Search Results - (Author, Cooperation:F. Kern)
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1Latest Papers from Table of Contents or Articles in PressAdrian Kolsch, Mahdi Heȷazi, Kai R. Stieger, Sven C. Feifel, Jan F. Kern, Frank Muh, Fred Lisdat, Heiko Lokstein, Athina Zouni
The American Society for Biochemistry and Molecular Biology (ASBMB)
Published 2018Staff ViewPublication Date: 2018-06-09Publisher: The American Society for Biochemistry and Molecular Biology (ASBMB)Print ISSN: 0021-9258Electronic ISSN: 1083-351XTopics: BiologyChemistry and PharmacologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressX. Wang ; Y. Yamamoto ; L. H. Wilson ; T. Zhang ; B. E. Howitt ; M. A. Farrow ; F. Kern ; G. Ning ; Y. Hong ; C. C. Khor ; B. Chevalier ; D. Bertrand ; L. Wu ; N. Nagarajan ; F. A. Sylvester ; J. S. Hyams ; T. Devers ; R. Bronson ; D. B. Lacy ; K. Y. Ho ; C. P. Crum ; F. McKeon ; W. Xian
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-06-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Bacterial Toxins/pharmacology ; Cell Differentiation/drug effects ; Cell Lineage ; Cells, Cultured ; Clone Cells/cytology/metabolism ; Clostridium difficile/physiology ; Colon/cytology/drug effects ; Enterocolitis, Pseudomembranous/microbiology/pathology ; Epigenesis, Genetic/genetics ; Epithelium/drug effects/metabolism ; Fetus/cytology ; Genomic Instability/genetics ; Humans ; Intestine, Small/cytology ; Intestines/*cytology/drug effects ; Organoids/cytology/growth & development ; Stem Cells/*cytology/*metabolismPublished by: -
3Articles: DFG German National LicensesCreutzfeldt, W. ; Andreu-Kern, F. ; Discher, R.
Oxford, UK : Blackwell Publishing Ltd
Published 1959Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0030-5383Topics: Linguistics and Literary StudiesEthnic SciencesHistoryNotes: BesprechungenURL: -
5Articles: DFG German National LicensesDöcke, W.-D. ; Kiessling, C. ; Worm, M. ; Friedrich, M. ; Pruss, A. ; Weitz, M. ; Prösch, S. ; Kern, F. ; Volk, H-D. ; Sterry, W. ; Asadullah, K.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary Background Microbiological infections are considered to be of pathophysiological importance in atopic dermatitis (AD). As yet, no information is available regarding cytomegalovirus (CMV) infection in this disease. This, however, is of interest because of the high prevalence of latent infections in the general population, the frequent reactivation in inflammatory diseases, and the immunomodulating capacity of CMV. Objectives To investigate the prevalence of latent CMV infection, the frequency of active CMV infection, and the immune response to CMV in patients with moderate to severe AD. Methods To detect active infection we analysed CMV antigen expression by peripheral blood mononuclear cells (PBMC) from 27 patients with moderate to severe AD in comparison with 53 healthy volunteers. We used three monoclonal antibodies recognizing different CMV-encoded antigens and immunocytological staining (alkaline phosphatase–antialkaline phosphatase technique). Results Patients with AD had a higher mean frequency of CMV-positive PBMC: 2·25 per 10 000 vs. 0·74 per 10 000 in controls (P = 0·001) as well as a higher incidence of CMV antigenaemia: 29·6% vs. 7·5% (P 〈 0·01). Seropositivity for anti-CMV IgG antibodies indicated subclinical activation of latent infection. Remarkably, a clearance of CMV antigenaemia was observed during anti-eczematous treatment. Significantly higher plasma levels of tumour necrosis factor-α, which is involved in CMV reactivation, and interleukin-12, which is crucial for an antiviral cellular immune response, were observed in AD patients in comparison with healthy volunteers. Furthermore, a significantly enhanced frequency of circulating activated HLA-DR+ T cells especially in CMV-seropositive AD patients (19·3% vs. 13·5% in seronegative AD patients vs. 10·2% in controls) suggested that the active CMV infection triggers a cellular immune response. This was also supported by a high frequency of CMV-specific interferon-γ-producing T cells in CMV-seropositive patients with AD. Conclusions Our data suggest that active, subclinical CMV infection is more frequent in patients with moderate to severe AD and may have immunopathophysiological relevance.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0005-2760Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0005-2760Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0005-2760Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0003-2697Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0022-2011Keywords: (sporozoa)? ; Crassostrea rhizophorae ; Nematopsis ; parasitism ; pathology ; stressSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0039-128XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesBestmann, H.J. ; Attygalle, A.B. ; Garbe, W. ; Kern, F. ; Martichonok, V. ; Schafer, D. ; Vostrowsky, O. ; Hasenfuβ, I.
Amsterdam : ElsevierStaff ViewISSN: 0965-1748Keywords: (Z)-5-dodecenal ; (Z)-5-dodecenoate ; (Z)-5-dodecenol (Z)-5-dodecenyl ; Final steps of biosynthesis ; Gastropacha quercifolia ; Sex pheromoneSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesBecker, S. ; Bollen, G. ; Kern, F. ; Kluge, H.-J. ; Moore, R.B. ; Savard, G. ; Schweikhard, L. ; Stolzenberg, H. ; Isolde Collaboration
Amsterdam : ElsevierStaff ViewISSN: 0168-1176Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0304-8853Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1434-6036Source: Springer Online Journal Archives 1860-2000Topics: PhysicsDescription / Table of Contents: Abstract Detailed cryomagnetic study has been made on two samples of deoxyribonucleic acid (DNA), prepared from calf thymus; one of them was “simple”, the other highly polymerized and of critically high purity. The susceptibility of the system may be represented over the temperature interval 80–300°K by the formula $$\left( {\chi - \chi _0 } \right)T = a\left( {1 - \frac{5}{3}x} \right)$$ whereχ 0 andα are two significant constants, characteristic of the double structure of the DNA molecule,x varying from zero to 1, between two limiting values corresponding respectively to the simple and the highly polymerized state, the most frequent. The parameterx varies spontaneously, often during the same thermomagnetic process. Extrinsic conductivity might be expected from the magnetic behavior of the system, with a number of carriers per unit mass of the order of 1019 — the radicals of the bases serving as the carriers of impurity in the double helix.Abstract: Zusammenfassung Zwei aus der Kalbsthymusdrüse gewonnene Desoxyribonucleinsäure (DNS)-Proben, die eine „einfach”, die andere hochpolymerisiert und sehr rein, sind untersucht worden. Das magnetische Verhalten des Systems läßt sich zwischen 80 und 300°K durch die Beziehung $$\left( {\chi - \chi _0 } \right)T = a\left( {1 - \frac{5}{3}x} \right)$$ wiedergeben, wobeiχ 0 undα zwei für die doppelte Struktur des DNS Moleküls charakteristische Konstanten sind; der Parameterx bewegt sich zwischen den Grenzenx=0 für den einfachen undx=1 für den hochpolymerisierten, am häufigsten vorkommenden Zustand. Im Verlauf einzelnerχ(T)-Messungen wurden sprunghafte Änderungen vonx beobachtet. Das magnetische Verhalten des Systems läßt Störstellen-Leitung erwarten mit einer Ladungsträgerkonzentration von ca. 1019 pro Gramm; als Störstellen dienen die Radikale der Basen.Notes: Résumé Deux échantillons d'acide desoxyribonucléique (ADN) sont étudiés, préparés à partir du thymus de veau, l'un «simple», l'autre hautement polymérisé et très pur. Le comportement magnétique du système est représenté entre 80 et 300°K par la relation $$\left( {\chi - \chi _0 } \right)T = a\left( {1 - \frac{5}{3}x} \right)$$ oùχ 0 etα sont deux constantes significatives, caractéristiques de la double structure de l'ADN, le système évoluant entre l'état simple et l'état hautement polymérisé, le plus fréquent: 0≤x≤1. En fait, le paramètrex varie spontanément, souvent pendant la même transformation thermomagnétique. Cette relation pourrait définir une conductivité d'impureté, les radicaux des bases en liaison avec une chaîne jouant le rôle des impuretés. Il s'agirait alors d'un ensemble macromoléculaire considérablement dopé, le nombre de porteurs par gramme, déduit de la constanteα, étant de l'ordre de 1019.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1432-1440Keywords: Renin-angiotensin system ; Extracellular matrix ; Fibronectin ; Laminin ; TenascinSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary A hallmark of vascular disease is the inappropriate proliferative and synthetic behaviour of vascular smooth muscle cells. This phenotypically immature behaviour arises as a consequence of the myocytes undergoing phenotypic conversion and/or clonal proliferation of a “fetal” type of smooth muscle cell preexisting in the vessel wall. De-differentiation and initiation of proliferation is not only induced by endothelial desquamation and acute exposure of smooth muscle cells to platelet-derived mitogens, but also occurs in the uninjured blood vessel. Therefore normal components of the blood vessel are implicit in the pathological process. These include vasoconstrictor peptides, growth factor peptides and extracellular matrix molecules. In vitro and in vivo experimentation has indicated that while some of these compounds individually are only mild stimulators of smooth muscle proliferative metabolism, they may act synergistically to induce robust responses. Here we discuss the effects of the vasoconstrictor peptide angiotensin II, which can be locally generated within the vessel wall itself, on the expression of extracellular matrix molecules in vitro and in vivo. We focus on the angiotensin II-modulated expression of extracellular matrix glycoproteins, e.g. thrombospondin, tenascin, fibronectin and laminin.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1432-1904Source: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1432-1904Source: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1432-1904Source: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralType of Medium: Electronic ResourceURL: