Search Results - (Author, Cooperation:G. Bono)

2012-04-07

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

2011-08-26

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

2013-03-08

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

1468-2982

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

According to International Headache Society classification criteria, the presence of pericranial muscle disorder in tension-type headache should be evaluated using one of the following methods: EMG, pressure algometry or manual palpation. The purpose of this study was to compare the results of these three methods in 15 patients with episodic tension-type headache, 29 with chronic tension-type headache and 22 presenting migraine without aura compared to those obtained in healthy individuals. Algometric and EMG recordings at the frontalis muscle during mental arithmetic were more impaired in episodic and chronic tension headache patients than in controls and migraine patients. Chronic tension headache patients were significantly impaired at the trapezius muscle in all three tests compared to controls. Our data indicate that when two or three tests were carried out the diagnostic capacity was significantly improved in comparison to only one test. Moreover, since a different pattern could be seen with pain and without pain, the existence of headache at the time of testing should be taken into consideration.

Electronic Resource

1468-2982

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Pain perception threshold (PFT) in the head was assessed with a pressure algometer in 58 cluster headache (CH) patients (52M, 6F; 41 episodic and 17 chronic). Fourteen patients in cluster period were retested in remission. Thresholds were assessed at 10 symmetrical points on each side of the head and at the deltoid. Compared with controls (n = 80), CH patients had lower PPT in the head and in the deltoid. PPT was lower on the symptomatic side than on the non-symptomatic side in patients with episodic CH during a cluster period (p〈0.001) and in patients with chronic CH (p〈0.05). This pattern was more evident during a cluster period than during remission (p〈0.05). A reduced PPT did not correlate with illness duration and pain side. The lowest PPT mean values were found at the anterior and intermediate levels of the temporal muscle on the symptomatic side. These results imply a central mechanism underlying the pathogenesis of CH.

Electronic Resource

1468-2982

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

The regulation of prolactin (PRL) secretion periodicity in cluster headache (CH) and in atypical facial pain (AFP) has been studied in nine and seven patients, respectively. The physiological periodicity of the hormone secretion, with its highest levels during night sleep and its lowest during the waking hours, is upset in CH, but not in AFP. A rhythmicity occurs in CH only in the presence of severe pain, which appears to be the synchronizing event. Lithium carbonate treatment does not interfere with the mentioned changes in PRL secretion in CH.

Electronic Resource

1749-6632

Blackwell Publishing Journal Backfiles 1879-2005

Natural Sciences in General

Electronic Resource

0022-4731

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Electronic Resource

0378-4320

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Electronic Resource

0378-4320

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Electronic Resource

0167-4943

Cerebrovascular disorders ; Cognitive impairment ; Dementia ; Idebenone

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Medicine

Electronic Resource

0167-4943

Memory ; Pramiracetam ; Scopolamine

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Medicine

Electronic Resource

1435-1463

Norepinephrine ; 3-methoxy-4-hydroxyphenylglycol ; neuropeptide Y ; Parkinson's disease ; multiple system atrophy ; dementia of Alzheimer type

Springer Online Journal Archives 1860-2000

Medicine

Summary Neuropeptide Y, one of the most abundant polypeptides within the nervous system, is co-stored with catecholamines, especially norepinephrine (NE), thus suggesting its possible involvement in pathologies characterized by a noradrenergic impairment. In Parkinson's disease (PD), as well as in multiple system atrophy (MSA), a central noradrenergic deficit has been demonstrated, and in the dementia of Alzheimer type (DAT) an impaired noradrenergic transmission has been postulated. In this study we determined CSF NE and MHPG levels in 29 PD, 15 MSA, 22 DAT patients and in 36 controls, while CSF NPY-immunoreactivity (NPY-ir) levels were measured in 10 PD, 7 MSA, 10 DAT patients and 20 controls. PD, MSA, and DAT patients showed a significant reduction in CSF NPY-ir and NE levels compared with controls, while CSF MHPG levels resulted in a reduction in only the MSA group. Furthermore, an inverse correlation between either NE or MHPG levels and the duration of the orthostatic hypotension was found in MSA patients while for DAT patients the MHPG levels were directly correlated to the severity of cognitive impairment, and inversely to the duration of illness.

Electronic Resource

0093-691X

PMSG ; cows ; hMG ; hormones ; superovulation

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Medicine

Electronic Resource

1439-0973

Springer Online Journal Archives 1860-2000

Medicine

Zusammenfassung Fosfomycin Trometamol wird in Italien seit mehreren Jahren klinisch eingesetzt. Eine Studie, die 1990 an drei akademischen Lehrkrankenhäusern in Genua, Parma und Catania durchgeführt wurde und 6.021 Bakterienstämme aus 23.816 Urinkulturen umfaßte, sollte die Resistenzsituation gegenüber Fosfomycin Trometamol im Vergleich zu acht anderen Antibiotika bestimmen. Es handelte sich vorwiegend um gramnegative Erreger, vor allemEscherichia coli (41,6%). Amoxicillin erwies sich als die am wenigsten wirksame Substanz mit einer Resistenzrate von 41,4% der Stämme. Fosfomycin wies mit 2,8% Resistenzen bei gramnegativen und 2,1% bei grampositiven Isolaten die niedrigste Resistenzrate auf. Es folgten Norfloxacin mit einer Resistenzrate von 11,8% und Netilmicin mit 12,2% Resistenzen unter den getesteten Isolaten. Diese Ergebnisse zeigen, daß Fosfomycin Trometamol auch weiterhin für die Einmaldosis-Therapie bei Harnwegsinfektionen eingesetzt werden kann, auch wenn kein mikrobiologischer Befund vorliegt. Die Resistenzrate gegen dieses Antibiotikum ist bei den Erregern von bakteriellen Harnwegsinfektionen derzeit so gering, daß ein Therapieversagen sehr unwahrscheinlich ist.

Summary In order to assess the resistance profile for fosfomycin trometamol after several years of clinical use in Italy, this study has explored the susceptibility to fosfomycin and eight other antibacterial drugs of 6,021 strains isolated from 23,816 urines during 1990 in three teaching hospitals located in Genoa, Parma and Catania. Gram-negative strains, notablyEscherichia coli (41.6%), were primarily involved. Amoxicillin was the least active compound with resistance in 41.4% of the isolates. Fosfomycin showed the lowest rate of resistance in both gram-negative (2.8%) and gram-positive (2.1%) pathogens. This was followed by norfloxacin with a resistance rate of 11.8% and netilmicin with 12.2%. These results indicate that fosfomycin-trometamol may continue to be used in single-dose treatment of urinary tract infections even in the absence of microbiological data since the prevalence of resistance to the drug is, at present, so low that therapeutic failure is highly improbable.

Electronic Resource

1435-1463

Monoamines ; cerebrospinal fluid ; dementia of Alzheimer type ; L-deprenyl

Springer Online Journal Archives 1860-2000

Medicine

Summary An impairment of the monoaminergic systems has frequently been reported for Alzheimer's disease (AD) as well as an overactivity of cerebral monoamineoxidase B (MAO-B). L-deprenyl (LD), a selective and irreversible MAO-B inhibitor, has recently been proposed for the treatment of AD. The cerebrospinal fluid (CSF) levels of norepinephrine (NE), epinephrine (E), dopamine (DA), 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA) were studied in 14 patients suffering from dementia of Alzheimer type (DAT) and in 14 controls. A three-month double-blind study comparing LD with placebo was carried out, in the DAT group, and the influence of the treatment on neurotransmitter levels and cognitive performance was evaluated. The basal study revealed a significant reduction in CSF NE and HVA levels in DAT patients when compared with controls; the treatment with LD determined a significant decrease in HVA levels only and, as to neuropsychological investigation, a global amelioration of cognitive performances.

Electronic Resource

1590-3478

Springer Online Journal Archives 1860-2000

Medicine

Sommario Scopo del lavoro è di discutere alcuni aspetti relativi all'inquadramento nosografico delle cosiddette cefalee sintomatiche o secondarie, con particolare riferimento alla Classificazione della International Headache Society (IHS), attualmente in corso di revisione. Le cefalee sintomatiche rappresentano infatti un gruppo eterogeneo di disordini e condizion talvolta di grande rilevanza clinica, come nel caso delle cefalee sintomatiche di patologia intracranica vascolare e non vascolare. Peraltro, rientrano invece in questo capitolo quadri clinici mal definiti (aspecifici) e con incerta relazione causa-effetto con i vari fattori ed eventi con i quali un quadro di cealea o di dolore cranio-facciale si associa. Esiste poi un'importanza speculativa per le cefalee secondarie, rappresentata dalla possibilità di considerare alcune forme quali modelli in vivo per approfondire i meccanismi patofisiologici alla base della produzione del dolore cefalico. Sulla base di queste considerazioni vengono discusse, rispettivamente, le cefalee di interesse neurochirurgico (come sintomi premonitori di patologia maggiore intracranica), le cefalee secondarie a variazioni degli ormoni sessuali nel corso della vita riproduttiva e nel caso della somministrazione di estroprogestinici, le cefalee post-traumatiche per il rilievo fisiopatologico che assumono nei confronti di alcune forme di emicrania e di cefalea cervicogenica.

Electronic Resource