Search Results - (Author, Cooperation:F. Weise)
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1Latest Papers from Table of Contents or Articles in PressL. F. Gomez ; K. R. Ferguson ; J. P. Cryan ; C. Bacellar ; R. M. Tanyag ; C. Jones ; S. Schorb ; D. Anielski ; A. Belkacem ; C. Bernando ; R. Boll ; J. Bozek ; S. Carron ; G. Chen ; T. Delmas ; L. Englert ; S. W. Epp ; B. Erk ; L. Foucar ; R. Hartmann ; A. Hexemer ; M. Huth ; J. Kwok ; S. R. Leone ; J. H. Ma ; F. R. Maia ; E. Malmerberg ; S. Marchesini ; D. M. Neumark ; B. Poon ; J. Prell ; D. Rolles ; B. Rudek ; A. Rudenko ; M. Seifrid ; K. R. Siefermann ; F. P. Sturm ; M. Swiggers ; J. Ullrich ; F. Weise ; P. Zwart ; C. Bostedt ; O. Gessner ; A. F. Vilesov
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-08-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: DNA binding site ; Site specific recombination ; β Protein (Streptococcus pyogenes)Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0022-2836Keywords: B. subtilis phages ; DNA helicases ; SPPI ; replication genes ; replication initiation mutantsSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1432-1440Keywords: Spectral analysis ; Heart rate variability ; Diabetic subjects ; Diabetic neuropathy ; Orthostatic loadSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Spectral analysis of heart rate variability (HRV) was used to assess the autonomic nervous control of cardiac function during orthostatic load in insulin-dependent diabetic patients and healthy subjects. The diabetic patients were divided into three groups: diabetics without neuropathy (group 1), diabetics with peripheral neuropathy (group 2), and diabetics with peripheral and autonomic neuropathy (group 3). Resting mid-frequency (MF, 0.05–0.15 Hz) and respiration-related (RF, power around respiration rate) HRV were significantly lower in group 2 and 3 diabetics than in controls, indicating a reduced parasympathetic nervous system influence on the heart. Standing MF and RF spectral power data were significantly lower in all diabetic groups than in controls, suggesting marked alterations in the autonomic cardiovascular control during a mild physical load not only in symptomatic diabetics but also in patients with no signs and symptoms of neuropathy. The difference between supine and standing MF power, an estimate ofβ-adrenergic influence on the heart, was significantly lower in all diabetic subject groups studied than in controls. This suggests a reduced sympathetic nervous system influence on the heart in diabetic patients. Our data suggest that computerized spectral analysis of HRV during orthostatic load seems to be a very sensitive method of evaluating of the autonomie nervous systems influence on the heart in patients suffering from diabetes niellitus.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesZiegler, D. ; Weise, F. ; Langen, K.-J. ; Piolot, R. ; Boy, C. ; Hübinger, A. ; Müller-Gärtner, H.-W. ; Gries, F. A.
Springer
Published 1998Staff ViewISSN: 1432-0428Keywords: Keywords Diabetic cardiovascular autonomic neuropathy ; MIBG scintigraphy ; sympathetic denervation ; autonomic function tests ; glycaemic control.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Diabetic cardiovascular autonomic neuropathy (CAN) has been directly characterized by reduced or absent myocardial [123I]metaiodobenzylguanidine (MIBG) uptake, but there is no information available on the relationship between the myocardial adrenergic innervation defects and long-term glycaemic control. In a prospective study over a mean of 4 years we examined myocardial sympathetic innervation in 12 Type 1 (insulin-dependent) diabetic patients using MIBG scintigraphy (absolute and relative global MIBG uptake at 2 h p. i.) in conjunction with cardiovascular autonomic function tests, QTc interval, and QT dispersion. Six healthy non-diabetic subjects served as controls for the MIBG scintigraphy at baseline. HbA1c was measured twice a year. One patient, in whom MIBG accumulation was reduced maximally, died during follow up. Among the remaining patients 5 had good or borderline glycaemic control (mean HbA1c 〈 7.6 %; Group 1), whereas 6 patients were poorly controlled (mean HbA1c L 7.6 %; Group 2). Absolute global MIBG uptake increased from baseline to follow-up by 260 (−190–540) [median (range) ] cpm/g in Group 1 and decreased by −150 (−450–224) cpm/g in Group 2 (p 〈 0.05 vs Group 1). Relative global MIBG uptake decreased by −1.7 (−3.4–9.4) % in Group 1 and by −4.7 (−17.4–1.3) % in Group 2 (p 〈 0.05 vs Group 1). No differences between the groups were noted for the changes in the automatic function tests, QTc interval, and QT dispersion. In conclusion, long-term poor glycaemic control constitutes an essential determinant in the progression of left ventricular adrenergic dysinnervation which may be prevented by near-normoglycaemia. Evaluation of susceptibility to metabolic intervention may be superior when CAN is characterized directly by MIBG scintigraphy rather than by indirect autonomic function testing. [Diabetologia (1998) 41: 443–451]Type of Medium: Electronic ResourceURL: