Size
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

17

Comment on "DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification"

Stewart, C., Leshchiner, I., Hess, J., Getz, G.
American Association for the Advancement of Science (AAAS)
Published 2018

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Publication Date:	2018-09-28
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Geosciences Computer Science Medicine Natural Sciences in General Physics
Keywords:	Genetics, Medicine, Diseases
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

18

Identification of a new nuclear gene (CEM1) encoding a protein homologous to a β-keto-acyl synthase which is essential for mitochondrial respiration in Saccharomyces cerevisiae

Harington, A. ; Herbert, C. J. ; Tung, B. ; Getz, G. S. ; Slonimski, P. P.

Oxford, UK : Blackwell Publishing Ltd
Published 1993

Staff View

ISSN:	1365-2958
Source:	Blackwell Publishing Journal Backfiles 1879-2005
Topics:	Biology Medicine
Notes:	We have analysed a new gene, CEM1, from Saccharomyces cerevisiae. Inactivation of this gene leads to a respiratory-deficient phenotype. The deduced protein sequence shows strong similarities with β-keto-acyl synthases or condensing enzymes. Typically, enzymes of this class are involved in the synthesis of fatty acids or similar molecules. An analysis of the mitochondrial lipids and fatty acids shows no major difference between the wild type and deleted strains. Implying that the CBM1 gene product is not involved in the synthesis of the bulk fatty acids. Thus it Is possible that the CEM1 protein is involved in the synthesis of a specialized molecule, probably related to a fatty acid, which is essential for mitochondrial respiration.
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1111/j.1365-2958.1993.tb01715.x

Articles: DFG German National Licenses

19

Heterogeneity of Liver Lecithin isolated by Chromatography on Silicic Acid Columns

HARRIS, P. M. ; ROBINSON, D. S. ; GETZ, G.

[s.l.] : Nature Publishing Group
Published 1960

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ISSN:	1476-4687
Source:	Nature Archives 1869 - 2009
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Notes:	[Auszug] Three rats were each injected intraperitoneally with 4 (Jic. of labelled orthophosphate. Three hr. later, the rats were killed and their livers were removed. The lip ids from the combined livers were extracted and freed from water-soluble components containing radioactive phosphorus by a procedure ...
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1038/188742a0

Articles: DFG German National Licenses

20

A Cardiolipin-like Compound in Rat Liver Mitochondria

GETZ, G. S. ; BARTLEY, W.

[s.l.] : Nature Publishing Group
Published 1959

Staff View

ISSN:	1476-4687
Source:	Nature Archives 1869 - 2009
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Notes:	[Auszug] In the course of a study of the lipids of rat liver cell organelles, we have found in the lipids of rat liver mitochondria (extracted with chloroform methanol 2:1 (v/v)), a fraction which is eluted off a silicic acid chromatography column3 with chloroform-methanol 7:1 (v/v) and which resembles in ...
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1038/1841229a0

Articles: DFG German National Licenses

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