Search Results - (Author, Cooperation:F. Papousek)
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1Latest Papers from Table of Contents or Articles in PressC. McDermott-Roe ; J. Ye ; R. Ahmed ; X. M. Sun ; A. Serafin ; J. Ware ; L. Bottolo ; P. Muckett ; X. Canas ; J. Zhang ; G. C. Rowe ; R. Buchan ; H. Lu ; A. Braithwaite ; M. Mancini ; D. Hauton ; R. Marti ; E. Garcia-Arumi ; N. Hubner ; H. Jacob ; T. Serikawa ; V. Zidek ; F. Papousek ; F. Kolar ; M. Cardona ; M. Ruiz-Meana ; D. Garcia-Dorado ; J. X. Comella ; L. E. Felkin ; P. J. Barton ; Z. Arany ; M. Pravenec ; E. Petretto ; D. Sanchis ; S. A. Cook
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-10-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Apoptosis ; Body Weight/genetics ; Cardiomegaly/*enzymology/genetics/*pathology/physiopathology ; Cell Respiration ; Chromosomes, Mammalian/genetics ; Crosses, Genetic ; Endodeoxyribonucleases/deficiency/genetics/*metabolism ; Female ; Gene Expression Regulation ; Genes, Mitochondrial/genetics ; Hypertrophy, Left Ventricular/enzymology/genetics/pathology/physiopathology ; Lipid Metabolism ; Male ; Mitochondria/genetics/*metabolism/pathology ; Organ Size/genetics ; Quantitative Trait Loci/genetics ; RNA-Binding Proteins/metabolism ; Rats ; Rats, Inbred Strains ; Reactive Oxygen Species/metabolism ; Receptors, Estrogen/metabolism ; Transcription Factors/metabolismPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1435-1803Keywords: rat heart ; verapamil ; ontogeny ; inotropic effectSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The negative inotropic effect of the calcium antagonist, verapamil, was compared in isolated hearts from 15-, 30-, 45-, 60-, and 90-day-old rats. Electrically paced hearts were perfused in vitro according to Langendorff, either under constant pressure or under constant flow conditions. An intraventricular-pressure curve was measured isovolumetrically and analyzed on-line using a microcomputer. Changes in pressure amplitude and maximum rate of pressure development were evaluated during a stepwise increase of the verapamil concentration in the perfusion solution (10−9–3.3×10−7 mol·l−1). It was found that the sensitivity of cardiac contractile function to verapamil declines gradually in the course of postnatal ontogeny. The higher sensitivity of the developing heart to calcium channel blockade is probably a consequence of a higher functional dependence of the immature myocardium on trans-sarcolemmal calcium influx.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1573-2584Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract In 26 patients with carcinoma of the prostate (CaP) the histochemical and histological characteristics of the tumour were compared with the clinical course in both untreated patients and in those receiving hormonal therapy. In the control group 16 patients with BPH were examined in the same way. It was found that histological types of CaP cannot be identified by grading. Higher frequency of very strong LDH activity in CaP was the only distinction against BPH.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesMitova, M. ; Bednařík, B. ; Černý, E. ; Foukal, T. ; Krátký, J. ; Papoušek, F.
Springer
Published 1983Staff ViewISSN: 1435-1803Keywords: isoproterenol-heart damage ; swimming exercise ; morphometric analysis ; electronmicroscopy ; ratsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The effect of swimming instantly following an injection of isoproterenol was studied in rats in whom the administration of the drug caused changes in the cardiac muscle. The animals were compared with those of a group kept only under normal cage activity after the administration. Oxygen inhalation in the exercised group of rats was higher than in the sedentary group and after 4 minutes of measuring, continually remained at a higher level. It was determined that swimming prevented the early death of the rats. This was more pronounced in the animals of higher body weight. The extent of myocardial damage in the exercised group was markedly smaller. The intensity of enzyme reaction, SDH, LDH and G6PDH, in the area of undamaged tissue was the same in both the exercised and sedentary groups, in areas of damage it was minimal. The intensity of α GP was lowered in the exercised group, but in the sedentary group it was lowered throughout the entire section. Electronoptic examination of the tissue, which under the light microscope appeared normal, revealed no substantial differences between the exercised and sedentary groups. We presume that the better condition of the rats was in part due to the peripheral breakdown of the catecholamine owing to be increased blood flow created by muscular activity.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1435-1803Keywords: Rat heart ; cardiac atrophy ; cardiac hypertrophy ; calcium ; postextrasystolic potentiationSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Atrophy of the rat heart induced by hemodynamic unloading after heterotopic transplantation is associated with impaired relaxation while systolic function remains normal when compared to the heart of the recipient animal. To identify possible underlying mechanisms for the above, we studied some aspects of membrane calcium handling using postextrasystolic potentiation of contractions in the isolated right ventricular papillary muscle and in the left ventricle of the Langendorff-perfused heart. We also compared the alterations of the unloaded heart with those of overloaded hypertrophic hearts of rats with suprarenal aortic constriction. In the atrophic heart the degree of potentiation after one extrasystole, considered to be proportional to the trans-sarcolemmal influx of Ca2+ during an action potential, was increased by 125% when compared with recipient hearts. The rate of decay of potentiation which reflects the fraction of activator Ca2+ recirculating in the cells via the sarcoplasmic reticulum, negatively correlated with the degree of potentiation, although its mean value was not significantly altered. In hypertrophic hearts the decay of potentiation was faster when compared with the hearts of sham-operated animals, indicating a decreased recirculating fraction of Ca2+. The data suggest that the relative importance of trans-sarcolemmal Ca2+ fluxes is increased both in cardiac atrophy and hypertrophy, but their quantitative role in the control of cardiac contraction might differ.Type of Medium: Electronic ResourceURL: