Search Results - (Author, Cooperation:G. Binder)
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1Cotter, T. G., Binder, M., Loftus, E. V., Abboud, R., McNally, M. A., Smyrk, T. C., Tremaine, W. J., Sandborn, W. J., Pardi, D. S.
BMJ Publishing Group
Published 2018Staff ViewPublication Date: 2018-02-09Publisher: BMJ Publishing GroupPrint ISSN: 0017-5749Electronic ISSN: 1468-3288Topics: MedicinePublished by: -
2M. G. Aartsen ; R. Abbasi ; Y. Abdou ; M. Ackermann ; J. Adams ; J. A. Aguilar ; M. Ahlers ; D. Altmann ; J. Auffenberg ; X. Bai ; M. Baker ; S. W. Barwick ; V. Baum ; R. Bay ; J. J. Beatty ; S. Bechet ; J. Becker Tjus ; K. H. Becker ; M. L. Benabderrahmane ; S. BenZvi ; P. Berghaus ; D. Berley ; E. Bernardini ; A. Bernhard ; D. Bertrand ; D. Z. Besson ; G. Binder ; D. Bindig ; M. Bissok ; E. Blaufuss ; J. Blumenthal ; D. J. Boersma ; S. Bohaichuk ; C. Bohm ; D. Bose ; S. Boser ; O. Botner ; L. Brayeur ; H. P. Bretz ; A. M. Brown ; R. Bruijn ; J. Brunner ; M. Carson ; J. Casey ; M. Casier ; D. Chirkin ; A. Christov ; B. Christy ; K. Clark ; F. Clevermann ; S. Coenders ; S. Cohen ; D. F. Cowen ; A. H. Cruz Silva ; M. Danninger ; J. Daughhetee ; J. C. Davis ; M. Day ; C. De Clercq ; S. De Ridder ; P. Desiati ; K. D. de Vries ; M. de With ; T. DeYoung ; J. C. Diaz-Velez ; M. Dunkman ; R. Eagan ; B. Eberhardt ; B. Eichmann ; J. Eisch ; R. W. Ellsworth ; S. Euler ; P. A. Evenson ; O. Fadiran ; A. R. Fazely ; A. Fedynitch ; J. Feintzeig ; T. Feusels ; K. Filimonov ; C. Finley ; T. Fischer-Wasels ; S. Flis ; A. Franckowiak ; K. Frantzen ; T. Fuchs ; T. K. Gaisser ; J. Gallagher ; L. Gerhardt ; L. Gladstone ; T. Glusenkamp ; A. Goldschmidt ; G. Golup ; J. G. Gonzalez ; J. A. Goodman ; D. Gora ; D. T. Grandmont ; D. Grant ; A. Gross ; C. Ha ; A. Haj Ismail ; P. Hallen ; A. Hallgren ; F. Halzen ; K. Hanson ; D. Heereman ; D. Heinen ; K. Helbing ; R. Hellauer ; S. Hickford ; G. C. Hill ; K. D. Hoffman ; R. Hoffmann ; A. Homeier ; K. Hoshina ; W. Huelsnitz ; P. O. Hulth ; K. Hultqvist ; S. Hussain ; A. Ishihara ; E. Jacobi ; J. Jacobsen ; K. Jagielski ; G. S. Japaridze ; K. Jero ; O. Jlelati ; B. Kaminsky ; A. Kappes ; T. Karg ; A. Karle ; J. L. Kelley ; J. Kiryluk ; J. Klas ; S. R. Klein ; J. H. Kohne ; G. Kohnen ; H. Kolanoski ; L. Kopke ; C. Kopper ; S. Kopper ; D. J. Koskinen ; M. Kowalski ; M. Krasberg ; K. Krings ; G. Kroll ; J. Kunnen ; N. Kurahashi ; T. Kuwabara ; M. Labare ; H. Landsman ; M. J. Larson ; M. Lesiak-Bzdak ; M. Leuermann ; J. Leute ; J. Lunemann ; J. Madsen ; G. Maggi ; R. Maruyama ; K. Mase ; H. S. Matis ; F. McNally ; K. Meagher ; M. Merck ; T. Meures ; S. Miarecki ; E. Middell ; N. Milke ; J. Miller ; L. Mohrmann ; T. Montaruli ; R. Morse ; R. Nahnhauer ; U. Naumann ; H. Niederhausen ; S. C. Nowicki ; D. R. Nygren ; A. Obertacke ; S. Odrowski ; A. Olivas ; A. O'Murchadha ; L. Paul ; J. A. Pepper ; C. Perez de los Heros ; C. Pfendner ; D. Pieloth ; E. Pinat ; J. Posselt ; P. B. Price ; G. T. Przybylski ; L. Radel ; M. Rameez ; K. Rawlins ; P. Redl ; R. Reimann ; E. Resconi ; W. Rhode ; M. Ribordy ; M. Richman ; B. Riedel ; J. P. Rodrigues ; C. Rott ; T. Ruhe ; B. Ruzybayev ; D. Ryckbosch ; S. M. Saba ; T. Salameh ; H. G. Sander ; M. Santander ; S. Sarkar ; K. Schatto ; F. Scheriau ; T. Schmidt ; M. Schmitz ; S. Schoenen ; S. Schoneberg ; A. Schonwald ; A. Schukraft ; L. Schulte ; O. Schulz ; D. Seckel ; Y. Sestayo ; S. Seunarine ; R. Shanidze ; C. Sheremata ; M. W. Smith ; D. Soldin ; G. M. Spiczak ; C. Spiering ; M. Stamatikos ; T. Stanev ; A. Stasik ; T. Stezelberger ; R. G. Stokstad ; A. Stossl ; E. A. Strahler ; R. Strom ; G. W. Sullivan ; H. Taavola ; I. Taboada ; A. Tamburro ; A. Tepe ; S. Ter-Antonyan ; G. Tesic ; S. Tilav ; P. A. Toale ; S. Toscano ; E. Unger ; M. Usner ; N. van Eijndhoven ; A. Van Overloop ; J. van Santen ; M. Vehring ; M. Voge ; M. Vraeghe ; C. Walck ; T. Waldenmaier ; M. Wallraff ; C. Weaver ; M. Wellons ; C. Wendt ; S. Westerhoff ; N. Whitehorn ; K. Wiebe ; C. H. Wiebusch ; D. R. Williams ; H. Wissing ; M. Wolf ; T. R. Wood ; K. Woschnagg ; D. L. Xu ; X. W. Xu ; J. P. Yanez ; G. Yodh ; S. Yoshida ; P. Zarzhitsky ; J. Ziemann ; S. Zierke ; M. Zoll
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-11-23Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
3Staff View
Publication Date: 2018-06-26Publisher: BMJ Publishing GroupPrint ISSN: 0022-2593Electronic ISSN: 1468-6244Topics: MedicineKeywords: Open accessPublished by: -
4Raynal, L. ; Harion, J-L. ; Favre-Marinet, M. ; Binder, G.
[S.l.] : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: The results of an experimental investigation of the instability of variable-density plane jets issuing into ambient air are reported. When the jet to ambient fluid density ratio S(S=ρj/ρ∞) is less than a critical value, an intense oscillating instability is observed. This instability is characterized by sharp peaks in the power spectral density measured in the near field of the jet. The effects of the control parameters S, Re, and H/θ (jet width to exit momentum thickness) on the instability regime are determined. It is shown that Re is a better scaling parameter than H/θ. The Strouhal number of the dominant mode StH increases with S and Re up to a constant value of 0.25, which is in rather good agreement with the theory and the experiments of Yu and Monkewitz [Phys. Fluids A 2, 1175 (1990); J. Fluid Mech. 255, 323 (1993)]. In the present experiments the critical value Sc above which the oscillating regime disappears is an increasing function of Re and Sc seems to reach a limiting value in the neighborhood of 0.7, which does not agree well either with the theory or with the experiments of Yu and Monkewitz [Phys. Fluids A 2, 1175 (1990); J. Fluid Mech. 255, 323 (1993)]. This difference is in qualitative agreement with the results of linear stability computations, also reported in the paper, which take into account differences in shape and relative positions of the density and velocity profiles. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
5Staff View
ISSN: 0003-2697Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
6Staff View
ISSN: 0026-7074Topics: Classical StudiesURL: -
7Staff View
ISSN: 0016-6480Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
8Staff View
ISSN: 0029-554XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Energy, Environment Protection, Nuclear Power EngineeringPhysicsType of Medium: Electronic ResourceURL: -
9Bassompierre, G. ; Binder, G. ; Dalpiaz, P. ; Dalpiaz, P.F. ; Ferro-Luzzi, M. ; Gissinger, G. ; Jacquey, S. ; Peroni, C. ; Mulhouse-Strasbourg-Torino Collaboration ; Schmitt, F.M. ; Tecchio, L. ; Schneegans, M.A.
Amsterdam : ElsevierStaff ViewISSN: 0029-554XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Energy, Environment Protection, Nuclear Power EngineeringPhysicsType of Medium: Electronic ResourceURL: -
10Bassompierre, G. ; Binder, G. ; Dalpiaz, P. ; Dalpiaz, P.F. ; Gissinger, G. ; Jacquey, S. ; Peroni, C. ; Ruzza, A. ; Tecchio, L. ; Scheegans, M.A.
Amsterdam : ElsevierStaff ViewISSN: 0370-2693Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
11Bassompierre, G. ; Binder, G. ; Dalpiaz, P. ; Dalpiaz, P.F. ; Gissinger, G. ; Jacquey, S. ; Peroni, C. ; Schneegans, M.A. ; Mulhouse-Strasbourg-Torino Collaboration ; Tecchio, L.
Amsterdam : ElsevierStaff ViewISSN: 0370-2693Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
12Bassompierre, G. ; Binder, G. ; Dalpiaz, P. ; Dalpiaz, P.F. ; Gissinger, G. ; Jacquey, S. ; Peroni, C. ; Schneegans, M.A. ; Tecchio, L.
Amsterdam : ElsevierStaff ViewISSN: 0370-2693Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 1432-1114Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract Quantitative results concerning the modulation of the ejection and bursting frequency in an unsteady channel flow obtained by flow visualizations are presented and compared with probe measurements. The frequency of the imposed velocity oscillations f covers a large range going from the quasi steady limit to the time mean bursting frequency in the corresponding steady flow. The imposed amplitudes of the velocity oscillations are 13% and 20% of the centerline velocity. The bursting process is identified by the intermittent lift up of the dye injected at the wall. Qualitative analysis of the flow visualizations show that the ejection activity at a given phase of the oscillation cycle is repetitive from one cycle to the other. The modulation amplitude of the ejection frequency 〈f e 〉 is sensitive to the imposed frequency. At low imposed frequency 〈f e 〉 is modulated as the wall shear stress, but the inner scaling does not hold when f + is high. Here, (+) corresponds to the quantities normalized with the inner variables, i.e. the friction velocity u τ and the viscosity ν. The grouping of the ejections into bursts show the coexistence of two categories of events which react differently to the forcing. The groups of ejections (Multiple Ejection Bursts) are governed by the modulation of the wall shear stress 〈τ〉 in the whole imposed frequency range. The solitary ejections (or the Single Ejection Bursts) have modulation amplitudes and phases which differ significantly from those of 〈τ〉 in the intermediate and high imposed frequency range. There is a good agreement between the flow visualization data and the probe measurements.Type of Medium: Electronic ResourceURL: -
14Staff View
ISSN: 1432-1076Keywords: Key words Gene ; Growth hormone ; Growth hormone deficiency ; Short statureSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract A family with isolated growth hormone deficiency (IGHD) in two children and their mother is reported. Genetic analysis revealed a heterozygous splice site mutation in intron III of the GH-1 gene. This mutation was de novo in the mother and was transmitted in a dominant way to her offspring. Conclusion De novo mutations in the GH-1 gene may be an important cause of congenital idiopathic IGHD. As these patients have normal fertility, pointing out this mutation is of great value for appropriate genetic counselling in patients with idiopathic IGHD.Type of Medium: Electronic ResourceURL: -
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ISSN: 1432-1076Keywords: Key words Tall stature ; Final height ; Height prediction ; Height reduction ; High-dose sex hormone treatmentSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract In 135 women and 85 men who initially presented for tall stature, the outcome in treated (56 women and 33 men; cases) and untreated (controls) was investigated. At the time of height prediction, cases were significantly taller (P≤0.03) than the controls, they had higher target heights (P〈0.001) and adult height predictions (P〈0.001) (according to Bailey and Pinneau) compared to the controls. Bone age (according to Greulich and Pyle) and chronological age were well matched in both groups. Final height was measured after cessation of growth at a mean age above 21.5 years. The final height prediction according to Bailey and Pinneau (BP method) overestimated the final height in controls. The mean error of estimation was −0.14 cm (±3.10) in women, and −1.86 cm (±4.37) in men. Age at the time of prediction did not significantly correlate with the degree of the prediction error. Sex hormone therapy comprised a daily oral dose of 7.5 mg conjugated oestrogens in girls (plus 5 mg dydrogesterone for 10 days a month), while boys received 500 mg testosterone enantate, intramuscularly, every 2 weeks. Therapy was well tolerated. The mean corrected effect of height reducing therapy was 3.6 cm (range: 11.9 cm to −3.3 cm) in women and 4.4 cm (range: 14.2 cm to −5.2 cm) in men. Therapy was significantly more effective when started at an earlier chronological (P〈0.01) and bone age (P〈0.01). The residual mean growth, after therapy was stopped, was 1.8 (±1.6) cm in women and 3.1 (±2.3) cm in men. In men, post-treatment growth was inversely correlated to chronological age (P〈0.01) and bone age (P〈0.05) at the end of treatment, while these correlations were not significant in women. Both groups had a higher educational level than the normal population. Treated tall women reported teasing because of tallness more frequently than controls. In tall men, practical issues such as clothing size predominated. Maximum tolerated height in males was 200 cm and in females 180 cm, thus being nearly analogous to the actual professional criteria for treatment recommendation. A positive attitude to treatment was documented in over 90% of treated individuals. Conclusions Our results show that the BP method gives acceptable adult height predictions in girls, but less accurate predictions in boys. The treatment with high doses of sex hormones was low effective in both sexes and showed a wide range of response. For success, treatment must be initiated in early puberty and terminated late. The answers to a questionnaire revealed no major psychological or social maladjustment of treated individuals compared to those untreated.Type of Medium: Electronic ResourceURL: -
16Saletu, B. ; Brandstätter, N. ; Stamenkovic, M. ; Anderer, P. ; Semlitsch, H. V. ; Grünberger, J. ; Linzmayer, L. ; Decker, K. ; Binder, G. ; Metka, M. ; Heytmanek, G. ; Huber, J. ; Kurz, Ch. ; Knogler, W. ; Koll, B.
Springer
Published 1995Staff ViewISSN: 1432-2072Keywords: Menopause ; Depression ; Hamilton Depression Rating Scale ; Kupperman Index ; Oestradiol ; Follicle stimulating hormone ; EEG mapping ; Vigilance ; Transdermal oestrogen therapySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract In a double-blind, placebo-controlled study, the antidepressant and vigilance-promoting properties of transdermal oestrogen in post-menopausal depression were investigated utilizing hormonal, syndromal and EEG mapping evaluations. Sixty-nine menopausal women, aged 45–60 years without previous hormonal replacement therapy, diagnosed as major depression without psychotic or suicidal symptoms (DSM-III-R criteria), were randomly assigned to a 3-month treatment with transdermal oestradiol [Estraderm TTS (ETTS) 50 µg, applied twice weekly] or placebo. No other psychoactive medication was allowed. After removal of protocol violators, 32 patients were evaluable in each group, which did not differ in age, height or weight. As five patients discontinued prematurely in both groups and in one placebo patient a post-drug EEG could not be obtained, 27 patients remained in the ETTS and 26 in the placebo group for efficacy analysis. While in the placebo group, oestradiol (E2) and follicle stimulating hormone (FSH) remained unchanged, E2 increased and FSH decreased significantly in the ETTS group. Syndromal evaluation showed a significant improvement in the Kupperman Index (KI) as well as Hamilton Depression Rating Scale (HAMD) in both groups, with no inter-group difference. However, EEG mapping demonstrated significant interdrug differences in brain function, mostly over the left temporal region. While ETTS patients showed an increase of alpha and alpha-adjacent theta activity and a decrease of beta activity, as well as an acceleration of the delta/theta centroid and a slowing of the alpha, beta and total power centroid, no changes occurred in the placebo-treated patients. These neurophysiological findings suggest improvement of vigilance by oestrogen, previously referred to as “mental tonic” effect. There were no changes, however, in the frontal alpha asymmetry index, reflecting left frontal hypo- and right frontal hyperactivation. Thus, this neurophysiological variable represents a state-independent marker for depression. The tolerability of ETTS was very good.Type of Medium: Electronic ResourceURL: -
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ISSN: 1573-2665Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Familial hypercholesterolaemia (FH) is an autosomal dominant disorder of lipid metabolism characterized by elevated low-density lipoproteins (LDL), the formation of tendon and skin xanthomata and the development of premature coronary atherosclerosis. It is caused by a defect in the receptor-mediated hepatic uptake of LDL due to mutations in the LDL receptor. In 25 FH families with a total of 160 members and in two individuals without available relatives, all of German origin, we identified LDL receptor mutations by a multiplex-PCR-based single-strand conformation polymorphism method followed by direct sequencing. Of the 24 mutations found, 15 are missense mutations, 2 are nonsense mutations, 4 are small deletions or insertions leading to frameshifts, 2 are an in-frame insertion and deletion, respectively, and one is a splice site mutation. Propositi carrying mutations that are known to completely abolish receptor function (nonsense and frameshift mutations, missense mutation V480M) had significantly higher untreated total and LDL-cholesterol levels compared to those patients carrying missense and in-frame insertion mutations of unknown functional consequence, which may lead to either reduced or completely abolished receptor function (11.30±1.64 vs 9.76±1.50 mmol/L, and 9.39±1.23 vs 7.99±1.45 mmol/L, respectively). These results confirm the clinical and molecular heterogeneity of FH and the influence of different functional classes of mutations on lipid values.Type of Medium: Electronic ResourceURL: -
18Staff View
ISSN: 1573-8876Source: Springer Online Journal Archives 1860-2000Topics: MathematicsNotes: Abstract It is proved that some classes $$\mathfrak{H}$$ of conjugate elements in a symmetric and in an alternating group are complete sets of complementing elements, i.e., subsets such that for each non-identity element A of the group there exists an element B ∉ $$\mathfrak{H}$$ such that A and B generate the group.Type of Medium: Electronic ResourceURL: -
19Staff View
ISSN: 1435-1536Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsType of Medium: Electronic ResourceURL: -
20Staff View
ISSN: 0947-5117Keywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsDescription / Table of Contents: New Polyolefines for apparatus I. Polybutene 1I. Polybutene 1In comparing its properties with seemingly similar polyolefines, the superiority of polybutene is apparent in three respects: It shows no stress cracking, its creep is very small, and its softening characteristic is favourable.These properties are interpreted with the aid of test results which show considerable advantages compared with other polyolefines.Examples are described of apparatus and piping made of this material.II. Polyolefines of low inflammabilityThe types of high-density polyethylene and polypropylene discussed here are of “low inflammability” as defined in German Standards, DIN 4102, Sheet 3. In this respect, they are, to some extent, comparable to PVC-resin. Their processibility is good and their mechanical, thermal and chemical properties are favourable.For outdoor applications, black polyethylene of low inflammability is suitable because of its high resistance to atmospheric agents. Practical experience now dates back five years. For indoor applications, flame-resistant polypropylene has advantages, e.g. a high thermal stability.Examples of suitability tests and applications are discussed.Notes: I. Polybutene-1Beim Eigenschaflsvergleich mit scheinbar ähnlichen Polyolefinen stellt 'sich die Überlegenheit des Polybutens in drei Richtungen heraus:Es zeigt keine Spannungsrisse,kriecht extrem wenig undhat eine günstige Erweichungscharakteristik.Diese Eigenschaften werden aufgrund von Meßwerten interpretiert, daraus ergeben sich beträchtliche Vorteile gegenüber anderen Polyolefinen.Das Thema wird abgerundet durch Beispiele im Apparate- und Rohrleitungsbau.II. Schwerentflammbare PolyolefineDie hier behandelten Typen von Polyäthylen hoher Dichte und Polypropylen sind schwerentflammbar nach DIN 4102 Blatt 3. Hinsichtlich Schwerentflammbarkeit sind sie etwa mit PVC-hart vergleichbar. Sie sind gut verarbeitbar und haben günstige mechanische, thermische und chemische Eigenschaften.Für den Außeneinsatz kann wegen der guten Bewitterungsstabilität schwarzes schwerentflammbares Polyäthylen verwendet werden. Einsatzerfahrungen bestehen über fünf Jahre. Im Inneneinsatz hat schwerentflammbares Polypropylen Vorteile, z. B. gute Temperaturstand-festigkeit.Beispiele für Eignungsprüfung und Einsatz werden erläutert.Additional Material: 10 Ill.Type of Medium: Electronic ResourceURL: