Search Results - (Author, Cooperation:G. Anderson)

2018-07-04

American Physical Society (APS)

1098-4402

Physics

Particle-Beam Sources

2014-08-15

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Base Sequence ; *CRISPR-Cas Systems ; Cell Transformation, Neoplastic/genetics ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Female ; *Genes, Tumor Suppressor ; Genes, p53/genetics ; Genetic Engineering/*methods ; Hepatocytes/metabolism/pathology ; Lipid Metabolism ; Liver/cytology/*metabolism/pathology ; Liver Neoplasms/genetics/metabolism/pathology ; Mice ; Molecular Sequence Data ; Mutagenesis/*genetics ; Mutation/*genetics ; Oncogenes/*genetics ; PTEN Phosphohydrolase/genetics ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; beta Catenin/genetics

2018-03-23

Nature Publishing Group (NPG)

2041-1723

Biology

Chemistry and Pharmacology

Natural Sciences in General

Physics

2018-05-25

Nature Publishing Group (NPG)

2041-4889

Biology

Medicine

2018-11-15

American Physical Society (APS)

0556-2821

1089-4918

Physics

Experiments in gravity, cosmology, cosmic rays

2018-12-04

The American Association for Cancer Research (AACR)

1078-0432

1557-3265

Medicine

2011-04-09

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Antigens, CD/*immunology/metabolism ; Antigens, CD28/*immunology ; Antigens, CD80/*immunology/metabolism ; Antigens, CD86/*immunology/metabolism ; CHO Cells ; CTLA-4 Antigen ; Cricetinae ; Cricetulus ; Dendritic Cells/immunology ; *Endocytosis ; Humans ; Jurkat Cells ; Ligands ; Lymphocyte Activation ; Mice ; Mice, Transgenic ; Models, Biological ; Ovalbumin/immunology ; Receptors, Antigen, T-Cell/immunology ; Recombinant Fusion Proteins/metabolism ; T-Lymphocyte Subsets/*immunology/metabolism ; T-Lymphocytes, Regulatory/immunology/metabolism

2013-01-12

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Biomimetics ; Borates/chemistry ; *Electric Power Supplies ; *Electricity ; Ethylene Glycols/chemistry ; Muscle Contraction ; Polymers/*chemistry ; Propylene Glycols/chemistry ; Pyrroles/*chemistry ; *Water

2011-03-12

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Adenosine Triphosphate/metabolism ; Fluorescent Dyes ; Introns ; Kinetics ; Microscopy, Fluorescence ; Protein Binding ; RNA Precursors/*metabolism ; *RNA Splicing ; RNA, Fungal/*metabolism ; Ribonucleoprotein, U1 Small Nuclear/metabolism ; Ribonucleoprotein, U2 Small Nuclear/metabolism ; Ribonucleoprotein, U4-U6 Small Nuclear/metabolism ; Ribonucleoprotein, U5 Small Nuclear/metabolism ; Ribonucleoproteins, Small Nuclear/*metabolism ; Saccharomyces cerevisiae/genetics/*metabolism/ultrastructure ; Saccharomyces cerevisiae Proteins/*metabolism ; Spliceosomes/*metabolism

2012-07-28

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Atmosphere/*chemistry ; Carbon Dioxide/chemistry ; Catalysis ; Chlorine Compounds/chemistry ; *Convection ; Methane/chemistry ; Ozone/*chemistry ; Radiation Dosage ; *Seasons ; *Steam ; *Ultraviolet Rays

2018-05-08

The American Association of Immunologists (AAI)

0022-1767

1550-6606

Medicine

2018-07-10

The American Association of Immunologists (AAI)

0022-1767

1550-6606

Medicine

2018-07-10

The American Association of Immunologists (AAI)

0022-1767

1550-6606

Medicine

2018-12-04

Rockefeller University Press

0022-1007

1540-9538

Medicine

1089-7550

AIP Digital Archive

Physics

This investigation has examined the use of the laminated antiferromagnet PtMn/IrMn to exchange bias spin valves in an attempt to combine the high exchange field and blocking temperature of PtMn with the good pinning profile of IrMn. The effect of varying the IrMn thickness was examined for top and bottom spin values exchange biased by CoFe20Å/IrMn/PtMn. For top spin valves, Hex rapidly decreases as IrMn thickness is increased, with the exchange pinning virtually disappearing by 20 Å. As the thickness continues to increase the pinning reappears, and by 40 Å of IrMn an exchange field of 500 Oe and coercivity of 100 Oe are observed. This exchange field is slightly higher than that observed for CoFe/IrMn40 spin valves (400 Oe as deposited, 470 Oe after annealing). For bottom spin valves the same trends are observed, although the pinning never completely disappears. Also, the exchange field of 600 Oe is lower than that obtained for IrMn (670 Oe), presumably due to the rougher interface of the PtMn underlayer. For both top and bottom spin valves the laminated antiferromagnet showed improvement in thermal stability compared to as deposited and annealed IrMn spin valves. © 2000 American Institute of Physics.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

This investigation focused on how spin-valve thermal stability is related to different antiferromagnetic materials: FeMn, IrMn, NiMn, PtMn, and PtPdMn. Measurements of the spin-valve exchange biasing field versus temperature show the following relationship in blocking temperatures: FeMn〈IrMn〈PtPdMn〈PtMn〈NiMn. Looking at the blocking temperature distributions, both FeMn and IrMn show sharp peaks, but at low temperatures (∼110 °C). In the case of the other materials, the distribution peaks at much higher temperature (〉250 °C), but are broader. Pinned angle rotation and giant magnetoresistance versus temperature measurements give the same thermal stability hierarchy, as well as providing information about interdiffusion in these spin-valves. For comparison, synthetic antiferromagnet spin-valves (based on IrMn and PtMn) were also measured. The synthetic structures did not show significantly different blocking temperatures or giant magnetoresistance temperature dependence than standard spin-valves. However, blocking temperature distribution and pinned layer rotation measurements showed improved stability for the synthetic structures, which may be attributed to the very thin effective pinned layer which results in high exchange biasing fields in these structures. © 2000 American Institute of Physics.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

The exchange bias field (Hex) between a ferromagnetic and antiferromagnetic film has been found to be sensitive to interface roughness, crystalline texture, and grain size. In order to isolate the effects of these three parameters, we deposited Si/UL/CoFe4/IrMn5/Ta5nm (top) and Si/UL/IrMn5/CoFe4/Ta5nm (bottom configuration) exchange coupled multilayers on three underlayers, namely Cu, Ru, and [Cu1/Ru1nm]n with thickness between 5 and 100 nm. With an increase in Cu (fcc) underlayer thickness, roughness and grain size increased rapidly up to 0.9 nm rms and 48 nm, respectively. For the Ru (hcp) underlayer, roughness increased gradually to 0.3 nm while the grain size increased to 30 nm. In case of Cu/Ru (hcp+fcc), the roughness observed is between that of Cu and Ru for comparable thickness. However, the grain size is much smaller compared to Ru and Cu. For both top and bottom exchange coupled films, Hex (200–300 Oe) is observed above a critical underlayer thickness (≥5 nm for Ru and ≥15 nm for Cu and Cu/Ru). In the top configuration, above the critical underlayer thickness, Hex decreases from 295 to 180 Oe with an increase in underlayer (UL) thickness due to the rougher interface. However, Hex did not change with roughness for the bottom case. The difference in Hex dependence on roughness for top and bottom cases can be explained in terms of magnetostatic effects on domain formation in the antiferromagnetic layer. In both cases, above the critical UL thickness, no correlation between Hex and the grain size and texture was found. After annealing at 225 °C for 1 h, high interfacial exchange energy (Jk∼0.22 ergs/cm2) for the top configuration is obtained for films deposited on UL which have large grain size. In the bottom case, a high Jk (∼0.3 ergs/cm2) is obtained for films with good fcc-IrMn(111) texture, corresponding to growth on Cu/Ru underlayers. © 2000 American Institute of Physics.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

Spin-valve (SV) films Si(100)/Ta30/NiFe50/CoFe20/Cu26/CoFe23/Ru7/CoFe20/IrMn50/Ta30 (in Å) exhibit a room temperature (RT) giant magnetoresitance (GMR) ratio of 8.5% with an effective exchange pinning field (Heex) of ∼1.3 kOe and an antiferromagnetic (AF) saturation field (Hs) of ∼6.0 kOe. The synthetic spin valve shows a GMR ratio of 5.0% at 150 °C with Heex〉500 Oe, while a conventional spin valve [Si(100)/Ta50/NiFe50/CoFe20/Cu28/CoFe22/IrMn50/Ta50 in Å] has a GMR ratio of 5.0% with Hex〈200 Oe. The synthetic sample also showed a superior thermal stability with a RT GMR value of 6.9% (compared to 6.1% for conventional sample) after an anneal at 250 °C for 10 h. Shielded narrow track synthetic SV readers demonstrated high amplitude, large dynamic range, and excellent magnetic stability, indicating extendibility for ultrahigh density read head applications. © 1999 American Institute of Physics.

Electronic Resource

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Abstract: The effect of moderate insulin deficiency of 2 weeks in duration on hypothalamic catecholamine metabolism in food-deprived and meal-fed rats was evaluated. Hypothalamic tyrosine content in food-deprived (from 0700 to 1600 h), diabetic rats was normal. Also normal were the rates of 3,4-dihydroxyphenylalanine accumulation following aromatic amino acid decarboxylase inhibition, norepinephrine and 3,4-dihydroxyphenylethylamine (dopamine) clearance after tyrosine hydroxylase inhibition, and intraneuronal amine accumulation following monoamine oxidase inhibition. Differences in hypothalamic amine metabolism were apparent, however, when diabetic and normal rats were fed 2-g meals. The 3-methoxy-4-hydroxyphenylethyleneglycol sulfate accumulation rate was depressed in diabetic rats by the carbohydrate meal but was stimulated by the tyrosine-supplemented protein meal. In contrast, the tyrosine-supplemented diet had no effect on 3, 4-dihydroxyphenylacetic acid accumulation in diabetic animals, whereas the production rate in normal rats was increased. We conclude that normal responses occurring in hypothalamic, catecholamine metabolism after the consumption of a meal are modified by the presence of diabetes.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

Electrodeposited magnetic Ni-Fe films are used in storage devices and are applicable as magnetic sensors. In this work, we demonstrate the electrochemical conditions for deposition of permalloy Ni-Fe nanocrystalline films onto InP(100) surfaces. The prepared Ni-Fe films were analyzed by scanning electron microscopy to determine surface morphology and by Auger electron spectroscopy for compositional depth profiling. Permalloy films with bulk composition of 81% Ni and 18% Fe were obtained by electrodeposition at −1.2 V (versus standard calomel electrode) in a bath of 0.5 M NiSO4, 0.02 M FeSO4, 0.4 M H3BO3, pH=3. Transmission electron microscopy measurements show that these films consist of fcc Ni-Fe nanocrystallites embedded in an amorphous matrix. The films also show good magnetic hysteresis loops, with low coercivity. The magnetic properties of these films are improved by an extended anneal at 100 °C. Interdiffusion occurred between Ni-Fe and the InP substrate after the sample was heated to 300 °C, and consequently a loss of ferromagnetic behavior was observed. © 1995 American Institute of Physics.

Electronic Resource