Search Results - (Author, Cooperation:G. Cooney)

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  1. 1
    M. Roffet-Salque ; M. Regert ; R. P. Evershed ; A. K. Outram ; L. J. Cramp ; O. Decavallas ; J. Dunne ; P. Gerbault ; S. Mileto ; S. Mirabaud ; M. Paakkonen ; J. Smyth ; L. Soberl ; H. L. Whelton ; A. Alday-Ruiz ; H. Asplund ; M. Bartkowiak ; E. Bayer-Niemeier ; L. Belhouchet ; F. Bernardini ; M. Budja ; G. Cooney ; M. Cubas ; E. M. Danaher ; M. Diniz ; L. Domboroczki ; C. Fabbri ; J. E. Gonzalez-Urquijo ; J. Guilaine ; S. Hachi ; B. N. Hartwell ; D. Hofmann ; I. Hohle ; J. J. Ibanez ; N. Karul ; F. Kherbouche ; J. Kiely ; K. Kotsakis ; F. Lueth ; J. P. Mallory ; C. Manen ; A. Marciniak ; B. Maurice-Chabard ; M. A. Mc Gonigle ; S. Mulazzani ; M. Ozdogan ; O. S. Peric ; S. R. Peric ; J. Petrasch ; A. M. Petrequin ; P. Petrequin ; U. Poensgen ; C. J. Pollard ; F. Poplin ; G. Radi ; P. Stadler ; H. Stauble ; N. Tasic ; D. Urem-Kotsou ; J. B. Vukovic ; F. Walsh ; A. Whittle ; S. Wolfram ; L. Zapata-Pena ; J. Zoughlami
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-11-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Africa, Northern ; Animals ; Archaeology ; Beekeeping/*history ; *Bees ; Ceramics/chemistry/history ; Europe ; Farmers/history ; Geographic Mapping ; History, Ancient ; Lipids/analysis/chemistry ; Middle East ; Spatio-Temporal Analysis ; Waxes/*analysis/chemistry/*history
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0006-291X(86)80551-4

    Articles: DFG German National Licenses
  3. 3
    Staff View
    ISSN:
    0006-291X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0006-291X(86)80551-4

    Articles: DFG German National Licenses
  4. 4
    Cooney, G.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0968-0004
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0968-0004(85)90250-6

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    1432-0428
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00418533

    Articles: DFG German National Licenses
  6. 6
    Sainsbury, A. ; Wilks, D. ; Cooney, G. J.
    Springer
    Published 2000
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Keywords Neuropeptide Y, intracerebroventricular, hyperinsulinaemia, adrenalectomy, atropine, dexamethasone, rat.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Aims/hypothesis. Hypothalamic neuropeptide Y is implicated in the aetiology of obesity and insulin resistance because of its hyperinsulinaemic, hyperphagic effects. We investigated the interaction of adrenal glucocorticoids and the parasympathetic nervous system in the hyperinsulinaemia caused by neuropeptide Y infusion in rats.¶Methods. Neuropeptide Y was intracerebroventricularly given to normal or adrenalectomised rats for 3–6 days with pair-feeding, with or without subcutaneous dexamethasone infusion. We measured basal and intravenous glucose-induced insulinaemia and the effect of prior atropine injection.¶Results. Neuropeptide Y increased basal plasma insulin and C-peptide concentrations (380 ± 90 and 1000 ± 60 pmol/l, vs 190 ± 20 and 590 ± 50 pmol/l in controls, p 〈 0.05). Neuropeptide Y also increased the plasma concentrations of these hormones as early as 60 s after glucose injection (1630 ± 170 and 3200 ± 170 pmol/l for insulin and C peptide, respectively, vs 1080 ± 80 and 1860 ± 130 pmol/l in controls, p 〈 0.05). Atropine reversed the effect of neuropeptide Y on basal plasma insulin and C-peptide concentrations but had no effect on post-glucose plasma concentrations. The hyperinsulinaemic effects of neuropeptide Y were prevented by adrenalectomy, but were restored by dexamethasone infusion. Dexamethasone in itself did not statistically significantly increase insulinaemia in adrenalectomised rats. As in intact rats, atropine attenuated the basal hyperinsulinaemia of adrenalectomised rats that had been infused with neuropeptide Y and dexamethasone but had no effect on post-glucose hyperinsulinaemia.¶Conclusion/interpretation. These data suggest firstly that neuropeptide Y infused centrally induces basal hyperinsulinaemia in rats through glucocorticoid-dependant parasympathetic activation to the pancreas. Secondly, neuropeptide Y potentiates glucose-induced insulinaemia through a pathway dependant on adrenal glucocorticoids that cannot be reversed by short-term blockade of the increased parasympathetic tonus. [Diabetologia (2000) 43: 859–865]
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001250051462

    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    1432-0428
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00418533

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    1432-2013
    Keywords:
    Pyruvate dehydrogenase complex ; Heart muscle ; Skeletal muscle ; Glucose metabolism ; Exercise
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Muscle glucose uptake is greatly stimulated by moderate exercise, but full oxidation of the glucose to CO2 depends on the activity of the pyruvate dehydrogenase (PDH) complex. Our aim was to determine how PDH complex in different muscle groups responds to varying periods of moderate exercise. Rats were run on a motor-driven treadmill for 5–30 min and muscle PDH complex activity was determined in heart, diaphragm and red quadriceps muscles after isolation of mitochondria in the presence of inhibitors of PDH complex interconversion. In heart and diaphragm muscle, exercise caused an increase in PDH complex activity after 5 min, but this was followed by a significant decrease in activity as exercise progressed. In red quadriceps muscle, PDH complex activity was reduced after 5 min of exercise and was decreased further as exercise continued. We conclude that increased duration of exercise can lead to reduced PDH complex activity in rat muscles. We propose that this is a consequence of elevated fatty acid oxidation, the products of which stimulate PDH kinase. This implies that increased glycolysis to lactate and increased fatty acid oxidation can simultaneously provide energy for contracting muscle.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00372995

    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    1432-1041
    Keywords:
    Key words Sufentanil ; pharmacokinetics ; haemo dynamics ; different infusion rates ; coronary surgery
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Medicine
    Notes:
    Abstract    Objective: Pharmacokinetics and haemodynamic effects of a total dose of 15 μg · kg−1 sufentanil, an opioid anaesthetic agent, were studied in patients undergoing aortocoronary bypass surgery at three infusion rates of 30 (group I), 5 (group II), and 2 (group III) μg · kg−1 · min−1, respectively. Results: Plasma concentrations of sufentanil could be optimally characterized by a linear biexponential pharmacokinetic model. Non-compartmental analyses indicated that there was no significant difference in the values of clearance (11.6, 13.3, 14.3 ml · min−1 · kg−1), steady-state volume of distribution (0.220, 0.255 and 0.331 l · kg−1) and mean residence time (18.8, 13.3 and 14.3 min) among the groups. The observed mean Cmax values of 421 (group I), 125 (group II), and 53 (group III) ng · ml−1 and observed mean AUC values from 0 to 3 min were all consistent with the dosing regimens. There were large inter-individual variations in haemodynamic response. Compared to plasma data, a delay in haemodynamic effects was found. Times to reach peak haemodynamic effect ranged from 4.3 to 4.9 min for group I, from 4.6 to 6.1 min for group II, and from 9.9 to 11.3 for group III. Except heart rate, peak haemodynamic effects in these study patients generally ranged from 20.9% to 35.2%. Significant reductions in the area under the effect-time profiles of mean arterial blood pressure and systemic vascular resistance were observed in group II and group III, but not in group I. Significant reductions in the area under the effect-time profiles of left ventricular stroke work index were observed in group III only. No effect on heart rate was found in any group. Conclusion: Our findings suggested that a slower infusion rate of sufentanil at a dose of 15 μg · kg−1 tends to give a greater reduction in mean arterial blood pressure, systemic vascular resistance, and left ventricular stroke work index than does a faster infusion rate.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002280050214

    Articles: DFG German National Licenses