Search Results - (Author, Cooperation:G. B. Mills)

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  1. 1
    Staff View
    Publication Date:
    2013-05-03
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Breast Neoplasms/genetics ; Chromosome Aberrations ; DNA Copy Number Variations/genetics ; DNA Mutational Analysis ; DNA Polymerase II/genetics ; DNA-Binding Proteins/genetics ; Endometrial Neoplasms/*classification/*genetics ; Exome/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Genome, Human/*genetics ; Genomics ; Humans ; Ovarian Neoplasms/genetics ; Signal Transduction ; Transcription Factors/genetics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Peng, G., Mills, G. B.
    The American Association for Cancer Research (AACR)
    Published 2018
    Staff View
    Publication Date:
    2018-02-02
    Publisher:
    The American Association for Cancer Research (AACR)
    Print ISSN:
    1078-0432
    Electronic ISSN:
    1557-3265
    Topics:
    Medicine
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2018-04-04
    Publisher:
    The American Association for Cancer Research (AACR)
    Print ISSN:
    1078-0432
    Electronic ISSN:
    1557-3265
    Topics:
    Medicine
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  4. 4
  5. 5
    Staff View
    Publication Date:
    2018-10-02
    Publisher:
    The American Association for Cancer Research (AACR)
    Print ISSN:
    1078-0432
    Electronic ISSN:
    1557-3265
    Topics:
    Medicine
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Latest Papers from Table of Contents or Articles in Press
  7. 7
    Staff View
    ISSN:
    1573-2592
    Keywords:
    Burns ; immunodeficiency ; T cell activation ; apoptosis
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Thermal injury-associated specific immune deficiency occurs despite indicators of systemic activation of the lymphoid compartment. We investigated the possibility that postburn immune failure and T cell activation are causally related through activation-induced (apoptotic) cell death. The relationship between the cellular immune response and cell mortality was examined in cultures of peripheral blood mononuclear cells (PBMC) from 14 immunosuppressed patients with extensive burns (35–90% total body surface area). Impaired cellular immunity coincided with significantly reduced cell viability as ascertained by propidium iodide staining and dye reduction assays. Following stimulation with the mitogenic lectin, phytohemagglutinin (PHA), the majority of DNA in patient cultures was fragmented, suggesting the occurrence of apoptotic cell death. Even without stimulation a portion of patient cells was apoptotic as indicated by oligonucleosomal bands on agarose gel electrophoresis. Exogenous interleukin-2 or phorbol ester markedly reduced constitutive as well as PHAinduced DNA fragmentation.In situ demonstration of DNA strand breaks in freshly isolated patient PBMC, by a TdT-based labeling technique, confirmed that a larger fraction (up to 60%) of circulating lymphocytes was undergoing apoptosis on the periphery. These novel observations suggest that apoptosis may play a major role in thermal injury-related cellular immunodeficiency.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    1618-2650
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses